Creatine (Herb/Suppl)

Brand and Other Names:amidinosarcosine, creatine citrate, more...creatine monohydrate, creatine phosphate, N-amidinosarcosine
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Suggested Dosing

Exercise Performance Enhancement

Load: 20 g PO qDay x 5 days

Maint: 2-3 g PO qDay

CHF

20 g PO daily x 5-10 day

Parkinson's Disease

10 g PO qDay

Gyrate Atrophy

1.5 g PO daily

McArdle Disease

Initial: 150 mg/kg/day x 5 day, THEN

60 mg/kg/day PO

Muscular Dystophies

10 g PO daily

Amyotrophic Lateral Sclerosis (ALS, Lou Gehrig's Disease)

10 g PO qDay x 12-16 months

Idiopathic Inflammatory Myopathies

20 g/day x 8 days, THEN

3 g/day x 6 months

Amyotrophic Lateral Sclerosis (Orphan)

Orphan indication sponsor

  • Avicena Group, Inc; 228 Hamilton Avenue; Palo Alto, CA 94301

Huntington's Disease (Orphan)

Indicated for treatment of mitochondrial cytopathies

Orphan indication sponsor

  • Avicena Group, Inc; 228 Hamilton Avenue; Palo Alto, CA 94301
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Suggested Uses

Amyotrophic lateral sclerosis, CHF, exercise performance enhancement, gyrate atrophy, McArdle disease, mitochondrial cytopathies, muscle mass builder, muscular dystrophies, neuromuscular disease, rheumatoid arthritis, Parkinson's disease,

Efficacy

Athletic performance: seems to enhance muscle performance during repeated bouts of brief, high-intensity exercise. Does not seem to improve performance in aerobic exercises, or benefit older individuals OR highly trained athletes

CHF: When taken orally improves exercise tolerance but does not affect the ejection fraction. IV creatinine improves cardiac function, including ejection fraction

Gyrate atrophy: seems to slow visual deterioration

McArdle's disease: Preliminary clinical evidence that it can increase exercise capacity & decrease exercise-induced muscle pain

Parkison's disease: Some evidence shows that it can decrease rate of disease progression in early stages

Idiopathic inflammatory myopathies: more evidence is needed to determine effectiveness

Possibly ineffective for amyotrophic lateral sclerosis, rheumatoid arthritis, & schizophrenia

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Interactions

Interaction Checker

and Creatine

No Results

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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Abdominal pain, arrhythmias, cardiac arrest, cardiomyopathy, dehydration, diarrhea, hypertension, ischemic stroke, muscle cramping, nausea, renal dysfunction, rhabdomyolysis, seizures, weight gain

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            Warnings

            Contraindications

            Diabetes mellitus, nephrotic syndrome

            Cautions

            Concurrent nephrotoxic agents

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            Pregnancy & Lactation

            Pregnancy Category: avoid use

            Lactation: avoid use

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Metabolism: N/A

            Excretion: N/A

            Mechanism of Action

            Phosphocreatine serves as phosphate donor to generate ATP from ADP

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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.