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      Drugs & Diseases

      Dong Quai (Herb/Suppl)

      Brand and Other Names:Angelica atropurpurea, Angelica dahurica, more...angelica sinensis, Chinese angelica, dang gui, ligustilides, Radix Angelicae Sinensis, tang-kuei
      • Print

      Suggested Dosing

      Extract

      1 ml PO TID, OR

      Other Information

      1-2 g steeped in boiling water TID

      Menopausal symptoms: 4.5 g powder PO qD

      3-4 g PO div TID with meals, OR

      520-1560 mg PO TID, OR

      Next:

      Suggested Uses

      Stimulate normal menstrual flow, prevent cramping

      Anemia, constipation, dysmenorrhea, hypertension, psoriasis, rheumatism, skin depigmentation, ulcers

      Efficacy

      Controversial; apparently more effective in combination with other herbs

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      Interactions

      Interaction Checker

      and Dong Quai

      No Results

         activity indicator 
        No Interactions Found
        Interactions Found

        Contraindicated

          Serious - Use Alternative

            Significant - Monitor Closely

              Minor

                All Interactions Sort By:
                 activity indicator 

                Contraindicated (0)

                  Serious - Use Alternative (3)

                  • aminolevulinic acid oral

                    aminolevulinic acid oral, dong quai. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period.

                  • aminolevulinic acid topical

                    dong quai, aminolevulinic acid topical. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Each drug may increase the photosensitizing effect of the other.

                  • methyl aminolevulinate

                    dong quai, methyl aminolevulinate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Each drug may increase the photosensitizing effect of the other.

                  Monitor Closely (68)

                  • aceclofenac

                    aceclofenac and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • acemetacin

                    acemetacin and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • agrimony

                    agrimony and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • alfalfa

                    alfalfa and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • alteplase

                    alteplase and dong quai both increase anticoagulation. Modify Therapy/Monitor Closely.

                  • American ginseng

                    American ginseng and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • antithrombin alfa

                    antithrombin alfa and dong quai both increase anticoagulation. Modify Therapy/Monitor Closely.

                  • antithrombin III

                    antithrombin III and dong quai both increase anticoagulation. Modify Therapy/Monitor Closely.

                  • argatroban

                    argatroban and dong quai both increase anticoagulation. Modify Therapy/Monitor Closely.

                  • aspirin

                    aspirin and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • aspirin rectal

                    aspirin rectal and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • aspirin/citric acid/sodium bicarbonate

                    aspirin/citric acid/sodium bicarbonate and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • bemiparin

                    bemiparin and dong quai both increase anticoagulation. Modify Therapy/Monitor Closely.

                  • bivalirudin

                    bivalirudin and dong quai both increase anticoagulation. Modify Therapy/Monitor Closely.

                  • celecoxib

                    celecoxib and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • choline magnesium trisalicylate

                    choline magnesium trisalicylate and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • cinnamon

                    cinnamon and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • cordyceps

                    cordyceps and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • dabigatran

                    dabigatran and dong quai both increase anticoagulation. Modify Therapy/Monitor Closely.

                  • dalteparin

                    dalteparin and dong quai both increase anticoagulation. Modify Therapy/Monitor Closely.

                  • diclofenac

                    diclofenac and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • diflunisal

                    diflunisal and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • enoxaparin

                    enoxaparin and dong quai both increase anticoagulation. Modify Therapy/Monitor Closely.

                  • epoprostenol

                    dong quai and epoprostenol both increase anticoagulation. Use Caution/Monitor.

                  • etodolac

                    etodolac and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • fennel

                    dong quai and fennel both increase anticoagulation. Use Caution/Monitor.

                  • fenoprofen

                    fenoprofen and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • feverfew

                    dong quai and feverfew both increase anticoagulation. Use Caution/Monitor.

                  • flurbiprofen

                    flurbiprofen and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • fondaparinux

                    fondaparinux and dong quai both increase anticoagulation. Modify Therapy/Monitor Closely.

