Hawthorn (Herb/Suppl)

Brand and Other Names:aubepine, Chinese hawthorn, more...crataegus laevigata, English hawthorn, hagthorn, hedgethorn, ladies' meat, maybush, mayflower, maythorn, oneseed hawthorn, shanzha, whitehorn
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Suggested Dosing

Brewed tea

TID after meals; 1 tsp of leaves and flowers/ 8 oz boiling water

Fruit

Dried powder: 300-1000 mg PO TID

Liquid extract: 0.5-1 ml PO TID

Tincture: 1-2 ml PO TID

Solid extract: 1/4-1/2 tsp PO qD

Syrup: 1 tsp PO BID-TID

Leaf/flower

Extract: 160-900 mg/d PO div BID-TID

Powder: 200-500 mg PO TID

Tincture: 20 gtts PO BID-TID

Other Information

Extract standardized to 1.8% vitexin-4-rhamnoside or 20% procyanidins

Up to 2 weeks of treatment necessary to produce observable effects

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Suggested Uses

Arrhythmias, atherosclerosis, Buerger's disease, circulatory disorders, CHF, hyperlipidemia, hypertension, hypotension, indigestion, tapeworm infections

Efficacy

Contradictory evidence about the effects of hawthorn extract in heart failure patients.

Increase coronary circulation confirmed by double-blind studies; comparable to captopril

Decrease serum lipids in animal studies

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Interactions

Interaction Checker

and Hawthorn

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Contraindicated (0)

              Serious - Use Alternative (1)

              • vandetanib

                hawthorn, vandetanib. Either increases toxicity of the other by QTc interval. Avoid or Use Alternate Drug. Avoid coadministration with drugs known to prolong QT interval; if a drug known to prolong QT interval must be used, more frequent ECG monitoring is recommended.

              Monitor Closely (48)

              • acebutolol

                hawthorn increases effects of acebutolol by pharmacodynamic synergism. Use Caution/Monitor.

              • adenosine

                hawthorn increases effects of adenosine by pharmacodynamic synergism. Use Caution/Monitor.

              • amiodarone

                hawthorn increases effects of amiodarone by pharmacodynamic synergism. Use Caution/Monitor.

              • amobarbital

                hawthorn increases effects of amobarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • azelastine

                hawthorn increases effects of azelastine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • brompheniramine

                hawthorn increases effects of brompheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • butabarbital

                hawthorn increases effects of butabarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • butalbital

                hawthorn increases effects of butalbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • carbinoxamine

                hawthorn increases effects of carbinoxamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • chloral hydrate

                hawthorn increases effects of chloral hydrate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • chlorpheniramine

                hawthorn increases effects of chlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • cinnarizine

                hawthorn increases effects of cinnarizine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • clemastine

                hawthorn increases effects of clemastine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • crizotinib

                crizotinib and hawthorn both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended, along with drugs that may prolong the QT interval.

              • cyclizine

                hawthorn increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • cyproheptadine

                hawthorn increases effects of cyproheptadine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • dexchlorpheniramine

                hawthorn increases effects of dexchlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • dexmedetomidine

                hawthorn increases effects of dexmedetomidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • digoxin

                hawthorn increases effects of digoxin by pharmacodynamic synergism. Use Caution/Monitor.

              • diltiazem

                hawthorn increases effects of diltiazem by pharmacodynamic synergism. Use Caution/Monitor.

              • dimenhydrinate

                hawthorn increases effects of dimenhydrinate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • diphenhydramine

                hawthorn increases effects of diphenhydramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • disopyramide

                hawthorn increases effects of disopyramide by pharmacodynamic synergism. Use Caution/Monitor.

              • doxylamine

                hawthorn increases effects of doxylamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • encainide

                hawthorn increases effects of encainide by pharmacodynamic synergism. Use Caution/Monitor.

              • esmolol

                hawthorn increases effects of esmolol by pharmacodynamic synergism. Use Caution/Monitor.

              • flecainide

                hawthorn increases effects of flecainide by pharmacodynamic synergism. Use Caution/Monitor.

              • hydroxyzine

                hawthorn increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • ibutilide

                hawthorn increases effects of ibutilide by pharmacodynamic synergism. Use Caution/Monitor.

              • indacaterol, inhaled

                indacaterol, inhaled, hawthorn. QTc interval. Use Caution/Monitor. Drugs that are known to prolong the QTc interval may have an increased the risk of ventricular arrhythmias.

              • lidocaine

                hawthorn increases effects of lidocaine by pharmacodynamic synergism. Use Caution/Monitor.

              • mexiletine

                hawthorn increases effects of mexiletine by pharmacodynamic synergism. Use Caution/Monitor.

              • olodaterol inhaled

                hawthorn and olodaterol inhaled both increase QTc interval. Use Caution/Monitor. Drugs that prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmias

              • pentobarbital

                hawthorn increases effects of pentobarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • phenobarbital

                hawthorn increases effects of phenobarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • phenytoin

                hawthorn increases effects of phenytoin by pharmacodynamic synergism. Use Caution/Monitor.

              • primidone

                hawthorn increases effects of primidone by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • procainamide

                hawthorn increases effects of procainamide by pharmacodynamic synergism. Use Caution/Monitor.

              • promethazine

                hawthorn increases effects of promethazine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • propafenone

                hawthorn increases effects of propafenone by pharmacodynamic synergism. Use Caution/Monitor.

              • propranolol

                hawthorn increases effects of propranolol by pharmacodynamic synergism. Use Caution/Monitor.

              • quetiapine

                quetiapine, hawthorn. Either increases toxicity of the other by QTc interval. Use Caution/Monitor. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT.

              • quinidine

                hawthorn increases effects of quinidine by pharmacodynamic synergism. Use Caution/Monitor.

              • secobarbital

                hawthorn increases effects of secobarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • sotalol

                hawthorn increases effects of sotalol by pharmacodynamic synergism. Use Caution/Monitor.

              • triclofos

                hawthorn increases effects of triclofos by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • triprolidine

                hawthorn increases effects of triprolidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • verapamil

                hawthorn increases effects of verapamil by pharmacodynamic synergism. Use Caution/Monitor.

              Minor (0)

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                Adverse Effects

                Frequency Not Defined

                Agitation

                Circulatory disturbances

                Dizziness

                Fatigue

                GI disturbances

                Headache

                Sleep disturbances

                Nausea

                Palpitations

                Sweating

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                Warnings

                Contraindications

                None reported

                Cautions

                Concurrent cardiovascular meds, vasodilatory agents, or CNS depressants

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                Pregnancy & Lactation

                Pregnancy Category: unsafe

                Lactation: avoid use

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Metabolism: N/A

                Excretion: N/A

                Mechanism of Action

                Proanthocyanidins: ACE inhibitor; vasodilator

                Dehydrocatechins: CNS depressant

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.