amoxicillin (Rx)

Brand and Other Names:Amoxil, Moxatag (DSC), more...Trimox
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

oral solution

  • 125mg/5mL
  • 200mg/5mL
  • 250mg/5mL
  • 400mg/5mL

capsule

  • 250mg
  • 500mg

tablet

  • 500mg
  • 875mg

tablet, chewable

  • 125mg
  • 250mg

Ear, Nose, & Throat Infections

Mild to moderate infections

  • 500 mg PO q12hr or 250 mg PO q8hr for 10-14 days

Severe infections

  • 875 mg PO q12hr or 500 mg PO q8hr for 10-14 days

Genitourinary Tract Infections

Mild to moderate infections

  • 500 mg PO q12hr or 250 mg PO q8hr

Severe infections

  • 875 mg PO q12hr or 500 mg PO q8hr

Spectrum of action

  • E coli, P mirabilis, or E faecalis

Skin & Skin Structure Infections

Mild to moderate infections

  • 500 mg PO q12hr or 250 mg PO q8hr

Severe infections

  • 875 mg PO q12hr or 500 mg PO q8hr

Lower Respiratory Tract Infections

875 mg PO q12hr or 500 mg PO q8hr for 10-14 days

Helicobacter Pylori

H pylori infection and active or 1-year history of duodenal ulcer

Triple therapy

  • 1 g PO q12hr for 14 days with lansoprazole (30 mg) and clarithromycin (500 mg)

Dual therapy

  • 1 g PO q8hr for 14 days with lansoprazole (30 mg) in patients intolerant of, or resistant to, clarithromycin

Anthrax

Postexposure inhalational prophylaxis

500 mg PO q8hr

Infective Endocarditis

Prophylaxis

2 g PO 30-60 min before procedure

Lyme Disease (Off-label)

Erythema migrans and other symptoms of early dissemination

500 mg PO q8hr (depending on size of patient) for 3-4week

50 mg/kg/day q8hr in divided doses; maximum 500 mg/dose  

Chlamydial Infection in Pregnant Women (Off-label)

First trimester: 500 mg PO q8hr for 7 days

Dosage Modifications

Renal impairment

  • Mild-to moderate (CrCl ≥30 mL/min): No dosage adjustment necessary
  • Severe (CrCl 10-30 mL/min): 250-500 mg q12hr, depending on severity of infection; should not receive 875 mg
  • Severe (CrCl <10 mL/min) or patients on hemodialysis: 250-500 mg q24hr, depending on severity of infection; patients on hemodialysis should receive an additional dose both during and at the end of dialysis

Dosing considerations

First trimester: Test to document chlamydial eradication and retest for infection 3 months after treatment

Second or third trimester: Test to document chlamydial eradication

AHA guidelines recommend prophylaxis only in high-risk patients undergoing invasive procedures who have a history of cardiac conditions that predispose them to a risk of infection

Limitation of Use

  • For use when susceptibility test results show susceptibility to amoxicillin, indicating no beta-lactamase production

Dosage Forms & Strengths

oral solution

  • 125mg/5mL
  • 200mg/5mL
  • 250mg/5mL
  • 400mg/5mL

capsule

  • 250mg
  • 500mg

tablet

  • 500mg
  • 875mg

tablet, chewable

  • 125mg
  • 250mg

Ear, Nose, & Throat Infections

Mild to moderate infections

  • <3 months: ≤30 mg/kg/day PO divided q12hr for 48-72 hours; for ≥10 days for S pyogenes infections
  • >3 months and <40 kg: 25 mg/kg/day PO divided q12hr or 20 mg/kg/day PO divided q8hr  
  • >40 kg: 500 mg PO q12hr or 250 mg PO q8hr for 10-14 days

Severe infections

  • <3 months: ≤30 mg/kg/day PO divided q12hr for 48-72 hours; for ≥10 days for S pyogenes infections
  • >3 months and <40 kg: 45 mg/kg/day PO divided q12hr or 40 mg/kg/day PO divided q8hr  
  • >40 kg: 875 mg PO q12hr or 500 mg PO q8hr for 10-14 days

