Suggested Dosing
Weight Loss
Seed extract: 200-1600 mg PO qDay; no more than 3 g/day
Cognitive Enhancement
Standardized dry extract: 150 mg PO qDay
Energy Enhancement
200-800 mg before breakfast or lunch PO qDay, no more than 3 g/day
Diuretic
486 mg PO qD
Diarrhea or Dysentery
1 g PO no more than QID
Suggested Uses
Weight loss, to enhance athletic performance, to reduce mental and physical fatigue, hypotension, chronic fatigue syndrome (CFS), stimulant, diuretic, and astringent, prevent malaria and dysentery
Efficacy
May cause weight loss when taken in combination with mate and damiana. More evidence is needed to rate effectiveness
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (0)
Minor (13)
- armodafinil
guarana increases effects of armodafinil by pharmacodynamic synergism. Minor/Significance Unknown.
- caffeine
guarana increases effects of caffeine by pharmacodynamic synergism. Minor/Significance Unknown.
- dexmethylphenidate
guarana increases effects of dexmethylphenidate by pharmacodynamic synergism. Minor/Significance Unknown.
- dextroamphetamine
guarana increases effects of dextroamphetamine by pharmacodynamic synergism. Minor/Significance Unknown.
- green tea
green tea, guarana. Other (see comment). Minor/Significance Unknown. Comment: Concurrent administration of guarana to patients taking caffeine may produce excessive caffeine-like side effects, such as nausea, irritability or nervousness. Caution in patients consuming large amounts of caffeine.
- lisdexamfetamine
guarana increases effects of lisdexamfetamine by pharmacodynamic synergism. Minor/Significance Unknown.
- methamphetamine
guarana increases effects of methamphetamine by pharmacodynamic synergism. Minor/Significance Unknown.
- methylenedioxymethamphetamine
guarana increases effects of methylenedioxymethamphetamine by pharmacodynamic synergism. Minor/Significance Unknown.
- methylphenidate
guarana increases effects of methylphenidate by pharmacodynamic synergism. Minor/Significance Unknown.
- modafinil
guarana increases effects of modafinil by pharmacodynamic synergism. Minor/Significance Unknown.
- phentermine
guarana increases effects of phentermine by pharmacodynamic synergism. Minor/Significance Unknown.
- serdexmethylphenidate/dexmethylphenidate
guarana increases effects of serdexmethylphenidate/dexmethylphenidate by pharmacodynamic synergism. Minor/Significance Unknown.
- yohimbine
guarana increases effects of yohimbine by pharmacodynamic synergism. Minor/Significance Unknown.
Adverse Effects
Frequency Not Defined
Agitation
Anxiety
Arrhythmias
Convulsions
Delirium
Dependence
Diarrhea
Diuresis
Dizziness
GI upset
Headache
Hyperglycemia
Hypertension
Increased respiration
Insomnia
Irritability
Muscle spasms
Nausea/vomiting
Nervousness
Restlessness
Tachycardia
Tinnitus
Withdrawal symptoms
Abdominal spasms (from overdose)
Painful urination (from overdose)
Warnings
Contraindications
Duodenal ulcer, gastric ulcer
Cautions
Anxiety disorders, arrhythmias, cardiac disease, depression, hypertension, kidney disease
Pregnancy & Lactation
Pregnancy Category: N/A
Lactation: avoid use
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Metabolism: N/A
Excretion: N/A
Mechanism of Action
Contains 2.5-5% caffeine; see caffeine
