ampicillin (Rx)

Brand and Other Names:Ampi, Omnipen, more...Penglobe, Principen
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsules

  • 250mg
  • 500mg

oral suspension

  • 125mg/5mL
  • 250mg/5mL

powder for injection

  • 125mg
  • 250mg
  • 500mg
  • 1g
  • 2g
  • 10g

General Dosing Guidelines

PO: 250-500 mg q6hr

IV/IM: 1-2 g q4-6hr or 50-250 mg/kg/day divided q4-6hr; not to exceed 12 g/day  

Endocarditis Prophylaxis (Off-label)

Dental, oral, or respiratory tract procedures

  • 2 g or 50 mg/kg IV/IM within 30-60 minutes before procedure in patients not allergic to penicillin and unable to take oral amoxicillin

Genitourinary and gastrointestinal tract procedures

  • Routine prophylaxis for GI/GU procedures no longer recommended by AHA; consider only patients with highest risk of adverse outcome from endocarditis (eg, prosthetic heart valve, previous endocarditis, some categories of congenital heart disease, cardiac valvulopathy in cardiac transplant patients) with established GI or GU enterococcal infection or for those already receiving antibiotic therapy to prevent a wound infection or sepsis associated with GI or GU procedure in which enterococcal coverage is desired
  • High-risk patients: 2 g IV/IM within 30 min prior to procedure, followed by ampicillin 1 g (or amoxicillin 1 g orally) 6 hr later, must be used in combination with gentamicin
  • Moderate-risk patients: 2 g IV/IM within 30 min prior to procedure

Endocarditis (Off-label)

Listeria endocarditis: 200 mg/kg/day IV divided q6hr; administer concomitantly with aminoglycoside for at least 4-6 wk

Genitourinary Tract Infections (Excluding Gonorrhea)

<40 kg: 50 mg/kg/day IV/IM divided q6-8hr

≥40 kg: 500 mg PO/IV/IM q6hr

Gastrointestinal Tract Infections

<40 kg: 50 mg/kg/day IV/IM divided q6-8hr

≥40 kg: 500 mg IV/IM q6hr; larger doses may be necessary in severe or chronic infection

Urinary Tract Infection (ampicillin-susceptible Enterococcus; Off-label)

1-2 g IV q4-6hr with or without an aminoglycoside

Gonorrhea

3.5 g IV administered once simultaneously with 1 g of probenecid

Respiratory Tract Infections

≥40 kg

  • 250 mg PO q6hr
  • 250-500 mg IV/IM q6hr

<40 kg

  • 25 to 50 mg/kg/day IV or IM divided q6-8hr

Bacterial Meningitis/Septicemia

150-200 mg/kg/day IV divided q6-8hr; initiate with IV infusion; may continue with IM injections if preferred; range 6-12 g/day  

Group B Streptococcus (Off-label)

Maternal dose for neonatal prophylaxis

2 g IV initially, followed by 1 g q4hr until delivery

Listeria Infection (Off-label)

2 g IV q4hr

Administration

Take oral dosage form on empty stomach

Dosing Modifications

Renal impairment

  • CrCl <10 mL/min: Administer q12-24hr
  • CrCl 10-50 mL/min: Administer q6-12hr
  • CrCl >50 mL/min: Administer q6hr

Hepatic impairment

  • Not studied

Dosage Forms & Strengths

capsules

  • 250mg
  • 500mg

oral suspension

  • 125mg/5mL
  • 250mg/5mL

powder for injection

  • 125mg
  • 250mg
  • 500mg
  • 1g
  • 2g

General Dosing Guidelines

25-200 mg/kg/day IV/IM divided q6-8hr; not to exceed 12 g/day  

50-100 mg/kg/day PO divided q6hr; not to exceed 2-4 g/day

Severe infection: 200-400 mg/kg/day IV/IM divided q6hr

Potential toxic dose <6 years: 300 mg/kg

Neonates (<28 Days)

<7 days

  • <2 kg: 50-100 mg/kg/day IV/IM divided q12hr  
  • >2 kg: 75-150 mg/kg/day IV/IM divided q8hr

>7 days

  • <1.2 kg: 50-100 mg/kg/day IV/IM divided q12hr
  • 1.2-2 kg: 75-150 mg/kg/day IV/IM divided q8hr
  • >2 kg: 100-200 mg/kg/day IV/IM divided q6hr

Endocarditis Prophylaxis (Off-label)

50 mg/kg IV/IM (+/- gentamicin 1.5 mg/kg for GI/GU) within 30-60 minutes before procedure  

