povidone iodine (OTC)

Frequency Not Defined

Hypothyroidism in neonates (<28 days old) after use by mother prior to delivery; use with caution in pregnancy, lactation and children

Severe pain on application

Irritation

Pruritus

Erythema

Rash

Edematous erythema

Acneform eruption

Contraindications

Hypersensitivity

Cautions

Do not apply over large areas of the body; toxicity may occur if applied in large areas or prolonged periods of time

Not for use in the eyes

Use caution in patients with burns

Ask a doctor in cases of deep or puncture wounds, serious burns, or animal bites

Use caution in renal impairment or thyroid disorders

Use with caution in children

Not for application to deep puncture wounds or serious burns

Discontinue if swelling, redness, pain, or irritation develop, or if condition persists or gets worse

Do not use for longer than 1 week

Keep out of reach of children, if swallowed, get medical help or contact poison control center right away

Pregnancy Category: B

Lactation: Use caution; enters breast

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Wide spectrum microbicidal; oxidizes cell constituents; iodinates proteins and inactivates them

Pharmacokinetics

Absorption: Systemic absorptoin as iodine