phenazopyridine (Rx, OTC)

Brand and Other Names:Azo Standard, Pyridium, more...Prodium, Pyridiate, Baridium, Uricalm, Urodine, UTI Relief
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablets

  • 95mg
  • 97.2mg
  • 100mg
  • 200mg

Dysuria, Irritation of Lower Urinary Tract Mucosa

100-200 mg PO after meals three times daily

Dosing considerations

  • When used concomitantly with antibiotic for UTI, do not use for longer than 2 days
  • Limit dosing in geriatric population due to decreased renal function

Administration

Give after food/meals to minimize GI side effects

Dosage Forms & Strengths

tablets

  • 95mg
  • 97.2mg
  • 100mg
  • 200mg

Dysuria, Irritation of Lower Urinary Tract Mucosa

<6 years: Safety and efficacy not established

6-12 years: 12 mg/kg/day PO after meals, divided q8hr  

>12 years: 100-200 mg PO after meals three times daily

Dosing considerations

  • When used concomitantly with antibiotic for UTI, do not use for longer than 2 days

Administration

Give after food/meals to minimize GI side effects

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Interactions

Interaction Checker

and phenazopyridine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined (Rare)

            Headache

            Vertigo

            Rash

            Pruritus

            Mild GI disturbances

            Methemoglobinemia

            Hemolytic anemia

            Skin pigmentation

            Transient ARF

            Renal calculi

            Staining of contact lenses

            Hepatic/renal toxicity

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            Warnings

            Contraindications

            Hypersensitivity

            Renal impairment (CrCl <50mL/min)

            Cautions

            Changes urine color; may affect UA based on spectrometry or color reactions

            May stain contact lenses

            Discontinue if yellowish color of skin or sclera, as this is an indication of drug accumulation due to renal failure; monitor geriatric patients due to greater risk

            Self-medication should not continue >2 days; if pain persists, consult physician

            Intended as analgesic, not for treatment of UTI

            Use caution in patients with G6PD deficiency; hemolytic anemia may occur in the setting of chronic overdose

            Not for treatment of urinary inferction; acts only as analgesic

            Discontinue over the counter use if symptoms last more than 2 days or adverse effects occur

            May stain fiber or clothing

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            Pregnancy & Lactation

            Pregnancy category: B

            Lactation: Not known if excreted in breast milk; exercise caution

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Azo dye; acts directly on urinary tract mucosa when excreted, to produce local analgesic effect

            Metabolism

            Metabolized by liver

            Elimination

            Excretion

            • Urine: Eliminated mainly through rapid excretion by kidneys (65% unchanged)
            • Feces: Minor amount
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            Images

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.