Dosing considerations

  • AHA Guidelines recommend only for high risk patients

Endocarditis Treatment

300 mg/kg/day IV divided q4-6hr in combination with other antibiotics; not to exceed 12 g/day

Genitourinary Tract Infections

<40 kg: 50-100 mg/kg/day IV/IM divided q6hr  

≥40 kg: 500 mg IV/IM q6hr

Gastrointestinal Tract Infections

<20 kg: 50-100 mg/kg/day PO divided q6hr  

>20 kg: 500 mg PO q6hr

<40 kg: 50 mg/kg/day IV/IM divided q6-8hr

>40 kg: 500 mg IV/IM q6hr

Gonorrhea

<20 kg: Safety and efficacy not established

>20 kg: 3.5 g PO administered once simultaneously with 1 g of probenecid

Respiratory Tract Infections

<20 kg: 50 mg/kg/day PO divided q6-8hr  

>20 kg: 250 mg PO q6hr

<40 kg: 25-50 mg/kg/day IV/IM divided q6-8hr

>40 kg: 250-500 mg IV/IM q6hr

Bacterial Meningitis/Septicemia

150-200 mg/kg/day IV/IM divided q3-4hr; should initiate with IV infusion therapy and continued with IM injections if preferred

Soft Tissue Infections

<40 kg: 25-50 mg/kg/day IV/IM divided q6-8hr

≥40 kg: 250-500 mg IV/IM q6hr

Community Acquired Pneumonia

< 3 months: Safety and efficacy not established

> 3 months:

Empiric treatment or S. pneumoniae

  • MICs to penicillin ≤ 2 mcg/mL or H. influenzae (beta-lactamase negative, preferred: 150-200 mg/kg/day IV/IM divided q6hr
  • MICs to penicillin ≥ 4 mg/mL; alternative to ceftriaxone: 300-400 mg/kg/day IV/IM divided q6hr

Group A Streptococcus

  • Moderate to severe (preferred): 200 mg/kg/day IVIM divided q6hr

Administration

Take oral dosage form on empty stomach

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Interactions

Interaction Checker

and ampicillin

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      Serious - Use Alternative

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            Contraindicated (0)

              Serious - Use Alternative (12)

              • BCG vaccine live

                ampicillin decreases effects of BCG vaccine live by pharmacodynamic antagonism. Contraindicated. Wait until Abx Tx complete to administer live bacterial vaccine.

              • cholera vaccine

                ampicillin, cholera vaccine. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Avoid coadministration of cholera vaccine with systemic antibiotics since these agents may be active against the vaccine strain. Do not administer cholera vaccine to patients who have received oral or parenteral antibiotics within 14 days prior to vaccination.

              • demeclocycline

                demeclocycline decreases effects of ampicillin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Tetracyclines may interfere with the bactericidal action of penicillins. Monitor for decreased therapeutic effects of penicillins if concomitantly used with a tetracycline.

              • doxycycline

                doxycycline decreases effects of ampicillin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Tetracyclines may interfere with the bactericidal action of penicillins. Monitor for decreased therapeutic effects of penicillins if concomitantly used with a tetracycline.

              • eravacycline

                eravacycline decreases effects of ampicillin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Tetracyclines may interfere with the bactericidal action of penicillins. Monitor for decreased therapeutic effects of penicillins if concomitantly used with a tetracycline.

              • minocycline

                minocycline decreases effects of ampicillin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Tetracyclines may interfere with the bactericidal action of penicillins. Monitor for decreased therapeutic effects of penicillins if concomitantly used with a tetracycline.

              • mycophenolate

                ampicillin, mycophenolate. Either increases levels of the other by decreasing renal clearance. Avoid or Use Alternate Drug.

              • omadacycline

                omadacycline decreases effects of ampicillin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Tetracyclines may interfere with the bactericidal action of penicillins. Monitor for decreased therapeutic effects of penicillins if concomitantly used with a tetracycline.

              • oxytetracycline

                oxytetracycline decreases effects of ampicillin by pharmacodynamic antagonism. Avoid or Use Alternate Drug.

              • sarecycline

                sarecycline decreases effects of ampicillin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Tetracyclines may interfere with the bactericidal action of penicillins. Monitor for decreased therapeutic effects of penicillins if concomitantly used with a tetracycline.

              • tetracycline

                tetracycline decreases effects of ampicillin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Tetracyclines may interfere with the bactericidal action of penicillins. Monitor for decreased therapeutic effects of penicillins if concomitantly used with a tetracycline.

              • typhoid vaccine live

                ampicillin decreases effects of typhoid vaccine live by pharmacodynamic antagonism. Contraindicated. Wait until Abx Tx complete to administer live bacterial vaccine.

