Cyclocort (amcinonide) dosing, indications, interactions, adverse effects, and more.

Sections

Sections amcinonide
Dosing & Uses
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout
Formulary

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

cream/ointment/lotion

0.1%

Corticosteroid-Responsive Dermatoses

Applied sparingly in a thin film to the affected area q8-12hr

Dosage Forms & Strengths

cream/ointment/lotion

0.1%

Corticosteroid-Responsive Dermatoses

Apply sparingly to affected area(s) q12hr

Limit to minimum amount necessary for therapeutic efficacy

Avoid face

Frequency Not Defined

Skin atrophy

Striae

Burning

Dryness

Irritation

Itching

Hypertrichosis

Acneform lesions

Secondary infection

Pigmentation changes

HPA suppression (with higher potency used >2 wk)

Contraindications

Underlying infection

Hypersensitivity

Use on groin, face, or axila

Ophthalmic use

Cautions

Chronic therapy may interfere with growth and development in children

Use med to very high potency for <2 wk to reduce local and systemic side effects

Use low potency for chronic therapy

Allergic contact dermatitis may occur

Should not use occlusive dressings in presence of infection or weeping lesions

Adrenal suppression may occur in younger patients or patients receiving high doses for prolonged periods

Development of Kaposi's sarcoma with prolonged use reported (discontinue therapy if it occurs)

Avoid medium to very high potency on face, folds, groin because can increase steroid absorption

Use lower potency for peds (ie, increase BSA/kg, therefore increase systemic absorption)

Pregnancy & Lactation

Pregnancy Category: C

Lactation: It is not known whether topical administration of topical corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. Use with caution.

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Pharmacology

Absorption: yes

Potency

High potency

Relative potency: ointment >cream >lotion >solution

Mechanism of Action

Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation

Pharmacokinetics

Metabolism: Liver

Excretion: Urine; feces

Absorption: Absorbed through intact skin; increases absorption with kin oclusion or inflammation

Images

No images available for this drug.

Patient Handout

A Patient Handout is not currently available for this monograph.

Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

Tier	Description
1	This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2	This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC	NOT COVERED – Drugs that are not covered by the plan.

Code	Definition
PA	Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL	Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST	Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR	Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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