Suggested Dosing
Sexual Dysfunction
15-30 mg PO daily
Bark tincture: 5-10 gtt PO TID
Yohimbe bark: Potential for side effects
Numerous regimens available, follow mfct recommendations
Suggested Uses
Erectile dysfunction, sexual dysfunction (male or female), sexual dysfunction (SSRI-induced)
Efficacy
Possibly effective for impotence
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Contraindicated (0)
Serious - Use Alternative (58)
- alfuzosin
yohimbe increases effects of alfuzosin by pharmacodynamic synergism. Contraindicated.
- amitriptyline
yohimbe, amitriptyline. Mechanism: unspecified interaction mechanism. Contraindicated. May cause increase or decrease in blood pressure.
- amoxapine
yohimbe, amoxapine. Mechanism: unspecified interaction mechanism. Contraindicated. May cause increase or decrease in blood pressure.
- asenapine
yohimbe increases effects of asenapine by pharmacodynamic synergism. Contraindicated.
- benzphetamine
yohimbe, benzphetamine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- chlorpromazine
yohimbe decreases effects of chlorpromazine by pharmacodynamic antagonism. Contraindicated.
- clomipramine
yohimbe, clomipramine. Mechanism: unspecified interaction mechanism. Contraindicated. May cause increase or decrease in blood pressure.
- clonidine
yohimbe decreases effects of clonidine by pharmacodynamic antagonism. Contraindicated.
- desipramine
yohimbe, desipramine. Mechanism: unspecified interaction mechanism. Contraindicated. May cause increase or decrease in blood pressure.
- dexfenfluramine
yohimbe, dexfenfluramine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- dexmethylphenidate
yohimbe, dexmethylphenidate. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- dextroamphetamine
yohimbe, dextroamphetamine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- diethylpropion
yohimbe, diethylpropion. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- dobutamine
yohimbe, dobutamine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- dopamine
yohimbe, dopamine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- dosulepin
yohimbe, dosulepin. Mechanism: unspecified interaction mechanism. Contraindicated. May cause increase or decrease in blood pressure.
- doxazosin
yohimbe increases effects of doxazosin by pharmacodynamic synergism. Contraindicated.
- doxepin
yohimbe, doxepin. Mechanism: unspecified interaction mechanism. Contraindicated. May cause increase or decrease in blood pressure.
- ephedrine
yohimbe, ephedrine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- epinephrine
yohimbe, epinephrine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- fenfluramine
yohimbe, fenfluramine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- fluphenazine
yohimbe decreases effects of fluphenazine by pharmacodynamic antagonism. Contraindicated.
- imipramine
yohimbe, imipramine. Mechanism: unspecified interaction mechanism. Contraindicated. May cause increase or decrease in blood pressure.
- isoproterenol
yohimbe, isoproterenol. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- lisdexamfetamine
yohimbe, lisdexamfetamine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- lofepramine
yohimbe, lofepramine. Mechanism: unspecified interaction mechanism. Contraindicated. May cause increase or decrease in blood pressure.
- maprotiline
yohimbe, maprotiline. Mechanism: unspecified interaction mechanism. Contraindicated. May cause increase or decrease in blood pressure.
- methamphetamine
yohimbe, methamphetamine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- methylenedioxymethamphetamine
yohimbe, methylenedioxymethamphetamine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- methylphenidate
yohimbe, methylphenidate. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- midodrine
yohimbe, midodrine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- moxisylyte
yohimbe increases effects of moxisylyte by pharmacodynamic synergism. Contraindicated.
- norepinephrine
yohimbe, norepinephrine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- nortriptyline
yohimbe, nortriptyline. Mechanism: unspecified interaction mechanism. Contraindicated. May cause increase or decrease in blood pressure.
- perphenazine
yohimbe decreases effects of perphenazine by pharmacodynamic antagonism. Contraindicated.
- phendimetrazine
yohimbe, phendimetrazine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- phenoxybenzamine
yohimbe increases effects of phenoxybenzamine by pharmacodynamic synergism. Contraindicated.
- phentermine
yohimbe, phentermine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- phentolamine
yohimbe increases effects of phentolamine by pharmacodynamic synergism. Contraindicated.
- phenylephrine
yohimbe, phenylephrine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- phenylephrine PO
yohimbe, phenylephrine PO. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- prazosin
yohimbe increases effects of prazosin by pharmacodynamic synergism. Contraindicated.
- prochlorperazine
yohimbe decreases effects of prochlorperazine by pharmacodynamic antagonism. Contraindicated.
- promazine
yohimbe decreases effects of promazine by pharmacodynamic antagonism. Contraindicated.
- promethazine
yohimbe decreases effects of promethazine by pharmacodynamic antagonism. Contraindicated.
- propylhexedrine
yohimbe, propylhexedrine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- protriptyline
yohimbe, protriptyline. Mechanism: unspecified interaction mechanism. Contraindicated. May cause increase or decrease in blood pressure.