              Monitor Closely (30)

              • aspirin

                ampicillin, aspirin. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

              • aspirin rectal

                ampicillin, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

              • aspirin/citric acid/sodium bicarbonate

                ampicillin, aspirin/citric acid/sodium bicarbonate. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

              • bazedoxifene/conjugated estrogens

                ampicillin will decrease the level or effect of bazedoxifene/conjugated estrogens by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor.

              • chloroquine

                chloroquine decreases levels of ampicillin by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate doses by at least 2 hr.

              • choline magnesium trisalicylate

                ampicillin, choline magnesium trisalicylate. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

                ampicillin, choline magnesium trisalicylate. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

              • deflazacort

                ampicillin and deflazacort both decrease serum potassium. Use Caution/Monitor.

              • dexlansoprazole

                dexlansoprazole will decrease the level or effect of ampicillin by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.

              • dienogest/estradiol valerate

                ampicillin will decrease the level or effect of dienogest/estradiol valerate by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor. An alternate or additional form of birth control may be advisable during concomitant use.

              • esomeprazole

                esomeprazole will decrease the level or effect of ampicillin by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.

              • ethinylestradiol

                ampicillin will decrease the level or effect of ethinylestradiol by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor.

              • ibuprofen/famotidine

                ibuprofen/famotidine will decrease the level or effect of ampicillin by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.

              • lansoprazole

                lansoprazole will decrease the level or effect of ampicillin by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.

              • lanthanum carbonate

                lanthanum carbonate decreases levels of ampicillin by cation binding in GI tract. Use Caution/Monitor. Administer ampicillin at least 2 hr before or after lanthanum. Interaction applies to oral ampicillin.

              • levonorgestrel oral/ethinylestradiol/ferrous bisglycinate

                ampicillin will decrease the level or effect of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor. Antibiotics may decrease hormonal contraceptive efficacy.

              • mestranol

                ampicillin will decrease the level or effect of mestranol by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor.

              • methotrexate

                ampicillin increases levels of methotrexate by decreasing renal clearance. Use Caution/Monitor. Increased serum concentrations of methotrexate with concomitant hematologic and gastrointestinal toxicity have been observed with concurrent administration of high or low doses of methotrexate and penicillins.

              • omeprazole

                omeprazole will decrease the level or effect of ampicillin by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.

              • pantoprazole

                pantoprazole will decrease the level or effect of ampicillin by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.

              • rabeprazole

                rabeprazole will decrease the level or effect of ampicillin by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.

              • rose hips

                ampicillin, rose hips. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              • sodium bicarbonate

                sodium bicarbonate will decrease the level or effect of ampicillin by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.

              • sodium citrate/citric acid

                sodium citrate/citric acid will decrease the level or effect of ampicillin by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.

              • sodium phenylacetate

                ampicillin, sodium phenylacetate. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              • sodium picosulfate/magnesium oxide/anhydrous citric acid

                ampicillin decreases effects of sodium picosulfate/magnesium oxide/anhydrous citric acid by altering metabolism. Use Caution/Monitor. Coadministration with antibiotics decreases efficacy by altering colonic bacterial flora needed to convert sodium picosulfate to active drug.

              • sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol

                ampicillin and sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol both decrease serum potassium. Modify Therapy/Monitor Closely.

              • spironolactone

                ampicillin increases effects of spironolactone by unspecified interaction mechanism. Use Caution/Monitor. Hyperkalemia.

              • sulfasalazine

                ampicillin, sulfasalazine. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

                ampicillin, sulfasalazine. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              • warfarin

                ampicillin increases effects of warfarin by Other (see comment). Use Caution/Monitor. Comment: Decr vitamin K-producing intestinal flora may increase INR after a few days.

              • willow bark

                ampicillin, willow bark. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              Minor (18)

              • allopurinol

                ampicillin, allopurinol. Mechanism: unknown. Minor/Significance Unknown. Increased incidence of rash.

              • atenolol

                ampicillin decreases levels of atenolol by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

              • azithromycin

                azithromycin decreases effects of ampicillin by pharmacodynamic antagonism. Minor/Significance Unknown.

              • bendroflumethiazide

                bendroflumethiazide increases effects of ampicillin by decreasing renal clearance. Minor/Significance Unknown. May increase side effects.

              • chloramphenicol

                chloramphenicol decreases effects of ampicillin by pharmacodynamic antagonism. Minor/Significance Unknown.

              • chlorothiazide

                chlorothiazide increases levels of ampicillin by decreasing renal clearance. Minor/Significance Unknown.

