Dosing & Uses
Dosage Forms & Strengths
suppository
- 60mg
- 120mg
- 200mg
- 300mg
- 600mg
Antipyretic/Analgesic
300-600 mg PR q4-6hr PRN
Administration
Patient should lie on left side with knees bent
Remove protective wrap before inserting
Gently insert tip into rectum with slight side-to-side movement (tip of suppository pointing toward navel)
Dosage Forms & Strengths
suppository
- 120mg
- 200mg
- 300mg
- 600mg
Antipyretic/Analgesic
<12 years: 10-15 mg/kg/dose PR q4-6hr; not to exceed 4 g/day
>12 years: As adults; 300-600 mg PR q4-6hr PRN
Renal Impairment
CrCl<10 mL: Not recommended
Hepatic Impairment
Not recommended
Administration
Patient should lie on left side with knees bent
Remove protective wrap before inserting
Gently insert tip into rectum with slight side-to-side movement (tip of suppository pointing toward navel)
Antipyretic/Analgesic
<12 years: 10-15 mg/kg/dose PR q4-6hr; not to exceed 4 g/day
>12 years: As adults; 300-600 mg PR q4-6hr PRN
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (2)
- dichlorphenamide
dichlorphenamide increases levels of aspirin rectal by unknown mechanism. Contraindicated. Coadministration of dichlorphenamide with high-dose aspirin may increase salicylate levels. Anorexia, tachypnea, lethargy, and coma reported.
- mifepristone
aspirin rectal, mifepristone. Other (see comment). Contraindicated. Comment: Aspirin induced antiplatelet activity may induce excessive bleeding after an abortion w/mifepristone (RU 486).
Serious - Use Alternative (26)
- abciximab
aspirin rectal increases effects of abciximab by pharmacodynamic synergism. Avoid or Use Alternate Drug. Enhanced risk of hemorrhage.
- anagrelide
aspirin rectal increases effects of anagrelide by pharmacodynamic synergism. Avoid or Use Alternate Drug. Enhanced risk of hemorrhage.
- benazepril
aspirin rectal, benazepril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
- captopril
aspirin rectal, captopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
- cilostazol
aspirin rectal increases effects of cilostazol by pharmacodynamic synergism. Avoid or Use Alternate Drug. Enhanced risk of hemorrhage.
- clopidogrel
aspirin rectal increases effects of clopidogrel by pharmacodynamic synergism. Avoid or Use Alternate Drug. Enhanced risk of hemorrhage.
- dipyridamole
aspirin rectal increases effects of dipyridamole by pharmacodynamic synergism. Avoid or Use Alternate Drug. Enhanced risk of hemorrhage.
- enalapril
aspirin rectal, enalapril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
- eptifibatide
aspirin rectal increases effects of eptifibatide by pharmacodynamic synergism. Avoid or Use Alternate Drug. Enhanced risk of hemorrhage.
- fosinopril
aspirin rectal, fosinopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
- ibuprofen
ibuprofen decreases effects of aspirin rectal by Other (see comment). Avoid or Use Alternate Drug. Comment: Ibuprofen decreases the antiplatelet effects of aspirin by blocking the active site of platelet cyclooxygenase. The effect of other NSAIDs on aspirin is not established.
- ibuprofen IV
ibuprofen IV decreases effects of aspirin rectal by Other (see comment). Avoid or Use Alternate Drug. Comment: Ibuprofen decreases the antiplatelet effects of aspirin by blocking the active site of platelet cyclooxygenase. The effect of other NSAIDs on aspirin is not established.
- ketorolac
aspirin rectal, ketorolac. Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated.
- lisinopril
aspirin rectal, lisinopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
- measles, mumps, rubella and varicella vaccine, live
aspirin rectal, measles, mumps, rubella and varicella vaccine, live. Mechanism: unspecified interaction mechanism. Avoid or Use Alternate Drug. Risk of Reye's Syndrome with combination; avoid salicylate use for 6 wks after vaccination.
- methotrexate
aspirin rectal increases levels of methotrexate by decreasing renal clearance. Avoid or Use Alternate Drug. The relative risk of interaction of different NSAIDs w/methotrexate is not established. Selective COX 2 inhibitors are believed to have minimal interaction. Greater risk in pts. with renal impairment. Greater toxicity with high dose methotrexate (e.g., anti neoplastic regimen).
- moexipril
aspirin rectal, moexipril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
- pemetrexed
aspirin rectal increases levels of pemetrexed by unspecified interaction mechanism. Avoid or Use Alternate Drug. Especially in pts. w/mild moderate renal insufficiency. D/C NSAIDs 2 5 d before and 2 d after pemetrexed administration.
- perindopril
aspirin rectal, perindopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
- probenecid
aspirin rectal decreases effects of probenecid by acidic (anionic) drug competition for renal tubular clearance. Avoid or Use Alternate Drug. Aspirin decreases uricosuric action of probenecid.
- quinapril
aspirin rectal, quinapril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
- ramipril
aspirin rectal, ramipril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
- ticlopidine
aspirin rectal increases effects of ticlopidine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Enhanced risk of hemorrhage.
- tirofiban
aspirin rectal increases effects of tirofiban by pharmacodynamic synergism. Avoid or Use Alternate Drug. Enhanced risk of hemorrhage.
- trandolapril
aspirin rectal, trandolapril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
- varicella virus vaccine live
aspirin rectal, varicella virus vaccine live. Mechanism: unspecified interaction mechanism. Avoid or Use Alternate Drug. Risk of Reye's Syndrome with combination; avoid salicylate use for 6 wks after vaccination.
