Aplisol, Mantoux (tuberculin purified protein derivative) dosing, indications, interactions, adverse effects, and more

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Sections tuberculin purified protein derivative
Dosing & Uses
Adverse Effects
Warnings
Pregnancy
Pharmacology
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Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

Intradermal solution

5 Unit/0.1mL

Tuberculosis

Diagnosis: Mantoux test, inject 0.1 mL (5 tuberculin units) intradermally; the result is read 48 to 72 hours after administration

Positive if 10 mm induration

Use 1 TU in sensitized patients, 250 TU if no response to 5 TU

Dosage Forms & Strengths

Intradermal solution

5 Unit/0.1mL

Tuberculosis

Diagnosis: Mantoux test, inject 0.1 mL (5 tuberculin units) intradermally; the result is read 48 to 72 hours after administration

Positive if 10 mm induration

Use 1 TU in sensitized patients, 250 TU if no response to 5 TU

Tuberculosis

Diagnosis: Mantoux test, inject 0.1 mL (5 tuberculin units) intradermally; the result is read 48-72 hours after administration

Positive if >10 mm induration

Use 1 TU in sensitized patients, 250 TU if no response to 5 TU

Adverse Effects

Suspected adverse events after administration of any vaccine may be reported to Vaccine Adverse Events Reporting System (VAERS), 1-800-822-7967

Frequency Not Defined

Rash

Itch

Vesiculation

Ulceration

Necrosis

Pain

Contraindications

Previous positive tuberculin skin test responsiveness suppressed within 6 weeks of viral infection, inactive TB, immunosuppression, geriatric

Cautions

Contains soluble growth products from tubercle bacillus

Old tuberculin (OT) is culture filtrate of uniform potency

PPD is more refined and is preferred product

Multiple puncture device (Aplitest, SclavoTest-PPD, Tine Test PPD) not as sensitive

Pregnancy & Lactation

Pregnancy Category: C

Lactation: not known if excreted in breast milk

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Antigenic purified protein derivative (PPD) of Mycobacterium tuberculosis; patients become sensitized to certain antigenic components of the M. tuberculosis organism.

Pharmacokinetics

Onset of action: 5-6hr (delayed hypersensitivity reactions)

Peak effect: 48-72 hr

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Patient Handout

Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

Tier	Description
1	This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2	This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC	NOT COVERED – Drugs that are not covered by the plan.

Code	Definition
PA	Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL	Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST	Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR	Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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Sections tuberculin purified protein derivative
Dosing & Uses
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout
Formulary

tuberculin purified protein derivative (Rx)

Dosing & Uses

Dosage Forms & Strengths

Intradermal solution

Tuberculosis

Dosage Forms & Strengths

Intradermal solution

Tuberculosis

Tuberculosis

Adverse Effects

Frequency Not Defined

Warnings

Contraindications

Cautions

Pregnancy & Lactation

Pregnancy Categories

Pharmacology

Mechanism of Action

Pharmacokinetics

Images

Patient Handout

Formulary

Plans

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