Dosing & Uses
African Trypanosomiasis (Sleeping Sickness)
Investigational drug
Not commercially available in US; however, available as treatment IND from CDC; 800-CDC-INFO (800-232-4636)
After 1 week: 3.6 mg/kg/day IV x3 days
Repeat again after 10-21 days: 3.6 mg/kg/day
African Trypanosomiasis (Sleeping Sickness)
Investigational drug
Not commercially available in US; however, available as treatment IND from CDC; 800-CDC-INFO (800-232-4636)
18-25 mg/kg total over 1 month
Initial 0.36 mg/kg IV
Incr gradually to 3.6 mg/kg IV at intervals of 1-5 days for total of 9-10 doses
Adverse Effects
Frequency Not Defined
Hypertension
Myocardial damage
Encephalopathy
Peripheral neuropathy
Colic
Vomiting
Albuminuria
Herxheimer-type reaction
Warnings
Contraindications
Glucose-6-phosphate dehydrogenase (G6PD) deficiency, hypersensitivity
Pregnancy & Lactation
Pregnancy Category: no studies conducted
Lactation: not known if excreted in breast milk
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Inhibits synthesis of ATP - the energy required for survival of the parasite
Pharmacokinetics
Distribution: Crosses blood-brain barrier
Vd: 100 L/kg
Half-life: mean terminal elimination: 35 hr
Excreted: urine
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Formulary
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