aspirin rectal (OTC)

Brand and Other Names:
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Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

suppository

  • 60mg
  • 120mg
  • 200mg
  • 300mg
  • 600mg

Antipyretic/Analgesic

300-600 mg PR q4-6hr PRN

Administration

Patient should lie on left side with knees bent

Remove protective wrap before inserting

Gently insert tip into rectum with slight side-to-side movement (tip of suppository pointing toward navel)

Dosage Forms & Strengths

suppository

  • 120mg
  • 200mg
  • 300mg
  • 600mg

Antipyretic/Analgesic

<12 years: 10-15 mg/kg/dose PR q4-6hr; not to exceed 4 g/day

>12 years: As adults; 300-600 mg PR q4-6hr PRN

Renal Impairment

CrCl<10 mL: Not recommended

Hepatic Impairment

Not recommended

Administration

Patient should lie on left side with knees bent

Remove protective wrap before inserting

Gently insert tip into rectum with slight side-to-side movement (tip of suppository pointing toward navel)

Antipyretic/Analgesic

<12 years: 10-15 mg/kg/dose PR q4-6hr; not to exceed 4 g/day

>12 years: As adults; 300-600 mg PR q4-6hr PRN

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Interactions

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            Contraindicated (2)

            • dichlorphenamide

              dichlorphenamide increases levels of aspirin rectal by unknown mechanism. Contraindicated. Coadministration of dichlorphenamide with high-dose aspirin may increase salicylate levels. Anorexia, tachypnea, lethargy, and coma reported.

            • mifepristone

              aspirin rectal, mifepristone. Other (see comment). Contraindicated. Comment: Aspirin induced antiplatelet activity may induce excessive bleeding after an abortion w/mifepristone (RU 486).

            Serious - Use Alternative (26)

            • abciximab

              aspirin rectal increases effects of abciximab by pharmacodynamic synergism. Avoid or Use Alternate Drug. Enhanced risk of hemorrhage.

            • anagrelide

              aspirin rectal increases effects of anagrelide by pharmacodynamic synergism. Avoid or Use Alternate Drug. Enhanced risk of hemorrhage.

            • benazepril

              aspirin rectal, benazepril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

            • captopril

              aspirin rectal, captopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

            • cilostazol

              aspirin rectal increases effects of cilostazol by pharmacodynamic synergism. Avoid or Use Alternate Drug. Enhanced risk of hemorrhage.

            • clopidogrel

              aspirin rectal increases effects of clopidogrel by pharmacodynamic synergism. Avoid or Use Alternate Drug. Enhanced risk of hemorrhage.

            • dipyridamole

              aspirin rectal increases effects of dipyridamole by pharmacodynamic synergism. Avoid or Use Alternate Drug. Enhanced risk of hemorrhage.

            • enalapril

              aspirin rectal, enalapril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

            • eptifibatide

              aspirin rectal increases effects of eptifibatide by pharmacodynamic synergism. Avoid or Use Alternate Drug. Enhanced risk of hemorrhage.

            • fosinopril

              aspirin rectal, fosinopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

            • ibuprofen

              ibuprofen decreases effects of aspirin rectal by Other (see comment). Avoid or Use Alternate Drug. Comment: Ibuprofen decreases the antiplatelet effects of aspirin by blocking the active site of platelet cyclooxygenase. The effect of other NSAIDs on aspirin is not established.

            • ibuprofen IV

              ibuprofen IV decreases effects of aspirin rectal by Other (see comment). Avoid or Use Alternate Drug. Comment: Ibuprofen decreases the antiplatelet effects of aspirin by blocking the active site of platelet cyclooxygenase. The effect of other NSAIDs on aspirin is not established.

            • ketorolac

              aspirin rectal, ketorolac. Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated.

            • lisinopril

              aspirin rectal, lisinopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

            • measles, mumps, rubella and varicella vaccine, live

              aspirin rectal, measles, mumps, rubella and varicella vaccine, live. Mechanism: unspecified interaction mechanism. Avoid or Use Alternate Drug. Risk of Reye's Syndrome with combination; avoid salicylate use for 6 wks after vaccination.

            • methotrexate

              aspirin rectal increases levels of methotrexate by decreasing renal clearance. Avoid or Use Alternate Drug. The relative risk of interaction of different NSAIDs w/methotrexate is not established. Selective COX 2 inhibitors are believed to have minimal interaction. Greater risk in pts. with renal impairment. Greater toxicity with high dose methotrexate (e.g., anti neoplastic regimen).

            • moexipril

              aspirin rectal, moexipril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

            • pemetrexed

              aspirin rectal increases levels of pemetrexed by unspecified interaction mechanism. Avoid or Use Alternate Drug. Especially in pts. w/mild moderate renal insufficiency. D/C NSAIDs 2 5 d before and 2 d after pemetrexed administration.

            • perindopril

              aspirin rectal, perindopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

            • probenecid

              aspirin rectal decreases effects of probenecid by acidic (anionic) drug competition for renal tubular clearance. Avoid or Use Alternate Drug. Aspirin decreases uricosuric action of probenecid.

            • quinapril

              aspirin rectal, quinapril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

            • ramipril

              aspirin rectal, ramipril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

            • ticlopidine

              aspirin rectal increases effects of ticlopidine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Enhanced risk of hemorrhage.

            • tirofiban

              aspirin rectal increases effects of tirofiban by pharmacodynamic synergism. Avoid or Use Alternate Drug. Enhanced risk of hemorrhage.

            • trandolapril

              aspirin rectal, trandolapril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

            • varicella virus vaccine live

              aspirin rectal, varicella virus vaccine live. Mechanism: unspecified interaction mechanism. Avoid or Use Alternate Drug. Risk of Reye's Syndrome with combination; avoid salicylate use for 6 wks after vaccination.

            Monitor Closely (218)

            • acebutolol

              acebutolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.

              aspirin rectal decreases effects of acebutolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

            • aceclofenac

              aceclofenac and aspirin rectal both increase anticoagulation. Use Caution/Monitor.

              aceclofenac and aspirin rectal both increase serum potassium. Use Caution/Monitor.

            • acemetacin

              acemetacin and aspirin rectal both increase anticoagulation. Use Caution/Monitor.

              acemetacin and aspirin rectal both increase serum potassium. Use Caution/Monitor.

