Suggested Dosing
Insufficent reliable evidence on effectiveness
Oral: 1-4 g PO TID
Crushed herb: 10-15 g/d PO (may div TID)
Liquid extract: 5-8 g/d PO (may div TID)
Topical: 3-5 g applied topically
Suggested Uses
Blood pressure problems, arrhythmias, weak heart, epistaxis, PMS
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Contraindicated (0)
Serious - Use Alternative (2)
- calcium/magnesium/potassium/sodium oxybates
shepherd's purse, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- sodium oxybate
shepherd's purse, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
Monitor Closely (161)
- albuterol
shepherd's purse increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- alfentanil
alfentanil and shepherd's purse both increase sedation. Use Caution/Monitor.
- alprazolam
alprazolam and shepherd's purse both increase sedation. Use Caution/Monitor.
- amitriptyline
amitriptyline and shepherd's purse both increase sedation. Use Caution/Monitor.
- amobarbital
amobarbital and shepherd's purse both increase sedation. Use Caution/Monitor.
- amoxapine
amoxapine and shepherd's purse both increase sedation. Use Caution/Monitor.
- apomorphine
apomorphine and shepherd's purse both increase sedation. Use Caution/Monitor.
- arformoterol
shepherd's purse increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- aripiprazole
aripiprazole and shepherd's purse both increase sedation. Use Caution/Monitor.
- armodafinil
shepherd's purse increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- azelastine
azelastine and shepherd's purse both increase sedation. Use Caution/Monitor.
- baclofen
baclofen and shepherd's purse both increase sedation. Use Caution/Monitor.
- belladonna and opium
belladonna and opium and shepherd's purse both increase sedation. Use Caution/Monitor.
- benperidol
benperidol and shepherd's purse both increase sedation. Use Caution/Monitor.
- benzphetamine
shepherd's purse increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- brompheniramine
brompheniramine and shepherd's purse both increase sedation. Use Caution/Monitor.
- buprenorphine
buprenorphine and shepherd's purse both increase sedation. Use Caution/Monitor.
- buprenorphine buccal
buprenorphine buccal and shepherd's purse both increase sedation. Use Caution/Monitor.
- butabarbital
butabarbital and shepherd's purse both increase sedation. Use Caution/Monitor.
- butalbital
butalbital and shepherd's purse both increase sedation. Use Caution/Monitor.
- butorphanol
butorphanol and shepherd's purse both increase sedation. Use Caution/Monitor.
- caffeine
shepherd's purse increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- carbinoxamine
carbinoxamine and shepherd's purse both increase sedation. Use Caution/Monitor.
- carisoprodol
carisoprodol and shepherd's purse both increase sedation. Use Caution/Monitor.
- chloral hydrate
chloral hydrate and shepherd's purse both increase sedation. Use Caution/Monitor.
- chlordiazepoxide
chlordiazepoxide and shepherd's purse both increase sedation. Use Caution/Monitor.
- chlorpheniramine
chlorpheniramine and shepherd's purse both increase sedation. Use Caution/Monitor.
- chlorpromazine
chlorpromazine and shepherd's purse both increase sedation. Use Caution/Monitor.
- chlorzoxazone
chlorzoxazone and shepherd's purse both increase sedation. Use Caution/Monitor.
- cinnarizine
cinnarizine and shepherd's purse both increase sedation. Use Caution/Monitor.
- clemastine
clemastine and shepherd's purse both increase sedation. Use Caution/Monitor.
- clomipramine
clomipramine and shepherd's purse both increase sedation. Use Caution/Monitor.
- clonazepam
clonazepam and shepherd's purse both increase sedation. Use Caution/Monitor.
- clorazepate
clorazepate and shepherd's purse both increase sedation. Use Caution/Monitor.
- clozapine
clozapine and shepherd's purse both increase sedation. Use Caution/Monitor.
- codeine
codeine and shepherd's purse both increase sedation. Use Caution/Monitor.
