Dosing & Uses
Dosing Form & Strengths
Oral Spray
- Oasis: Water, glycerin, sorbitol, poloxamer 338, PEG-60, hydrogenated castor oil, copovidone, sodium benzoate, carboxymethylcellulose (473 mL); ethanol free, sugar free, mild mint flavor
- Aquoral: Oxidized glycerol triesters and silicon dioxide (40 mL); contains aspartame, delivers 400 sprays, citrus flavor
- Mouth Kote: Water, xylitol, sorbitol, citric acid, yerba santa, ascorbic acid, sodium benzoate, sodium saccharin
- Mol-Stir: Water, sodium carboxymethylcellulose, sorbitol, propylparaben, potassium chloride, dibasic sodium phosphate, magnesium chloride, sodium chloride, calcium chloride, methylparaben
Oral Solution
- Caphosol: Dibasic sodium phosphate 0.032%, monobasic sodium phosphate 0.009%, calcium chloride 0.052%, sodium chloride 0.569%, purified water (30 mL); packaged in two 15 mL ampuls when mixed together provide one 30 mL dose
- Entertainer's secret: Aloe vera gel, sodium carboxymethylcellulose, glycerin (60 mL); ethanol free; honey-apple flavor
Lozenge
- SalivaSure: Xylitol, citric acid, apple acid, sodium citrate dihydrate, sodium carboxymethylcellulose, dibasic calcium phosphate, silica colloidal, magnesium stearate, stearic acid
- Numoisyn: Sorbitol 0.3 g/lozenge; polyethylene glycol, calcium phosphate dibasic, hydrogenated cottonseed oil, silicon dioxide, magnesium stearate, citric acid, malic acid, sodium citrate
Liquid Oral
- Numoisyn: Chondrus crispus, potassium sorbate, sorbitol, water, linseed extract, sodium benzoate, dipotassium phosphate, propylparaben, methylparaben
Gel
- Biotene Oral Balance: Water, sunflower oil, starch, propylene glycol, glycerine, purified milk extract, xylitol (sugar free)
Discs Extended Release
- XyliMelts: 500 mg xylitol: Dye free, gluten free, preservative free, soy free, yeast free
Powder For Reconstitution
- NeutraSal: Chloride, silicon dioxide, bicarbonate, sodium, phosphates, calcium
Xerostomia
Caphosol, NeutraSal: Swish and spit; 2-10 doses/day
Oasis spray: 1-2 sprays PRN; not to exceed 60 sprays/day
Oasis mouthwash: Rinse mouth with ~30 mL q12hr PRN; do not swallow
Aquoral: 2 sprays PO q6-8hr PRN
Entertainer's secret: Spray PRN
Mouth Kote spray: Spray 3-5 times; swish for 8-10 seconds and spit or swallow PRN
Biotene: Apply 0.5 inch length onto tongue and spread evenly; repeat as often as needed
Numoisyn liquid: Use 2 mL PRN
Numoisyn lozenges: Dissolve 1 lozenge slowly; not to exceed 16 lozenges/day
SalivaSure: Dissolve 1 lozenge in mouth PRN; 1 lozenge/hr recommended
XyliMelts: Apply 2 discs before bed, 1 on each side of mouth, in lower or upper part of cheek; during the day, use as needed; swallow as it slowly dissolves (the tan, dimpled side will adhere to teeth or gums); before bedtime, use 2 discs, placing one on each side of the mouth
Not established
Adverse Effects
Frequency Not Defined
Altered speech
Abnormal taste
Digestive problems
Dysphagia
Warnings
Contraindications
Documented hypersensitivity
Fructose intolerance (Numoisyn lozenges)
Cautions
Caphosol contains 75 mg of sodium per 30 mL dose
Pregnancy & Lactation
Pregnancy Category: A
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Mixture consisting of protein or electrolyte that lubricate, moisten and provide coating on oral mucosa used in absence of saliva
Xylitol stimulates saliva production