Acute Otitis Media

>3 months and <40kg: 80-90 mg/kg/day PO divided q8-12hr  

>40 kg: 500 mg PO q12hr or 250 mg PO q8hr for 10-14 days

Lower Respiratory Tract Infections

Mild, moderate, or severe infections

  • <3 months: ≤30 mg/kg/day PO divided q12hr for 48-72 hours; for ≥10 days for S pyogenes infections  
  • >3 months and <40 kg: 45 mg/kg/day PO divided q12hr or 40 mg/kg/day PO divided q8hr
  • >40kg: 875 mg PO q12hr or 500 mg PO q8hr for 10-14 days

Pneumonia, community-acquired (Off-label)

  • <3 months: Safety and efficacy not established
  • ≥3 months:
  • Immediate release
    • Empiric treatment: 90 mg/kg/day PO divided q12 hr for 10 days; not to exceed 4,000 mg/day
    • Group A Streptococcus: 50-75 mg/kg/day PO divided q12hr for 10 days; not to exceed 4,000 mg/day
    • H. influenza: 75-100 mg/kg/day PO divided q8hr for 10 days; not to exceed 4,000 mg/day
    • S. pneumoniae (mild infection or step-down therapy or when MICs to penicillin ≤2.0 mcg/mL): 90 mg/kg/day PO divided q12hr or 45 mg/kg/day divided q8hr for 10 days; not to exceed 4,000 mg/day

Anthrax (Off-label)

<40 kg: 15 mg/kg PO q8hr (minimum recommended dose; should not be <45 mg/kg/day or >q8hr  

>40 kg: 500 mg PO q8hr

80 mg/kg/day PO divided q8hr for 4 weeks (with concomitant vaccine) or for 60 days (without vaccine)

Infective Endocarditis (Off-label)

Prophylaxis

50 mg/kg PO 30-60 min before procedure  

Dosing considerations

  • AHA guidelines recommend prophylaxis only in high-risk patients undergoing invasive procedures with history of cardiac conditions that predispose them to infection

Lyme Disease (Off-label)

Erythema migrans and other symptoms of early dissemination

<3 months: Safety and efficacy not established

>3 months and 40 kg: 25-50 mg/kg/day divided q8hr; not to exceed 500 mg  

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Interactions

Interaction Checker

and amoxicillin

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (13)

              • BCG vaccine live

                amoxicillin decreases effects of BCG vaccine live by pharmacodynamic antagonism. Contraindicated. Wait until Abx Tx complete to administer live bacterial vaccine.

              • cholera vaccine

                amoxicillin, cholera vaccine. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Avoid coadministration of cholera vaccine with systemic antibiotics since these agents may be active against the vaccine strain. Do not administer cholera vaccine to patients who have received oral or parenteral antibiotics within 14 days prior to vaccination.

              • demeclocycline

                demeclocycline decreases effects of amoxicillin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Tetracyclines may interfere with the bactericidal action of penicillins. Monitor for decreased therapeutic effects of penicillins if concomitantly used with a tetracycline.

              • doxycycline

                doxycycline decreases effects of amoxicillin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Tetracyclines may interfere with the bactericidal action of penicillins. Monitor for decreased therapeutic effects of penicillins if concomitantly used with a tetracycline.

              • eravacycline

                eravacycline decreases effects of amoxicillin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Tetracyclines may interfere with the bactericidal action of penicillins. Monitor for decreased therapeutic effects of penicillins if concomitantly used with a tetracycline.

              • minocycline

                minocycline decreases effects of amoxicillin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Tetracyclines may interfere with the bactericidal action of penicillins. Monitor for decreased therapeutic effects of penicillins if concomitantly used with a tetracycline.

              • mycophenolate

                amoxicillin will decrease the level or effect of mycophenolate by Other (see comment). Avoid or Use Alternate Drug. Effect may be due to impairment of enterohepatic recirculation

              • omadacycline

                omadacycline decreases effects of amoxicillin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Tetracyclines may interfere with the bactericidal action of penicillins. Monitor for decreased therapeutic effects of penicillins if concomitantly used with a tetracycline.