Monitor Closely (216)
- acebutolol
acebutolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.
aspirin rectal decreases effects of acebutolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. - aceclofenac
aceclofenac and aspirin rectal both increase anticoagulation. Use Caution/Monitor.
aceclofenac and aspirin rectal both increase serum potassium. Use Caution/Monitor. - acemetacin
acemetacin and aspirin rectal both increase anticoagulation. Use Caution/Monitor.
acemetacin and aspirin rectal both increase serum potassium. Use Caution/Monitor. - acetazolamide
acetazolamide, aspirin rectal. Either increases levels of the other by Other (see comment). Use Caution/Monitor. Comment: Carbonic anhydrase inhibitors (CAIs) and salicylates inhibit each other's renal tubular secretion, resulting in increased plasma levels. CAIs also shift salicylates from plasma to the CNS, leading to potential neurotoxicity.
acetazolamide, aspirin rectal. Mechanism: passive renal tubular reabsorption due to increased pH. Use Caution/Monitor. Salicylate levels increased at moderate doses; risk of CNS toxicity. Salicylate levels decreased at large doses (d/t increased renal excretion of unchanged salicylic acid). - agrimony
aspirin rectal and agrimony both increase anticoagulation. Use Caution/Monitor.
- albuterol
aspirin rectal increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- alfalfa
aspirin rectal and alfalfa both increase anticoagulation. Use Caution/Monitor.
- alfuzosin
aspirin rectal decreases effects of alfuzosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- aliskiren
aspirin rectal will decrease the level or effect of aliskiren by Other (see comment). Use Caution/Monitor. In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs with drugs that affect RAAS may increase the risk of renal impairment (including acute renal failure) and cause loss of antihypertensive effect. Monitor renal function periodically.
- alteplase
aspirin rectal and alteplase both increase anticoagulation. Modify Therapy/Monitor Closely.
- American ginseng
aspirin rectal and American ginseng both increase anticoagulation. Use Caution/Monitor.
- amiloride
amiloride and aspirin rectal both increase serum potassium. Modify Therapy/Monitor Closely.
- amoxicillin
amoxicillin, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.
amoxicillin, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor. - ampicillin
ampicillin, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.
- antithrombin alfa
antithrombin alfa and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.
- antithrombin III
antithrombin III and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.
- arformoterol
aspirin rectal increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- argatroban
argatroban and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.
- asenapine
aspirin rectal decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- atenolol
atenolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.
aspirin rectal decreases effects of atenolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. - azilsartan
aspirin rectal, azilsartan. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
aspirin rectal decreases effects of azilsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. - bemiparin
bemiparin and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.
- bendroflumethiazide
aspirin rectal increases and bendroflumethiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- betaxolol
betaxolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.
aspirin rectal decreases effects of betaxolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. - betrixaban
aspirin rectal, betrixaban. Either increases levels of the other by anticoagulation. Use Caution/Monitor.
- bimatoprost
bimatoprost, aspirin rectal. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).
- bisoprolol
bisoprolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.
aspirin rectal decreases effects of bisoprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. - bivalirudin
bivalirudin and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.
- brinzolamide
brinzolamide, aspirin rectal. Either increases levels of the other by Other (see comment). Use Caution/Monitor. Comment: Carbonic anhydrase inhibitors (CAIs) and salicylates inhibit each other's renal tubular secretion, resulting in increased plasma levels. CAIs also shift salicylates from plasma to the CNS, leading to potential neurotoxicity.
- budesonide
aspirin rectal, budesonide. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.
- bumetanide
aspirin rectal increases and bumetanide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
aspirin rectal decreases effects of bumetanide by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis. - candesartan
candesartan and aspirin rectal both increase serum potassium. Use Caution/Monitor.
- carbenoxolone
aspirin rectal increases and carbenoxolone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- carvedilol
carvedilol and aspirin rectal both increase serum potassium. Use Caution/Monitor.
aspirin rectal decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. - celecoxib
aspirin rectal and celecoxib both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and celecoxib both increase serum potassium. Use Caution/Monitor. - celiprolol
celiprolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.
aspirin rectal decreases effects of celiprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. - chlorothiazide
aspirin rectal increases and chlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- chlorpropamide
aspirin rectal increases effects of chlorpropamide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
- chlorthalidone
aspirin rectal increases and chlorthalidone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- cinnamon
aspirin rectal and cinnamon both increase anticoagulation. Use Caution/Monitor.
- citalopram
citalopram, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. If possible, avoid concurrent use.
- clomipramine
clomipramine, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. Clomipramine inhib. serotonin uptake by platelets.
- clopidogrel
clopidogrel, aspirin rectal. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Clopidogrel and NSAIDs both inhibit platelet aggregation.
- cordyceps
aspirin rectal and cordyceps both increase anticoagulation. Use Caution/Monitor.
- cortisone
aspirin rectal, cortisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.
- cyclopenthiazide
aspirin rectal increases and cyclopenthiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- dabigatran
dabigatran and aspirin rectal both increase anticoagulation. Use Caution/Monitor. Both drugs have the potential to cause bleeding. Concomitant use may increase risk of bleeding.
- dalteparin
dalteparin and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.
- defibrotide
defibrotide increases effects of aspirin rectal by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Defibrotide may enhance effects of platelet inhibitors.
- deflazacort
aspirin rectal, deflazacort. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.
- dexamethasone
aspirin rectal, dexamethasone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.
- diclofenac
aspirin rectal and diclofenac both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and diclofenac both increase serum potassium. Use Caution/Monitor. - dicloxacillin
dicloxacillin, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.
dicloxacillin, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor. - diflunisal
aspirin rectal and diflunisal both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and diflunisal both increase serum potassium. Use Caution/Monitor. - digoxin
aspirin rectal and digoxin both increase serum potassium. Use Caution/Monitor.
- dobutamine
aspirin rectal increases and dobutamine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- dong quai
aspirin rectal and dong quai both increase anticoagulation. Use Caution/Monitor.
- dopexamine
aspirin rectal increases and dopexamine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- doxazosin
aspirin rectal decreases effects of doxazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- drospirenone
drospirenone and aspirin rectal both increase serum potassium. Modify Therapy/Monitor Closely.
- duloxetine
duloxetine, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
- edoxaban
edoxaban, aspirin rectal. Either increases toxicity of the other by anticoagulation. Modify Therapy/Monitor Closely. Both drugs have the potential to cause bleeding, monitor closely. Promptly evaluate any signs or symptoms of blood loss.
