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      News & Perspective Drugs & Diseases CME & Education Academy Video Decision Point
      Drugs & Diseases

      brompheniramine (Rx, OTC)

      Brand and Other Names:Dimetane, Respa-BR
      • Print

      Dosing & Uses

      AdultPediatricGeriatric

      Dosage Forms & Strengths

      tablet extended release

      • 11mg

      oral suspension

      • 12mg/5mL

      oral liquid

      • 1mg/1mL
      • 2 mg/5mL

      Symptomatic relief of upper respiratory symptoms, including nasal congestion, associated with allergy or common cold

      4 mg PO q4-6hr (no more than 24 mg qDay) PRN

      Extended-release: 8-12 mg tablet PO q12hr or 12-24 mg capsule PO qDay

      Other Indications & Uses

      Perennial & seasonal allergic & vasomotor rhinitis, urticaria, angioedema, anaphylactic reactions, pruritus, allergic conjunctivitis

      Dosage Forms & Strengths

      tablet

      • 11mg

      oral suspension

      • 12mg/5mL

      liquid

      • 1mg/mL
      • 2mg/5mL

      Symptomatic relief of upper respiratory symptoms, including nasal congestion, associated with allergy or common cold

      <12 Years Old

      0.5 mg/kg/day divided q6hr PO  

      Nonanticholinergic antihistamines should be considered first when treating allergic reactions (Beers Criteria)

      Avoid use in elderly because of high incidence of anticholinergic effects

      Clearance reduced with advanced age, greater risk of confusion, dry mouth, constipation, and other anticholinergic effects and toxicity

      May exacerbate existing lower urinary conditions or benign prostatic hyperplasia

      Next:

      Interactions

      Interaction Checker

      and brompheniramine

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          Serious - Use Alternative

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                 activity indicator 

                Contraindicated (0)

                  Serious - Use Alternative (9)

                  • calcium/magnesium/potassium/sodium oxybates

                    brompheniramine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

                  • eluxadoline

                    brompheniramine, eluxadoline. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that cause constipation. Increases risk for constipation related serious adverse reactions.

                  • isocarboxazid

                    isocarboxazid increases effects of brompheniramine by Other (see comment). Avoid or Use Alternate Drug. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .

                  • metoclopramide intranasal

                    brompheniramine, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.

                  • olopatadine intranasal

                    brompheniramine and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.

                  • pitolisant

                    brompheniramine decreases effects of pitolisant by Other (see comment). Avoid or Use Alternate Drug. Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant.

                  • selinexor

                    selinexor, brompheniramine. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.

                  • sodium oxybate

                    brompheniramine, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

                  • tranylcypromine

                    tranylcypromine increases effects of brompheniramine by Other (see comment). Avoid or Use Alternate Drug. Comment: Tranylcypromine should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .

                  Monitor Closely (211)

                  • acrivastine

                    acrivastine and brompheniramine both increase sedation. Use Caution/Monitor.

                  • albuterol

                    brompheniramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • alfentanil

                    brompheniramine and alfentanil both increase sedation. Use Caution/Monitor.

                  • alprazolam

                    brompheniramine and alprazolam both increase sedation. Use Caution/Monitor.

                  • amifampridine

                    brompheniramine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.

                  • amisulpride

                    amisulpride and brompheniramine both increase sedation. Use Caution/Monitor.

                  • amitriptyline

                    brompheniramine and amitriptyline both increase sedation. Use Caution/Monitor.

                  • amobarbital

                    brompheniramine and amobarbital both increase sedation. Use Caution/Monitor.

                  • amoxapine

                    brompheniramine and amoxapine both increase sedation. Use Caution/Monitor.

                  • apomorphine

                    brompheniramine and apomorphine both increase sedation. Use Caution/Monitor.

                  • arformoterol

                    brompheniramine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • aripiprazole

                    brompheniramine and aripiprazole both increase sedation. Use Caution/Monitor.

                  • armodafinil

                    brompheniramine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • asenapine

                    asenapine and brompheniramine both increase sedation. Use Caution/Monitor.

