thyroid desiccated (Rx)

Brand and Other Names:Armour Thyroid, Nature-Throid
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Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

tablet

  • 15mg, 16.25mg, 30mg, 32.5mg, 48.75 mg, 60mg, 65mg, 81.25, 90mg, 97.5 mg, 113.75 mg
  • 120mg, 130mg, 146.25, 162.5mg, 180mg, 195mg, 240mg, 260 mg, 300mg, 325 mg

Hypothyroidism

Mild: initial 15-30 mg PO qDay, may increase by 15 mg/day q2-3Weeks (or 30 mg/day q30Days)

Myxedema: start 15 mg PO qDay, THEN after 2 weeks 30 mg PO qDay, THEN after 2 weeks 60 mg PO qDay

Maintentance: 60-120 mg PO qDay

Administration: before breakfast

Other Indications & Uses

As diagnostic agents in suppression tests to differentiate suspected mild hyperthyroidism or thyroid gland autonomy

Dosage Forms & Strengths

tablet

  • 15mg, 16.25mg, 30mg, 32.5mg, 48.75 mg, 60mg, 65mg, 81.25, 90mg, 97.5 mg, 113.75 mg
  • 120mg, 130mg, 146.25, 162.5mg, 180mg, 195mg, 240mg, 260 mg, 300mg, 325 mg

Hypothyroidism

6 months: 4.8-6 mg/kg PO qDay  

6-12 months: 3.6-4.8 mg/kg PO qDay

1-5 years: 3-3.6 mg/kg PO qDay

6-12 years: 2.4-3 mg/kg PO qDay

12 years or older: 1.2-1.8 mg/kg PO qDay

Not recommended

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Interactions

Interaction Checker

and thyroid desiccated

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            Adverse Effects

            Frequency Not Defined

            Tachycardia

            Alopecia

            Myalgia

            Arrhythmias

            Nervousness

            Tremor

            Diarrhea

            Cramps

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            Warnings

            Contraindications

            Hypersensitivity to thyroid hormone

            AMI uncomplicated by hypothyroidism, untreated thyrotoxicosis, untreated adrenal insufficiency

            Cautions

            Angina, cardiovascular disease, HTN, endocrine disorders, elderly

            Judicious use in AMI complicated or caused by hypothyroidism may be considered

            Ineffective in the treatment of obesity or of infertility uncomplicated by hypothyroidism

            Myxedemous patients are very sensitive to thyroid hormone; start at low dosage

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            Pregnancy & Lactation

            Pregnancy Category: A

            Lactation: small amount excreted into breast milk, use caution

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Natural thyroid hormone from animals; increase basal metabolic rate, increase utilization and mobilization of glycogen store, promotes gluconeogenesis

            Pharmacokinetics

            Onset: Initial effect: 3hr

            Bioavailability: 48-80%

            Protein Bound: >99%

            Metabolism: Hepatic; also in kidney and intestinal walls

            Metabolites: Levothyroxine (T4), liothyronine (T3), reverse triiodothyronine (rT3)

            Excretion: Urine (major), feces (partially)

            Time to peak

            • T4: 2-4 hr
            • T3: 2-3 days

            Half-Life

            • T4: 6-7 days (euthyroid); 3-4 days (hyperthyroid); 9-10 (hypothyroid)
            • T3: 2.5 days
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            Formulary

            FormularyPatient Discounts

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            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
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            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.