- cyclizine
cyclizine and shepherd's purse both increase sedation. Use Caution/Monitor.
- cyclobenzaprine
cyclobenzaprine and shepherd's purse both increase sedation. Use Caution/Monitor.
- cyproheptadine
cyproheptadine and shepherd's purse both increase sedation. Use Caution/Monitor.
- dantrolene
dantrolene and shepherd's purse both increase sedation. Use Caution/Monitor.
- desipramine
desipramine and shepherd's purse both increase sedation. Use Caution/Monitor.
- dexchlorpheniramine
dexchlorpheniramine and shepherd's purse both increase sedation. Use Caution/Monitor.
- dexfenfluramine
shepherd's purse increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dexmedetomidine
dexmedetomidine and shepherd's purse both increase sedation. Use Caution/Monitor.
- dexmethylphenidate
shepherd's purse increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextroamphetamine
shepherd's purse increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextromoramide
dextromoramide and shepherd's purse both increase sedation. Use Caution/Monitor.
- diamorphine
diamorphine and shepherd's purse both increase sedation. Use Caution/Monitor.
- diazepam
diazepam and shepherd's purse both increase sedation. Use Caution/Monitor.
- diethylpropion
shepherd's purse increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- difenoxin hcl
difenoxin hcl and shepherd's purse both increase sedation. Use Caution/Monitor.
- diltiazem
shepherd's purse, diltiazem. Other (see comment). Use Caution/Monitor. Comment: Theoretically, shepherd's purse may interfere with BP control.
- dimenhydrinate
dimenhydrinate and shepherd's purse both increase sedation. Use Caution/Monitor.
- diphenhydramine
diphenhydramine and shepherd's purse both increase sedation. Use Caution/Monitor.
- diphenoxylate hcl
diphenoxylate hcl and shepherd's purse both increase sedation. Use Caution/Monitor.
- dipipanone
dipipanone and shepherd's purse both increase sedation. Use Caution/Monitor.
- dobutamine
shepherd's purse increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dopamine
shepherd's purse increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dopexamine
shepherd's purse increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- doxepin
doxepin and shepherd's purse both increase sedation. Use Caution/Monitor.
- doxylamine
doxylamine and shepherd's purse both increase sedation. Use Caution/Monitor.
- droperidol
droperidol and shepherd's purse both increase sedation. Use Caution/Monitor.
- ephedrine
shepherd's purse increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine
shepherd's purse increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine racemic
shepherd's purse increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- estazolam
estazolam and shepherd's purse both increase sedation. Use Caution/Monitor.
- ethanol
ethanol and shepherd's purse both increase sedation. Use Caution/Monitor.
- etomidate
etomidate and shepherd's purse both increase sedation. Use Caution/Monitor.
- fenfluramine
shepherd's purse increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- fluphenazine
fluphenazine and shepherd's purse both increase sedation. Use Caution/Monitor.
- flurazepam
flurazepam and shepherd's purse both increase sedation. Use Caution/Monitor.
- formoterol
shepherd's purse increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- haloperidol
haloperidol and shepherd's purse both increase sedation. Use Caution/Monitor.
- hydromorphone
hydromorphone and shepherd's purse both increase sedation. Use Caution/Monitor.
- hydroxyzine
hydroxyzine and shepherd's purse both increase sedation. Use Caution/Monitor.
- iloperidone
iloperidone and shepherd's purse both increase sedation. Use Caution/Monitor.
- imipramine
imipramine and shepherd's purse both increase sedation. Use Caution/Monitor.
- isoproterenol
shepherd's purse increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- ketotifen, ophthalmic
ketotifen, ophthalmic and shepherd's purse both increase sedation. Use Caution/Monitor.
- levalbuterol
shepherd's purse increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- levorphanol
levorphanol and shepherd's purse both increase sedation. Use Caution/Monitor.
- lisdexamfetamine
shepherd's purse increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- lofepramine
lofepramine and shepherd's purse both increase sedation. Use Caution/Monitor.