- serdexmethylphenidate/dexmethylphenidate
yohimbe, serdexmethylphenidate/dexmethylphenidate. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- silodosin
yohimbe increases effects of silodosin by pharmacodynamic synergism. Contraindicated.
- terazosin
yohimbe increases effects of terazosin by pharmacodynamic synergism. Contraindicated.
- thioridazine
yohimbe decreases effects of thioridazine by pharmacodynamic antagonism. Contraindicated.
- trazodone
yohimbe, trazodone. Mechanism: unspecified interaction mechanism. Contraindicated. May cause increase or decrease in blood pressure.
- trifluoperazine
yohimbe decreases effects of trifluoperazine by pharmacodynamic antagonism. Contraindicated.
- trimipramine
yohimbe, trimipramine. Mechanism: unspecified interaction mechanism. Contraindicated. May cause increase or decrease in blood pressure.
- tyramine
yohimbe, tyramine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode. Tyramine containing foods include cheese, red wine, caviar, herring, canned figs, fermented meats, fava beans, yeast extracts, miso, avocado.
- xylometazoline
yohimbe, xylometazoline. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- yohimbine
yohimbe, yohimbine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.
- zotepine
yohimbe increases effects of zotepine by pharmacodynamic synergism. Contraindicated.
Monitor Closely (5)
- isocarboxazid
yohimbe increases effects of isocarboxazid by pharmacodynamic synergism. Use Caution/Monitor.
- linezolid
yohimbe increases effects of linezolid by pharmacodynamic synergism. Use Caution/Monitor.
- phenelzine
yohimbe increases effects of phenelzine by pharmacodynamic synergism. Use Caution/Monitor.
- procarbazine
yohimbe increases effects of procarbazine by pharmacodynamic synergism. Use Caution/Monitor.
- tranylcypromine
yohimbe increases effects of tranylcypromine by pharmacodynamic synergism. Use Caution/Monitor.
Minor (16)
- acebutolol
acebutolol decreases toxicity of yohimbe by pharmacodynamic antagonism. Minor/Significance Unknown.
- atenolol
atenolol decreases toxicity of yohimbe by pharmacodynamic antagonism. Minor/Significance Unknown.
- betaxolol
betaxolol decreases toxicity of yohimbe by pharmacodynamic antagonism. Minor/Significance Unknown.
- bisoprolol
bisoprolol decreases toxicity of yohimbe by pharmacodynamic antagonism. Minor/Significance Unknown.
- carvedilol
carvedilol decreases toxicity of yohimbe by pharmacodynamic antagonism. Minor/Significance Unknown.
- celiprolol
celiprolol decreases toxicity of yohimbe by pharmacodynamic antagonism. Minor/Significance Unknown.
- esmolol
esmolol decreases toxicity of yohimbe by pharmacodynamic antagonism. Minor/Significance Unknown.
- labetalol
labetalol decreases toxicity of yohimbe by pharmacodynamic antagonism. Minor/Significance Unknown.
- metoprolol
metoprolol decreases toxicity of yohimbe by pharmacodynamic antagonism. Minor/Significance Unknown.
- nadolol
nadolol decreases toxicity of yohimbe by pharmacodynamic antagonism. Minor/Significance Unknown.
- nebivolol
nebivolol decreases toxicity of yohimbe by pharmacodynamic antagonism. Minor/Significance Unknown.
- penbutolol
penbutolol decreases toxicity of yohimbe by pharmacodynamic antagonism. Minor/Significance Unknown.
- pindolol
pindolol decreases toxicity of yohimbe by pharmacodynamic antagonism. Minor/Significance Unknown.
- propranolol
propranolol decreases toxicity of yohimbe by pharmacodynamic antagonism. Minor/Significance Unknown.
- sotalol
sotalol decreases toxicity of yohimbe by pharmacodynamic antagonism. Minor/Significance Unknown.
- timolol
timolol decreases toxicity of yohimbe by pharmacodynamic antagonism. Minor/Significance Unknown.
Adverse Effects
Anxiety, cardiac coduction disturbances, cardiac failure, dizziness, excitation, fluid retention, gastric intolerance, headache, hypertension, hypotension, insomnia, irritability, nausea/vomiting, paralysis, respiratory depression, salivation, sinusitis, tachycardia, tremor, urinary frequency
Warnings
Contraindications
Angina, anxiety, BPH, concomitant MAO inhibitors, concomitant sympathomimetic drugs, depression, diabetes mellitus, heart disease, hypertension, hypotension, kidney disease, liver disease, post-traumatic stress disorder, prostate inflammation, tyramine-containing foods
Cautions
Schizophrenia
Pregnancy & Lactation
Pregnancy Category: unsafe
Lactation: avoid use
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Metabolism: N/A
Excretion: N/A
Mechanism of Action
Yohimbine is an alpha-2-adrenergic blocker