              • pexidartinib

                amoxicillin and pexidartinib both increase Other (see comment). Avoid or Use Alternate Drug. Pexidartinib can cause hepatotoxicity. Avoid coadministration of pexidartinib with other products know to cause hepatoxicity.

              • pretomanid

                amoxicillin, pretomanid. Either increases toxicity of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Pretomanid regimen associated with hepatotoxicity. Avoid alcohol and hepatotoxic agents, including herbal supplements and drugs other than bedaquiline and linezolid.

              • sarecycline

                sarecycline decreases effects of amoxicillin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Tetracyclines may interfere with the bactericidal action of penicillins. Monitor for decreased therapeutic effects of penicillins if concomitantly used with a tetracycline.

              • tetracycline

                tetracycline decreases effects of amoxicillin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Tetracyclines may interfere with the bactericidal action of penicillins. Monitor for decreased therapeutic effects of penicillins if concomitantly used with a tetracycline.

              • typhoid vaccine live

                amoxicillin decreases effects of typhoid vaccine live by pharmacodynamic antagonism. Contraindicated. Wait until Abx Tx complete to administer live bacterial vaccine.

              Monitor Closely (27)

              • acyclovir

                amoxicillin, acyclovir. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              • allopurinol

                allopurinol decreases toxicity of amoxicillin by Other (see comment). Use Caution/Monitor. Comment: Allopurinol may increase potential for allergic or hypersensitivity reactions to amoxicillin.

              • aspirin

                amoxicillin, aspirin. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

                amoxicillin, aspirin. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              • aspirin rectal

                amoxicillin, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

                amoxicillin, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

              • aspirin/citric acid/sodium bicarbonate

                amoxicillin, aspirin/citric acid/sodium bicarbonate. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

                amoxicillin, aspirin/citric acid/sodium bicarbonate. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

              • bazedoxifene/conjugated estrogens

                amoxicillin will decrease the level or effect of bazedoxifene/conjugated estrogens by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor.

              • bendroflumethiazide

                amoxicillin, bendroflumethiazide. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              • chlorothiazide

                amoxicillin, chlorothiazide. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              • choline magnesium trisalicylate

                amoxicillin, choline magnesium trisalicylate. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

                amoxicillin, choline magnesium trisalicylate. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

              • cyclopenthiazide

                amoxicillin, cyclopenthiazide. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              • dienogest/estradiol valerate

                amoxicillin will decrease the level or effect of dienogest/estradiol valerate by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor. An alternate or additional form of birth control may be advisable during concomitant use.

              • estradiol

                amoxicillin will decrease the level or effect of estradiol by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor.

              • ethinylestradiol

                amoxicillin will decrease the level or effect of ethinylestradiol by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor. Antibiotics may decrease hormonal contraceptive efficacy.

              • hydrochlorothiazide

                amoxicillin, hydrochlorothiazide. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              • levonorgestrel oral/ethinylestradiol/ferrous bisglycinate

                amoxicillin will decrease the level or effect of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor. Antibiotics may decrease hormonal contraceptive efficacy.

              • mestranol

                amoxicillin will decrease the level or effect of mestranol by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor.

              • methotrexate

                amoxicillin increases levels of methotrexate by decreasing renal clearance. Use Caution/Monitor. Increased serum concentrations of methotrexate with concomitant hematologic and gastrointestinal toxicity have been observed with concurrent administration of high or low doses of methotrexate and penicillins.

              • methyclothiazide

                amoxicillin, methyclothiazide. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              • metolazone

                amoxicillin, metolazone. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              • rose hips

                amoxicillin, rose hips. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              • salicylates (non-asa)

                amoxicillin, salicylates (non-asa). Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

              • salsalate

                amoxicillin, salsalate. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

              • sodium phenylacetate

                amoxicillin, sodium phenylacetate. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              • sodium picosulfate/magnesium oxide/anhydrous citric acid

                amoxicillin decreases effects of sodium picosulfate/magnesium oxide/anhydrous citric acid by altering metabolism. Use Caution/Monitor. Coadministration with antibiotics decreases efficacy by altering colonic bacterial flora needed to convert sodium picosulfate to active drug.