                  • forskolin

                    dong quai and forskolin both increase anticoagulation. Use Caution/Monitor.

                  • garlic

                    dong quai and garlic both increase anticoagulation. Use Caution/Monitor.

                  • ginger

                    dong quai and ginger both increase anticoagulation. Use Caution/Monitor.

                  • ginkgo biloba

                    dong quai and ginkgo biloba both increase anticoagulation. Use Caution/Monitor.

                  • heparin

                    heparin and dong quai both increase anticoagulation. Modify Therapy/Monitor Closely.

                  • horse chestnut seed

                    dong quai and horse chestnut seed both increase anticoagulation. Use Caution/Monitor.

                  • ibuprofen

                    ibuprofen and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • ibuprofen IV

                    ibuprofen IV and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • indomethacin

                    indomethacin and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • ketoprofen

                    ketoprofen and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • ketorolac

                    ketorolac and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • ketorolac intranasal

                    ketorolac intranasal and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • lornoxicam

                    lornoxicam and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • meclofenamate

                    meclofenamate and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • mefenamic acid

                    mefenamic acid and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • meloxicam

                    meloxicam and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • mistletoe

                    dong quai increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • nabumetone

                    nabumetone and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • naproxen

                    naproxen and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • nettle

                    dong quai increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • oxaprozin

                    oxaprozin and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • panax ginseng

                    dong quai and panax ginseng both increase anticoagulation. Use Caution/Monitor.

                  • parecoxib

                    parecoxib and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • pau d'arco

                    dong quai and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                  • phenindione

                    phenindione and dong quai both increase anticoagulation. Modify Therapy/Monitor Closely.

                  • phytoestrogens

                    dong quai and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                  • piroxicam

                    piroxicam and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • protamine

                    protamine and dong quai both increase anticoagulation. Modify Therapy/Monitor Closely.

                  • reishi

                    dong quai and reishi both increase anticoagulation. Use Caution/Monitor.

                  • reteplase

                    reteplase and dong quai both increase anticoagulation. Modify Therapy/Monitor Closely.

                  • salicylates (non-asa)

                    salicylates (non-asa) and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • salsalate

                    salsalate and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • Siberian ginseng

                    dong quai and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                  • sulfasalazine

                    sulfasalazine and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • sulindac

                    sulindac and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • tenecteplase

                    tenecteplase and dong quai both increase anticoagulation. Modify Therapy/Monitor Closely.

                  • tolfenamic acid

                    tolfenamic acid and dong quai both increase anticoagulation. Use Caution/Monitor.

                  • tolmetin

                    tolmetin and dong quai both increase anticoagulation. Use Caution/Monitor.

                  Minor (4)

                  • anamu

                    anamu and dong quai both increase anticoagulation. Minor/Significance Unknown.

                  • danshen

                    danshen and dong quai both increase anticoagulation. Minor/Significance Unknown.

                  • devil's claw

                    devil's claw and dong quai both increase anticoagulation. Minor/Significance Unknown.

                  • green tea

                    green tea, dong quai. Other (see comment). Minor/Significance Unknown. Comment: Use caution when combining green tea with herbs that exhibit antiplatelet effects or anticoagulant activity.

                  Previous
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                  Adverse Effects

                  Frequency Not Defined

                  Photodermatitis (especially A. archangelica)

                  Safrole, in essential oil, is carcinogen

                  Photosensitivity

                  Potential mutagen

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                  Warnings

                  Contraindications

                  Breast cancer, endometriosis, hormone sensitive conditions, ovarian cancer, uterine cancer, uterine fibroids

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                  Pregnancy & Lactation

                  Pregnancy Category: avoid use

                  Lactation: avoid use

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Metabolism: N/A

                  Excretion: N/A

                  Mechanism of Action

                  Phytoestrogen modulate endogenous estrogen effects; also contains coumarins

                  Previous
                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
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