            • acetazolamide

              acetazolamide, aspirin rectal. Either increases levels of the other by Other (see comment). Use Caution/Monitor. Comment: Carbonic anhydrase inhibitors (CAIs) and salicylates inhibit each other's renal tubular secretion, resulting in increased plasma levels. CAIs also shift salicylates from plasma to the CNS, leading to potential neurotoxicity.

              acetazolamide, aspirin rectal. Mechanism: passive renal tubular reabsorption due to increased pH. Use Caution/Monitor. Salicylate levels increased at moderate doses; risk of CNS toxicity. Salicylate levels decreased at large doses (d/t increased renal excretion of unchanged salicylic acid).

            • agrimony

              aspirin rectal and agrimony both increase anticoagulation. Use Caution/Monitor.

            • albuterol

              aspirin rectal increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • alfalfa

              aspirin rectal and alfalfa both increase anticoagulation. Use Caution/Monitor.

            • alfuzosin

              aspirin rectal decreases effects of alfuzosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

            • aliskiren

              aspirin rectal will decrease the level or effect of aliskiren by Other (see comment). Use Caution/Monitor. In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs with drugs that affect RAAS may increase the risk of renal impairment (including acute renal failure) and cause loss of antihypertensive effect. Monitor renal function periodically.

            • alteplase

              aspirin rectal and alteplase both increase anticoagulation. Modify Therapy/Monitor Closely.

            • American ginseng

              aspirin rectal and American ginseng both increase anticoagulation. Use Caution/Monitor.

            • amiloride

              amiloride and aspirin rectal both increase serum potassium. Modify Therapy/Monitor Closely.

            • amoxicillin

              amoxicillin, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              amoxicillin, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

            • ampicillin

              ampicillin, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

            • antithrombin alfa

              antithrombin alfa and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.

            • antithrombin III

              antithrombin III and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.

            • arformoterol

              aspirin rectal increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • argatroban

              argatroban and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.

            • asenapine

              aspirin rectal decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

            • atenolol

              atenolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.

              aspirin rectal decreases effects of atenolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

            • azilsartan

              aspirin rectal, azilsartan. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

              aspirin rectal decreases effects of azilsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.

            • bemiparin

              bemiparin and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.

            • bendroflumethiazide

              aspirin rectal increases and bendroflumethiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • betaxolol

              betaxolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.

              aspirin rectal decreases effects of betaxolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

            • betrixaban

              aspirin rectal, betrixaban. Either increases levels of the other by anticoagulation. Use Caution/Monitor.

            • bimatoprost

              bimatoprost, aspirin rectal. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

            • bisoprolol

              bisoprolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.

              aspirin rectal decreases effects of bisoprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

            • bivalirudin

              bivalirudin and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.

            • brinzolamide

              brinzolamide, aspirin rectal. Either increases levels of the other by Other (see comment). Use Caution/Monitor. Comment: Carbonic anhydrase inhibitors (CAIs) and salicylates inhibit each other's renal tubular secretion, resulting in increased plasma levels. CAIs also shift salicylates from plasma to the CNS, leading to potential neurotoxicity.

            • budesonide

              aspirin rectal, budesonide. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

            • bumetanide

              aspirin rectal increases and bumetanide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

              aspirin rectal decreases effects of bumetanide by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

            • candesartan

              candesartan and aspirin rectal both increase serum potassium. Use Caution/Monitor.

            • carbenoxolone

              aspirin rectal increases and carbenoxolone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • carvedilol

              carvedilol and aspirin rectal both increase serum potassium. Use Caution/Monitor.

              aspirin rectal decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

            • celecoxib

              aspirin rectal and celecoxib both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and celecoxib both increase serum potassium. Use Caution/Monitor.

            • celiprolol

              celiprolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.

              aspirin rectal decreases effects of celiprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

            • chlorothiazide

              aspirin rectal increases and chlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • chlorpropamide

              aspirin rectal increases effects of chlorpropamide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

            • chlorthalidone

              aspirin rectal increases and chlorthalidone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • cinnamon

              aspirin rectal and cinnamon both increase anticoagulation. Use Caution/Monitor.

            • citalopram

              citalopram, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. If possible, avoid concurrent use.

            • clobetasone

              aspirin rectal, clobetasone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

            • clomipramine

              clomipramine, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. Clomipramine inhib. serotonin uptake by platelets.

            • clopidogrel

              clopidogrel, aspirin rectal. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Clopidogrel and NSAIDs both inhibit platelet aggregation.

            • cordyceps

              aspirin rectal and cordyceps both increase anticoagulation. Use Caution/Monitor.

            • cortisone

              aspirin rectal, cortisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

            • cyclopenthiazide

              aspirin rectal increases and cyclopenthiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • dabigatran

              dabigatran and aspirin rectal both increase anticoagulation. Use Caution/Monitor. Both drugs have the potential to cause bleeding. Concomitant use may increase risk of bleeding.

            • dalteparin

              dalteparin and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.

            • defibrotide

              defibrotide increases effects of aspirin rectal by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Defibrotide may enhance effects of platelet inhibitors.

            • deflazacort

              aspirin rectal, deflazacort. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

            • dexamethasone

              aspirin rectal, dexamethasone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

            • diclofenac

              aspirin rectal and diclofenac both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and diclofenac both increase serum potassium. Use Caution/Monitor.

            • dicloxacillin

              dicloxacillin, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              dicloxacillin, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

            • diflunisal

              aspirin rectal and diflunisal both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and diflunisal both increase serum potassium. Use Caution/Monitor.

            • digoxin

              aspirin rectal and digoxin both increase serum potassium. Use Caution/Monitor.

            • dobutamine

              aspirin rectal increases and dobutamine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • dong quai

              aspirin rectal and dong quai both increase anticoagulation. Use Caution/Monitor.

            • dopexamine

              aspirin rectal increases and dopexamine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • doxazosin

              aspirin rectal decreases effects of doxazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

            • drospirenone

              drospirenone and aspirin rectal both increase serum potassium. Modify Therapy/Monitor Closely.

            • duloxetine

              duloxetine, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

            • edoxaban

              edoxaban, aspirin rectal. Either increases toxicity of the other by anticoagulation. Modify Therapy/Monitor Closely. Both drugs have the potential to cause bleeding, monitor closely. Promptly evaluate any signs or symptoms of blood loss.

