Gotu Kola (Herb/Suppl)

Brand and Other Names:brahmabuti, centella asiatica, more...hydrocotyle, Indian pennywort, Indian water navelwort, madescassol, marsh penny, talepetrako, thick-leaved pennywort, white rot
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Suggested Dosing

Extract

60mg PO BID-TID

Dried leaves

600 mg PO TID

Tea

1 cup PO TID; 600 mg dried leaves/150 ml water

Other Information

Topical: apply 1% cream daily

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Suggested Uses

Abdominal disorders, aphrodisiac, common cold/flu, fatigue, memory enhancer, varicose veins, venous insufficiency

Topical: hypertrophic scarring, psoriasis, wound healing

Efficacy

Possibly effective for listed uses

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Interactions

Interaction Checker

and Gotu Kola

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (25)

                • amobarbital

                  gotu kola increases effects of amobarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • azelastine

                  gotu kola increases effects of azelastine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • brompheniramine

                  gotu kola increases effects of brompheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • butabarbital

                  gotu kola increases effects of butabarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • butalbital

                  gotu kola increases effects of butalbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • carbinoxamine

                  gotu kola increases effects of carbinoxamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • chloral hydrate

                  gotu kola increases effects of chloral hydrate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • chlorpheniramine

                  gotu kola increases effects of chlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • cinnarizine

                  gotu kola increases effects of cinnarizine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • clemastine

                  gotu kola increases effects of clemastine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • cyclizine

                  gotu kola increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • cyproheptadine

                  gotu kola increases effects of cyproheptadine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • dexchlorpheniramine

                  gotu kola increases effects of dexchlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • dexmedetomidine

                  gotu kola increases effects of dexmedetomidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • dimenhydrinate

                  gotu kola increases effects of dimenhydrinate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • diphenhydramine

                  gotu kola increases effects of diphenhydramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • doxylamine

                  gotu kola increases effects of doxylamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • hydroxyzine

                  gotu kola increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • pentobarbital

                  gotu kola increases effects of pentobarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • phenobarbital

                  gotu kola increases effects of phenobarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • primidone

                  gotu kola increases effects of primidone by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • promethazine

                  gotu kola increases effects of promethazine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • secobarbital

                  gotu kola increases effects of secobarbital by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • triclofos

                  gotu kola increases effects of triclofos by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • triprolidine

                  gotu kola increases effects of triprolidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                Minor (23)

                • acarbose

                  gotu kola increases effects of acarbose by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • chlorpropamide

                  gotu kola increases effects of chlorpropamide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • glimepiride

                  gotu kola increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • glipizide

                  gotu kola increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • glyburide

                  gotu kola increases effects of glyburide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • insulin aspart

                  gotu kola increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • insulin detemir

                  gotu kola increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • insulin glargine

                  gotu kola increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • insulin glulisine

                  gotu kola increases effects of insulin glulisine by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • insulin lispro

                  gotu kola increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • insulin NPH

                  gotu kola increases effects of insulin NPH by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • insulin regular human

                  gotu kola increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • metformin

                  gotu kola increases effects of metformin by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • miglitol

                  gotu kola increases effects of miglitol by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • nateglinide

                  gotu kola increases effects of nateglinide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • pioglitazone

                  gotu kola increases effects of pioglitazone by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • repaglinide

                  gotu kola increases effects of repaglinide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • rosiglitazone

                  gotu kola increases effects of rosiglitazone by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • saxagliptin

                  gotu kola increases effects of saxagliptin by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • sitagliptin

                  gotu kola increases effects of sitagliptin by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • tolazamide

                  gotu kola increases effects of tolazamide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • tolbutamide

                  gotu kola increases effects of tolbutamide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • vildagliptin

                  gotu kola increases effects of vildagliptin by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

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                Adverse Effects

                Frequency Not Defined

                GI upset

                Nausea

                Photosensitivity

                Pruritis

                Topical: Allergic contact dermatitis

                Burning

                Large dose: Drowsiness

                Hypercholesterolemia

                Hyperglycemia

                Hypertension

                Hypertriglyceridemia

                Sedation

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                Warnings

                Contraindications

                None reported

                Cautions

                Concurrent sedative agents, diabetes mellitus, hyperlipidemia

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                Pregnancy & Lactation

                Pregnancy Category: avoid use

                Lactation: avoid use

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Metabolism: N/A

                Excretion: N/A

                Mechanism of Action

                Triterpene compounds stimulate connective tissue repair, keratinization

                Asiaticoside derivatives protect neurons from beta-amyloid toxicity

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.