              • clarithromycin

                clarithromycin decreases effects of ampicillin by pharmacodynamic antagonism. Minor/Significance Unknown.

              • colestipol

                colestipol decreases levels of ampicillin by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

              • didanosine

                didanosine will decrease the level or effect of ampicillin by increasing gastric pH. Applies only to oral form of both agents. Minor/Significance Unknown.

              • erythromycin base

                erythromycin base decreases effects of ampicillin by pharmacodynamic antagonism. Minor/Significance Unknown.

              • erythromycin ethylsuccinate

                erythromycin ethylsuccinate decreases effects of ampicillin by pharmacodynamic antagonism. Minor/Significance Unknown.

              • erythromycin lactobionate

                erythromycin lactobionate decreases effects of ampicillin by pharmacodynamic antagonism. Minor/Significance Unknown.

              • erythromycin stearate

                erythromycin stearate decreases effects of ampicillin by pharmacodynamic antagonism. Minor/Significance Unknown.

              • hydrochlorothiazide

                hydrochlorothiazide increases levels of ampicillin by decreasing renal clearance. Minor/Significance Unknown.

              • methyclothiazide

                methyclothiazide increases levels of ampicillin by decreasing renal clearance. Minor/Significance Unknown.

              • metolazone

                metolazone increases levels of ampicillin by decreasing renal clearance. Minor/Significance Unknown.

              • rifampin

                rifampin decreases levels of ampicillin by increasing metabolism. Minor/Significance Unknown.

              • roxithromycin

                roxithromycin decreases effects of ampicillin by pharmacodynamic antagonism. Minor/Significance Unknown.

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              Adverse Effects

              Frequency Not Defined

              Erythema multiforme

              Exfoliative dermatitis

              Rash

              Urticaria

              Fever

              Seizure

              Black hairy tongue

              Diarrhea

              Enterocolitis

              Glossitis

              Nausea

              Oral candidiasis

              Pseudomembranous colitis

              Stomatitis

              Vomiting

              Agranulocytosis

              Anemia

              Hemolytic anemia

              Eosinophilia

              Leukopenia

              Thrombocytopenia purpura

              Anaphylaxis

              Aspartate aminotransferase increased

              Interstitial nephritis

              Laryngeal stridor

              Serum sickness-like reaction

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              Warnings

              Contraindications

              Hypersensitivity

              Cautions

              Use caution in allergy to cephalosporins, carbapenems

              Adjust dose in renal failure; evaluate rash and differentiate from hypersensitivity reaction

              Endocarditis prophylaxis: Use only for high-risk patients, per AHA Guidelines

              Prolonged use associated with fungal or bacterial superinfection

              Rash has developed during therapy in high percentage of patients with infectious mononucleosis receiving ampicillin class antibiotics; avoid therapy in these patients

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              Pregnancy & Lactation

              Pregnancy category: B

              Lactation: Excreted in breast milk; use caution

              Pregnancy Categories

              A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

              B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

              C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

              D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

              X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

              NA: Information not available.

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              Pharmacology

              Mechanism of Action

              Broad-spectrum penicillin; interferes with bacterial cell wall synthesis during active replication, causing bactericidal activity against susceptible organisms; alternative to amoxicillin when unable to take medication orally

              Absorption

              Peak plasma time: 1-2 hr (oral)

              Bioavailability: 30-40%

              Distribution

              Protein bound: 15-25%

              Blister and tissue fluids, bile, and CSF with inflamed meninges

              Metabolism

              Liver

              Elimination

              Half-life: 1-1.8 hr (normal renal function); 7-20 hr (anuria/end-stage renal disease)

              Excretion: Urine (90% within 24 hr)

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              Administration

              IV Incompatibilities

              Solution: Dextran and dextrose solutions, LR, Ringer's, Na-bicarb, Na-lactate 1/6 M, IV fat emulsions, invert sugar solutions

              Additive: Amikacin, aztreonam(?), cefepime(?), chlorpromazine, dopamine, gentamicin, heparin(?), hydralazine, hydrocortisone, prochlorperazine,

              Syringe: Erythromycin, gentamicin, hydromorphone, kanamycin, lincomycin, metoclopramide, polymyxin B SO4, streptomycin

              Y-site: Amphotericin B cholesteryl SO4, Ca gluconate, cisatracurium (at high cisatracurium concentration; may be compatible at low concentrations), diltiazem, epinephrine, fenoldopam, fluconazole, hydralazine, midazolam, nicardipine, ondansetron, sargramostim, verapamil, vinorelbine

              IV Compatibilities

              Solution: NS (some contrary reports)