            • eltrombopag

              eltrombopag increases levels of aspirin rectal by decreasing metabolism. Use Caution/Monitor. UGT inhibition; significance of interaction unclear.

            • elvitegravir/cobicistat/emtricitabine/tenofovir DF

              elvitegravir/cobicistat/emtricitabine/tenofovir DF, aspirin rectal. Either increases toxicity of the other by decreasing renal clearance. Modify Therapy/Monitor Closely. Toxicity may result from coadministration of emtricitabine and tenofovir with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion including high-dose or multiple-dose NSAIDs; alternatives to NSAIDs should be considered.

            • enoxaparin

              enoxaparin and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.

            • ephedrine

              aspirin rectal increases and ephedrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • epinephrine

              aspirin rectal increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • epinephrine racemic

              aspirin rectal increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • epoprostenol

              aspirin rectal and epoprostenol both increase anticoagulation. Use Caution/Monitor.

            • eprosartan

              eprosartan and aspirin rectal both increase serum potassium. Use Caution/Monitor.

            • escitalopram

              escitalopram, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

            • esmolol

              esmolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.

              aspirin rectal decreases effects of esmolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

            • ethacrynic acid

              aspirin rectal increases and ethacrynic acid decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • etodolac

              aspirin rectal and etodolac both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and etodolac both increase serum potassium. Use Caution/Monitor.

            • fenbufen

              aspirin rectal and fenbufen both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and fenbufen both increase serum potassium. Use Caution/Monitor.

            • fennel

              aspirin rectal and fennel both increase anticoagulation. Use Caution/Monitor.

            • fenoprofen

              aspirin rectal and fenoprofen both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and fenoprofen both increase serum potassium. Use Caution/Monitor.

            • feverfew

              aspirin rectal and feverfew both increase anticoagulation. Use Caution/Monitor.

            • fish oil triglycerides

              fish oil triglycerides will increase the level or effect of aspirin rectal by anticoagulation. Use Caution/Monitor. Prolonged bleeding reported in patients taking antiplatelet agents or anticoagulants and oral omega-3 fatty acids. Periodically monitor bleeding time in patients receiving fish oil triglycerides and concomitant antiplatelet agents or anticoagulants.

            • flucloxacillin

              flucloxacillin, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              flucloxacillin, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

            • fludrocortisone

              aspirin rectal, fludrocortisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

            • fluoxetine

              fluoxetine, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

            • flurbiprofen

              aspirin rectal and flurbiprofen both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and flurbiprofen both increase serum potassium. Use Caution/Monitor.

            • fluvoxamine

              fluvoxamine, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding SSRIs inhib. serotonin uptake by platelets.

            • fondaparinux

              fondaparinux and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.

            • formoterol

              aspirin rectal increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • forskolin

              aspirin rectal and forskolin both increase anticoagulation. Use Caution/Monitor.

            • furosemide

              aspirin rectal increases and furosemide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • garlic

              aspirin rectal and garlic both increase anticoagulation. Use Caution/Monitor.

            • gentamicin

              aspirin rectal increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • ginger

              aspirin rectal and ginger both increase anticoagulation. Use Caution/Monitor.

            • ginkgo biloba

              aspirin rectal and ginkgo biloba both increase anticoagulation. Use Caution/Monitor.

            • glimepiride

              aspirin rectal increases effects of glimepiride by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

            • glipizide

              aspirin rectal increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

            • glyburide

              aspirin rectal increases effects of glyburide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

            • green tea

              green tea increases effects of aspirin rectal by pharmacodynamic synergism. Use Caution/Monitor. (Theoretical, due to caffeine content). Combination may increase risk of bleeding.

            • griseofulvin

              griseofulvin decreases levels of aspirin rectal by unknown mechanism. Use Caution/Monitor.

            • heparin

              heparin and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.

            • horse chestnut seed

              aspirin rectal and horse chestnut seed both increase anticoagulation. Use Caution/Monitor.

            • hyaluronidase

              aspirin rectal decreases effects of hyaluronidase by Other (see comment). Use Caution/Monitor. Comment: Salicylates, when given in large systemic doses, may render tissues partially resistant to the action of hyaluronidase. Patients may require larger amounts of hyaluronidase for equivalent dispersing effect.

            • hydralazine

              aspirin rectal decreases effects of hydralazine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

            • hydrochlorothiazide

              aspirin rectal increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • hydrocortisone

              aspirin rectal, hydrocortisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

            • ibrutinib

              ibrutinib will increase the level or effect of aspirin rectal by anticoagulation. Use Caution/Monitor. Ibrutinib may increase the risk of hemorrhage in patients receiving antiplatelet or anticoagulant therapies and monitor for signs of bleeding.

            • ibuprofen

              aspirin rectal and ibuprofen both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and ibuprofen both increase serum potassium. Use Caution/Monitor.

            • ibuprofen IV

              aspirin rectal will increase the level or effect of ibuprofen IV by acidic (anionic) drug competition for renal tubular clearance. Modify Therapy/Monitor Closely.

              aspirin rectal and ibuprofen IV both increase anticoagulation. Modify Therapy/Monitor Closely.

              aspirin rectal and ibuprofen IV both increase serum potassium. Modify Therapy/Monitor Closely.

            • imatinib

              imatinib, aspirin rectal. Either increases toxicity of the other by Other (see comment). Modify Therapy/Monitor Closely. Comment: Imatinib may cause thrombocytopenia; bleeding risk increased when imatinib is coadministered with anticoagulants, NSAIDs, platelet inhibitors, and thrombolytic agents.

            • indapamide

              aspirin rectal increases and indapamide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • indomethacin

              aspirin rectal and indomethacin both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and indomethacin both increase serum potassium. Use Caution/Monitor.

            • irbesartan

              irbesartan and aspirin rectal both increase serum potassium. Use Caution/Monitor.

            • isoproterenol

              aspirin rectal increases and isoproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • ketoprofen

              aspirin rectal and ketoprofen both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and ketoprofen both increase serum potassium. Use Caution/Monitor.

            • ketorolac

              aspirin rectal and ketorolac both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and ketorolac both increase serum potassium. Use Caution/Monitor.

            • labetalol

              labetalol and aspirin rectal both increase serum potassium. Use Caution/Monitor.

              aspirin rectal decreases effects of labetalol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

            • latanoprost

              latanoprost, aspirin rectal. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

            • latanoprostene bunod ophthalmic

              latanoprostene bunod ophthalmic, aspirin rectal. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

            • levalbuterol

              aspirin rectal increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • levomilnacipran

              levomilnacipran, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. SNRIs may further impair platelet activity in patients taking antiplatelet or anticoagulant drugs.