              • sulfasalazine

                amoxicillin, sulfasalazine. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

                amoxicillin, sulfasalazine. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              • warfarin

                amoxicillin increases effects of warfarin by Other (see comment). Use Caution/Monitor. Comment: Amoxicillin may enhance anticoagulant effect of vitamin K antagonists.

              • willow bark

                amoxicillin, willow bark. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              Minor (10)

              • amiloride

                amiloride decreases levels of amoxicillin by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown. Administer each drug at least 2 hours apart from each other; monitor for reduced antibiotic efficacy.

              • azithromycin

                azithromycin decreases effects of amoxicillin by pharmacodynamic antagonism. Minor/Significance Unknown.

              • aztreonam

                aztreonam, amoxicillin. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Combination may be used synergistically against Enterobacteriaceae.

              • chloramphenicol

                chloramphenicol decreases effects of amoxicillin by pharmacodynamic antagonism. Minor/Significance Unknown.

              • clarithromycin

                clarithromycin decreases effects of amoxicillin by pharmacodynamic antagonism. Minor/Significance Unknown.

              • erythromycin base

                erythromycin base decreases effects of amoxicillin by pharmacodynamic antagonism. Minor/Significance Unknown.

              • erythromycin ethylsuccinate

                erythromycin ethylsuccinate decreases effects of amoxicillin by pharmacodynamic antagonism. Minor/Significance Unknown.

              • erythromycin lactobionate

                erythromycin lactobionate decreases effects of amoxicillin by pharmacodynamic antagonism. Minor/Significance Unknown.

              • erythromycin stearate

                erythromycin stearate decreases effects of amoxicillin by pharmacodynamic antagonism. Minor/Significance Unknown.

              • pyridoxine (Antidote)

                amoxicillin will decrease the level or effect of pyridoxine (Antidote) by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

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              Adverse Effects

              Frequency Not Defined

              Anaphylaxis

              Anemia

              AST/ALT elevation

              Mucocutaneous candidiasis

              Diarrhea

              Headache

              Nausea

              Vomiting

              Rash

              Pseudomembranous colitis

              Serum sickness-like reactions

              Postmarketing Reports

              Mucocutaneous candidiasis

              Gastrointestinal (eg, black hairy tongue and hemorrhagic/pseudomembranous colitis, which may occur during or after treatment)

              Hypersensitivity reactions (eg, anaphylaxis, serum sickness–like reactions, erythematous maculopapular rashes, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, hypersensitivity vasculitis, urticaria)

              Moderate increase in AST and/or ALT; hepatic dysfunction (eg, cholestatic jaundice, hepatic cholestasis and acute cytolytic hepatitis have been reported)

              Renal (eg, crystalluria)

              Anemia (eg, hemolytic anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia, agranulocytosis)

              CNS reactions (eg, reversible hyperactivity, agitation, anxiety, insomnia, confusion, convulsions, behavioral changes, dizziness)

              Tooth discoloration (brown, yellow, or gray staining); may be reduced or eliminated with brushing or dental cleaning

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              Warnings

              Contraindications

              Documented hypersensitivity to penicillins, cephalosporins, imipenem

              Cautions

              Anaphylaxis has been reported rarely but is more likely to occur following parenteral therapy with penicillins

              Clostridium difficile-associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents; severity may range from mild diarrhea to fatal colitis; CDAD may occur over 2 months after discontinuation of therapy; if CDAD is suspected or confirmed, discontinue immediately and begin appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C difficile, and surgical evaluation

              Do not administer in patients with infectious mononucleosis because of risk of development of erythematous skin rash

              Do not administer to patients in the absence of a proven or suspected bacterial infection because of risk of development of drug-resistant bacteria

              Superinfections with bacterial or fungal pathogens may occur during therapy; if suspected, discontinue immediately and begin appropriate treatment