- lofexidine
lofexidine and shepherd's purse both increase sedation. Use Caution/Monitor.
- loprazolam
loprazolam and shepherd's purse both increase sedation. Use Caution/Monitor.
- lorazepam
lorazepam and shepherd's purse both increase sedation. Use Caution/Monitor.
- lormetazepam
lormetazepam and shepherd's purse both increase sedation. Use Caution/Monitor.
- loxapine
loxapine and shepherd's purse both increase sedation. Use Caution/Monitor.
- loxapine inhaled
loxapine inhaled and shepherd's purse both increase sedation. Use Caution/Monitor.
- maprotiline
maprotiline and shepherd's purse both increase sedation. Use Caution/Monitor.
- marijuana
marijuana and shepherd's purse both increase sedation. Use Caution/Monitor.
- melatonin
melatonin and shepherd's purse both increase sedation. Use Caution/Monitor.
- meperidine
meperidine and shepherd's purse both increase sedation. Use Caution/Monitor.
- meprobamate
meprobamate and shepherd's purse both increase sedation. Use Caution/Monitor.
- metaproterenol
shepherd's purse increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- metaxalone
metaxalone and shepherd's purse both increase sedation. Use Caution/Monitor.
- methadone
methadone and shepherd's purse both increase sedation. Use Caution/Monitor.
- methamphetamine
shepherd's purse increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- methocarbamol
methocarbamol and shepherd's purse both increase sedation. Use Caution/Monitor.
- methylenedioxymethamphetamine
shepherd's purse increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- midazolam
midazolam and shepherd's purse both increase sedation. Use Caution/Monitor.
- midodrine
shepherd's purse increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- mirtazapine
mirtazapine and shepherd's purse both increase sedation. Use Caution/Monitor.
- modafinil
shepherd's purse increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- morphine
morphine and shepherd's purse both increase sedation. Use Caution/Monitor.
- motherwort
motherwort and shepherd's purse both increase sedation. Use Caution/Monitor.
- moxonidine
moxonidine and shepherd's purse both increase sedation. Use Caution/Monitor.
- nabilone
nabilone and shepherd's purse both increase sedation. Use Caution/Monitor.
- nalbuphine
nalbuphine and shepherd's purse both increase sedation. Use Caution/Monitor.
- norepinephrine
shepherd's purse increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- nortriptyline
nortriptyline and shepherd's purse both increase sedation. Use Caution/Monitor.
- olanzapine
olanzapine and shepherd's purse both increase sedation. Use Caution/Monitor.
- opium tincture
opium tincture and shepherd's purse both increase sedation. Use Caution/Monitor.
- orphenadrine
orphenadrine and shepherd's purse both increase sedation. Use Caution/Monitor.
- oxazepam
oxazepam and shepherd's purse both increase sedation. Use Caution/Monitor.
- oxycodone
oxycodone and shepherd's purse both increase sedation. Use Caution/Monitor.
- oxymorphone
oxymorphone and shepherd's purse both increase sedation. Use Caution/Monitor.
- paliperidone
paliperidone and shepherd's purse both increase sedation. Use Caution/Monitor.
- papaveretum
papaveretum and shepherd's purse both increase sedation. Use Caution/Monitor.
- papaverine
papaverine and shepherd's purse both increase sedation. Use Caution/Monitor.
- pentazocine
pentazocine and shepherd's purse both increase sedation. Use Caution/Monitor.
- pentobarbital
pentobarbital and shepherd's purse both increase sedation. Use Caution/Monitor.
- perphenazine
perphenazine and shepherd's purse both increase sedation. Use Caution/Monitor.
- phendimetrazine
shepherd's purse increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenobarbital
phenobarbital and shepherd's purse both increase sedation. Use Caution/Monitor.
- phentermine
shepherd's purse increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine
shepherd's purse increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine PO
shepherd's purse increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- pholcodine
pholcodine and shepherd's purse both increase sedation. Use Caution/Monitor.
