Creatine (Herb/Suppl)

Brand and Other Names:amidinosarcosine, creatine citrate, more...creatine monohydrate, creatine phosphate, N-amidinosarcosine
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Suggested Dosing

Exercise Performance Enhancement

Load: 20 g PO qDay x 5 days

Maint: 2-3 g PO qDay


20 g PO daily x 5-10 day

Parkinson's Disease

10 g PO qDay

Gyrate Atrophy

1.5 g PO daily

McArdle Disease

Initial: 150 mg/kg/day x 5 day, THEN

60 mg/kg/day PO

Muscular Dystophies

10 g PO daily

Amyotrophic Lateral Sclerosis (ALS, Lou Gehrig's Disease)

10 g PO qDay x 12-16 months

Idiopathic Inflammatory Myopathies

20 g/day x 8 days, THEN

3 g/day x 6 months

Amyotrophic Lateral Sclerosis (Orphan)

Orphan indication sponsor

  • Avicena Group, Inc; 228 Hamilton Avenue; Palo Alto, CA 94301

Huntington's Disease (Orphan)

Indicated for treatment of mitochondrial cytopathies

Orphan indication sponsor

  • Avicena Group, Inc; 228 Hamilton Avenue; Palo Alto, CA 94301

Suggested Uses

Amyotrophic lateral sclerosis, CHF, exercise performance enhancement, gyrate atrophy, McArdle disease, mitochondrial cytopathies, muscle mass builder, muscular dystrophies, neuromuscular disease, rheumatoid arthritis, Parkinson's disease,


Athletic performance: seems to enhance muscle performance during repeated bouts of brief, high-intensity exercise. Does not seem to improve performance in aerobic exercises, or benefit older individuals OR highly trained athletes

CHF: When taken orally improves exercise tolerance but does not affect the ejection fraction. IV creatinine improves cardiac function, including ejection fraction

Gyrate atrophy: seems to slow visual deterioration

McArdle's disease: Preliminary clinical evidence that it can increase exercise capacity & decrease exercise-induced muscle pain

Parkison's disease: Some evidence shows that it can decrease rate of disease progression in early stages

Idiopathic inflammatory myopathies: more evidence is needed to determine effectiveness

Possibly ineffective for amyotrophic lateral sclerosis, rheumatoid arthritis, & schizophrenia



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            Adverse Effects

            Abdominal pain, arrhythmias, cardiac arrest, cardiomyopathy, dehydration, diarrhea, hypertension, ischemic stroke, muscle cramping, nausea, renal dysfunction, rhabdomyolysis, seizures, weight gain




            Diabetes mellitus, nephrotic syndrome


            Concurrent nephrotoxic agents


            Pregnancy & Lactation

            Pregnancy Category: avoid use

            Lactation: avoid use

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.



            Metabolism: N/A

            Excretion: N/A

            Mechanism of Action

            Phosphocreatine serves as phosphate donor to generate ATP from ADP

            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.