              Chewable tablets contain aspartame, which contains phenylalanine

              Use caution in patients with allergy to cephalosporins, carbapenems

              Endocarditis prophylaxis: use for only high-risk patients, as per recent AHA guidelines

              High doses may cause false urine glucose test by some methods

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              Pregnancy & Lactation

              Pregnancy

              Available data from published epidemiologic studies and pharmacovigilance case reports over several decades with amoxicillin use have not established drug-associated risks of major birth defects, miscarriage, or adverse maternal or fetal outcomes

              Animal data

              • No adverse developmental effects were observed in animal reproduction studies with administration of amoxicillin to pregnant mice and rats at doses up to 12.5 and 25 times the recommended human dose

              Lactation

              Data from a published clinical lactation study reports that amoxicillin is present in human milk; published adverse effects with amoxicillin exposure in breastfed infant include diarrhea

              There are no data on effects of amoxicillin on milk production; the developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for therapy and any potential adverse effects on breast-fed child from drug or from underlying maternal condition

              Pregnancy Categories

              A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

              B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

              C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

              D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

              X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

              NA: Information not available.

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              Pharmacology

              Mechanism of Action

              Derivative of ampicillin and has similar antibacterial spectrum (certain gram-positive and gram-negative organisms); similar bactericidal action as penicillin; acts on susceptible bacteria during multiplication stage by inhibiting cell wall mucopeptide biosynthesis; superior bioavailability and stability to gastric acid and has broader spectrum of activity than penicillin; less active than penicillin against Streptococcus pneumococcus; penicillin-resistant strains also resistant to amoxicillin, but higher doses may be effective; more effective against gram-negative organisms (eg, N meningitidis, H influenzae) than penicillin

              Absorption

              Rapidly absorbed

              Bioavailability: 74-92%

              Peak plasma time: 2hr (capsule); 3.1 hr (extended release tab); 1 hr (suspension)

              Distribution

              Most body fluids and bone, CSF <1%

              Protein bound: 17-20%

              Metabolism

              Hepatic

              Elimination

              Excretion: Urine

              Half-life: 3.7 hr (full-term neonates); 1-2 hr (infants and children); 0.7-1.4 hr (adults)

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              Administration

              Oral Suspension Preparation

              Tap bottle until all powder flows freely

              Add ~1/3 of the total amount of water for reconstitution and shake vigorously to wet powder; add remaining water and again shake vigorously

              Amount of water for mixing oral suspension

              • Oral Suspension (125 mg /5 mL): Reconstitute with 66 mL (80-mL bottle), 83 mL (100-mL bottle), or 125 mL (150-mL bottle)
              • Oral Suspension (200 mg /5 mL): Reconstitute with 39 mL (50-mL bottle), 59 mL (75-mL bottle), or 78 mL (100-mL bottle)
              • Oral Suspension (250 mg /5 mL): Reconstitute with 59 mL (80-mL bottle), 73 mL (100-mL bottle), or 110 mL (150-mL bottle)
              • Oral Suspension (400 mg /5 mL): Reconstitute with 34 mL (50-mL bottle), 51 mL (75-mL bottle), or 68 mL (100-mL bottle)

              May also add the required amount of suspension to formula, milk, fruit juice, water, ginger ale, or cold drinks; these preparations must be used immediately

              Oral Administration

              Tablets: Take without regard to meals

              Suspension: Shake well before use; may be mixed with formula, milk, fruit juice, water, ginger ale, or cold drinks; administer dose immediately after mixing

              Storage

              Tablets: Store at 20-25°C (68-77°F)

              Prepared oral suspension: Refrigeration preferred; once reconstituted, discard 14 days