                  • asenapine transdermal

                    asenapine transdermal and brompheniramine both increase sedation. Use Caution/Monitor.

                  • avapritinib

                    avapritinib and brompheniramine both increase sedation. Use Caution/Monitor.

                  • azelastine

                    azelastine and brompheniramine both increase sedation. Use Caution/Monitor.

                  • baclofen

                    brompheniramine and baclofen both increase sedation. Use Caution/Monitor.

                  • belladonna and opium

                    brompheniramine and belladonna and opium both increase sedation. Use Caution/Monitor.

                  • benperidol

                    brompheniramine and benperidol both increase sedation. Use Caution/Monitor.

                  • benzhydrocodone/acetaminophen

                    benzhydrocodone/acetaminophen and brompheniramine both increase sedation. Use Caution/Monitor.

                  • benzphetamine

                    brompheniramine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • brexanolone

                    brexanolone, brompheniramine. Either increases toxicity of the other by sedation. Use Caution/Monitor.

                  • brexpiprazole

                    brexpiprazole and brompheniramine both increase sedation. Use Caution/Monitor.

                  • brimonidine

                    brimonidine and brompheniramine both increase sedation. Use Caution/Monitor.

                  • brivaracetam

                    brivaracetam and brompheniramine both increase sedation. Use Caution/Monitor.

                  • buprenorphine

                    brompheniramine and buprenorphine both increase sedation. Use Caution/Monitor.

                  • buprenorphine buccal

                    brompheniramine and buprenorphine buccal both increase sedation. Use Caution/Monitor.

                  • buprenorphine subdermal implant

                    buprenorphine subdermal implant and brompheniramine both increase sedation. Use Caution/Monitor.

                  • buprenorphine transdermal

                    buprenorphine transdermal and brompheniramine both increase sedation. Use Caution/Monitor.

                  • butabarbital

                    brompheniramine and butabarbital both increase sedation. Use Caution/Monitor.

                  • butalbital

                    brompheniramine and butalbital both increase sedation. Use Caution/Monitor.

                  • butorphanol

                    brompheniramine and butorphanol both increase sedation. Use Caution/Monitor.

                  • caffeine

                    brompheniramine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • carbinoxamine

                    brompheniramine and carbinoxamine both increase sedation. Use Caution/Monitor.

                  • carisoprodol

                    brompheniramine and carisoprodol both increase sedation. Use Caution/Monitor.

                  • cenobamate

                    cenobamate, brompheniramine. Either increases effects of the other by sedation. Use Caution/Monitor.

                  • chloral hydrate

                    brompheniramine and chloral hydrate both increase sedation. Use Caution/Monitor.

                  • chlordiazepoxide

                    brompheniramine and chlordiazepoxide both increase sedation. Use Caution/Monitor.

                  • chlorpheniramine

                    brompheniramine and chlorpheniramine both increase sedation. Use Caution/Monitor.

                  • chlorpromazine

                    brompheniramine and chlorpromazine both increase sedation. Use Caution/Monitor.

                  • chlorzoxazone

                    brompheniramine and chlorzoxazone both increase sedation. Use Caution/Monitor.

                  • cinnarizine

                    brompheniramine and cinnarizine both increase sedation. Use Caution/Monitor.

                  • clemastine

                    brompheniramine and clemastine both increase sedation. Use Caution/Monitor.

                  • clobazam

                    brompheniramine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).

                  • clomipramine

                    brompheniramine and clomipramine both increase sedation. Use Caution/Monitor.

                  • clonazepam

                    brompheniramine and clonazepam both increase sedation. Use Caution/Monitor.

                  • clorazepate

                    brompheniramine and clorazepate both increase sedation. Use Caution/Monitor.

                  • clozapine

                    brompheniramine and clozapine both increase sedation. Use Caution/Monitor.

                  • codeine

                    brompheniramine and codeine both increase sedation. Use Caution/Monitor.

                  • cyclizine

                    brompheniramine and cyclizine both increase sedation. Use Caution/Monitor.

                  • cyclobenzaprine

                    brompheniramine and cyclobenzaprine both increase sedation. Use Caution/Monitor.

