benzocaine (OTC)

Brand and Other Names:EjectDelay
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

gel/topical solution

  • 6.3%
  • 7.5%
  • 10%
  • 20%

liquid

  • 5%
  • 6.3%
  • 7.5%
  • 10%
  • 20%

Bee Stings, Minor Burns, Sunburn, Insect Bites

Apply 5-20% to affected area q6-8hr PRN; remove sting prior to application if a bee sting

Mouth and Gum Irritation

Apply 10-20% solution (or other topical formulation) PRN

Sore Throat/Mouth Pain

1 lozenge dissolved in mouth; repeat q2hr PRN (generally use <2 days)

Apply 1 spray to affected area; spit after 1 min; may repeat up to 4 times

Hemorrhoids

Apply 5-20% externally to affected area q4hr

Dental pain

Use 2.5-20% solution (or other topical formulation) PRN

Boils

Apply 20% to affected area; not to exceed q12hr

Premature Ejaculation

EjectDelay (7.5% gel): Apply small amount to the penis gland 15-20 min before sexual intercourse

It can be applied with or without a condom

Washed off after intercourse

Dosage Forms & Strengths

gel/topical solution

  • 6.3%
  • 7.5%
  • 10%
  • 20%

liquid

  • 5%
  • 6.3%
  • 7.5%
  • 10%
  • 20%

Teething Pain

<4 years

  • Safety and efficacy not established

≥4 years

  • Apply 7.5-10% to affected gum area; not to exceed q6hr

Bee Stings, Boils, Minor Burns, Sunburn, Insect Bites

<2 years

  • Safety and efficacy not established

≥2 years

  • Apply 5-20% to affected area q6-8hr PRN; remove sting prior to application if a bee sting

Mouth and Gum Irritation

<2 years: safety and efficacy not established

≥2 years: Apply 10-20% solution (or other topical formulation) PRN

Sore Throat/Mouth Pain

<5 years: Safety and efficacy not established

≥5 years

  • Oral lozenge: 1 lozenge dissolved in mouth; repeat q2hr PRN (generally use <2 days)
  • Oral spray: Apply 1 spray to affected area; spit after 1 min; may repeat up to 4 times

Hemorrhoids

<12 years: Safety and efficacy not established

≥12 years: Apply 5-20% externally to affected area q4hr

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Adverse Effects

Frequency Not Defined

Burning

Contact dermatitis

Edema

Pruritus

Erythema

Rash

Stinging tenderness

Urticaria

Methemoglobenemia

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Warnings

Contraindications

Hypersensitivity to benzocaine or other ester-type local anesthetics

Secondary bacterial infection of treated area

Cautions

Not for use in open wounds, for prolonged time and/or on large portions of the body; avoid contact with eyes

Some dosage forms may contain benzyl alcohol; large amounts of benzyl alcohol associated with potentially fatal toxicity in neonates (gasping syndrome)

Some dosage forms contain propylene glycol; large amounts are potentially toxic as they are associated with lactic acidosis, hyperosmolality, seizures and respiratory depression

Rectal dosage form is for external use only; not for inserting into rectum using fingers or any mechanical device

Irregular heartbeats, respiratory depression, seizures, and death reported in patients who applied topical anesthetics, without supervision of a trained professional, in large amounts or large areas of the skin, used wraps/dressing to cover skin, or left products on for prolonged periods of time

Methemoglobinemia

  • Methemoglobinemia reported following topical use, especially when high concentrations (14-20%) of spray formulations applied to mouth or mucous membranes; suspected cases should be confirmed by co-oximetry, as it yields accurate measures of methemoglobin levels
  • Not for use for teething or mouth pain in infants and children <2 years due to risk of methemoglobinemia
  • Use caution in patients with heart disease, hemoglobin or enzyme abnormalities, inflamed or damaged mucosa, or respiratory problems, including asthma, bronchitis, and emphysema in smokers; patients at risk should consider alternatives to benzocaine sprays
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Pregnancy & Lactation

Pregnancy Category: C

Lactation: excretion in milk unknown; use with caution

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

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Pharmacology

Mechanism of Action

Local anesthetics prevent generation/conduction of nerve impulses by reducing sodium permeability and by increasing action potential threshold

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Images

BRAND FORM. UNIT PRICE PILL IMAGE
HurriCaine mucous membrane
-
20 % aerosol
HurriCaine mucous membrane
-
20 % solution
Anbesol (benzocaine) Maximum Strength mucous membrane
-
20 % gel
Anbesol (benzocaine) mucous membrane
-
10 % liquid
Oral Anesthetic mucous membrane
-
20 % gel
Unguentine topical
-
6.6-3-2.5-2.2 % ointment
Hurricaine One mucous membrane
-
20 % liquid
Hurricaine One mucous membrane
-
20 % liquid
Boil Relief topical
-
20 % ointment
Pain Relieving (benzocaine) topical
-
20 % ointment

Copyright © 2010 First DataBank, Inc.

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Patient Handout

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Patient Education
benzocaine mucous membrane

BENZOCAINE - MUCOUS MEMBRANE

(BEN-zoe-kane)

COMMON BRAND NAME(S): Anbesol, HurriCaine

USES: Benzocaine is used short term to relieve pain from minor mouth problems (such as toothache, canker sores, sore gums/throat, mouth/gum injury). It is a local anesthetic that works by numbing the painful area.Do not use this product for children younger than 2 years due to risk of serious side effects. Ask your doctor for more details.

HOW TO USE: Follow all directions on the product package. If your doctor has prescribed this medication, use it as directed. If you have any questions, ask your doctor or pharmacist.Do not use this medication more than 4 times a day unless directed by your doctor. Allow medication to stay on painful area for at least 1 minute before spitting out or rinsing the mouth.Do not use large amounts of this drug or use more often than directed because the risk for serious side effects (including rarely fatal methemoglobinemia) will increase.Avoid getting this medication in the eyes.Stop using this medication and tell your doctor if your sore throat is severe or if it lasts for more than 2 days, or if your sore mouth symptoms last more than 7 days, or if you have a fever, headache, rash, swelling, nausea, or vomiting. You may have a serious medical problem that may require different treatment. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away.

SIDE EFFECTS: Slight burning, tingling, or stinging may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.This medication has rarely caused a very serious (possibly fatal) blood disorder (methemoglobinemia). This effect is more likely if you have breathing problems, certain diseases of the blood, or if you smoke (see also Precautions section). The symptoms of this disorder may occur within minutes to a couple of hours after using this medication. Stop using this medication and get medical help right away if you develop any symptoms of methemoglobinemia, including: pale/bluish/gray skin, unusual tiredness, shortness of breath, fast heartbeat, dizziness, headache, confusion.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using benzocaine, tell your doctor or pharmacist if you are allergic to it; or to other "caine" anesthetics (such as procaine) or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.If you have any of the following health problems, consult your doctor or pharmacist before using this product: heart disease, certain blood disorders (G6PD deficiency, pyruvate kinase deficiency, hemoglobin-M disease, NADH-methemoglobin reductase deficiency), breathing problems (such as asthma, bronchitis, emphysema, smoking history).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).During pregnancy, this product should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this product passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: slow/shallow breathing, seizures, irregular heartbeat.

NOTES: Keep all regular medical, dental, and laboratory appointments.

MISSED DOSE: Not applicable.

STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised February 2022. Copyright(c) 2022 First Databank, Inc.

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.