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              Images

              BRAND FORM. UNIT PRICE PILL IMAGE
              Moxatag oral
              -
              775 mg tablet
              amoxicillin oral
              -
              500 mg capsule
              amoxicillin oral
              -
              250 mg capsule
              amoxicillin oral
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              875 mg tablet
              amoxicillin oral
              -
              200 mg/5 mL suspension
              amoxicillin oral
              -
              200 mg/5 mL suspension
              amoxicillin oral
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              amoxicillin oral
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              amoxicillin oral
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              amoxicillin oral
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              amoxicillin oral
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              250 mg/5 mL suspension
              amoxicillin oral
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              400 mg/5 mL suspension
              amoxicillin oral
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              125 mg/5 mL suspension
              amoxicillin oral
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              125 mg/5 mL suspension
              amoxicillin oral
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              250 mg/5 mL suspension
              amoxicillin oral
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              500 mg capsule
              amoxicillin oral
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              200 mg/5 mL suspension
              amoxicillin oral
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              875 mg tablet
              amoxicillin oral
              -
              400 mg/5 mL suspension
              amoxicillin oral
              -
              250 mg capsule
              amoxicillin oral
              -
              500 mg capsule
              amoxicillin oral
              -
              400 mg/5 mL suspension
              amoxicillin oral
              -
              875 mg tablet
              amoxicillin oral
              -
              400 mg/5 mL suspension
              amoxicillin oral
              -
              250 mg/5 mL suspension
              amoxicillin oral
              -
              400 mg/5 mL suspension
              amoxicillin oral
              -
              400 mg/5 mL suspension
              amoxicillin oral
              -
              875 mg tablet
              amoxicillin oral
              -
              500 mg tablet
              amoxicillin oral
              -
              250 mg/5 mL suspension
              amoxicillin oral
              -
              250 mg capsule
              amoxicillin oral
              -
              250 mg capsule
              amoxicillin oral
              -
              875 mg tablet
              amoxicillin oral
              -
              125 mg/5 mL suspension
              amoxicillin oral
              -
              400 mg/5 mL suspension
              amoxicillin oral
              -
              400 mg/5 mL suspension
              amoxicillin oral
              -
              500 mg tablet
              amoxicillin oral
              -
              400 mg/5 mL suspension
              amoxicillin oral
              -
              500 mg capsule
              amoxicillin oral
              -
              500 mg capsule
              amoxicillin oral
              -
              250 mg capsule
              amoxicillin oral
              -
              250 mg capsule
              amoxicillin oral
              -
              200 mg/5 mL suspension
              amoxicillin oral
              -
              250 mg chewable tablet
              amoxicillin oral
              -
              200 mg/5 mL suspension
              amoxicillin oral
              -
              400 mg/5 mL suspension
              amoxicillin oral
              -
              400 mg/5 mL suspension
              amoxicillin oral
              -
              400 mg/5 mL suspension
              amoxicillin oral
              -
              200 mg/5 mL suspension
              amoxicillin oral
              -
              200 mg/5 mL suspension
              amoxicillin oral
              -
              200 mg/5 mL suspension
              amoxicillin oral
              -
              250 mg/5 mL suspension
              amoxicillin oral
              -
              500 mg capsule
              amoxicillin oral
              -
              500 mg tablet
              amoxicillin oral
              -
              250 mg capsule
              amoxicillin oral
              -
              250 mg capsule
              amoxicillin oral
              -
              500 mg capsule
              amoxicillin oral
              -
              875 mg tablet
              amoxicillin oral
              -
              200 mg/5 mL suspension
              amoxicillin oral
              -
              200 mg/5 mL suspension
              amoxicillin oral
              -
              125 mg/5 mL suspension
              amoxicillin oral
              -
              250 mg/5 mL suspension
              amoxicillin oral
              -
              250 mg/5 mL suspension
              amoxicillin oral
              -
              400 mg/5 mL suspension
              amoxicillin oral
              -
              125 mg/5 mL suspension
              amoxicillin oral
              -
              125 mg/5 mL suspension
              amoxicillin oral
              -
              125 mg/5 mL suspension
              amoxicillin oral
              -
              400 mg/5 mL suspension
              amoxicillin oral
              -
              125 mg/5 mL suspension
              amoxicillin oral
              -
              125 mg/5 mL suspension
              amoxicillin oral
              -
              400 mg/5 mL suspension
              amoxicillin oral
              -
              200 mg/5 mL suspension
              amoxicillin oral
              -
              125 mg chewable tablet
              amoxicillin oral
              -
              200 mg/5 mL suspension
              amoxicillin oral
              -
              500 mg tablet
              amoxicillin oral
              -
              250 mg/5 mL suspension
              amoxicillin oral
              -
              250 mg/5 mL suspension
              amoxicillin oral
              -
              250 mg/5 mL suspension

              Copyright © 2010 First DataBank, Inc.

