prednisolone/sulfacetamide ophthalmic (Rx)

Brand and Other Names:Blephamide, Blephamide S.O.P.
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

prednisolone/sulfacetamide ophthalmic

ophthalmic suspension

  • 0.2%/10% (Blephamide)

ophthalmic ointment

  • 0.2%/10% (Blephamide S.O.P.)
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Conjunctivitis

Ointment: Apply 0.5-inch ribbon of ointment to lacrimal sac of affected eye(s) q6-8hr and qHS, OR

Suspension: Instill 2 gtt q4hr to affected eye(s) during day and qHS

Dosage Forms & Strengths

prednisolone/sulfacetamide ophthalmic

ophthalmic suspension

  • 0.2%/10%

ophthalmic ointment

  • 0.2%/10%
more...

Conjunctivitis

<6 years

  • Safety and efficacy not established

≥6 years

  • Ointment: Apply 0.5-inch ribbon of ointment to lacrimal sac of affected eye(s) q6-8hr and qHS, OR
  • Suspension: Instill 2 gtt to affected eye(s) q4hr during day and qHS
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Interactions

Interaction Checker

and prednisolone/sulfacetamide ophthalmic

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    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Cataract

            Dizziness

            Eye discharge

            Eyelid edema

            Eyelid erythema

            Eye irritation

            Eye pain

            Eye pruritus

            Hypersensitivity including rash, skin pruritus, urticaria, ocular hyperemia, and visual disturbance (blurry vision)

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            Warnings

            Contraindications

            Hypersensitivity to sulfa; active glaucoma, herpes, vaccinia, varicella, and other viral diseases of cornea or conjunctiva, mycobacterial infection of eye, fungal diseases of ocular structures, hypersensitivity to any ingredients

            Cautions

            Use for short term only because of steroid concerns

            Watch for hypersensitivity to sulfas and steroid side effects (superinfection, glaucoma, etc)

            Blood dyscrasias including aplastic anemia, agranulocytosis, and others reported with sulfonamides regardless of route

            Stevens-Johnson syndrome, toxic epidermal necrolysis and other reactions reported with sulfonamides regardless of route

            Fatal hepatic necrosis reported with sulfonamides regardless of route

            Steroids may mask infections or enhance existing ocular infections

            Prolonged use of steroids may result in injury to the optic nerve, glaucoma, defects in visual acuity with prolonged use; steroid use may delay healing after cataract surgery; perforation may occur with topical steroids in diseases that thin the cornea or sclera

            Prolonged use of corticosteroids may result in posterior subcapsular cataract formation and may increase intraocular pressure in susceptible individuals, resulting in ocular hypertension/glaucoma with damage to the optic nerve

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Not known whether topical application is excreted into milk; use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Sulfacetamide: Inhibits bacterial folic acid synthesis through competitive inhibition of PABA, which in turn interferes with bacterial growth

            Prednisolone: Prevents/reduces irritation and swelling by suppressing normal immune response, decreasing inflammatory mediators and reverses capillary permeability

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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