- eltrombopag
eltrombopag increases levels of aspirin rectal by decreasing metabolism. Use Caution/Monitor. UGT inhibition; significance of interaction unclear.
- elvitegravir/cobicistat/emtricitabine/tenofovir DF
elvitegravir/cobicistat/emtricitabine/tenofovir DF, aspirin rectal. Either increases toxicity of the other by decreasing renal clearance. Modify Therapy/Monitor Closely. Toxicity may result from coadministration of emtricitabine and tenofovir with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion including high-dose or multiple-dose NSAIDs; alternatives to NSAIDs should be considered.
- enoxaparin
enoxaparin and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.
- ephedrine
aspirin rectal increases and ephedrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- epinephrine
aspirin rectal increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- epinephrine racemic
aspirin rectal increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- epoprostenol
aspirin rectal and epoprostenol both increase anticoagulation. Use Caution/Monitor.
- eprosartan
eprosartan and aspirin rectal both increase serum potassium. Use Caution/Monitor.
- escitalopram
escitalopram, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
- esmolol
esmolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.
aspirin rectal decreases effects of esmolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. - ethacrynic acid
aspirin rectal increases and ethacrynic acid decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- etodolac
aspirin rectal and etodolac both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and etodolac both increase serum potassium. Use Caution/Monitor. - fenbufen
aspirin rectal and fenbufen both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and fenbufen both increase serum potassium. Use Caution/Monitor. - fennel
aspirin rectal and fennel both increase anticoagulation. Use Caution/Monitor.
- fenoprofen
aspirin rectal and fenoprofen both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and fenoprofen both increase serum potassium. Use Caution/Monitor. - feverfew
aspirin rectal and feverfew both increase anticoagulation. Use Caution/Monitor.
- fish oil triglycerides
fish oil triglycerides will increase the level or effect of aspirin rectal by anticoagulation. Use Caution/Monitor. Prolonged bleeding reported in patients taking antiplatelet agents or anticoagulants and oral omega-3 fatty acids. Periodically monitor bleeding time in patients receiving fish oil triglycerides and concomitant antiplatelet agents or anticoagulants.
- fludrocortisone
aspirin rectal, fludrocortisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.
- fluoxetine
fluoxetine, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
- flurbiprofen
aspirin rectal and flurbiprofen both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and flurbiprofen both increase serum potassium. Use Caution/Monitor. - fluvoxamine
fluvoxamine, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding SSRIs inhib. serotonin uptake by platelets.
- fondaparinux
fondaparinux and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.
- formoterol
aspirin rectal increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- forskolin
aspirin rectal and forskolin both increase anticoagulation. Use Caution/Monitor.
- furosemide
aspirin rectal increases and furosemide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- garlic
aspirin rectal and garlic both increase anticoagulation. Use Caution/Monitor.
- gentamicin
aspirin rectal increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- ginger
aspirin rectal and ginger both increase anticoagulation. Use Caution/Monitor.
- ginkgo biloba
aspirin rectal and ginkgo biloba both increase anticoagulation. Use Caution/Monitor.
- glimepiride
aspirin rectal increases effects of glimepiride by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
- glipizide
aspirin rectal increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
- glyburide
aspirin rectal increases effects of glyburide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
- green tea
green tea increases effects of aspirin rectal by pharmacodynamic synergism. Use Caution/Monitor. (Theoretical, due to caffeine content). Combination may increase risk of bleeding.
- griseofulvin
griseofulvin decreases levels of aspirin rectal by unknown mechanism. Use Caution/Monitor.
- heparin
heparin and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.
- horse chestnut seed
aspirin rectal and horse chestnut seed both increase anticoagulation. Use Caution/Monitor.
- hyaluronidase
aspirin rectal decreases effects of hyaluronidase by Other (see comment). Use Caution/Monitor. Comment: Salicylates, when given in large systemic doses, may render tissues partially resistant to the action of hyaluronidase. Patients may require larger amounts of hyaluronidase for equivalent dispersing effect.
- hydralazine
aspirin rectal decreases effects of hydralazine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- hydrochlorothiazide
aspirin rectal increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- hydrocortisone
aspirin rectal, hydrocortisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.
- ibrutinib
ibrutinib will increase the level or effect of aspirin rectal by anticoagulation. Use Caution/Monitor. Ibrutinib may increase the risk of hemorrhage in patients receiving antiplatelet or anticoagulant therapies and monitor for signs of bleeding.
- ibuprofen
aspirin rectal and ibuprofen both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and ibuprofen both increase serum potassium. Use Caution/Monitor. - ibuprofen IV
aspirin rectal will increase the level or effect of ibuprofen IV by acidic (anionic) drug competition for renal tubular clearance. Modify Therapy/Monitor Closely.
aspirin rectal and ibuprofen IV both increase anticoagulation. Modify Therapy/Monitor Closely.
aspirin rectal and ibuprofen IV both increase serum potassium. Modify Therapy/Monitor Closely. - imatinib
imatinib, aspirin rectal. Either increases toxicity of the other by Other (see comment). Modify Therapy/Monitor Closely. Comment: Imatinib may cause thrombocytopenia; bleeding risk increased when imatinib is coadministered with anticoagulants, NSAIDs, platelet inhibitors, and thrombolytic agents.
- indapamide
aspirin rectal increases and indapamide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- indomethacin
aspirin rectal and indomethacin both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and indomethacin both increase serum potassium. Use Caution/Monitor. - irbesartan
irbesartan and aspirin rectal both increase serum potassium. Use Caution/Monitor.
- isoproterenol
aspirin rectal increases and isoproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- ketoprofen
aspirin rectal and ketoprofen both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and ketoprofen both increase serum potassium. Use Caution/Monitor. - ketorolac
aspirin rectal and ketorolac both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and ketorolac both increase serum potassium. Use Caution/Monitor. - labetalol
labetalol and aspirin rectal both increase serum potassium. Use Caution/Monitor.
aspirin rectal decreases effects of labetalol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. - latanoprost
latanoprost, aspirin rectal. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).
- latanoprostene bunod ophthalmic
latanoprostene bunod ophthalmic, aspirin rectal. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).
