Green Tea (Herb/Suppl)

Brand and Other Names:camellia sinensis, camellia thea, more...Chinese tea, Dexatrim (reformulated), green tea extract, GTE, Japanese tea, Matsu-cha tea, Theaceae, Theanine, theifers
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Suggested Dosing

1-10 cups PO qD; 1 tsp tea leaves/ 8 oz boiling water

Mental Alertness

1 cup or 60 mg caffeine (3 cups = 240-320 mg polyphenols)

Hyperlipidemia

>10 cups/day

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Suggested Uses

Cancer (prevention), cognitive improvement, Crohn's disease, diuresis, genital warts, headaches, heart disease (prevention), Parkinson's disease (prevention), stomach disorders, weight loss (combination products), hypercholesterolemia

Efficacy

Possibly effective for listed uses

Studies show benefit in prevention of bladder, esophageal, pancreatic cancer; neg. results for stomach cancer

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Interactions

Interaction Checker

and Green Tea

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      Serious - Use Alternative

        Significant - Monitor Closely

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            Contraindicated (1)

            • bortezomib

              green tea decreases effects of bortezomib by Other (see comment). Contraindicated. Comment: Avoid green tea in patients being treated with bortezomib.

            Serious - Use Alternative (0)

              Monitor Closely (108)

              • abciximab

                green tea increases effects of abciximab by pharmacodynamic synergism. Use Caution/Monitor. (Theoretical interaction). Combination may increase risk of bleeding.

              • adenosine

                green tea decreases effects of adenosine by unspecified interaction mechanism. Use Caution/Monitor. (Theoretical interaction).

              • albuterol

                green tea increases effects of albuterol by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.

              • alteplase

                green tea, alteplase. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • anagrelide

                green tea increases effects of anagrelide by pharmacodynamic synergism. Use Caution/Monitor. (Theoretical interaction). Combination may increase risk of bleeding.

              • antithrombin alfa

                green tea, antithrombin alfa. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding, caution is advised.

              • antithrombin III

                green tea, antithrombin III. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding, caution is advised.

              • arformoterol

                green tea increases effects of arformoterol by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.

              • argatroban

                green tea, argatroban. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding, caution is advised.

              • aspirin

                green tea increases effects of aspirin by pharmacodynamic synergism. Use Caution/Monitor. (Theoretical, due to caffeine content). Combination may increase risk of bleeding.

              • aspirin rectal

                green tea increases effects of aspirin rectal by pharmacodynamic synergism. Use Caution/Monitor. (Theoretical, due to caffeine content). Combination may increase risk of bleeding.

              • aspirin/citric acid/sodium bicarbonate

                green tea increases effects of aspirin/citric acid/sodium bicarbonate by pharmacodynamic synergism. Use Caution/Monitor. (Theoretical, due to caffeine content). Combination may increase risk of bleeding.

              • benzphetamine

                green tea, benzphetamine. Other (see comment). Use Caution/Monitor. Comment: Green tea may include caffeine. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Caffeine should be avoided or used cautiously.

              • bivalirudin

                green tea, bivalirudin. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding, caution is advised.

              • caffeine

                green tea increases effects of caffeine by Other (see comment). Use Caution/Monitor. Comment: Potential for increased risk of CNS stimulation due to caffeine component of green tea. Caution advised.

              • cilostazol

                green tea increases effects of cilostazol by pharmacodynamic synergism. Use Caution/Monitor. (Theoretical interaction). Combination may increase risk of bleeding.

              • citalopram

                green tea, citalopram. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • clopidogrel

                green tea increases effects of clopidogrel by pharmacodynamic synergism. Use Caution/Monitor. (Theoretical interaction). Combination may increase risk of bleeding.

              • clozapine

                green tea decreases effects of clozapine by Other (see comment). Use Caution/Monitor. Comment: (Theoretical, due to caffeine content) High caffeine doses (400 1000mg/day) may increase levels/toxicity of clozapine. Clozapine clearance may decrease during coadministration of caffeine, and a documented increase in clozapine serum concentrations has occurred in selected patients. .

              • dabigatran

                green tea, dabigatran. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding, caution is advised.

              • dalteparin

                green tea, dalteparin. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding, caution is advised.

              • darunavir

                green tea, darunavir. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • dasatinib

                green tea, dasatinib. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • deferasirox

                green tea, deferasirox. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • desirudin

                green tea, desirudin. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • dextroamphetamine

                green tea, dextroamphetamine. Other (see comment). Use Caution/Monitor. Comment: Green tea may include caffeine. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Caffeine should be avoided or used cautiously.