            • lithium

              aspirin rectal increases levels of lithium by decreasing renal clearance. Use Caution/Monitor.

            • lornoxicam

              aspirin rectal and lornoxicam both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and lornoxicam both increase serum potassium. Use Caution/Monitor.

            • losartan

              losartan and aspirin rectal both increase serum potassium. Use Caution/Monitor.

            • meclofenamate

              aspirin rectal and meclofenamate both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and meclofenamate both increase serum potassium. Use Caution/Monitor.

            • mefenamic acid

              aspirin rectal and mefenamic acid both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and mefenamic acid both increase serum potassium. Use Caution/Monitor.

            • meloxicam

              aspirin rectal and meloxicam both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and meloxicam both increase serum potassium. Use Caution/Monitor.

            • mesalamine

              mesalamine, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive nephrotoxicity.

            • metaproterenol

              aspirin rectal increases and metaproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • methazolamide

              methazolamide, aspirin rectal. Either increases levels of the other by Other (see comment). Use Caution/Monitor. Comment: Carbonic anhydrase inhibitors (CAIs) and salicylates inhibit each other's renal tubular secretion, resulting in increased plasma levels. CAIs also shift salicylates from plasma to the CNS, leading to potential neurotoxicity.

            • methotrexate

              aspirin rectal will increase the level or effect of methotrexate by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.

            • methylprednisolone

              aspirin rectal, methylprednisolone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

            • metolazone

              aspirin rectal increases and metolazone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • metoprolol

              metoprolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.

              aspirin rectal decreases effects of metoprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

            • milnacipran

              milnacipran, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

            • mistletoe

              aspirin rectal increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • moxisylyte

              aspirin rectal decreases effects of moxisylyte by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

            • mycophenolate

              aspirin rectal will increase the level or effect of mycophenolate by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.

            • nabumetone

              aspirin rectal and nabumetone both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and nabumetone both increase serum potassium. Use Caution/Monitor.

            • nadolol

              nadolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.

              aspirin rectal decreases effects of nadolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

            • nafcillin

              nafcillin, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              nafcillin, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

            • naproxen

              aspirin rectal and naproxen both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and naproxen both increase serum potassium. Use Caution/Monitor.

            • nebivolol

              nebivolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.

              aspirin rectal decreases effects of nebivolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

            • nefazodone

              nefazodone, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

            • nettle

              aspirin rectal increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • norepinephrine

              aspirin rectal increases and norepinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • olmesartan

              olmesartan and aspirin rectal both increase serum potassium. Use Caution/Monitor.

            • oxacillin

              oxacillin, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              oxacillin, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

            • oxaprozin

              aspirin rectal and oxaprozin both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and oxaprozin both increase serum potassium. Use Caution/Monitor.

            • panax ginseng

              aspirin rectal and panax ginseng both increase anticoagulation. Use Caution/Monitor.

            • parecoxib

              aspirin rectal and parecoxib both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and parecoxib both increase serum potassium. Use Caution/Monitor.

            • paroxetine

              paroxetine, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

            • pau d'arco

              aspirin rectal and pau d'arco both increase anticoagulation. Use Caution/Monitor.

            • penbutolol

              penbutolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.

              aspirin rectal decreases effects of penbutolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

            • penicillin G aqueous

              penicillin G aqueous, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              penicillin G aqueous, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

            • phenindione

              phenindione and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.

            • phenoxybenzamine

              aspirin rectal decreases effects of phenoxybenzamine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

            • phentolamine

              aspirin rectal decreases effects of phentolamine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

            • phytoestrogens

              aspirin rectal and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

            • pindolol

              pindolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.

              aspirin rectal decreases effects of pindolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

            • pirbuterol

              aspirin rectal increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • piroxicam

              aspirin rectal and piroxicam both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and piroxicam both increase serum potassium. Use Caution/Monitor.

            • pivmecillinam

              pivmecillinam, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              pivmecillinam, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

            • potassium acid phosphate

              aspirin rectal and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.

            • potassium chloride

              aspirin rectal and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

            • potassium citrate

              aspirin rectal and potassium citrate both increase serum potassium. Use Caution/Monitor.

            • potassium iodide

              potassium iodide and aspirin rectal both increase serum potassium. Use Caution/Monitor.

            • pralatrexate

              aspirin rectal increases levels of pralatrexate by decreasing renal clearance. Use Caution/Monitor.

            • prasugrel

              aspirin rectal, prasugrel. pharmacodynamic synergism. Use Caution/Monitor. The need for simultaneous use of low-dose aspirin and anticoagulant or antiplatelet agents are common for patients with cardiovascular disease; monitor closely.

            • prazosin

              aspirin rectal decreases effects of prazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

            • prednisolone

              aspirin rectal, prednisolone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

            • prednisone

              aspirin rectal, prednisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

            • propranolol

              propranolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.

              aspirin rectal decreases effects of propranolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

            • protamine

              protamine and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.

            • reishi

              aspirin rectal and reishi both increase anticoagulation. Use Caution/Monitor.

            • reteplase

              aspirin rectal and reteplase both increase anticoagulation. Modify Therapy/Monitor Closely.

            • sacubitril/valsartan

              sacubitril/valsartan and aspirin rectal both increase serum potassium. Use Caution/Monitor.

            • salicylates (non-asa)

              aspirin rectal and salicylates (non-asa) both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and salicylates (non-asa) both increase serum potassium. Use Caution/Monitor.

            • salmeterol

              aspirin rectal increases and salmeterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • salsalate

              aspirin rectal and salsalate both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and salsalate both increase serum potassium. Use Caution/Monitor.

            • saw palmetto

              saw palmetto increases toxicity of aspirin rectal by unspecified interaction mechanism. Use Caution/Monitor. May increase risk of bleeding.

            • sertraline

              sertraline, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

            • Siberian ginseng

              aspirin rectal and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

            • silodosin

              aspirin rectal decreases effects of silodosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

            • sodium picosulfate/magnesium oxide/anhydrous citric acid

              aspirin rectal, sodium picosulfate/magnesium oxide/anhydrous citric acid. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May be associated with fluid and electrolyte imbalances.

