Dosing & Uses
Dosage Forms & Strengths
vaginal cream
- 15%
Candida Vulvovaginitis
1 applicatorful (~6 g) intravaginally qDay or q12hr for 30 days
Safety & efficacy not established
Adverse Effects
Frequency Not Defined
Local sensitivity reactions (discomfort, burning)
Warnings
Contraindications
Hypersensitivity to sulfonamides
Cautions
Third trimester of pregnancy
Severe blook reactions including aplastic anemia, agranulocytosis, and other blood dyscrasias reported
Severe reactions including toxic epidermal necrolysis, and Stevens Johnson syndrome reported
Fulminant hepatic necrosis reported with sulfonamides regardless of route
Discontinue if skin rash reaction occurs
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Not recommended
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Has bacteriostatic effect by inhibiting para-aminiobenzoic acid; interferes with microbial folic acid synthesis and growth
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Formulary
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