              Additive: Clindamycin, erythromycin, floxacillin, furosemide, metronidazole, verapamil

              Syringe: Chloramphenicol, colistimethate, heparin, lidocaine

              Y-site (partial list): Acyclovir, aztreonam, clarithromycin, cyclophosphamide, esmolol, famotidine, heparin, labetalol, linezolid, KCl, MgSO4, meperidine, propofol, vancomycin, vitamins B/C

              IV Preparation

              Reconstitute with sterile water for injection or bacteriostatic water for injection

              Use 5 mL for 125 mg, 250 mg, or 500 mg vials; 7.4 mL for 1 g vials; or 14.8 mL for 2 g vials

              IV Administration

              Use initial dilution within 1 hr

              Give direct IV over 3-5 min for (125-500 mg) and over 10-15 minutes for larger doses (1-2 g)

              Do not exceed a rate of 100 mg/min

              For intermittent infusion, dilute in 50-100 mL of NS and give over 15-30 min

              Give IV intermittently to prevent vein irritation (change site q48hr)

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              Images

              BRAND FORM. UNIT PRICE PILL IMAGE
              ampicillin oral
              -
              250 mg capsule
              ampicillin oral
              -
              500 mg capsule

              Copyright © 2010 First DataBank, Inc.

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              Patient Handout

              Patient Education
              ampicillin oral

              AMPICILLIN - ORAL

              (AM-pi-SIL-in)

              COMMON BRAND NAME(S): Principen

              USES: Ampicillin is used to treat a wide variety of bacterial infections. It is a penicillin-type antibiotic. It works by stopping the growth of bacteria.This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.

              HOW TO USE: Take this medication by mouth usually 4 times a day (every 6 hours), or as directed by your doctor. Take ampicillin on an empty stomach (1 hour before or 2 hours after a meal) with a full glass of water. Drink plenty of fluids while using this medication unless your doctor tells you otherwise.The dosage is based on your medical condition and response to therapy.For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.Continue to take this medication until the full-prescribed amount is finished even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection.Inform your doctor if your condition persists or worsens.

              SIDE EFFECTS: Nausea, vomiting, diarrhea, or mouth/tongue sores may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if any of these rare but very serious side effects occur: dark urine, persistent nausea or vomiting, stomach/abdominal pain, yellowing eyes or skin, easy bruising or bleeding, persistent sore throat or fever.This medication may rarely cause a severe intestinal condition due to a bacteria called C. difficile. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: diarrhea that doesn't stop, abdominal or stomach pain/cramping, blood/mucus in your stool.If you have these symptoms, do not use anti-diarrhea or opioid products because they may make symptoms worse.Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection (oral or vaginal fungal infection). Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge or other new symptoms.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.Ampicillin can commonly cause a mild rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe allergic reaction. Therefore, seek immediate medical attention if you develop any rash.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

              PRECAUTIONS: Before taking ampicillin, tell your doctor or pharmacist if you are allergic to it; or to penicillin or cephalosporin antibiotics; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, a certain type of viral infection (infectious mononucleosis).Ampicillin may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to.Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be more sensitive to this drug.This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.Ampicillin passes into breast milk. Consult your doctor before breast-feeding.

              DRUG INTERACTIONS: Your healthcare professionals (such as your doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: methotrexate, tetracyclines.Ampicillin may cause false positive results with certain diabetic urine testing products (cupric sulfate-type). This drug may also affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use this drug.This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

              OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe vomiting, persistent diarrhea, unusual change in the amount of urine, or seizures.

              NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.With prolonged treatment, laboratory and/or medical tests (e.g., kidney and liver function, complete blood counts) should be performed periodically to monitor your progress or check for side effects. Consult the doctor for more details.

              MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

              STORAGE: Store at room temperature between 59-86 degrees F (15-30 degrees C), away from excessive heat and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

              Information last revised October 2020. Copyright(c) 2021 First Databank, Inc.

              IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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              Formulary

              FormularyPatient Discounts

              Adding plans allows you to compare formulary status to other drugs in the same class.

              To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

              Adding plans allows you to:

              • View the formulary and any restrictions for each plan.
              • Manage and view all your plans together – even plans in different states.
              • Compare formulary status to other drugs in the same class.
              • Access your plan list on any device – mobile or desktop.

              The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

              Tier Description
              1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
              2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
              3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
              4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              NC NOT COVERED – Drugs that are not covered by the plan.
              Code Definition
              PA Prior Authorization
              Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
              QL Quantity Limits
              Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
              ST Step Therapy
              Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
              OR Other Restrictions
              Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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              Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.