            • sodium sulfate/?magnesium sulfate/potassium chloride

              sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of aspirin rectal by Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment.

            • sodium sulfate/potassium sulfate/magnesium sulfate

              sodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of aspirin rectal by Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment.

            • sotalol

              sotalol and aspirin rectal both increase serum potassium. Use Caution/Monitor.

              aspirin rectal decreases effects of sotalol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

            • spironolactone

              spironolactone and aspirin rectal both increase serum potassium. Modify Therapy/Monitor Closely.

              aspirin rectal decreases effects of spironolactone by unspecified interaction mechanism. Use Caution/Monitor. When used concomitantly, spironolactone dose may need to be titrated to higher maintenance dose and the patient should be observed closely to determine if the desired effect is obtained.

            • succinylcholine

              aspirin rectal and succinylcholine both increase serum potassium. Use Caution/Monitor.

            • sulfasalazine

              aspirin rectal and sulfasalazine both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and sulfasalazine both increase serum potassium. Use Caution/Monitor.

            • sulindac

              aspirin rectal and sulindac both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and sulindac both increase serum potassium. Use Caution/Monitor.

            • tafluprost

              tafluprost, aspirin rectal. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

            • telmisartan

              telmisartan and aspirin rectal both increase serum potassium. Use Caution/Monitor.

            • temocillin

              temocillin, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              temocillin, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

            • tenecteplase

              aspirin rectal and tenecteplase both increase anticoagulation. Modify Therapy/Monitor Closely.

            • terazosin

              aspirin rectal decreases effects of terazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

            • terbutaline

              aspirin rectal increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • ticarcillin

              ticarcillin, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

              ticarcillin, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.

            • timolol

              timolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.

              aspirin rectal decreases effects of timolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

            • tolazamide

              aspirin rectal increases effects of tolazamide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

            • tolbutamide

              aspirin rectal increases effects of tolbutamide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

            • tolfenamic acid

              aspirin rectal and tolfenamic acid both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and tolfenamic acid both increase serum potassium. Use Caution/Monitor.

            • tolmetin

              aspirin rectal and tolmetin both increase anticoagulation. Use Caution/Monitor.

              aspirin rectal and tolmetin both increase serum potassium. Use Caution/Monitor.

            • tolvaptan

              aspirin rectal and tolvaptan both increase serum potassium. Use Caution/Monitor.

            • torsemide

              aspirin rectal increases and torsemide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • travoprost ophthalmic

              travoprost ophthalmic, aspirin rectal. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

            • trazodone

              trazodone, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

            • triamcinolone acetonide injectable suspension

              aspirin rectal, triamcinolone acetonide injectable suspension. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Aspirin in conjunction with corticosteroids in hypoprothrombinemia should used with caution. Clearance of salicylates may increase with concurrent use of corticosteroids.

            • triamterene

              triamterene and aspirin rectal both increase serum potassium. Modify Therapy/Monitor Closely.

            • valproic acid

              aspirin rectal increases levels of valproic acid by plasma protein binding competition. Use Caution/Monitor.

            • valsartan

              valsartan and aspirin rectal both increase serum potassium. Use Caution/Monitor.

            • venlafaxine

              venlafaxine, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

            • vitamin K1 (phytonadione)

              aspirin rectal increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • voclosporin

              voclosporin, aspirin rectal. Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely. Coadministration with drugs associated with nephrotoxicity may increase the risk for acute and/or chronic nephrotoxicity.

            • vorapaxar

              aspirin rectal, vorapaxar. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive antiplatelet effect may occur.

            • vortioxetine

              aspirin rectal, vortioxetine. Either increases effects of the other by anticoagulation. Use Caution/Monitor. Risk minimal with low-dose aspirin.

            • warfarin

              warfarin and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.

            • zanubrutinib

              aspirin rectal, zanubrutinib. Either increases effects of the other by anticoagulation. Modify Therapy/Monitor Closely. Zanubrutinib-induced cytopenias increases risk of hemorrhage. Coadministration of zanubritinib with antiplatelets or anticoagulants may further increase this risk.

            • zotepine

              aspirin rectal decreases effects of zotepine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

            Minor (118)

            • aceclofenac

              aceclofenac will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • acemetacin

              acemetacin will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • acyclovir

              aspirin rectal will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • alendronate

              aspirin rectal, alendronate. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of GI ulceration.

            • aluminum hydroxide

              aluminum hydroxide, aspirin rectal. Mechanism: passive renal tubular reabsorption due to increased pH. Minor/Significance Unknown. Salicylate levels increased at moderate doses; salicylate levels decreased at large doses (d/t increased renal excretion of unchanged salicylic acid).

            • amikacin

              aspirin rectal increases levels of amikacin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

            • aminohippurate sodium

              aspirin rectal will increase the level or effect of aminohippurate sodium by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • anamu

              aspirin rectal and anamu both increase anticoagulation. Minor/Significance Unknown.

            • ascorbic acid

              ascorbic acid will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

              ascorbic acid increases levels of aspirin rectal by decreasing renal clearance. Minor/Significance Unknown.

              aspirin rectal decreases levels of ascorbic acid by increasing renal clearance. Minor/Significance Unknown.

            • balsalazide

              aspirin rectal will increase the level or effect of balsalazide by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • bendroflumethiazide

              bendroflumethiazide will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • bismuth subsalicylate

              bismuth subsalicylate increases effects of aspirin rectal by pharmacodynamic synergism. Minor/Significance Unknown.

            • budesonide

              budesonide decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.

            • bumetanide

              aspirin rectal, bumetanide. Other (see comment). Minor/Significance Unknown. Comment: Salicylates are less likely than other NSAIDs to interact w/bumetanide.

            • calcium carbonate

              calcium carbonate, aspirin rectal. Mechanism: passive renal tubular reabsorption due to increased pH. Minor/Significance Unknown. Salicylate levels increased at moderate doses; salicylate levels decreased at large doses (d/t increased renal excretion of unchanged salicylic acid).

            • cefadroxil

              cefadroxil will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • cefamandole

              cefamandole will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • cefepime

              cefepime will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • cefixime

              cefixime will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • cefpirome

              cefpirome will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • cefprozil

              cefprozil will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • ceftazidime

              ceftazidime will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • ceftibuten

              ceftibuten will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • celecoxib

              aspirin rectal will increase the level or effect of celecoxib by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • cephalexin

              cephalexin will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • chlorothiazide

              chlorothiazide will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • chlorpropamide

              aspirin rectal will increase the level or effect of chlorpropamide by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

              aspirin rectal increases effects of chlorpropamide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.

