felodipine (Rx)

Brand and Other Names:Cabren, Cardioplen XL, more...Felendil XL, Felogen XL, Felotens XL, Keloc SR, Neofel XL, Plendil, Renedil, Vascalpha
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Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

tablets, extended release

  • 2.5mg
  • 5mg
  • 10mg
more...

Hypertension

Initial 2.5-5 mg PO qD

Maint: 2.5-10 mg PO qD; some recommend up to 20 mg/day

Hepatic Impairment

Initial: 2.5 mg PO qD

Other Indications & Uses

Off-label: congestive heart failure, angina

Good choice in hyperlipidemia patients

Dosage Forms & Strengths

tablets, extended release

  • 2.5mg
  • 5mg
  • 10mg
more...

Hypertension (Off-label)

Initial 2.5 mg PO qD; no more than 10 mg PO qD

Other Indications & Uses

Safety & efficacy not established

Initial dose: 2.5 mg PO qD; dosage should be adjusted according to patient response, and any increase made at intervals of at least 2 weeks.

Maximum dosage is 10 mg PO once daily.

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Interactions

Interaction Checker

and felodipine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Headache (11-15%)

            1-10%

            Peripheral edema (2-17%)

            Flushing (4-7%)

            Dizziness (1.1-3.4%)

            Tachycardia (0.4-2.5%)

            Frequency Not Defined

            Gingival hyperplasia

            Rash

            Upper respiratory infection

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            Warnings

            Contraindications

            Hypersensitivity

            Cautions

            CHF, aortic stenosis, hypotension (initially or after dose increases), persistent progressive dermatologic rxns, exacerbation of angina (during initiation of tx, after dose incr, or withdrawal of beta blocker), liver impairment

            Pts w/ heart failure or compromised ventricular function (especially with beta blocker)

            Avoid taking with grapefruit juice

            Sustained release product

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: excretion in milk unknown/not recommended

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Half-Life: 10-16 hr

            Onset: 2-5 hr

            Duration: 24 hr

            Peak Plasma Time: 2-5 hr

            Tx range: 4-6 nmol/L

            Toxic range: >30 nmol/L

            Excretion

            Urine: 37%

            Feces: 10%

            Other Information

            Bioavailability: 20%

            Protein Bound: 99%

            Vd: 10 L/kg

            Metabolism: hepatic P450 enzyme CYP3A4

            Metabolites: pyridine analog (inactive)

            Clearance: 823 mL/min

            Dialyzable: HD: no

            Mechanism of Action

            Ca channel blocker: inhibits transmembrane influx of extracellular Ca ions across myocardial & vascular smooth muscle cell membranes, without changing serum calcium concentrations, resulting in inhibition of cardiac & vascular smooth muscle contraction, thereby dilating main coronary & systemic arteries

            Produces vasodilation and decreases peripheral resistance

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            Images

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.