- levalbuterol
aspirin rectal increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- levomilnacipran
levomilnacipran, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. SNRIs may further impair platelet activity in patients taking antiplatelet or anticoagulant drugs.
- lithium
aspirin rectal increases levels of lithium by decreasing renal clearance. Use Caution/Monitor.
- lornoxicam
aspirin rectal and lornoxicam both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and lornoxicam both increase serum potassium. Use Caution/Monitor. - losartan
losartan and aspirin rectal both increase serum potassium. Use Caution/Monitor.
- meclofenamate
aspirin rectal and meclofenamate both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and meclofenamate both increase serum potassium. Use Caution/Monitor. - mefenamic acid
aspirin rectal and mefenamic acid both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and mefenamic acid both increase serum potassium. Use Caution/Monitor. - meloxicam
aspirin rectal and meloxicam both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and meloxicam both increase serum potassium. Use Caution/Monitor. - mesalamine
mesalamine, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive nephrotoxicity.
- metaproterenol
aspirin rectal increases and metaproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- methazolamide
methazolamide, aspirin rectal. Either increases levels of the other by Other (see comment). Use Caution/Monitor. Comment: Carbonic anhydrase inhibitors (CAIs) and salicylates inhibit each other's renal tubular secretion, resulting in increased plasma levels. CAIs also shift salicylates from plasma to the CNS, leading to potential neurotoxicity.
- methotrexate
aspirin rectal will increase the level or effect of methotrexate by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.
- methylprednisolone
aspirin rectal, methylprednisolone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.
- metolazone
aspirin rectal increases and metolazone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- metoprolol
metoprolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.
aspirin rectal decreases effects of metoprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. - milnacipran
milnacipran, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
- mistletoe
aspirin rectal increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- moxisylyte
aspirin rectal decreases effects of moxisylyte by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- mycophenolate
aspirin rectal will increase the level or effect of mycophenolate by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.
- nabumetone
aspirin rectal and nabumetone both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and nabumetone both increase serum potassium. Use Caution/Monitor. - nadolol
nadolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.
aspirin rectal decreases effects of nadolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. - nafcillin
nafcillin, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.
nafcillin, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor. - naproxen
aspirin rectal and naproxen both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and naproxen both increase serum potassium. Use Caution/Monitor. - nebivolol
nebivolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.
aspirin rectal decreases effects of nebivolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. - nefazodone
nefazodone, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
- nettle
aspirin rectal increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- norepinephrine
aspirin rectal increases and norepinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- olmesartan
olmesartan and aspirin rectal both increase serum potassium. Use Caution/Monitor.
- oxacillin
oxacillin, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.
oxacillin, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor. - oxaprozin
aspirin rectal and oxaprozin both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and oxaprozin both increase serum potassium. Use Caution/Monitor. - panax ginseng
aspirin rectal and panax ginseng both increase anticoagulation. Use Caution/Monitor.
- parecoxib
aspirin rectal and parecoxib both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and parecoxib both increase serum potassium. Use Caution/Monitor. - paroxetine
paroxetine, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
- pau d'arco
aspirin rectal and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- penbutolol
penbutolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.
aspirin rectal decreases effects of penbutolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. - penicillin G aqueous
penicillin G aqueous, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.
penicillin G aqueous, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor. - phenindione
phenindione and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.
- phenoxybenzamine
aspirin rectal decreases effects of phenoxybenzamine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- phentolamine
aspirin rectal decreases effects of phentolamine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- phytoestrogens
aspirin rectal and phytoestrogens both increase anticoagulation. Use Caution/Monitor.
- pindolol
pindolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.
aspirin rectal decreases effects of pindolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. - pirbuterol
aspirin rectal increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- piroxicam
aspirin rectal and piroxicam both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and piroxicam both increase serum potassium. Use Caution/Monitor. - pivmecillinam
pivmecillinam, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.
pivmecillinam, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor. - potassium acid phosphate
aspirin rectal and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.
- potassium chloride
aspirin rectal and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.
- potassium citrate
aspirin rectal and potassium citrate both increase serum potassium. Use Caution/Monitor.
- potassium iodide
potassium iodide and aspirin rectal both increase serum potassium. Use Caution/Monitor.
- pralatrexate
aspirin rectal increases levels of pralatrexate by decreasing renal clearance. Use Caution/Monitor.
- prasugrel
aspirin rectal, prasugrel. pharmacodynamic synergism. Use Caution/Monitor. The need for simultaneous use of low-dose aspirin and anticoagulant or antiplatelet agents are common for patients with cardiovascular disease; monitor closely.
- prazosin
aspirin rectal decreases effects of prazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- prednisolone
aspirin rectal, prednisolone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.
- prednisone
aspirin rectal, prednisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.
- propranolol
propranolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.
aspirin rectal decreases effects of propranolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. - protamine
protamine and aspirin rectal both increase anticoagulation. Modify Therapy/Monitor Closely.
- reishi
aspirin rectal and reishi both increase anticoagulation. Use Caution/Monitor.
- reteplase
aspirin rectal and reteplase both increase anticoagulation. Modify Therapy/Monitor Closely.
- sacubitril/valsartan
sacubitril/valsartan and aspirin rectal both increase serum potassium. Use Caution/Monitor.
- salicylates (non-asa)
aspirin rectal and salicylates (non-asa) both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and salicylates (non-asa) both increase serum potassium. Use Caution/Monitor. - salmeterol
aspirin rectal increases and salmeterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- salsalate
aspirin rectal and salsalate both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and salsalate both increase serum potassium. Use Caution/Monitor. - saw palmetto
saw palmetto increases toxicity of aspirin rectal by unspecified interaction mechanism. Use Caution/Monitor. May increase risk of bleeding.
- sertraline
sertraline, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
- Siberian ginseng
aspirin rectal and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- silodosin
aspirin rectal decreases effects of silodosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- sodium picosulfate/magnesium oxide/anhydrous citric acid
aspirin rectal, sodium picosulfate/magnesium oxide/anhydrous citric acid. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May be associated with fluid and electrolyte imbalances.
