buprenorphine/samidorphan (Pending FDA Approval)

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Dosing & Uses

AdultPediatric

Major Depressive Disorder

Pending FDA approval for adjunctive treatment of major depressive disorder in patients with inadequate response to standard therapies

Safety and efficacy not established

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Pharmacology

Mechanism of Action

Buprenorphine: Partial mu-opioid receptor agonist and kappa-opioid receptor antagonist

Samidorphan: Mu-opioid antagonist

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.