              • diclofenac

                green tea, diclofenac. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • diethylpropion

                green tea, diethylpropion. Other (see comment). Use Caution/Monitor. Comment: Green tea may include caffeine. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Caffeine should be avoided or used cautiously.

              • diflunisal

                green tea, diflunisal. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • dipyridamole

                green tea increases effects of dipyridamole by pharmacodynamic synergism. Use Caution/Monitor. (Theoretical interaction). Dipyridamole is a platelet inhibitor and green tea has demonstrated antiplatelet effects in animals, it may be prudent to avoid the concomitant use of green tea with chronic dipyridamole therapy as the risk of bleeding may be increased.

              • disulfiram

                disulfiram increases levels of green tea by decreasing elimination. Use Caution/Monitor. Combination may increase caffeine levels. Caution should be taken due to increased risk of adverse effects due to caffeine in green tea.

              • dobutamine

                green tea increases effects of dobutamine by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.

              • dopamine

                green tea increases effects of dopamine by pharmacodynamic synergism. Use Caution/Monitor. Combination may increase CNS stimulatory effects due to caffeine in green tea.

              • duloxetine

                green tea, duloxetine. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • enoxaparin

                green tea, enoxaparin. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding, caution is advised.

              • ephedrine

                green tea increases effects of ephedrine by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.

              • epinephrine

                green tea increases effects of epinephrine by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.

              • epinephrine racemic

                green tea increases effects of epinephrine racemic by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.

              • eptifibatide

                green tea increases effects of eptifibatide by pharmacodynamic synergism. Use Caution/Monitor. (Theoretical interaction). Combination may increase risk of bleeding.

              • escitalopram

                green tea, escitalopram. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • ethinylestradiol

                ethinylestradiol increases levels of green tea by decreasing elimination. Use Caution/Monitor.

              • etodolac

                green tea, etodolac. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • fenoprofen

                green tea, fenoprofen. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • ferric maltol

                green tea, ferric maltol. Other (see comment). Use Caution/Monitor. Comment: When possible, do not consume green tea or green tea extract within 1 hour before or 2 hours after giving iron salts.

              • ferrous fumarate

                green tea, ferrous fumarate. Other (see comment). Use Caution/Monitor. Comment: When possible, do not consume green tea or green tea extract within 1 hour before or 2 hours after giving iron salts.

              • ferrous sulfate

                green tea, ferrous sulfate. Other (see comment). Use Caution/Monitor. Comment: When possible, do not consume green tea or green tea extract within 1 hour before or 2 hours after giving iron salts.

              • fluoxetine

                green tea, fluoxetine. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • flurbiprofen

                green tea, flurbiprofen. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • fluvoxamine

                green tea, fluvoxamine. Either increases toxicity of the other by anticoagulation. Use Caution/Monitor.

              • folic acid

                green tea, folic acid. Other (see comment). Use Caution/Monitor. Comment: Concomitant consumption of green tea with folic acid is not recommended in pregnant women, megaloblastic anemia, or when a reduction in folic acid may have clinical consequences. A folate transporter interaction has been described, leading to decreases in bioavailability of folic acid.

              • fondaparinux

                green tea, fondaparinux. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding, caution is advised.

              • fosphenytoin

                fosphenytoin decreases levels of green tea by increasing metabolism. Use Caution/Monitor. Potential for decreased effects of caffeine in green tea. .

              • heparin

                green tea, heparin. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding, caution is advised.

              • ibuprofen

                green tea, ibuprofen. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • ibuprofen IV

                green tea, ibuprofen IV. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • indomethacin

                green tea, indomethacin. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • isocarboxazid

                green tea, isocarboxazid. Other (see comment). Use Caution/Monitor. Comment: Avoid combination or excessive consumption of green tea. Combination may increase risk of cardiac arrhythmias or severe hypertension can occur due to caffeine component of green tea.

              • isoniazid

                green tea, isoniazid. Other (see comment). Use Caution/Monitor. Comment: Avoid combination or excessive consumption of green tea. Combination may increase risk of cardiac arrhythmias or severe hypertension can occur due to caffeine component of green tea.

              • isoproterenol

                green tea increases effects of isoproterenol by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.

              • ketoprofen

                green tea, ketoprofen. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • ketorolac

                green tea, ketorolac. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • levalbuterol

                green tea increases effects of levalbuterol by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.

              • linezolid

                green tea, linezolid. Other (see comment). Use Caution/Monitor. Comment: Avoid combination or excessive consumption of green tea. Combination may increase risk of cardiac arrhythmias or severe hypertension can occur due to caffeine component of green tea.

              • lisdexamfetamine

                green tea, lisdexamfetamine. Other (see comment). Use Caution/Monitor. Comment: Green tea may include caffeine. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Caffeine should be avoided or used cautiously.