- sodium sulfate/?magnesium sulfate/potassium chloride
sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of aspirin rectal by Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment.
- sodium sulfate/potassium sulfate/magnesium sulfate
sodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of aspirin rectal by Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment.
- sotalol
sotalol and aspirin rectal both increase serum potassium. Use Caution/Monitor.
aspirin rectal decreases effects of sotalol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. - sparsentan
aspirin rectal and sparsentan both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Coadministration of NSAIDS, including selective COX-2 inhibitors, may result in deterioration of kidney function (eg, possible kidney failure). Monitor for signs of worsening renal function with concomitant use with NSAIDs.
- spironolactone
spironolactone and aspirin rectal both increase serum potassium. Modify Therapy/Monitor Closely.
aspirin rectal decreases effects of spironolactone by unspecified interaction mechanism. Use Caution/Monitor. When used concomitantly, spironolactone dose may need to be titrated to higher maintenance dose and the patient should be observed closely to determine if the desired effect is obtained. - succinylcholine
aspirin rectal and succinylcholine both increase serum potassium. Use Caution/Monitor.
- sulfasalazine
aspirin rectal and sulfasalazine both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and sulfasalazine both increase serum potassium. Use Caution/Monitor. - sulindac
aspirin rectal and sulindac both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and sulindac both increase serum potassium. Use Caution/Monitor. - tafluprost
tafluprost, aspirin rectal. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).
- telmisartan
telmisartan and aspirin rectal both increase serum potassium. Use Caution/Monitor.
- temocillin
temocillin, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.
temocillin, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor. - tenecteplase
aspirin rectal and tenecteplase both increase anticoagulation. Modify Therapy/Monitor Closely.
- terazosin
aspirin rectal decreases effects of terazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- terbutaline
aspirin rectal increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- ticarcillin
ticarcillin, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.
ticarcillin, aspirin rectal. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor. - timolol
timolol and aspirin rectal both increase serum potassium. Use Caution/Monitor.
aspirin rectal decreases effects of timolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. - tolazamide
aspirin rectal increases effects of tolazamide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
- tolbutamide
aspirin rectal increases effects of tolbutamide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
- tolfenamic acid
aspirin rectal and tolfenamic acid both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and tolfenamic acid both increase serum potassium. Use Caution/Monitor. - tolmetin
aspirin rectal and tolmetin both increase anticoagulation. Use Caution/Monitor.
aspirin rectal and tolmetin both increase serum potassium. Use Caution/Monitor. - tolvaptan
aspirin rectal and tolvaptan both increase serum potassium. Use Caution/Monitor.
- torsemide
aspirin rectal increases and torsemide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- travoprost ophthalmic
travoprost ophthalmic, aspirin rectal. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).
- trazodone
trazodone, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
- triamcinolone acetonide injectable suspension
aspirin rectal, triamcinolone acetonide injectable suspension. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Aspirin in conjunction with corticosteroids in hypoprothrombinemia should used with caution. Clearance of salicylates may increase with concurrent use of corticosteroids.
- triamterene
triamterene and aspirin rectal both increase serum potassium. Modify Therapy/Monitor Closely.
- valproic acid
aspirin rectal increases levels of valproic acid by plasma protein binding competition. Use Caution/Monitor.
- valsartan
valsartan and aspirin rectal both increase serum potassium. Use Caution/Monitor.
- venlafaxine
venlafaxine, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
- vitamin K1 (phytonadione)
aspirin rectal increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- voclosporin
voclosporin, aspirin rectal. Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely. Coadministration with drugs associated with nephrotoxicity may increase the risk for acute and/or chronic nephrotoxicity.
- vorapaxar
aspirin rectal, vorapaxar. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive antiplatelet effect may occur.
- vortioxetine
aspirin rectal, vortioxetine. Either increases effects of the other by anticoagulation. Use Caution/Monitor. Risk minimal with low-dose aspirin.
- zanubrutinib
aspirin rectal, zanubrutinib. Either increases effects of the other by anticoagulation. Modify Therapy/Monitor Closely. Zanubrutinib-induced cytopenias increases risk of hemorrhage. Coadministration of zanubritinib with antiplatelets or anticoagulants may further increase this risk.
- zotepine
aspirin rectal decreases effects of zotepine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
Minor (118)
- aceclofenac
aceclofenac will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- acemetacin
acemetacin will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- acyclovir
aspirin rectal will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- alendronate
aspirin rectal, alendronate. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of GI ulceration.
- aluminum hydroxide
aluminum hydroxide, aspirin rectal. Mechanism: passive renal tubular reabsorption due to increased pH. Minor/Significance Unknown. Salicylate levels increased at moderate doses; salicylate levels decreased at large doses (d/t increased renal excretion of unchanged salicylic acid).
- amikacin
aspirin rectal increases levels of amikacin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.
- aminohippurate sodium
aspirin rectal will increase the level or effect of aminohippurate sodium by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- anamu
aspirin rectal and anamu both increase anticoagulation. Minor/Significance Unknown.
- ascorbic acid
ascorbic acid will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
ascorbic acid increases levels of aspirin rectal by decreasing renal clearance. Minor/Significance Unknown.
aspirin rectal decreases levels of ascorbic acid by increasing renal clearance. Minor/Significance Unknown. - balsalazide
aspirin rectal will increase the level or effect of balsalazide by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- bendroflumethiazide
bendroflumethiazide will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- bismuth subsalicylate
bismuth subsalicylate increases effects of aspirin rectal by pharmacodynamic synergism. Minor/Significance Unknown.
- budesonide
budesonide decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.
- bumetanide
aspirin rectal, bumetanide. Other (see comment). Minor/Significance Unknown. Comment: Salicylates are less likely than other NSAIDs to interact w/bumetanide.
- calcium carbonate
calcium carbonate, aspirin rectal. Mechanism: passive renal tubular reabsorption due to increased pH. Minor/Significance Unknown. Salicylate levels increased at moderate doses; salicylate levels decreased at large doses (d/t increased renal excretion of unchanged salicylic acid).