            • chlorthalidone

              chlorthalidone will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • chromium

              aspirin rectal increases levels of chromium by unspecified interaction mechanism. Minor/Significance Unknown.

            • clopidogrel

              clopidogrel increases levels of aspirin rectal by decreasing metabolism. Minor/Significance Unknown.

            • cortisone

              cortisone decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.

            • creatine

              creatine, aspirin rectal. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction) Combination may have additive nephrotoxic effects.

            • cyanocobalamin

              aspirin rectal decreases levels of cyanocobalamin by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

            • cyclopenthiazide

              cyclopenthiazide will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • danshen

              aspirin rectal and danshen both increase anticoagulation. Minor/Significance Unknown.

            • deflazacort

              deflazacort decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.

            • devil's claw

              aspirin rectal and devil's claw both increase anticoagulation. Minor/Significance Unknown.

            • dexamethasone

              dexamethasone decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.

            • dexrazoxane

              aspirin rectal increases levels of dexrazoxane by unspecified interaction mechanism. Minor/Significance Unknown.

            • diclofenac

              aspirin rectal will increase the level or effect of diclofenac by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • diflunisal

              aspirin rectal will increase the level or effect of diflunisal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • diltiazem

              diltiazem increases effects of aspirin rectal by unknown mechanism. Minor/Significance Unknown. Enhanced antiplatelet activity.

            • eplerenone

              aspirin rectal decreases effects of eplerenone by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis.

            • ethanol

              ethanol increases toxicity of aspirin rectal by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of GI bleeding.

            • etodolac

              aspirin rectal will increase the level or effect of etodolac by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • fenbufen

              aspirin rectal will increase the level or effect of fenbufen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • fenoprofen

              aspirin rectal will increase the level or effect of fenoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • feverfew

              aspirin rectal decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

            • fludrocortisone

              fludrocortisone decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.

            • flurbiprofen

              aspirin rectal will increase the level or effect of flurbiprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • folic acid

              aspirin rectal decreases levels of folic acid by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

            • furosemide

              aspirin rectal decreases effects of furosemide by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis.

            • ganciclovir

              aspirin rectal will increase the level or effect of ganciclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • gentamicin

              aspirin rectal increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

            • glimepiride

              aspirin rectal increases effects of glimepiride by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.

            • glipizide

              aspirin rectal increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.

            • glyburide

              aspirin rectal increases effects of glyburide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.

            • hydrochlorothiazide

              hydrochlorothiazide will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • hydrocortisone

              hydrocortisone decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.

            • ibuprofen

              aspirin rectal will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • imidapril

              aspirin rectal decreases effects of imidapril by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis.

            • indapamide

              indapamide will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • indomethacin

              aspirin rectal will increase the level or effect of indomethacin by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • insulin aspart

              aspirin rectal increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown. Large dose of salicylate.

            • insulin lispro

              aspirin rectal increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown. Large dose of salicylate.

            • insulin regular human

              aspirin rectal increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown. Large dose of salicylate.

            • ketoprofen

              aspirin rectal will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • ketorolac

              aspirin rectal will increase the level or effect of ketorolac by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • L-methylfolate

              aspirin rectal decreases levels of L-methylfolate by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

            • lornoxicam

              aspirin rectal will increase the level or effect of lornoxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • meclofenamate

              aspirin rectal will increase the level or effect of meclofenamate by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • mefenamic acid

              aspirin rectal will increase the level or effect of mefenamic acid by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • meloxicam

              aspirin rectal will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • mesalamine

              aspirin rectal will increase the level or effect of mesalamine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • methylprednisolone

              methylprednisolone decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.

            • metolazone

              metolazone will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • nabumetone

              aspirin rectal will increase the level or effect of nabumetone by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • naproxen

              aspirin rectal will increase the level or effect of naproxen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • neomycin PO

              aspirin rectal increases levels of neomycin PO by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

            • noni juice

              aspirin rectal and noni juice both increase serum potassium. Minor/Significance Unknown.

            • ofloxacin

              ofloxacin, aspirin rectal. Other (see comment). Minor/Significance Unknown. Comment: Risk of CNS stimulation/seizure. Mechanism: Displacement of GABA from receptors in brain.

            • oxaprozin

              aspirin rectal will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • parecoxib

              aspirin rectal will increase the level or effect of parecoxib by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • paromomycin

              aspirin rectal increases levels of paromomycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

            • pegaspargase

              pegaspargase increases effects of aspirin rectal by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of bleeding events.

            • penicillin VK

              penicillin VK, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Minor/Significance Unknown.

            • pentazocine

              aspirin rectal, pentazocine. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Possible risk of renal papillary necrosis w/chronic Tx.

            • piperacillin

              piperacillin will increase the level or effect of aspirin rectal by plasma protein binding competition. Minor/Significance Unknown. Salicylic acid could be displaced from protein binding sites or it could itself displace other protein-bound drugs and result in an enhanced effect of the displaced drug

            • piroxicam

              aspirin rectal will increase the level or effect of piroxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • prednisolone

              prednisolone decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.

            • prednisone

              prednisone decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.

            • rivastigmine

              rivastigmine increases toxicity of aspirin rectal by pharmacodynamic synergism. Minor/Significance Unknown. Increased GI symptoms.

            • rose hips

              rose hips will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

              rose hips increases levels of aspirin rectal by decreasing renal clearance. Minor/Significance Unknown.

              aspirin rectal decreases levels of rose hips by increasing renal clearance. Minor/Significance Unknown.

            • salicylates (non-asa)

              aspirin rectal will increase the level or effect of salicylates (non-asa) by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • salsalate

              aspirin rectal will increase the level or effect of salsalate by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • sodium bicarbonate

              sodium bicarbonate, aspirin rectal. Mechanism: passive renal tubular reabsorption due to increased pH. Minor/Significance Unknown. Salicylate levels increased at moderate doses; salicylate levels decreased at large doses (d/t increased renal excretion of unchanged salicylic acid).