                  • cyproheptadine

                    brompheniramine and cyproheptadine both increase sedation. Use Caution/Monitor.

                  • dantrolene

                    brompheniramine and dantrolene both increase sedation. Use Caution/Monitor.

                  • daridorexant

                    brompheniramine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.

                  • desflurane

                    desflurane and brompheniramine both increase sedation. Use Caution/Monitor.

                  • desipramine

                    brompheniramine and desipramine both increase sedation. Use Caution/Monitor.

                  • deutetrabenazine

                    brompheniramine and deutetrabenazine both increase sedation. Use Caution/Monitor.

                  • dexchlorpheniramine

                    brompheniramine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.

                  • dexfenfluramine

                    brompheniramine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dexmedetomidine

                    brompheniramine and dexmedetomidine both increase sedation. Use Caution/Monitor.

                  • dexmethylphenidate

                    brompheniramine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dextroamphetamine

                    brompheniramine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dextromoramide

                    brompheniramine and dextromoramide both increase sedation. Use Caution/Monitor.

                  • diamorphine

                    brompheniramine and diamorphine both increase sedation. Use Caution/Monitor.

                  • diazepam

                    brompheniramine and diazepam both increase sedation. Use Caution/Monitor.

                  • diazepam intranasal

                    diazepam intranasal, brompheniramine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.

                  • diethylpropion

                    brompheniramine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • difelikefalin

                    difelikefalin and brompheniramine both increase sedation. Use Caution/Monitor.

                  • difenoxin hcl

                    brompheniramine and difenoxin hcl both increase sedation. Use Caution/Monitor.

                  • dimenhydrinate

                    brompheniramine and dimenhydrinate both increase sedation. Use Caution/Monitor.

                  • diphenhydramine

                    brompheniramine and diphenhydramine both increase sedation. Use Caution/Monitor.

                  • diphenoxylate hcl

                    brompheniramine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.

                  • dipipanone

                    brompheniramine and dipipanone both increase sedation. Use Caution/Monitor.

                  • dobutamine

                    brompheniramine increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • donepezil transdermal

                    donepezil transdermal, brompheniramine. Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.

                  • dopamine

                    brompheniramine increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dopexamine

                    brompheniramine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dosulepin

                    brompheniramine and dosulepin both increase sedation. Use Caution/Monitor.

                  • doxepin

                    brompheniramine and doxepin both increase sedation. Use Caution/Monitor.

                  • doxylamine

                    brompheniramine and doxylamine both increase sedation. Use Caution/Monitor.

                  • droperidol

                    brompheniramine and droperidol both increase sedation. Use Caution/Monitor.

                  • ephedrine

                    brompheniramine increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • epinephrine

                    brompheniramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • epinephrine racemic

                    brompheniramine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • esketamine intranasal

                    esketamine intranasal, brompheniramine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.

                  • estazolam

                    brompheniramine and estazolam both increase sedation. Use Caution/Monitor.

                  • ethanol

                    brompheniramine and ethanol both increase sedation. Use Caution/Monitor.

                  • etomidate

                    etomidate and brompheniramine both increase sedation. Use Caution/Monitor.

                  • fenfluramine

                    brompheniramine increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • fentanyl

                    fentanyl, brompheniramine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

                    fentanyl and brompheniramine both increase sedation. Use Caution/Monitor.

                  • fentanyl intranasal

                    fentanyl intranasal, brompheniramine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

                    fentanyl intranasal and brompheniramine both increase sedation. Use Caution/Monitor.

                  • fentanyl iontophoretic transdermal system

                    fentanyl iontophoretic transdermal system and brompheniramine both increase sedation. Use Caution/Monitor.

                  • fentanyl transdermal

                    fentanyl transdermal, brompheniramine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

                    fentanyl transdermal and brompheniramine both increase sedation. Use Caution/Monitor.

                  • fentanyl transmucosal

                    fentanyl transmucosal, brompheniramine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

                  • flibanserin

                    brompheniramine and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.

                  • fluphenazine

                    brompheniramine and fluphenazine both increase sedation. Use Caution/Monitor.