- cefadroxil
cefadroxil will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- cefamandole
cefamandole will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- cefepime
cefepime will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- cefixime
cefixime will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- cefpirome
cefpirome will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- cefprozil
cefprozil will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- ceftazidime
ceftazidime will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- ceftibuten
ceftibuten will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- celecoxib
aspirin rectal will increase the level or effect of celecoxib by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- cephalexin
cephalexin will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- chlorothiazide
chlorothiazide will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- chlorpropamide
aspirin rectal will increase the level or effect of chlorpropamide by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
aspirin rectal increases effects of chlorpropamide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate. - chlorthalidone
chlorthalidone will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- chromium
aspirin rectal increases levels of chromium by unspecified interaction mechanism. Minor/Significance Unknown.
- clopidogrel
clopidogrel increases levels of aspirin rectal by decreasing metabolism. Minor/Significance Unknown.
- cortisone
cortisone decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.
- creatine
creatine, aspirin rectal. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction) Combination may have additive nephrotoxic effects.
- cyanocobalamin
aspirin rectal decreases levels of cyanocobalamin by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.
- cyclopenthiazide
cyclopenthiazide will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- danshen
aspirin rectal and danshen both increase anticoagulation. Minor/Significance Unknown.
- deflazacort
deflazacort decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.
- devil's claw
aspirin rectal and devil's claw both increase anticoagulation. Minor/Significance Unknown.
- dexamethasone
dexamethasone decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.
- dexrazoxane
aspirin rectal increases levels of dexrazoxane by unspecified interaction mechanism. Minor/Significance Unknown.
- diclofenac
aspirin rectal will increase the level or effect of diclofenac by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- diflunisal
aspirin rectal will increase the level or effect of diflunisal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- diltiazem
diltiazem increases effects of aspirin rectal by unknown mechanism. Minor/Significance Unknown. Enhanced antiplatelet activity.
- eplerenone
aspirin rectal decreases effects of eplerenone by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis.
- ethanol
ethanol increases toxicity of aspirin rectal by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of GI bleeding.
- etodolac
aspirin rectal will increase the level or effect of etodolac by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- fenbufen
aspirin rectal will increase the level or effect of fenbufen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- fenoprofen
aspirin rectal will increase the level or effect of fenoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- feverfew
aspirin rectal decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- fludrocortisone
fludrocortisone decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.
- flurbiprofen
aspirin rectal will increase the level or effect of flurbiprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- folic acid
aspirin rectal decreases levels of folic acid by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.
- furosemide
aspirin rectal decreases effects of furosemide by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis.
- ganciclovir
aspirin rectal will increase the level or effect of ganciclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- gentamicin
aspirin rectal increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.
- glimepiride
aspirin rectal increases effects of glimepiride by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
- glipizide
aspirin rectal increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
- glyburide
aspirin rectal increases effects of glyburide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
- hydrochlorothiazide
hydrochlorothiazide will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- hydrocortisone
hydrocortisone decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.
- ibuprofen
aspirin rectal will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- imidapril
aspirin rectal decreases effects of imidapril by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis.
- indapamide
indapamide will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- indomethacin
aspirin rectal will increase the level or effect of indomethacin by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- insulin aspart
aspirin rectal increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown. Large dose of salicylate.
- insulin lispro
aspirin rectal increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown. Large dose of salicylate.
- insulin regular human
aspirin rectal increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown. Large dose of salicylate.
- ketoprofen
aspirin rectal will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- ketorolac
aspirin rectal will increase the level or effect of ketorolac by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- L-methylfolate
aspirin rectal decreases levels of L-methylfolate by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.
- lornoxicam
aspirin rectal will increase the level or effect of lornoxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- meclofenamate
aspirin rectal will increase the level or effect of meclofenamate by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- mefenamic acid
aspirin rectal will increase the level or effect of mefenamic acid by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- meloxicam
aspirin rectal will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- mesalamine
aspirin rectal will increase the level or effect of mesalamine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- methylprednisolone
methylprednisolone decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.
- metolazone
metolazone will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- nabumetone
aspirin rectal will increase the level or effect of nabumetone by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- naproxen
aspirin rectal will increase the level or effect of naproxen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- neomycin PO
aspirin rectal increases levels of neomycin PO by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.
- noni juice
aspirin rectal and noni juice both increase serum potassium. Minor/Significance Unknown.
- ofloxacin
ofloxacin, aspirin rectal. Other (see comment). Minor/Significance Unknown. Comment: Risk of CNS stimulation/seizure. Mechanism: Displacement of GABA from receptors in brain.
- oxaprozin
aspirin rectal will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- parecoxib
aspirin rectal will increase the level or effect of parecoxib by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- paromomycin
aspirin rectal increases levels of paromomycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.
- pegaspargase
pegaspargase increases effects of aspirin rectal by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of bleeding events.
- penicillin VK
penicillin VK, aspirin rectal. Either increases levels of the other by decreasing renal clearance. Minor/Significance Unknown.
- pentazocine
aspirin rectal, pentazocine. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Possible risk of renal papillary necrosis w/chronic Tx.
- piperacillin
piperacillin will increase the level or effect of aspirin rectal by plasma protein binding competition. Minor/Significance Unknown. Salicylic acid could be displaced from protein binding sites or it could itself displace other protein-bound drugs and result in an enhanced effect of the displaced drug
- piroxicam
aspirin rectal will increase the level or effect of piroxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- prednisolone
prednisolone decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.
- prednisone
prednisone decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.
- rivastigmine
rivastigmine increases toxicity of aspirin rectal by pharmacodynamic synergism. Minor/Significance Unknown. Increased GI symptoms.
- rose hips
rose hips will increase the level or effect of aspirin rectal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
rose hips increases levels of aspirin rectal by decreasing renal clearance. Minor/Significance Unknown.
aspirin rectal decreases levels of rose hips by increasing renal clearance. Minor/Significance Unknown. - salicylates (non-asa)
aspirin rectal will increase the level or effect of salicylates (non-asa) by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- salsalate
aspirin rectal will increase the level or effect of salsalate by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- sodium bicarbonate
sodium bicarbonate, aspirin rectal. Mechanism: passive renal tubular reabsorption due to increased pH. Minor/Significance Unknown. Salicylate levels increased at moderate doses; salicylate levels decreased at large doses (d/t increased renal excretion of unchanged salicylic acid).
