Red Clover (Herb/Suppl)

Brand and Other Names:beebread, cow clover, more...meadow clover, purple clover, trefle des pres, trefoil, trifolium pratense, wild clover
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Suggested Dosing

Typical Dosing Guideline

Standardized commercially prepared isoflavins

40-80 mg/day

Flower Tops

4 g PO TID

Tea

1 cup PO TID; 4 g flower tops/150 mL water

Liquid Extract

1.5-3 mL PO TID; 1:1 in 25% alcohol

Tincture

1-2 mL PO TID; 1:10 in 45% alcohol

Topical

Dosage varies

Hot Flash

Isoflavone extract: 40-160 mg/day PO

Cyclic Mastalgia

Isoflavones: 40-80 mg/day

Osteoporosis

Specific extract (Promensil): 40 mg/day

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Suggested Uses

Oral

Menopausal symptoms and hot flashes, mastalgia, PMS, cancer prevention, indigestion, hypercholesterolemia, whooping cough, asthma, bronchitis, & STD's

Topical

Cancer, skin sores, burns, sore eyes, and chronic skin diseases including eczema

Efficacy

Hypercholesterolemia

  • Does not significantly reduce total or LDL cholesterol, OR increase HDL in women 49-65. More studies are needed

Menopausal symptoms

  • Does not seem to reduce menopausal symptoms

BPH

  • May decrease nocturnal urinary frequency, international prostate symptom scores, and improve the quality of life
  • Does not affect urine flow rate, PSA values, or prostate size

Breast Cancer (prevention)

  • May not significantly affect breast cancer risk

Endometrial cancer

  • It is not known if has any effect on risk. More studies are needed

Mastalgia

  • Preliminary evidence suggests reduction in breast pain & tenderness in 45% of patients

Osteoporosis

  • More studies are needed. 40 mg isoflavones qDay did not seem to increase BMD
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Interactions

Interaction Checker

and Red Clover

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (1)

                • phytoestrogens

                  phytoestrogens, red clover. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Both contain phytoestrogens.

                Minor (0)

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                  Adverse Effects

                  Estrogen-like effects, rash

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                  Warnings

                  Contraindications

                  Cancer (breast, ovarian, uterine), endometriosis, hormone sensitive conditions, uterine fibroids

                  Cautions

                  Coagulation disorders, concurrent CYP3A4 substrates

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                  Pregnancy & Lactation

                  Pregnancy Category: avoid use

                  Lactation: avoid use

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Metabolism: N/A

                  Excretion: N/A

                  Mechanism of Action

                  Antispasmodic, expectorant constituents

                  Isoflavones (e.g., daidzein, genistein) are phytoestrogens: weak estrogenic/antiestrogenic properties

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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.