Indication-specific dosing for apricot vine, corona de cristo, Fleischfarbige passion flower in combination, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

Sections

Sections Passion Flower
Suggested Dosing
Suggested Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology

Suggested Dosing

General Dosing Guidlines

Dried

0.25-2 g PO TID

Tea

1 cup PO BID-TID and 30 min before bedtime; 0.25-2 g/150 ml water

Liquid Extract

0.5-1 ml PO TID; 1:1 in 25% alcohol

Tincture

0.5-2 ml PO TID; 1:8 in 45% alcohol

Anxiety Disorder

Liquid extract: 45 gtt PO daily

Opiate Withdrawal

Liquid extract: 60 gtt PO daily

Suggested Uses

ADHD, cardiac rhythm abnormalities, generalized anxiety disorder, GI upset, hemorrhoids (topical), insomnia, nervousness/excitability, neuralgias, opiate withdrawal symptoms, pain

Efficacy

Possibly effective for nervous restlessness, anxiety, opiate withdrawal when used in combo with clonidine

Interaction Checker

Enter a drug name and Passion Flower

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No Interactions Found

Interactions Found

Contraindicated

Serious - Use Alternative

Significant - Monitor Closely

Minor

All Interactions Sort By:

Contraindicated (0)

Serious - Use Alternative (0)

Monitor Closely (25)

amobarbital
passion flower increases effects of amobarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
azelastine
passion flower increases effects of azelastine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
brompheniramine
passion flower increases effects of brompheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
butabarbital
passion flower increases effects of butabarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
butalbital
passion flower increases effects of butalbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
carbinoxamine
passion flower increases effects of carbinoxamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
chloral hydrate
passion flower increases effects of chloral hydrate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
chlorpheniramine
passion flower increases effects of chlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
cinnarizine
passion flower increases effects of cinnarizine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
clemastine
passion flower increases effects of clemastine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
cyclizine
passion flower increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
cyproheptadine
passion flower increases effects of cyproheptadine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
dexchlorpheniramine
passion flower increases effects of dexchlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
dexmedetomidine
passion flower increases effects of dexmedetomidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
dimenhydrinate
passion flower increases effects of dimenhydrinate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
diphenhydramine
passion flower increases effects of diphenhydramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
doxylamine
passion flower increases effects of doxylamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
hydroxyzine
passion flower increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
pentobarbital
passion flower increases effects of pentobarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
phenobarbital
passion flower increases effects of phenobarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
primidone
passion flower increases effects of primidone by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
promethazine
passion flower increases effects of promethazine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
secobarbital
passion flower increases effects of secobarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
triclofos
passion flower increases effects of triclofos by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
triprolidine
passion flower increases effects of triprolidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

Minor (0)

amobarbital
Monitor Closely (1)passion flower increases effects of amobarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
azelastine
Monitor Closely (1)passion flower increases effects of azelastine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
brompheniramine
Monitor Closely (1)passion flower increases effects of brompheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
butabarbital
Monitor Closely (1)passion flower increases effects of butabarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
butalbital
Monitor Closely (1)passion flower increases effects of butalbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
carbinoxamine
Monitor Closely (1)passion flower increases effects of carbinoxamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
chloral hydrate
Monitor Closely (1)passion flower increases effects of chloral hydrate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
chlorpheniramine
Monitor Closely (1)passion flower increases effects of chlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
cinnarizine
Monitor Closely (1)passion flower increases effects of cinnarizine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
clemastine
Monitor Closely (1)passion flower increases effects of clemastine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
cyclizine
Monitor Closely (1)passion flower increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
cyproheptadine
Monitor Closely (1)passion flower increases effects of cyproheptadine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
dexchlorpheniramine
Monitor Closely (1)passion flower increases effects of dexchlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
dexmedetomidine
Monitor Closely (1)passion flower increases effects of dexmedetomidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
dimenhydrinate
Monitor Closely (1)passion flower increases effects of dimenhydrinate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
diphenhydramine
Monitor Closely (1)passion flower increases effects of diphenhydramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
doxylamine
Monitor Closely (1)passion flower increases effects of doxylamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
hydroxyzine
Monitor Closely (1)passion flower increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
pentobarbital
Monitor Closely (1)passion flower increases effects of pentobarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
phenobarbital
Monitor Closely (1)passion flower increases effects of phenobarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
primidone
Monitor Closely (1)passion flower increases effects of primidone by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
promethazine
Monitor Closely (1)passion flower increases effects of promethazine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
secobarbital
Monitor Closely (1)passion flower increases effects of secobarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
triclofos
Monitor Closely (1)passion flower increases effects of triclofos by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
triprolidine
Monitor Closely (1)passion flower increases effects of triprolidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

Frequency Not Defined

Altered consciousness

Ataxia

Confusion

Dizziness

Drowsiness

Liver toxicity

Nausea/vomiting

Pancreas toxicity

Prolonged QT interval

Vasculitis

Ventricular tachycardia

Contraindications

None reported

Cautions

Concurrent sedative agents

Pregnancy & Lactation

Pregnancy Category: unsafe

Lactation: avoid use

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Pharmacology

Metabolism: N/A

Excretion: N/A

Mechanism of Action

Apigenin: benzodiazepine receptor agonist

May have some MAOI activity

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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Sections Passion Flower
Suggested Dosing
Suggested Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology

Passion Flower (Herb/Suppl)