- sodium citrate/citric acid
sodium citrate/citric acid, aspirin rectal. Mechanism: passive renal tubular reabsorption due to increased pH. Minor/Significance Unknown. Salicylate levels increased at moderate doses; salicylate levels decreased at large doses (d/t increased renal excretion of unchanged salicylic acid).
- streptomycin
aspirin rectal increases levels of streptomycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.
- sulfadiazine
aspirin rectal increases levels of sulfadiazine by unspecified interaction mechanism. Minor/Significance Unknown.
- sulfamethoxazole
aspirin rectal increases levels of sulfamethoxazole by unspecified interaction mechanism. Minor/Significance Unknown.
- sulfasalazine
aspirin rectal will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- sulfisoxazole
aspirin rectal increases levels of sulfisoxazole by unspecified interaction mechanism. Minor/Significance Unknown.
- sulindac
aspirin rectal will increase the level or effect of sulindac by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- teniposide
aspirin rectal increases levels of teniposide by unspecified interaction mechanism. Minor/Significance Unknown.
- tiludronate
aspirin rectal decreases levels of tiludronate by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.
- tobramycin
aspirin rectal increases levels of tobramycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.
- tolazamide
aspirin rectal increases effects of tolazamide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
- tolbutamide
aspirin rectal increases effects of tolbutamide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
- tolfenamic acid
aspirin rectal will increase the level or effect of tolfenamic acid by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- tolmetin
aspirin rectal will increase the level or effect of tolmetin by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- triamcinolone acetonide injectable suspension
triamcinolone acetonide injectable suspension decreases levels of aspirin rectal by increasing renal clearance. Minor/Significance Unknown.
- triamterene
triamterene, aspirin rectal. Other (see comment). Minor/Significance Unknown. Comment: Risk of acute renal failure. Mechanism: NSAIDs decrease prostaglandin synthesis, which normally protect against nephrotoxicity.
aspirin rectal increases toxicity of triamterene by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis, increasing the risk of nephrotoxicity. - valganciclovir
aspirin rectal will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.
- vancomycin
aspirin rectal increases levels of vancomycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in neonates.
- verapamil
verapamil increases effects of aspirin rectal by unknown mechanism. Minor/Significance Unknown. Enhanced antiplatelet activity.
- willow bark
willow bark increases effects of aspirin rectal by pharmacodynamic synergism. Minor/Significance Unknown. Willow bark contains salicylic acid, which may have additive effects/toxicity with salicylate drugs.
aspirin rectal will increase the level or effect of willow bark by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. - zafirlukast
aspirin rectal increases levels of zafirlukast by unknown mechanism. Minor/Significance Unknown.
- zoledronic acid
aspirin rectal decreases levels of zoledronic acid by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.
Adverse Effects
Frequency Not Defined
Common
- Rectal discomfort
- Tinnitus (high or chronic dose)
- Rash
- Urticaria
Angioedema
DIC
Hypotension
Tachycardia
CNS alteration
Dizziness
Headache
Dermatologic problems
Hives
Electrolyte disturbances; dehydration, hyperkalemia, metabolic acidosis, respiratory alkalosis
Platelet aggregation inhibition
Prolonged prothrombin time
Thrombocytopenia
Hepatotoxicity
Hearing loss
Renal damage
Bronchospasm
Pulmonary edema (salicylate-induced/noncardiogenic)
Reye syndrome
Warnings
Contraindications
Hypersensitivity to aspirin or NSAIDs
Hepatitis or severe hepatic/renal impairment
Do not use in children or adolescents with viral infections (eg, influenza, chickenpox) because of risk of Reye syndrome
Cautions
Many dosage forms, check label carefully!
Gastrointestinal bleeding; particular caution in patients w/ history of GI bleed, alcoholism, or bleeding disorders
Avoid w/ active peptic ulcer disease
Avoid in severe renal impairment (ie, CrCl <10 mL/min)
Avoid in severe hepatic impairment
Pregnancy & Lactation
Pregnancy category: D; avoid during pregnancy, particularly in third trimester because of risk for premature closure of the ductus arteriosus
Lactation: excreted in breast milk; do not breast feed
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Inhibits prostaglandin synthesis by cyclooxygenase-1 and -2 via acetylation; inhibits formation of prostaglandin derivative, thromboxane A2 via acetylation of platelete cyclooxygenase, which in turn inhibits platelet aggregation
Pharmacokinetics
Absorption: 60%
Onset: 4-5 hr
Half-life: 4.7-9 hr
Protein Bound: 50-80%
Volume of Distribution: 150 mL/kg
Metabolism: Hydrolyzed by esterases in liver (mostly) & erythrocytes to salicylic acid
Metabolites: salicyluric acid, salicyl acyl glucuronide, salicyl phenolic glucuronide, gentisic acid
Excretion: (urine) 5.6-35.6% Hemodialysis: Yes
Pharmacogenomics
Aspirin associated hypersensitivity reactions include:
Aspirin-induced urticaria: associated with HLA-DRB1*1302-DQB1*0609 haplotype
Aspirin-intolerant asthma: associated with HLA-DPB1*0301
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| Bayer Aspirin oral - | 325 mg tablet |  | |
| Extra Strength Bayer oral - | 500 mg tablet |  | |
| Ecotrin Low Strength oral - | 81 mg tablet |  | |
| aspirin oral - | 81 mg chewable tablet |  | |
| aspirin oral - | 81 mg chewable tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 325 mg tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 81 mg chewable tablet |  | |
| aspirin oral - | 325 mg tablet |  | |
| aspirin oral - | 325 mg tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 81 mg chewable tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 325 mg tablet |  | |
| aspirin oral - | 325 mg tablet |  | |
| aspirin oral - | 325 mg tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 325 mg tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 325 mg tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 81 mg chewable tablet |  | |
| aspirin oral - | 325 mg tablet |  | |
| aspirin oral - | 325 mg tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 325 mg tablet |  | |
| aspirin oral - | 81 mg chewable tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 81 mg chewable tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 81 mg tablet |  | |
| aspirin oral - | 81 mg chewable tablet |  | |
| aspirin oral - | 325 mg tablet |  | |
| aspirin oral - | 325 mg tablet |  | |
| aspirin oral - | 81 mg chewable tablet |  | |
| aspirin oral - | 81 mg chewable tablet |  | |
| aspirin oral - | 325 mg tablet |  | |
| aspirin oral - | 325 mg tablet |  | |
| aspirin oral - | 325 mg tablet |  | |
| aspirin oral - | 81 mg chewable tablet |  | |
| aspirin oral - | 325 mg tablet |  | |
| aspirin oral - | 325 mg tablet |  | |
| Bayer Chewable Low Dose Aspirin oral - | 81 mg chewable tablet |  | |
| Bayer Chewable Low Dose Aspirin oral - | 81 mg chewable tablet |  | |
| St Joseph Aspirin oral - | 81 mg chewable tablet | | |
| Bayer Advanced oral - | 500 mg tablet |  | |
| Durlaza oral - | 162.5 mg capsule |  | |
| Children's Aspirin oral - | 81 mg chewable tablet | | |
| Children's Aspirin oral - | 81 mg chewable tablet | | |
| Adult Aspirin Regimen oral - | 81 mg tablet | | |
| Adult Aspirin Regimen oral - | 81 mg tablet | | |
| aspirin rectal - | 300 mg suppos |  | |
| aspirin rectal - | 600 mg suppos |  |
Copyright © 2010 First DataBank, Inc.