                  • flurazepam

                    brompheniramine and flurazepam both increase sedation. Use Caution/Monitor.

                  • formoterol

                    brompheniramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • gabapentin

                    gabapentin, brompheniramine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

                  • gabapentin enacarbil

                    gabapentin enacarbil, brompheniramine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

                  • ganaxolone

                    brompheniramine and ganaxolone both increase sedation. Use Caution/Monitor.

                  • glycopyrronium tosylate topical

                    glycopyrronium tosylate topical, brompheniramine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.

                  • gotu kola

                    gotu kola increases effects of brompheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                  • haloperidol

                    brompheniramine and haloperidol both increase sedation. Use Caution/Monitor.

                  • hawthorn

                    hawthorn increases effects of brompheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                  • hops

                    hops increases effects of brompheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                  • hyaluronidase

                    brompheniramine decreases effects of hyaluronidase by Other (see comment). Use Caution/Monitor. Comment: Antihistamines, when given in large systemic doses, may render tissues partially resistant to the action of hyaluronidase. Patients may require larger amounts of hyaluronidase for equivalent dispersing effect.

                  • hydromorphone

                    brompheniramine and hydromorphone both increase sedation. Use Caution/Monitor.

                  • hydroxyzine

                    brompheniramine and hydroxyzine both increase sedation. Use Caution/Monitor.

                  • iloperidone

                    brompheniramine and iloperidone both increase sedation. Use Caution/Monitor.

                  • imipramine

                    brompheniramine and imipramine both increase sedation. Use Caution/Monitor.

                  • isoproterenol

                    brompheniramine increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • kava

                    kava increases effects of brompheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                  • ketamine

                    ketamine and brompheniramine both increase sedation. Use Caution/Monitor.

                  • ketotifen, ophthalmic

                    brompheniramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                  • lasmiditan

                    lasmiditan, brompheniramine. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.

                  • lemborexant

                    lemborexant, brompheniramine. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.

                  • levalbuterol

                    brompheniramine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • levorphanol

                    brompheniramine and levorphanol both increase sedation. Use Caution/Monitor.

                  • lisdexamfetamine

                    brompheniramine increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • lofepramine

                    brompheniramine and lofepramine both increase sedation. Use Caution/Monitor.

                  • lofexidine

                    brompheniramine and lofexidine both increase sedation. Use Caution/Monitor.

                  • loprazolam

                    brompheniramine and loprazolam both increase sedation. Use Caution/Monitor.

                  • lorazepam

                    brompheniramine and lorazepam both increase sedation. Use Caution/Monitor.

                  • lormetazepam

                    brompheniramine and lormetazepam both increase sedation. Use Caution/Monitor.

                  • loxapine

                    brompheniramine and loxapine both increase sedation. Use Caution/Monitor.

                  • loxapine inhaled

                    brompheniramine and loxapine inhaled both increase sedation. Use Caution/Monitor.

                  • lurasidone

                    lurasidone, brompheniramine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.

                  • maprotiline

                    brompheniramine and maprotiline both increase sedation. Use Caution/Monitor.

                  • marijuana

                    brompheniramine and marijuana both increase sedation. Use Caution/Monitor.

                  • melatonin

                    brompheniramine and melatonin both increase sedation. Use Caution/Monitor.

                  • meperidine

                    brompheniramine and meperidine both increase sedation. Use Caution/Monitor.

                  • meprobamate

                    brompheniramine and meprobamate both increase sedation. Use Caution/Monitor.

                  • metaproterenol

                    brompheniramine increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • metaxalone

                    brompheniramine and metaxalone both increase sedation. Use Caution/Monitor.

                  • methadone

                    brompheniramine and methadone both increase sedation. Use Caution/Monitor.

                  • methamphetamine

                    brompheniramine increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • methocarbamol

                    brompheniramine and methocarbamol both increase sedation. Use Caution/Monitor.

                  • methylenedioxymethamphetamine

                    brompheniramine increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • midazolam

                    brompheniramine and midazolam both increase sedation. Use Caution/Monitor.

                  • midazolam intranasal

                    midazolam intranasal, brompheniramine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.