- pimozide
pimozide and shepherd's purse both increase sedation. Use Caution/Monitor.
- pirbuterol
shepherd's purse increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- primidone
primidone and shepherd's purse both increase sedation. Use Caution/Monitor.
- prochlorperazine
prochlorperazine and shepherd's purse both increase sedation. Use Caution/Monitor.
- promethazine
promethazine and shepherd's purse both increase sedation. Use Caution/Monitor.
- propylhexedrine
shepherd's purse increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- protriptyline
protriptyline and shepherd's purse both increase sedation. Use Caution/Monitor.
- quazepam
quazepam and shepherd's purse both increase sedation. Use Caution/Monitor.
- quetiapine
quetiapine and shepherd's purse both increase sedation. Use Caution/Monitor.
- ramelteon
ramelteon and shepherd's purse both increase sedation. Use Caution/Monitor.
- risperidone
risperidone and shepherd's purse both increase sedation. Use Caution/Monitor.
- salmeterol
shepherd's purse increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- scullcap
scullcap and shepherd's purse both increase sedation. Use Caution/Monitor.
- secobarbital
secobarbital and shepherd's purse both increase sedation. Use Caution/Monitor.
- sufentanil
sufentanil and shepherd's purse both increase sedation. Use Caution/Monitor.
- tapentadol
tapentadol and shepherd's purse both increase sedation. Use Caution/Monitor.
- temazepam
temazepam and shepherd's purse both increase sedation. Use Caution/Monitor.
- terbutaline
shepherd's purse increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- thioridazine
thioridazine and shepherd's purse both increase sedation. Use Caution/Monitor.
- thiothixene
thiothixene and shepherd's purse both increase sedation. Use Caution/Monitor.
- topiramate
shepherd's purse and topiramate both increase sedation. Modify Therapy/Monitor Closely.
- tramadol
tramadol and shepherd's purse both increase sedation. Use Caution/Monitor.
- trazodone
trazodone and shepherd's purse both increase sedation. Use Caution/Monitor.
- triazolam
triazolam and shepherd's purse both increase sedation. Use Caution/Monitor.
- triclofos
triclofos and shepherd's purse both increase sedation. Use Caution/Monitor.
- trifluoperazine
trifluoperazine and shepherd's purse both increase sedation. Use Caution/Monitor.
- trimipramine
trimipramine and shepherd's purse both increase sedation. Use Caution/Monitor.
- triprolidine
triprolidine and shepherd's purse both increase sedation. Use Caution/Monitor.
- xylometazoline
shepherd's purse increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- yohimbine
shepherd's purse increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- ziconotide
shepherd's purse and ziconotide both increase sedation. Use Caution/Monitor.
- ziprasidone
ziprasidone and shepherd's purse both increase sedation. Use Caution/Monitor.
Minor (78)
- acebutolol
shepherd's purse, acebutolol. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- ambrisentan
shepherd's purse, ambrisentan. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- amiloride
shepherd's purse, amiloride. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- amlodipine
shepherd's purse, amlodipine. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- atenolol
shepherd's purse, atenolol. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- bendroflumethiazide
shepherd's purse, bendroflumethiazide. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- betaxolol
shepherd's purse, betaxolol. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- bisoprolol
shepherd's purse, bisoprolol. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- bosentan
shepherd's purse, bosentan. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- bumetanide
shepherd's purse, bumetanide. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- candesartan
shepherd's purse, candesartan. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- carvedilol
shepherd's purse, carvedilol. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- celiprolol
shepherd's purse, celiprolol. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- chlorothiazide
shepherd's purse, chlorothiazide. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- chlorthalidone
shepherd's purse, chlorthalidone. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- clevidipine
shepherd's purse, clevidipine. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- clonidine
shepherd's purse, clonidine. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- cyclopenthiazide
shepherd's purse, cyclopenthiazide. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- digoxin
shepherd's purse, digoxin. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with cardiovascular therapy.
