Indication-specific dosing for basket willow, bay willow, brittle willow willow bark in combination, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

Sections

Sections Willow Bark
Suggested Dosing
Suggested Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology

Suggested Dosing

Extract

120-240 mg salicin PO TID-QID

Dried Bark

1-3 g PO TID-QID

Tea

1 cup PO TID-QID; prepared with 1-3 g bark/150 ml water

Liquid Extract

1-3 ml PO qDay; 1:1 25% alcohol

Suggested Uses

Fever, gouty arthritis, headaches, inflammation, influenza symptoms, muscle/joint aches, pain, rheumatoid arthritis

Interaction Checker

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Contraindicated

Serious - Use Alternative

Significant - Monitor Closely

Minor

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Frequency Not Defined

Blood in stool

GI complaints

Hypersensitivity reactions

Kidney damage

Liver necrosis

Nausea/vomiting

Salicylate toxicity

Skin rash (topical use)

Tinnitus

Contraindications

Aspirin hypersensitivity, asthma, diabetes mellitus, gout, hemophilia, hypoprothrombinemia, kidney disease, liver disease, PUD, viral infection (peds)

Pregnancy & Lactation

Pregnancy Category: N/A

Lactation: unsafe

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Contains salicin, which is converted to salicylic acid

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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