Patient Handout
aspirin oral
ASPIRIN EXTENDED-RELEASE CAPSULE - ORAL
(AS-pir-in)
COMMON BRAND NAME(S): Durlaza
USES: This medication is a low dose of aspirin used to reduce the risk of having a heart attack in people who have heart disease. It is also used to reduce the risk of stroke in people who have previously had a stroke or "mini-stroke" (transient ischemic attack). Aspirin is known as a salicylate and a nonsteroidal anti-inflammatory drug (NSAID). This medication works by stopping platelets from clumping together and forming blood clots that can cause a heart attack or stroke.This medication is a long-acting form of aspirin and does not work right away. Other forms of aspirin (immediate-release) should be used when a fast effect is needed, such as right after a heart attack or for pain relief.
HOW TO USE: Take this medication by mouth as directed by your doctor, usually once a day. Swallow the capsule whole. Do not cut, crush, or chew the capsules. Doing so can release all of the drug at once, increasing the risk of side effects. If stomach upset occurs while taking this medication, take it with food or milk.Take this medication by mouth with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. Do not lie down for at least 10 minutes after taking this medication.Do not take this medication 2 hours before or 1 hour after drinking alcoholic beverages.NSAIDs (such as ibuprofen, naproxen) may decrease aspirin's ability to prevent heart attack/stroke. If you use a NSAID, take it at least 8 hours before or at least 2 to 4 hours after this medication (see also Drug Interactions section).Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.
SIDE EFFECTS: Upset stomach or heartburn may occur. If either of these effects lasts or gets worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, uncontrolled bleeding from gums or nose, loss of appetite, dark urine, yellowing eyes/skin, unusual tiredness, signs of kidney problems (such as change in the amount of urine).This drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. If you notice any of the following unlikely but serious side effects, stop taking this medication and consult your doctor or pharmacist right away: stomach/abdominal pain that doesn't go away, black stools, vomit that looks like coffee grounds.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before taking aspirin, tell your doctor or pharmacist if you are allergic to it; or to other salicylates (such as choline salicylate); or to NSAIDs (such as ibuprofen, naproxen); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs), bleeding/blood problems (such as hemophilia, vitamin K deficiency, low platelets), kidney disease, liver disease, stomach problems (such as ulcers, heartburn), growths in the nose (nasal polyps).This medicine may cause stomach bleeding. Daily use of alcohol and tobacco while using this medicine may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Ask your doctor or pharmacist about how much alcohol you may safely drink.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).This drug contains aspirin. Children and teenagers younger than 18 should not take aspirin if they have chickenpox, flu, or any undiagnosed illness or if they have recently received a vaccine. In these cases, taking aspirin increases the risk of Reye's syndrome, a rare but serious illness.Older adults may be more sensitive to the side effects of this drug, especially stomach/intestinal bleeding and ulcers.Aspirin is not recommended for use to treat pain or fever during pregnancy. Before using this medication, women of childbearing age should talk with their doctor(s) about the benefits and risks. Tell your doctor if you are pregnant or if you plan to become pregnant. This medication may harm an unborn baby and cause problems with normal labor/delivery. It is not recommended for use in pregnancy from 20 weeks until delivery. If your doctor decides that you need to use this medication between 20 and 30 weeks of pregnancy, you should use the lowest effective dose for the shortest possible time. In some cases, low-dose aspirin (usually 81-162 milligrams a day) may be used safely during pregnancy to prevent certain conditions. Talk to your doctor for more details.Aspirin passes into breast milk. When used in large amounts (such as to treat pain or fever), it may harm a nursing infant and breast-feeding while using this drug is not recommended. However, low-dose aspirin for heart attack or stroke prevention may be used if directed by your doctor. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: See also How to Use section.Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: mifepristone, other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, "blood thinners" such as warfarin/dabigatran), corticosteroids (such as prednisone), ginkgo biloba.Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (including aspirin, NSAIDs such as ibuprofen, ketorolac, naproxen). These drugs are similar to this medication and may increase your risk of side effects if taken together. Daily use of NSAIDs may decrease aspirin's ability to prevent heart attack/stroke. Ask your doctor or pharmacist for details.This medication may interfere with certain lab tests, possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: ringing in the ears, sweating, rapid breathing.
NOTES: Do not share this medication with others.
MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised August 2021. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
