brinzolamide (Rx)

Brand and Other Names:Azopt
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ophthalmic suspension

  • 1%

Ocular Hypertension or Open-Angle Glaucoma

1 gtt in affected eye q8hr

Administration

May be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure; if more than one topical ophthalmic drug being used, administer at least ten min apart

Safety & efficacy not established

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Interactions

Interaction Checker

and brinzolamide

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     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            1-10%

            Blurred vision (1-5%)

            Bitter, sour or unusual taste (1-5%)

            Blepharitis (1-5%)

            Dermatitis (1-5%)

            Dry eye (1-5%)

            Foreign body sensation (1-5%)

            Headache (1-5%)

            Hyperemia (1-5%)

            Ocular discharge (1-5%)

            Ocular discomfort (1-5%)

            Ocular keratitis (1-5%)

            Ocular pain (1-5%)

            Ocular pruritus (1-5%)

            Rhinitis (1-5%)

            <1%

            Allergic reactions

            Alopecia

            Chest pain

            Conjunctivitis

            Diarrhea

            Diplopia

            Dizziness

            Dry mouth

            Dyspnea

            Dyspepsia

            Eye fatigue

            Hypertonia

            Keratoconjunctivitis

            Keratopathy

            Kidney pain

            Lid margin crusting or sticky sensation

            Nausea

            Pharyngitis

            Tearing

            Urticaria

            Stevens-Johnson syndrome

            Toxic epidermal necrolysis

            Fulminant hepatic necrosis

            Agranulocytosis

            Aplastic anemia

            Other blood dyscrasias

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            Warnings

            Contraindications

            Hypersensitivity

            Severe renal impairment (CrCl <30 mL/min)

            Cautions

            Hepatic impairment

            Corneal edema may occur in patients with low endothelial cell counts

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Not known if distributed in breast milk; not recommedned (discontinue drug or do not nurse)

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Inhibits carbonic anhydrase, which in turn causes aqueous humor secretion to decrease. This effect reduces intraocular pressure.

            Pharmacokinetics

            Half-Life: 3.5-4 mo

            Absorption: Some systemic

            Distribution: to RBCs

            Protein binding: 60%

            Excretion: Urine

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.