            • sodium citrate/citric acid

              sodium citrate/citric acid, aspirin rectal. Mechanism: passive renal tubular reabsorption due to increased pH. Minor/Significance Unknown. Salicylate levels increased at moderate doses; salicylate levels decreased at large doses (d/t increased renal excretion of unchanged salicylic acid).

            • streptomycin

              aspirin rectal increases levels of streptomycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

            • sulfadiazine

              aspirin rectal increases levels of sulfadiazine by unspecified interaction mechanism. Minor/Significance Unknown.

            • sulfamethoxazole

              aspirin rectal increases levels of sulfamethoxazole by unspecified interaction mechanism. Minor/Significance Unknown.

            • sulfasalazine

              aspirin rectal will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • sulfisoxazole

              aspirin rectal increases levels of sulfisoxazole by unspecified interaction mechanism. Minor/Significance Unknown.

            • sulindac

              aspirin rectal will increase the level or effect of sulindac by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • teniposide

              aspirin rectal increases levels of teniposide by unspecified interaction mechanism. Minor/Significance Unknown.

            • tiludronate

              aspirin rectal decreases levels of tiludronate by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

            • tobramycin

              aspirin rectal increases levels of tobramycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

            • tolazamide

              aspirin rectal increases effects of tolazamide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.

            • tolbutamide

              aspirin rectal increases effects of tolbutamide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.

            • tolfenamic acid

              aspirin rectal will increase the level or effect of tolfenamic acid by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • tolmetin

              aspirin rectal will increase the level or effect of tolmetin by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • triamcinolone acetonide injectable suspension

              triamcinolone acetonide injectable suspension decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.

            • triamterene

              triamterene, aspirin rectal. Other (see comment). Minor/Significance Unknown. Comment: Risk of acute renal failure. Mechanism: NSAIDs decrease prostaglandin synthesis, which normally protect against nephrotoxicity.

              aspirin rectal increases toxicity of triamterene by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis, increasing the risk of nephrotoxicity.

            • valganciclovir

              aspirin rectal will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • vancomycin

              aspirin rectal increases levels of vancomycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in neonates.

            • verapamil

              verapamil increases effects of aspirin rectal by unknown mechanism. Minor/Significance Unknown. Enhanced antiplatelet activity.

            • willow bark

              willow bark increases effects of aspirin rectal by pharmacodynamic synergism. Minor/Significance Unknown. Willow bark contains salicylic acid, which may have additive effects/toxicity with salicylate drugs.

              aspirin rectal will increase the level or effect of willow bark by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

            • zafirlukast

              aspirin rectal increases levels of zafirlukast by unknown mechanism. Minor/Significance Unknown.

            • zoledronic acid

              aspirin rectal decreases levels of zoledronic acid by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

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            Adverse Effects

            Frequency Not Defined

            Common

            • Rectal discomfort
            • Tinnitus (high or chronic dose)
            • Rash
            • Urticaria

            Angioedema

            DIC

            Hypotension

            Tachycardia

            CNS alteration

            Dizziness

            Headache

            Dermatologic problems

            Hives

            Electrolyte disturbances; dehydration, hyperkalemia, metabolic acidosis, respiratory alkalosis

            Platelet aggregation inhibition

            Prolonged prothrombin time

            Thrombocytopenia

            Hepatotoxicity

            Hearing loss

            Renal damage

            Bronchospasm

            Pulmonary edema (salicylate-induced/noncardiogenic)

            Reye syndrome

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            Warnings

            Contraindications

            Hypersensitivity to aspirin or NSAIDs

            Hepatitis or severe hepatic/renal impairment

            Do not use in children or adolescents with viral infections (eg, influenza, chickenpox) because of risk of Reye syndrome

            Cautions

            Many dosage forms, check label carefully!

            Gastrointestinal bleeding; particular caution in patients w/ history of GI bleed, alcoholism, or bleeding disorders

            Avoid w/ active peptic ulcer disease

            Avoid in severe renal impairment (ie, CrCl <10 mL/min)

            Avoid in severe hepatic impairment

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            Pregnancy & Lactation

            Pregnancy category: D; avoid during pregnancy, particularly in third trimester because of risk for premature closure of the ductus arteriosus

            Lactation: excreted in breast milk; do not breast feed

            Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Inhibits prostaglandin synthesis by cyclooxygenase-1 and -2 via acetylation; inhibits formation of prostaglandin derivative, thromboxane A2 via acetylation of platelete cyclooxygenase, which in turn inhibits platelet aggregation

            Pharmacokinetics

            Absorption: 60%

            Onset: 4-5 hr

            Half-life: 4.7-9 hr

            Protein Bound: 50-80%

            Volume of Distribution: 150 mL/kg

            Metabolism: Hydrolyzed by esterases in liver (mostly) & erythrocytes to salicylic acid

            Metabolites: salicyluric acid, salicyl acyl glucuronide, salicyl phenolic glucuronide, gentisic acid

            Excretion: (urine) 5.6-35.6% Hemodialysis: Yes

            Pharmacogenomics

            Aspirin associated hypersensitivity reactions include:

