Guarana (Herb/Suppl)

Brand and Other Names:Brazilian cocoa, guarana gum, more...guarana paste, guaranine, paullinia cupana, Uabano, Uaranzeiro, zoom
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Suggested Dosing

Weight Loss

Seed extract: 200-1600 mg PO qDay; no more than 3 g/day

Cognitive Enhancement

Standardized dry extract: 150 mg PO qDay

Energy Enhancement

200-800 mg before breakfast or lunch PO qDay, no more than 3 g/day

Diuretic

486 mg PO qD

Diarrhea or Dysentery

1 g PO no more than QID

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Suggested Uses

Weight loss, to enhance athletic performance, to reduce mental and physical fatigue, hypotension, chronic fatigue syndrome (CFS), stimulant, diuretic, and astringent, prevent malaria and dysentery

Efficacy

May cause weight loss when taken in combination with mate and damiana. More evidence is needed to rate effectiveness

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Interactions

Interaction Checker

and Guarana

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (0)

                  Minor (12)

                  • armodafinil

                    guarana increases effects of armodafinil by pharmacodynamic synergism. Minor/Significance Unknown.

                  • caffeine

                    guarana increases effects of caffeine by pharmacodynamic synergism. Minor/Significance Unknown.

                  • dexmethylphenidate

                    guarana increases effects of dexmethylphenidate by pharmacodynamic synergism. Minor/Significance Unknown.

                  • dextroamphetamine

                    guarana increases effects of dextroamphetamine by pharmacodynamic synergism. Minor/Significance Unknown.

                  • green tea

                    green tea, guarana. Other (see comment). Minor/Significance Unknown. Comment: Concurrent administration of guarana to patients taking caffeine may produce excessive caffeine-like side effects, such as nausea, irritability or nervousness. Caution in patients consuming large amounts of caffeine.

                  • lisdexamfetamine

                    guarana increases effects of lisdexamfetamine by pharmacodynamic synergism. Minor/Significance Unknown.

                  • methamphetamine

                    guarana increases effects of methamphetamine by pharmacodynamic synergism. Minor/Significance Unknown.

                  • methylenedioxymethamphetamine

                    guarana increases effects of methylenedioxymethamphetamine by pharmacodynamic synergism. Minor/Significance Unknown.

                  • methylphenidate

                    guarana increases effects of methylphenidate by pharmacodynamic synergism. Minor/Significance Unknown.

                  • modafinil

                    guarana increases effects of modafinil by pharmacodynamic synergism. Minor/Significance Unknown.

                  • phentermine

                    guarana increases effects of phentermine by pharmacodynamic synergism. Minor/Significance Unknown.

                  • yohimbine

                    guarana increases effects of yohimbine by pharmacodynamic synergism. Minor/Significance Unknown.

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                  Adverse Effects

                  Frequency Not Defined

                  Agitation

                  Anxiety

                  Arrhythmias

                  Convulsions

                  Delirium

                  Dependence

                  Diarrhea

                  Diuresis

                  Dizziness

                  GI upset

                  Headache

                  Hyperglycemia

                  Hypertension

                  Increased respiration

                  Insomnia

                  Irritability

                  Muscle spasms

                  Nausea/vomiting

                  Nervousness

                  Restlessness

                  Tachycardia

                  Tinnitus

                  Withdrawal symptoms

                  Abdominal spasms (from overdose)

                  Painful urination (from overdose)

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                  Warnings

                  Contraindications

                  Duodenal ulcer, gastric ulcer

                  Cautions

                  Anxiety disorders, arrhythmias, cardiac disease, depression, hypertension, kidney disease

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                  Pregnancy & Lactation

                  Pregnancy Category: N/A

                  Lactation: avoid use

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Metabolism: N/A

                  Excretion: N/A

                  Mechanism of Action

                  Contains 2.5-5% caffeine; see caffeine

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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.