Arestin (minocycline dental) dosing, indications, interactions, adverse effects, and more.

Sections

Sections minocycline dental
Dosing & Uses
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout
Formulary

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

cartridge

Periodontitis

Varies depending on size, shape, & number of pockets

Up to 121 1-mg cartridges have been used in a single visit

Administration

Does not require local anesthesia

Insert unit-dose cartridge to the base of the periodontal pocket & press thumb ring in the handle mechanism to expel powder while gradually withdrawing the tip from pocket base

Handle mechanism should be sterilized between patients

Does not have to be removed (bioresorbable), nor is an adhesive or dressing required

Other Indications & Uses

Adjunct during dental scaling & root planing to reduce pocket depth in adults with periodontitis

Safety & efficacy not established

Adverse Effects

Mostly comparable to control; only those markedly higher are listed

1-10%

Dyspepsia

Mouth ulceration

Mucous membrane disorder

Pharyngitis

Contraindications

Hypersensitivity to minocycline or tetracyclines

Acutely abscessed periodontal pockets

Cautions

May cause tooth discoloration in utero

Pregnancy & Lactation

Pregnancy Category: D

Lactation: tetracyclines excreted in milk, discontinue drug or do not nurse

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Antibiotic of the tetracycline class

Pharmacokinetics

Distribution: saliva > serum

Images

No images available for this drug.

Patient Handout

A Patient Handout is not currently available for this monograph.

Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

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Create Your List of Plans

Adding plans allows you to:

View the formulary and any restrictions for each plan.
Manage and view all your plans together – even plans in different states.
Compare formulary status to other drugs in the same class.
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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

Tier	Description
1	This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2	This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC	NOT COVERED – Drugs that are not covered by the plan.

Code	Definition
PA	Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL	Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST	Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR	Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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