Dosing & Uses
Dosage Forms & Strengths
cream/topical ointment
- 2%
nasal ointment
- 2%
Impetigo
Apply 2% ointment to affected area q8hr
If no response in 3-5 days, reevaluate
Secondary Skin Infection
Apply cream to affected area q8hr x10 days
If no response in 3-5 days, reevaluate
Elimination of MRSA Colonization
Intranasal: Apply one-half of ointment from a single-use tube into each nostril q12hr for 5 days
Dosage Forms & Strengths
cream/topical ointment
- 2%
nasal ointment
- 2%
Impetigo
>2 months: Apply 2% ointment to affected area q8hr
If no response in 3-5 days, reevaluate
Secondary Skin Infection
>3 months: Apply cream to affected area q8hr x10 days
If no response in 3-5 days, reevaluate
Elimination of MRSA Colonization
Safety and efficacy not established
>12 years (intranasal): Apply one-half of ointment from a single-use tube into each nostril q12hr for 5 days
Adverse Effects
1-10%
Headache (1.7%)
Nausea (1.7%)
Burning (1-3%)
Stinging (1-3%)
Pain (1-3%)
Pruritus (1-3%)
Rash (1-3%)
Cellulitis (1%)
Dry skin (1%)
Erythema (1%)
Incr exudate (1%)
Pain or bleeding secondary to eczema (1%)
Secondary wound infection (1%)
Swelling (1%)
Tenderness (1%)
Urticaria (1%)
Frequency Not Defined
Abdominal pain
Dizziness
Ulcerative stomatitis
Warnings
Contraindications
Hypersensitivity
Cautions
Anaphylaxis, urticaria, angioedema, and generalized rash reported
Manufacturer cautions against use of mupirocin ointment in burn patients, particularly those with extensive burns, since potentially toxic amounts of polyethylene glycol (PEG) contained in the vehicle may be absorbed percutaneously
Avoid contact with eyes; in case of accidental contact, rinse well with water
Discontinue use in event of sensitization or severe local irritation from ointment
Clostridium difficile-associated diarrhea (CDAD) reported with use; if CDAD suspected or confirmed, discontinue ongoing antibacterial drug use not directed against C. difficile; institute appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C. difficile, and surgical evaluation, as clinically indicated
Prolonged use may result in overgrowth of nonsusceptible organisms, including fungi
Not formulated for use on mucosal surfaces; intranasal use has been associated with isolated reports of stinging and drying
Not for use in conditions where absorption of large quantities of polyethylene glycol possible, especially if there is evidence of moderate or severe renal impairment; polyethylene glycol can be absorbed from open wounds and damaged skin and is excreted by the kidneys
Ointment should not be used with intravenous cannulae or at central intravenous sites because of the potential to promote fungal infections and antimicrobial resistance
Pregnancy & Lactation
Pregnancy
There are insufficient human data to establish whether there is drug-associated risk with therapy in pregnant women; systemic absorption of mupirocin through intact human skin is minimal following topical administration of mupirocin ointment; no developmental toxicity was observed in rats or rabbits treated with mupirocin subcutaneously during organogenesis at doses of 160 or 40 mg per kg per day, respectively (22 and 11 times the human topical dose based on calculations of dose divided by the entire body surface area)
Lactation
Not known whether mupirocin is present in human milk, has effects on breastfed child, or has effects on milk production; however, breastfeeding is not expected to result in exposure of child to drug due to minimal systemic absorption following topical administration; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed child from therapy or from underlying maternal condition
To minimize oral exposure of drug to children, a breast and/or nipple being treated with mupirocin ointment should be thoroughly washed prior to breastfeeding
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Bactericidal; inhibits protein synthesis in susceptible bacteria by reversibly binding to bacterial isoleucine-tRNA ligase (isoleucyl-tRNA synthetase), the enzyme that catalyzes the formation of isoleucyl-tRNA from isoleucine and tRNA
Absorption
<0.3%
Distribution
Protein bound: 95-97% in vitro
Metabolism
Enzymes present within skin may partially inactivate mupirocin by metabolizing drug to monic acid
Elimination
Excretion: Urinary concentrations range from undetectable to 10.03 mcg/mL in adults and from undetectable to 1.3 mcg/mL in children
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| Centany topical - | 2 % ointment |  | |
| mupirocin topical - | 2 % ointment |  | |
| mupirocin topical - | 2 % ointment |  | |
| mupirocin topical - | 2 % ointment |  | |
| mupirocin topical - | 2 % ointment |  | |
| mupirocin topical - | 2 % ointment |  | |
| mupirocin topical - | 2 % ointment |  | |
| mupirocin topical - | 2 % ointment |  | |
| Centany AT topical - | 2 % kit |  |
Copyright © 2010 First DataBank, Inc.
Patient Handout
mupirocin topical
MUPIROCIN OINTMENT - TOPICAL
(mue-PIR-oh-sin)
COMMON BRAND NAME(S): Bactroban
USES: Mupirocin is used to treat certain skin infections (such as impetigo). It is an antibiotic. It works by stopping the growth of certain bacteria.
HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start using mupirocin and each time you get a refill. If you have any questions, ask your doctor or pharmacist.Use this medication only on the skin. Clean and dry the affected area first. Then apply a small amount of ointment to the area as directed by your doctor, usually 3 times a day. You may cover the treated area with a bandage.Use this medication regularly to get the most benefit from it. Continue to use it for the full time prescribed, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.Avoid using this medication around your eyes, nose, mouth, or on large areas of damaged or broken skin unless otherwise directed by your doctor. If you accidentally get it in your eyes, nose, or mouth, rinse well with plenty of water.Tell your doctor if your condition does not get better in 3 to 5 days.
SIDE EFFECTS: Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Although uncommon, mild burning or stinging after using this medication may occur. If you have severe burning, stinging, or irritation, stop using this medication and tell your doctor right away.This medication may rarely cause a severe intestinal condition due to a bacteria called C. difficile. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: diarrhea that doesn't stop, abdominal or stomach pain/cramping, blood/mucus in your stool.If you have these symptoms, do not use anti-diarrhea or opioid products because they may make symptoms worse.Use of this medication for prolonged or repeated periods may result in a new skin infection caused by fungus or yeast. Tell your doctor right away if you notice signs of a new infection, or if your current infection does not get better or if it gets worse.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before using mupirocin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as polyethylene glycol found in some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease (if you are using a brand of mupirocin that contains polyethylene glycol).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.
MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.
STORAGE: Store at room temperature. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised August 2021. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