                  • midodrine

                    brompheniramine increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • mirtazapine

                    brompheniramine and mirtazapine both increase sedation. Use Caution/Monitor.

                  • modafinil

                    brompheniramine increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • morphine

                    brompheniramine and morphine both increase sedation. Use Caution/Monitor.

                  • motherwort

                    brompheniramine and motherwort both increase sedation. Use Caution/Monitor.

                  • moxonidine

                    brompheniramine and moxonidine both increase sedation. Use Caution/Monitor.

                  • nabilone

                    brompheniramine and nabilone both increase sedation. Use Caution/Monitor.

                  • nalbuphine

                    brompheniramine and nalbuphine both increase sedation. Use Caution/Monitor.

                  • norepinephrine

                    brompheniramine increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • nortriptyline

                    brompheniramine and nortriptyline both increase sedation. Use Caution/Monitor.

                  • olanzapine

                    brompheniramine and olanzapine both increase sedation. Use Caution/Monitor.

                  • opium tincture

                    brompheniramine and opium tincture both increase sedation. Use Caution/Monitor.

                  • orphenadrine

                    brompheniramine and orphenadrine both increase sedation. Use Caution/Monitor.

                  • oxazepam

                    brompheniramine and oxazepam both increase sedation. Use Caution/Monitor.

                  • oxycodone

                    brompheniramine and oxycodone both increase sedation. Use Caution/Monitor.

                  • oxymorphone

                    brompheniramine and oxymorphone both increase sedation. Use Caution/Monitor.

                  • paliperidone

                    brompheniramine and paliperidone both increase sedation. Use Caution/Monitor.

                  • papaveretum

                    brompheniramine and papaveretum both increase sedation. Use Caution/Monitor.

                  • papaverine

                    brompheniramine and papaverine both increase sedation. Use Caution/Monitor.

                  • passion flower

                    passion flower increases effects of brompheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                  • pentazocine

                    brompheniramine and pentazocine both increase sedation. Use Caution/Monitor.

                  • pentobarbital

                    brompheniramine and pentobarbital both increase sedation. Use Caution/Monitor.

                  • perampanel

                    perampanel and brompheniramine both increase sedation. Use Caution/Monitor.

                  • perphenazine

                    brompheniramine and perphenazine both increase sedation. Use Caution/Monitor.

                  • phendimetrazine

                    brompheniramine increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • phenelzine

                    phenelzine increases effects of brompheniramine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Coadministration of phenelzine and antihistamines may result in additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .

                  • phenobarbital

                    brompheniramine and phenobarbital both increase sedation. Use Caution/Monitor.

                  • phentermine

                    brompheniramine increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • phenylephrine

                    brompheniramine increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • phenylephrine PO

                    brompheniramine increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

                  • pholcodine

                    brompheniramine and pholcodine both increase sedation. Use Caution/Monitor.

                  • pimozide

                    brompheniramine and pimozide both increase sedation. Use Caution/Monitor.

                  • pirbuterol

                    brompheniramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • pregabalin

                    pregabalin, brompheniramine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

                  • primidone

                    brompheniramine and primidone both increase sedation. Use Caution/Monitor.

                  • prochlorperazine

                    brompheniramine and prochlorperazine both increase sedation. Use Caution/Monitor.

                  • promethazine

                    brompheniramine and promethazine both increase sedation. Use Caution/Monitor.

                  • propofol

                    propofol and brompheniramine both increase sedation. Use Caution/Monitor.

                  • propylhexedrine

                    brompheniramine increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • protriptyline

                    brompheniramine and protriptyline both increase sedation. Use Caution/Monitor.

                  • quazepam

                    brompheniramine and quazepam both increase sedation. Use Caution/Monitor.

                  • quetiapine

                    brompheniramine and quetiapine both increase sedation. Use Caution/Monitor.

                  • ramelteon

                    brompheniramine and ramelteon both increase sedation. Use Caution/Monitor.

                  • risperidone

                    brompheniramine and risperidone both increase sedation. Use Caution/Monitor.