              • meclofenamate

                green tea, meclofenamate. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • mefenamic acid

                green tea, mefenamic acid. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • meloxicam

                green tea, meloxicam. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • metaproterenol

                green tea increases effects of metaproterenol by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.

              • methamphetamine

                green tea, methamphetamine. Other (see comment). Use Caution/Monitor. Comment: Green tea may include caffeine. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Caffeine should be avoided or used cautiously.

              • methylphenidate

                green tea, methylphenidate. Other (see comment). Use Caution/Monitor. Comment: Green tea may include caffeine. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Caffeine should be avoided or used cautiously.

              • mexiletine

                mexiletine increases levels of green tea by decreasing elimination. Use Caution/Monitor. (Caffeine). Combination may increase caffeine levels. Caution should be taken in patients with cardiac arrhythmias. Avoid or limit intake of caffeine.

              • milnacipran

                green tea, milnacipran. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • modafinil

                green tea, modafinil. Other (see comment). Use Caution/Monitor. Comment: Green tea may include caffeine. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Caffeine should be avoided or used cautiously.

              • nabumetone

                green tea, nabumetone. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • naproxen

                green tea, naproxen. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • nicotine inhaled

                green tea, nicotine inhaled. Other (see comment). Use Caution/Monitor. Comment: Green tea may include caffeine. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Caffeine should be avoided or used cautiously.

              • nicotine intranasal

                green tea, nicotine intranasal. Other (see comment). Use Caution/Monitor. Comment: Green tea may include caffeine. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Caffeine should be avoided or used cautiously.

              • norepinephrine

                green tea increases effects of norepinephrine by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.

              • oxaprozin

                green tea, oxaprozin. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • paroxetine

                green tea, paroxetine. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • phendimetrazine

                green tea, phendimetrazine. Other (see comment). Use Caution/Monitor. Comment: Green tea may include caffeine. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Caffeine should be avoided or used cautiously.

              • phenelzine

                green tea, phenelzine. Other (see comment). Use Caution/Monitor. Comment: Avoid combination or excessive consumption of green tea. Combination may increase risk of cardiac arrhythmias or severe hypertension can occur due to caffeine component of green tea.

              • phentermine

                green tea, phentermine. Other (see comment). Use Caution/Monitor. Comment: Green tea may include caffeine. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Caffeine should be avoided or used cautiously.

              • phenytoin

                phenytoin decreases levels of green tea by increasing metabolism. Use Caution/Monitor. (Caffeine). Potential for decreased effects of caffeine in green tea. .

              • pirbuterol

                green tea increases effects of pirbuterol by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.

              • piroxicam

                green tea, piroxicam. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • prasugrel

                green tea increases effects of prasugrel by pharmacodynamic synergism. Use Caution/Monitor. (Theoretical interaction). Combination may increase risk of bleeding.

              • procarbazine

                green tea, procarbazine. Other (see comment). Use Caution/Monitor. Comment: Avoid combination or excessive consumption of green tea. Combination may increase risk of cardiac arrhythmias or severe hypertension can occur due to caffeine component of green tea.

              • rasagiline

                green tea, rasagiline. Other (see comment). Use Caution/Monitor. Comment: Avoid combination or excessive consumption of green tea. Combination may increase risk of cardiac arrhythmias or severe hypertension can occur due to caffeine component of green tea.

              • reteplase

                green tea, reteplase. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • salmeterol

                green tea increases effects of salmeterol by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.

              • selegiline

                green tea, selegiline. Other (see comment). Use Caution/Monitor. Comment: Avoid combination or excessive consumption of green tea. Combination may increase risk of cardiac arrhythmias or severe hypertension can occur due to caffeine component of green tea.

              • selegiline transdermal

                green tea, selegiline transdermal. Other (see comment). Use Caution/Monitor. Comment: Avoid combination or excessive consumption of green tea. Combination may increase risk of cardiac arrhythmias or severe hypertension can occur due to caffeine component of green tea.

              • sertraline

                green tea, sertraline. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • sulindac

                green tea, sulindac. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • tenecteplase

                green tea, tenecteplase. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • terbutaline

                green tea increases effects of terbutaline by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.

              • theophylline

                green tea increases levels of theophylline by decreasing renal clearance. Use Caution/Monitor. Due to caffeine content.

              • ticlopidine

                green tea increases effects of ticlopidine by pharmacodynamic synergism. Use Caution/Monitor. (Theoretical interaction). Combination may increase risk of bleeding.

              • tirofiban

                green tea increases effects of tirofiban by pharmacodynamic synergism. Use Caution/Monitor. (Theoretical interaction). Combination may increase risk of bleeding.