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              Patient Handout

              Patient Education
              amoxicillin oral

              AMOXICILLIN CHEWABLE TABLET - ORAL

              (a-MOX-i-SIL-in)

              COMMON BRAND NAME(S): Amoxil

              USES: Amoxicillin is used to treat a wide variety of bacterial infections. This medication is a penicillin-type antibiotic. It works by stopping the growth of bacteria.This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.Amoxicillin is also used with other medications to treat stomach/intestinal ulcers caused by the bacteria H. pylori and to prevent the ulcers from returning.

              HOW TO USE: Chew the tablets thoroughly and swallow, followed by a full glass of water (8 ounces or 240 milliliters). Take this medication with or without food as directed by your doctor, usually every 8 or 12 hours. The dosage is based on your medical condition and response to treatment.Drink plenty of fluids while using this medication unless your doctor tells you otherwise.For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection.Tell your doctor if your condition persists or worsens.

              SIDE EFFECTS: Nausea, vomiting, or diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.This medicine may cause temporary staining of the teeth. Proper brushing will usually remove any stains and may prevent them from occurring.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection (oral or vaginal fungal infection). Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge or other new symptoms.Tell your doctor right away if any of these rare but serious side effects occur: dark urine, persistent nausea or vomiting, stomach/abdominal pain, yellowing eyes or skin, easy bruising or bleeding, persistent sore throat or fever.This medication may rarely cause a severe intestinal condition due to a bacteria called C. difficile. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: diarrhea that doesn't stop, abdominal or stomach pain/cramping, blood/mucus in your stool.If you have these symptoms, do not use anti-diarrhea or opioid products because they may make symptoms worse.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.Amoxicillin can commonly cause a mild rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe allergic reaction. Get medical help right away if you develop any rash.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

              PRECAUTIONS: Before taking amoxicillin, tell your doctor or pharmacist if you are allergic to it; or to penicillin or cephalosporin antibiotics; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, a certain type of viral infection (infectious mononucleosis).This medication may contain aspartame. If you have phenylketonuria (PKU) or any other condition that requires you to limit/avoid aspartame (or phenylalanine) in your diet, ask your doctor or pharmacist about using this medication safely.Amoxicillin may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.Amoxicillin passes into breast milk. Consult your doctor before breast-feeding.

              DRUG INTERACTIONS: The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.A product that may interact with this drug is: methotrexate.Amoxicillin may cause false positive results with certain diabetic urine testing products (cupric sulfate-type). This drug may also affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use this drug.This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.

              OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe vomiting, persistent diarrhea, a severe decrease in the amount of urine, or seizures.

              NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.With prolonged treatment, laboratory and/or medical tests (such as kidney and liver function, complete blood counts) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

              MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

              STORAGE: Store at room temperature according to the product labeling, away from light and moisture. Different brands of this medication have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

              Information last revised August 2021. Copyright(c) 2021 First Databank, Inc.

              IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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              Formulary

              FormularyPatient Discounts

              Adding plans allows you to compare formulary status to other drugs in the same class.

              To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

              Adding plans allows you to:

              • View the formulary and any restrictions for each plan.
              • Manage and view all your plans together – even plans in different states.
              • Compare formulary status to other drugs in the same class.
              • Access your plan list on any device – mobile or desktop.

              The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

              Tier Description
              1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
              2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
              3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
              4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              NC NOT COVERED – Drugs that are not covered by the plan.
              Code Definition
              PA Prior Authorization
              Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
              QL Quantity Limits
              Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
              ST Step Therapy
              Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
              OR Other Restrictions
              Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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              Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.