                  • salmeterol

                    brompheniramine increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • scullcap

                    brompheniramine and scullcap both increase sedation. Use Caution/Monitor.

                  • secobarbital

                    brompheniramine and secobarbital both increase sedation. Use Caution/Monitor.

                  • sevoflurane

                    sevoflurane and brompheniramine both increase sedation. Use Caution/Monitor.

                  • shepherd's purse

                    brompheniramine and shepherd's purse both increase sedation. Use Caution/Monitor.

                  • sufentanil

                    brompheniramine and sufentanil both increase sedation. Use Caution/Monitor.

                  • tapentadol

                    brompheniramine and tapentadol both increase sedation. Use Caution/Monitor.

                  • temazepam

                    brompheniramine and temazepam both increase sedation. Use Caution/Monitor.

                  • terbutaline

                    brompheniramine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • thioridazine

                    brompheniramine and thioridazine both increase sedation. Use Caution/Monitor.

                  • thiothixene

                    brompheniramine and thiothixene both increase sedation. Use Caution/Monitor.

                  • topiramate

                    brompheniramine and topiramate both increase sedation. Modify Therapy/Monitor Closely.

                  • tramadol

                    brompheniramine and tramadol both increase sedation. Use Caution/Monitor.

                  • trazodone

                    brompheniramine and trazodone both increase sedation. Use Caution/Monitor.

                  • triazolam

                    brompheniramine and triazolam both increase sedation. Use Caution/Monitor.

                  • triclofos

                    brompheniramine and triclofos both increase sedation. Use Caution/Monitor.

                  • trifluoperazine

                    brompheniramine and trifluoperazine both increase sedation. Use Caution/Monitor.

                  • trimipramine

                    brompheniramine and trimipramine both increase sedation. Use Caution/Monitor.

                  • triprolidine

                    brompheniramine and triprolidine both increase sedation. Use Caution/Monitor.

                  • valerian

                    valerian increases effects of brompheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                  • xylometazoline

                    brompheniramine increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • yohimbine

                    brompheniramine increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • ziconotide

                    brompheniramine and ziconotide both increase sedation. Use Caution/Monitor.

                  • ziprasidone

                    brompheniramine and ziprasidone both increase sedation. Use Caution/Monitor.

                  • zotepine

                    brompheniramine and zotepine both increase sedation. Use Caution/Monitor.

                  Minor (6)

                  • ashwagandha

                    ashwagandha increases effects of brompheniramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                  • brimonidine

                    brimonidine increases effects of brompheniramine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                  • eucalyptus

                    brompheniramine and eucalyptus both increase sedation. Minor/Significance Unknown.

                  • nettle

                    nettle increases effects of brompheniramine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                  • sage

                    brompheniramine and sage both increase sedation. Minor/Significance Unknown.

                  • Siberian ginseng

                    Siberian ginseng increases effects of brompheniramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

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                  Adverse Effects

                  Varies in incidence & severity with the individual drug; also individual patients vary in susceptibility

                  Frequency Not Defined

                  CNS depression

                  Drowsiness

                  Sedation ranging from mild drowsiness to deep sleep (most frequent)

                  Dizziness

                  Lassitude

                  Disturbed coordination

                  Muscular weakness

                  Restlessness, insomnia, tremors, euphoria, nervousness, delirium, palpitation, seizures is less common

                  Epigastric distress

                  Anorexia

                  Nausea

                  Vomiting

                  Diarrhea

                  Constipation

                  Cholestasis, hepatitis, hepatic failure, hepatic function abnormality, jaundice is rare

                  Tachycardia, palpitation ECG changes (eg, widened QRS)

                  Arrhythmias (eg, extrasystole, heart block)

