tazarotene (Rx)

Brand and Other Names:Avage, Tazorac, more...Fabior
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

cream, topical (Avage)

  • 0.1%

cream/gel, topical (Tazorac)

  • 0.05%
  • 0.1%

foam, topical (Fabior)

  • 0.1%
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Acne Vulgaris (Tazorac, Fabior)

Tazorac, Fabior

  • Cream 0.1% indicated for acne vulgaris and gel 0.1% indicated for mild-to-moderate acne vulgaris; whereas, foam 0.1% indicated for moderate-to-severe acne
  • Cream/gel/foam 0.1%: Apply to affected area qDay

Psoriasis (Tazorac)

Tazorac

  • Indicated for topical treatment of stable plaque psoriasis; gel indicated for up to 20% BSA
  • Cream/gel 0.05% or 0.1%: apply to affected area qDay

Wrinkles (Avage)

Indicated to mitigate signs of chronic sunlight exposure (eg, coarse or deep wrinkling, tactile roughness, telangiectasia, skin laxity, keratinocytic atypia, melanocytic atypia, or dermal elastosis)

Not indicated for prevention of actinic keratoses, skin neoplasms, or lentigo maligna

Cream 0.1%: Apply to affected areas qHS

Limitations Of Use

Does not eliminate or prevent wrinkles or restore more youthful skin

Does not repair sun damaged skin or reverse photoaging

Dosage Forms & Strengths

cream/gel, topical (Tazorac)

  • 0.05%
  • 0.1%

foam, topical (Fabior)

  • 0.1%
more...

Acne Vulgaris

Cream 0.1% indicated for acne vulgaris and gel 0.1% indicated for mild-to-moderate acne vulgaris; whereas, foam 0.1% indicated for moderate-to-severe acne

<12 years: Safety and efficacy not established

≥12 years: Apply to affected area qDay

Psoriasis

Cream indicated for topical treatment of stable plaque psoriasis; gel indicated for up to 20% BSA

<12 years: Safety and efficacy not established

≥12 years: Apply to affected area qDay

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Adverse Effects

>10%

Desquamation

Erythema

Burning/stinging

Dry skin

1-10%

Skin irritation (1% -22%)

Skin pain

Pruritis

Irritant or contact dermatitis

Stinging

Acne

Photosensitivity

Rash

Cheilitis

Frequency Not Defined

Worsening of psoriasis

Eczema

Rash

Dry skin

Skin inflammation

Fissuring

Bleeding

Peripheral edema

Hypertriglyceridemia

Postmarketing Reports

Blister, rash, skin discoloration (including skin hyperpigmentation or skin hypopigmentation), and pain

Embryofetal toxicity

Photosensitivity and risk of sunburn

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Warnings

Contraindications

Pregnancy (teratogenic); hypersensitivity, eczema

Cautions

Re-evaluate if not healed in 10 days

May cause fetal harm when administered to a pregnant woman; obtain a pregnancy test in females of reproductive potential within 2 weeks prior to initiating treatment; advise females of reproductive potential to use effective contraception

Some individuals may experience excessive pruritus, burning, skin redness, or peeling; if these reactions occur, discontinue therapy until integrity of skin has been restored or reduce dosing interval; avoid use on eczematous skin, as such use may cause severe irritation

Local tolerability reactions and hypersensitivity adverse reactions have been observed with topical tazarotene, including blistering, skin desquamation, and urticaria; if adverse reactions occur, discontinue medication until integrity of skin is restored, or reduce dosing to an interval the patient can tolerate

Closely monitor frequency of application by carefully observing therapeutic response and skin tolerance

Avoid using cream if patient is also taking drugs known to be photosensitizers (e.g., thiazides, tetracyclines, fluoroquinolones, phenothiazines, sulfonamides) because of increased possibility of augmented photosensitivity

Use of sunscreens (minimum strength of SPF 15) & protective clothing recommended during use

Avoid exposure to sunlight, sunlamps, and weather extremes; in sunburn, do not use tazarotene until full recovery

Ask patients if they are using other drugs that could potentially increase sunlight sensitivity (eg, fluoroquinolone or tetracycline anti-infectives, thiazide diuretics, sulfonamides, phenothiazines)

Nof for use in lentigo maligna; carefully assess facial pigmented lesions of concern before application of cream

Pregnancy testing is recommended for females of reproductive potential within 2 weeks prior to initiating therapy which should begin during a menstrual period; advise females of reproductive potential to use effective contraception during treatment

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Pregnancy & Lactation

Pregnancy: Based on data from animal reproduction studies, retinoid pharmacology, and the potential for systemic absorption may cause fetal harm when administered to a pregnant female and is contraindicated during pregnancy; safety in pregnant females has not been established; the potential risk to fetus outweighs the potential benefit to the mother during pregnancy; therefore, discontinue as soon as pregnancy is recognized

Lactation: The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for therapy and any potential adverse effects on the breastfed child from therapy or from the underlying maternal condition

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

more...
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Pharmacology

Mechanism of Action

Retinoid: appears to affect expression of genes that modulate cell (eg, epidermal) differentiation, proliferation, and inflammation, leading to normalization of keratinocyte differentiation and a reduction in cellular hyperproliferation and inflammation

Absorption

<1% systemically absorbed

Metabolism

Hydrolyzed to its active metabolite, tazarotenic acid

Elimination

Half-Life: 18 hr

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.