            Aspirin-induced urticaria: associated with HLA-DRB1*1302-DQB1*0609 haplotype

            Aspirin-intolerant asthma: associated with HLA-DPB1*0301

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            Images

            BRAND FORM. UNIT PRICE PILL IMAGE
            Ecotrin Low Strength oral
            -
            81 mg tablet
            Bayer Aspirin oral
            -
            325 mg tablet
            Bayer Chewable Low Dose Aspirin oral
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            81 mg chewable tablet
            Bayer Chewable Low Dose Aspirin oral
            -
            81 mg chewable tablet
            Children's Aspirin oral
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            81 mg chewable tablet
            Children's Aspirin oral
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            81 mg chewable tablet
            aspirin oral
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            81 mg chewable tablet
            aspirin oral
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            81 mg chewable tablet
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            325 mg tablet
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            81 mg tablet
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            81 mg chewable tablet
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            325 mg tablet
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            81 mg chewable tablet
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            325 mg tablet
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            81 mg tablet
            aspirin oral
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            81 mg tablet
            aspirin oral
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            81 mg tablet
            aspirin oral
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            81 mg tablet
            aspirin oral
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            81 mg tablet
            aspirin oral
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            325 mg tablet
            aspirin oral
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            81 mg chewable tablet
            aspirin oral
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            325 mg tablet
            aspirin oral
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            325 mg tablet
            aspirin oral
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            81 mg tablet
            aspirin oral
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            81 mg tablet
            aspirin oral
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            325 mg tablet
            aspirin oral
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            81 mg tablet
            aspirin oral
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            325 mg tablet
            aspirin oral
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            325 mg tablet
            aspirin oral
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            81 mg chewable tablet
            aspirin oral
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            325 mg tablet
            aspirin oral
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            81 mg chewable tablet
            aspirin oral
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            81 mg chewable tablet
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            325 mg tablet
            aspirin oral
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            325 mg tablet
            aspirin oral
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            81 mg tablet
            aspirin oral
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            325 mg tablet
            aspirin oral
            -
            325 mg tablet
            aspirin oral
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            81 mg tablet
            aspirin oral
            -
            81 mg tablet
            aspirin oral
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            81 mg chewable tablet
            aspirin oral
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            81 mg tablet
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            325 mg tablet
            aspirin oral
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            325 mg tablet
            aspirin oral
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            aspirin oral
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            aspirin oral
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            81 mg chewable tablet
            aspirin oral
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            81 mg chewable tablet
            aspirin oral
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            325 mg tablet
            aspirin oral
            -
            325 mg tablet
            Durlaza oral
            -
            162.5 mg capsule
            Extra Strength Bayer oral
            -
            500 mg tablet
            Adult Aspirin Regimen oral
            -
            81 mg tablet
            Adult Aspirin Regimen oral
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            81 mg tablet
            Adult Aspirin Regimen oral
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            81 mg tablet
            Adult Aspirin Regimen oral
            -
            81 mg tablet
            aspirin rectal
            -
            600 mg suppos
            aspirin rectal
            -
            300 mg suppos
            St Joseph Aspirin oral
            -
            81 mg chewable tablet
            Bayer Advanced oral
            -
            500 mg tablet

            Copyright © 2010 First DataBank, Inc.

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            Patient Handout

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            Patient Education
            aspirin oral

            ASPIRIN EXTENDED-RELEASE CAPSULE - ORAL

            (AS-pir-in)

            COMMON BRAND NAME(S): Durlaza

            USES: This medication is a low dose of aspirin used to reduce the risk of having a heart attack in people who have heart disease. It is also used to reduce the risk of stroke in people who have previously had a stroke or "mini-stroke" (transient ischemic attack). Aspirin is known as a salicylate and a nonsteroidal anti-inflammatory drug (NSAID). This medication works by stopping platelets from clumping together and forming blood clots that can cause a heart attack or stroke.This medication is a long-acting form of aspirin and does not work right away. Other forms of aspirin (immediate-release) should be used when a fast effect is needed, such as right after a heart attack or for pain relief.

            HOW TO USE: Take this medication by mouth as directed by your doctor, usually once a day. Swallow the capsule whole. Do not cut, crush, or chew the capsules. Doing so can release all of the drug at once, increasing the risk of side effects. If stomach upset occurs while taking this medication, take it with food or milk.Take this medication by mouth with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. Do not lie down for at least 10 minutes after taking this medication.Do not take this medication 2 hours before or 1 hour after drinking alcoholic beverages.NSAIDs (such as ibuprofen, naproxen) may decrease aspirin's ability to prevent heart attack/stroke. If you use a NSAID, take it at least 8 hours before or at least 2 to 4 hours after this medication (see also Drug Interactions section).Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

            SIDE EFFECTS: Upset stomach or heartburn may occur. If either of these effects lasts or gets worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, uncontrolled bleeding from gums or nose, loss of appetite, dark urine, yellowing eyes/skin, unusual tiredness, signs of kidney problems (such as change in the amount of urine).This drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. If you notice any of the following unlikely but serious side effects, stop taking this medication and consult your doctor or pharmacist right away: stomach/abdominal pain that doesn't go away, black stools, vomit that looks like coffee grounds.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

            PRECAUTIONS: Before taking aspirin, tell your doctor or pharmacist if you are allergic to it; or to other salicylates (such as choline salicylate); or to NSAIDs (such as ibuprofen, naproxen); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs), bleeding/blood problems (such as hemophilia, vitamin K deficiency, low platelets), kidney disease, liver disease, stomach problems (such as ulcers, heartburn), growths in the nose (nasal polyps).This medicine may cause stomach bleeding. Daily use of alcohol and tobacco while using this medicine may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Ask your doctor or pharmacist about how much alcohol you may safely drink.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).This drug contains aspirin. Children and teenagers younger than 18 should not take aspirin if they have chickenpox, flu, or any undiagnosed illness or if they have recently received a vaccine. In these cases, taking aspirin increases the risk of Reye's syndrome, a rare but serious illness.Older adults may be more sensitive to the side effects of this drug, especially stomach/intestinal bleeding and ulcers.Aspirin is not recommended for use to treat pain or fever during pregnancy. Before using this medication, women of childbearing age should talk with their doctor(s) about the benefits and risks. Tell your doctor if you are pregnant or if you plan to become pregnant. This medication may harm an unborn baby and cause problems with normal labor/delivery. It is not recommended for use in pregnancy from 20 weeks until delivery. If your doctor decides that you need to use this medication between 20 and 30 weeks of pregnancy, you should use the lowest effective dose for the shortest possible time. In some cases, low-dose aspirin (usually 81-162 milligrams a day) may be used safely during pregnancy to prevent certain conditions. Talk to your doctor for more details.Aspirin passes into breast milk. When used in large amounts (such as to treat pain or fever), it may harm a nursing infant and breast-feeding while using this drug is not recommended. However, low-dose aspirin for heart attack or stroke prevention may be used if directed by your doctor. Consult your doctor before breast-feeding.

            DRUG INTERACTIONS: See also How to Use section.Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: mifepristone, other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, "blood thinners" such as warfarin/dabigatran), corticosteroids (such as prednisone), ginkgo biloba.Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (including aspirin, NSAIDs such as ibuprofen, ketorolac, naproxen). These drugs are similar to this medication and may increase your risk of side effects if taken together. Daily use of NSAIDs may decrease aspirin's ability to prevent heart attack/stroke. Ask your doctor or pharmacist for details.This medication may interfere with certain lab tests, possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

            OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: ringing in the ears, sweating, rapid breathing.

            NOTES: Do not share this medication with others.

            MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

            STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

            Information last revised August 2021. Copyright(c) 2021 First Databank, Inc.

            IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.