                  Hypotension

                  Hypertension

                  Dizziness, sedation, and hypotension may occur in geriatric patients

                  Dryness of mouth, nose, and throat

                  Dysuria

                  Urinary retention

                  Impotence

                  Vertigo

                  Visual disturbances

                  Blurred vision

                  Diplopia; tinnitus

                  Acute labyrinthitis

                  Insomnia

                  Tremors

                  Nervousness

                  Irritability

                  Facial dyskinesia

                  Tightness of the chest

                  Thickening of bronchial secretions

                  Wheezing

                  Nasal stuffiness

                  Sweating

                  Chills

                  Early menses

                  Toxic psychosis

                  Headache

                  Faintness

                  Paresthesia

                  Agranulocytosis

                  Hemolytic anemia

                  Leukopenia

                  Thrombocytopenia

                  Pancytopenia

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                  Warnings

                  Contraindications

                  Newborn infants, premature infants

                  Nursing mothers

                  Severe hypertension, severe coronary artery disease, severe ischemic heart disease

                  Within 14 days of taking monoamine oxidase (MAO) inhibitors

                  Narrow-angle glaucoma

                  Urinary retention

                  Peptic ulcer

                  During asthma attack

                  Treatment of lower respiratory tract conditions including asthma

                  Caution

                  Therapy may diminish mental alertness, and may cause hyperexcitability, especially in children

                  At doses higher than recommended dose, nervousness, dizziness, or sleeplessness may occur

                  Especially in infants and small children, antihistamines in overdosage may cause hallucinations, convulsions, and death

                  Use with caution in patients with hypertension, ischemic heart disease, and persons >60 years old

                  Not for administration to children who have a chronic pulmonary disease, breathing problems such as chronic bronchitis, glaucoma, or those who are taking sedatives or tranquilizers without first consulting with a doctor

                  Use caution in patients with hypertension, diabetes mellitus, ischemic heart disease, hyperthyroidism, increased intraocular pressure, and prostatic hypertrophy

                  Do not exceed recommended dosage

                  Discontinue use and contact healthcare professional if nervousness, dizziness, or sleeplessness occurs

                  Drug interaction overview

                  • Not for use in patients taking a prescription monoamine oxidase (MAO) inhibitor (certain drugs used for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping MAO inhibitor
                  • MAO inhibitors prolong and intensify anticholinergic effects of antihistamines and may enhance effect of pseudoephedrine HCl
                  • Sympathomimetic agents may reduce effects of anti-hypertensive drugs
                  • Antihistamines have additive effects with alcohol and other CNS (central nervous system) depressants (hypnotics, sedatives, tranquilizers, anti-anxiety agents, etc)
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                  Pregnancy & Lactation

                  Pregnancy

                  Animal reproductive studies not performed with brompheniramine; also, not known if it can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity; therapy should be given to a pregnant woman only if clearly needed

                  Lactation

                  Because of higher risk of intolerance of antihistamines in small infants generally, and in newborns and premature in particular, therapy is contraindicated in nursing mothers

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Mechanism of Action

                  Histamine H1-receptor antagonist

                  Pharmacokinetics

                  Half-Life: 11.8-34.7 hr

                  Onset: 30 min

                  Peak Plasma Time: 2-5 hr

                  Vd: 11.7 L/kg

                  Metabolism: mainly liver

                  Metabolites: Propionic acid derivative conjugated with glycine

                  Excretion: urine

                  Antihistamine activity: high

                  Sedative effect: Low

                  Anticholinergic effects: Moderate

                  Duration

                  • Antihistamine: 3-9 hr, may last 48 hr
                  • Antipruritic: 9-24 hr
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                  Images

                  No images available for this drug.
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                  Patient Handout

                  A Patient Handout is not currently available for this monograph.
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                  Formulary

                  FormularyPatient Discounts

                  Adding plans allows you to compare formulary status to other drugs in the same class.

                  To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

                  Create Your List of Plans

                  Adding plans allows you to:

                  • View the formulary and any restrictions for each plan.
                  • Manage and view all your plans together – even plans in different states.
                  • Compare formulary status to other drugs in the same class.
                  • Access your plan list on any device – mobile or desktop.

                  The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                  View explanations for tiers and restrictions
                  Tier Description
                  1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                  2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                  3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                  4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  NC NOT COVERED – Drugs that are not covered by the plan.
                  Code Definition
                  PA Prior Authorization
                  Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                  QL Quantity Limits
                  Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
                  ST Step Therapy
                  Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
                  OR Other Restrictions
                  Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
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