atropine ophthalmic (Rx)

Brand and Other Names:IsoptoAtropine
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ointment

  • 1%

solution

  • 1%

Mydriasis/Cycloplegia

1-2 gtts solution, cycloplegia 1 hour before refraction & mydriasis 7-14 days

Uveitis

1-2 gtt up to four times daily

Overdose Management

Ocular: Flush eyes with water

Ingestion: Emesis, lavage

Dosage Forms & Strengths

ointment

  • 1%

solution

  • 1%

Uveitis (Off-label)

1 gtts (0.5%) qDay to three times daily

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Adverse Effects

Frequency Not Defined

Local irritation

Hyperemia

Edema

Dry eyes

Exudate

Follicular conjunctivitis

Vascular congestion

Dermatitis

Blurred vision

Hyperreactive response in Down's syndrome children (atropine)

Drowsiness

Increased intraocular pressure

Physostigmine

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Warnings

Contraindications

Hypersensitivity or known allergic reaction to any ingredient of the formulation

Cautions

Elevation in blood pressure from systemic absorption reported following conjunctival instillation of recommended doses of this medication

Although mydriatic/cycloplegic effects last for up to 2 wk in an uninflamed eye, an inflamed eye may require 2-4 times DAILY dosing to see an effective pharmacologic effect

Nor for injection; topical use only

While pupils are dilated patients are advised not to engage in hazardous activities like driving

Administration to infants requires caution; may produce systemic symptoms (discontinue medication if this occurs

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Pregnancy & Lactation

Pregnancy

There are no adequate and well-controlled studies in pregnant women to inform a drug-associated risk; adequate animal development and reproduction studies have not been conducted with atropine sulfate; in humans, 1% atropine sulfate is systemically bioavailable following topical ocular administration; the drug should only be used during pregnancy if the potential benefit justifies potential risk to fetus

Lactation

There is no information to inform risk regarding presence of drug in human milk following ocular administrations of the drug to the mother; effects on breastfed infants and effects on milk production are also unknown

Developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for the drug and any potential adverse effects on breastfed child from the drug

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

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Pharmacology

Absorption: transconjunctivally

Excretion: urine

Mechanism of Action

Blocks the action of acetylcholine resulting in relaxation of the cholinergically innervated sphincter muscle of the iris

Cholinergic stimulation of the accommodative ciliary muscle of the lens is also blocked

Anticholinergic effects of atropine sulfate in the eye produce dilation of the pupil (mydriasis) and paralysis of accommodation (cycloplegia)

Pharmacokinetics

Absorption: Transconjunctival

Excretion: Urine

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Images

BRAND FORM. UNIT PRICE PILL IMAGE
atropine injection
-
1 mg/mL vial
atropine injection
-
0.4 mg/mL vial
atropine injection
-
0.05 mg/mL solution
atropine injection
-
0.1 mg/mL solution
atropine injection
-
0.1 mg/mL solution
atropine injection
-
0.1 mg/mL solution
atropine injection
-
0.4 mg/mL vial
atropine injection
-
0.1 mg/mL solution
atropine injection
-
0.4 mg/mL vial
atropine injection
-
0.4 mg/mL vial
atropine injection
-
0.4 mg/mL vial
atropine injection
-
0.4 mg/mL vial
atropine injection
-
0.1 mg/mL solution
Isopto Atropine ophthalmic (eye)
-
1 % drops
atropine ophthalmic (eye)
-
1 % drops
atropine ophthalmic (eye)
-
1 % drops
atropine ophthalmic (eye)
-
1 % drops
atropine ophthalmic (eye)
-
1 % ointment
atropine intravenous
-
0.4 mg/mL vial
atropine intravenous
-
1 mg/mL vial
atropine intravenous
-
1 mg/mL vial

Copyright © 2010 First DataBank, Inc.

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Patient Handout

Select a drug:
Patient Education
atropine injection

NO MONOGRAPH AVAILABLE AT THIS TIME

USES: Consult your pharmacist.

HOW TO USE: Consult your pharmacist.

SIDE EFFECTS: Consult your pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Consult your pharmacist.

DRUG INTERACTIONS: Consult your pharmacist.Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: No monograph available at this time.

MISSED DOSE: Consult your pharmacist.

STORAGE: Consult your pharmacist.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised July 2016. Copyright(c) 2022 First Databank, Inc.

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.