- drospirenone
shepherd's purse, drospirenone. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- enalapril
shepherd's purse, enalapril. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- eplerenone
shepherd's purse, eplerenone. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- epoprostenol
shepherd's purse, epoprostenol. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- eprosartan
shepherd's purse, eprosartan. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- esmolol
shepherd's purse, esmolol. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- ethacrynic acid
shepherd's purse, ethacrynic acid. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- eucalyptus
eucalyptus and shepherd's purse both increase sedation. Minor/Significance Unknown.
- felodipine
shepherd's purse, felodipine. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- fenoldopam
shepherd's purse, fenoldopam. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- fosinopril
shepherd's purse, fosinopril. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- furosemide
shepherd's purse, furosemide. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- guanfacine
shepherd's purse, guanfacine. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- hydralazine
shepherd's purse, hydralazine. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- hydrochlorothiazide
shepherd's purse, hydrochlorothiazide. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- iloprost
shepherd's purse, iloprost. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- imidapril
shepherd's purse, imidapril. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- indapamide
shepherd's purse, indapamide. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- irbesartan
shepherd's purse, irbesartan. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- isradipine
shepherd's purse, isradipine. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- ketanserin
shepherd's purse, ketanserin. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- labetalol
shepherd's purse, labetalol. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- levothyroxine
shepherd's purse decreases effects of levothyroxine by unspecified interaction mechanism. Minor/Significance Unknown. Theoretical interaction.
- liothyronine
shepherd's purse decreases effects of liothyronine by unspecified interaction mechanism. Minor/Significance Unknown. Theoretical interaction.
- lisinopril
shepherd's purse, lisinopril. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- losartan
shepherd's purse, losartan. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- mecamylamine
shepherd's purse, mecamylamine. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- methyclothiazide
shepherd's purse, methyclothiazide. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- metolazone
shepherd's purse, metolazone. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- metoprolol
shepherd's purse, metoprolol. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- metyrosine
shepherd's purse, metyrosine. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- minoxidil
shepherd's purse, minoxidil. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- moexipril
shepherd's purse, moexipril. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- moxonidine
shepherd's purse, moxonidine. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- nadolol
shepherd's purse, nadolol. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- nebivolol
shepherd's purse, nebivolol. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- nicardipine
shepherd's purse, nicardipine. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- nifedipine
shepherd's purse, nifedipine. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- nisoldipine
shepherd's purse, nisoldipine. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- olmesartan
shepherd's purse, olmesartan. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- penbutolol
shepherd's purse, penbutolol. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- perindopril
shepherd's purse, perindopril. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- pindolol
shepherd's purse, pindolol. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- propranolol
shepherd's purse, propranolol. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- quinapril
shepherd's purse, quinapril. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- ramipril
shepherd's purse, ramipril. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- sacubitril/valsartan
shepherd's purse, sacubitril/valsartan. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- sage
sage and shepherd's purse both increase sedation. Minor/Significance Unknown.
- sotalol
shepherd's purse, sotalol. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- spironolactone
shepherd's purse, spironolactone. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- telmisartan
shepherd's purse, telmisartan. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- thyroid desiccated
shepherd's purse decreases effects of thyroid desiccated by unspecified interaction mechanism. Minor/Significance Unknown. Theoretical interaction.
- timolol
shepherd's purse, timolol. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- torsemide
shepherd's purse, torsemide. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- trandolapril
shepherd's purse, trandolapril. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- treprostinil
shepherd's purse, treprostinil. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- triamterene
shepherd's purse, triamterene. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- valsartan
shepherd's purse, valsartan. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
- verapamil
shepherd's purse, verapamil. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.
Warnings
Contraindications
Pregnancy
Pregnancy & Lactation
Pregnancy Category: do not use
Lactation: N/A
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Influences blood pressure, boosts cardiac output/heart rate, promotes uterine contractions; contains saponins, bursinic acid, flavonoids, choline, beta carotene, and Vitamins B, C, and K