Dosing & Uses
Dosage Forms & Strengths
cream
- 2% plus zinc acetate 0.1%
- 1% plus zinc acetate 0.1%
gel
- 2%
spray
- 2% plus zinc acetate 0.1%
- 2% with menthol 1%
stick
- 2% plus zinc acetate 0.1%
Pruritus
Indicated for temporary relief of pain and itching associated with insect bites, minor skin irritations, and rashes due to poison ivy, poison oak, or poison sumac
Apply 1-2% topically to affected area; not to exceed 3-4 times daily
Not for use on large areas of the body
Dosage Forms & Strengths
cream
- 2% plus zinc acetate 0.1%
- 1% plus zinc acetate 0.1%
gel
- 2%
spray
- 2% plus zinc acetate 0.1%
- 2% with menthol 1%
stick
- 2% plus zinc acetate 0.1%
Pruritus
Indicated for temporary relief of pain and itching associated with insect bites, minor skin irritations, and rashes due to poison ivy, poison oak, or poison sumac
<2 years: Safety & efficacy not established
>2 years: Apply 1-2% topically to affected area; not to exceed 3-4 times daily
Not for use on large areas of the body
Adverse Effects
Frequency Not Defined
Skin rash
Urticaria
Photosensitivity
Warnings
Contraindications
Hypersensitivity
Neonates or premature infants
Breast-feeding
Cautions
Not for use in large areas of the body; not to be taken with any other product containing diphenhydramine, including the ones administered orally
With physician approval may use on chickenpox or on measles
Avoid contact with eyes
Ask a healthcare professional if condition worsens or does not improve within 7 days, or symptoms persist for more than 7 days, or clear up and occur again
Keep out of reach of children; if swallowed, get medical help, or contact a poison control center right away
Pregnancy & Lactation
Pregnancy Category: B
Lactation: Unknown if topical diphenhydramine excreted in human breastmilk; orally administered diphenhydramine is excreted into human milk and regular use is known to inhibit lactation
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Histamine H1-receptor antagonist
Pharmacokinetics
Metabolism: Liver, first-pass
Excretion: Urine