              • tolmetin

                green tea, tolmetin. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • tranylcypromine

                green tea, tranylcypromine. Other (see comment). Use Caution/Monitor. Comment: Avoid combination or excessive consumption of green tea. Combination may increase risk of cardiac arrhythmias or severe hypertension can occur due to caffeine component of green tea.

              • trazodone

                green tea, trazodone. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • treprostinil

                green tea, treprostinil. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • venlafaxine

                green tea, venlafaxine. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

              • verapamil

                verapamil increases levels of green tea by decreasing elimination. Use Caution/Monitor. (Caffeine). Verapamil reduces clearance of caffeine and increases serum caffeine concentrations, presumably via inhibition of hepatic metabolism. May advise patients to limit or minimize the intake of caffeinated products to minimize caffeine-related side effects.

              • warfarin

                green tea decreases effects of warfarin by pharmacodynamic antagonism. Use Caution/Monitor. Combination may decrease warfarin efficacy. Potential for increased risk of bleeding. Important to monitor INR.

              • yohimbine

                green tea, yohimbine. Other (see comment). Use Caution/Monitor. Comment: Avoid combination or excessive consumption of green tea. Combination may increase risk of cardiac arrhythmias or severe hypertension can occur due to caffeine component of green tea.

              Minor (36)

              • acetaminophen

                green tea increases effects of acetaminophen by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical, due to caffeine content).

              • acetaminophen IV

                green tea increases effects of acetaminophen IV by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical, due to caffeine content).

              • acetaminophen rectal

                green tea increases effects of acetaminophen rectal by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical, due to caffeine content).

              • alprazolam

                green tea decreases effects of alprazolam by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.

              • American ginseng

                green tea, American ginseng. Other (see comment). Minor/Significance Unknown. Comment: Use caution when combining green tea with herbs that exhibit antiplatelet effects or anticoagulant activity.

              • carbamazepine

                carbamazepine will decrease the level or effect of green tea by increasing metabolism. Minor/Significance Unknown.

              • chlordiazepoxide

                green tea decreases effects of chlordiazepoxide by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.

              • cimetidine

                cimetidine will increase the level or effect of green tea by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown. Green tea may contain caffeine. CYP1A2 inhibitors may inhibit the hepatic oxidative metabolism of caffeine.

              • ciprofloxacin

                ciprofloxacin increases levels of green tea by decreasing elimination. Minor/Significance Unknown. (Caffeine). Some quinolones can inhibit the hepatic clearance of caffeine. Caution is advised.

              • clonazepam

                green tea decreases effects of clonazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.

              • clorazepate

                green tea decreases effects of clorazepate by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.

              • diazepam

                green tea decreases effects of diazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.

              • dihydroergotamine

                green tea increases levels of dihydroergotamine by enhancing GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown. Due to caffeine content.

              • dihydroergotamine intranasal

                green tea increases levels of dihydroergotamine intranasal by enhancing GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown. Due to caffeine content.

              • dong quai

                green tea, dong quai. Other (see comment). Minor/Significance Unknown. Comment: Use caution when combining green tea with herbs that exhibit antiplatelet effects or anticoagulant activity.

              • ergotamine

                green tea increases levels of ergotamine by enhancing GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown. Due to caffeine content.

              • feverfew

                green tea, feverfew. Other (see comment). Minor/Significance Unknown. Comment: Use caution when combining green tea with herbs that exhibit antiplatelet effects or anticoagulant activity.

              • formoterol

                green tea increases effects of formoterol by pharmacodynamic synergism. Minor/Significance Unknown. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.

              • garlic

                green tea, garlic. Other (see comment). Minor/Significance Unknown. Comment: Use caution when combining green tea with herbs that exhibit antiplatelet effects or anticoagulant activity.

              • ginger

                green tea, ginger. Other (see comment). Minor/Significance Unknown. Comment: Use caution when combining green tea with herbs that exhibit antiplatelet effects or anticoagulant activity.

              • ginkgo biloba

                green tea, ginkgo biloba. Other (see comment). Minor/Significance Unknown. Comment: Use caution when combining green tea with herbs that exhibit antiplatelet effects or anticoagulant activity.

              • grapefruit

                grapefruit will increase the level or effect of green tea by Other (see comment). Minor/Significance Unknown. This food-drug interaction might potentiate the clinical effects and duration of action of caffeine.

              • guarana

                green tea, guarana. Other (see comment). Minor/Significance Unknown. Comment: Concurrent administration of guarana to patients taking caffeine may produce excessive caffeine-like side effects, such as nausea, irritability or nervousness. Caution in patients consuming large amounts of caffeine.

              • levofloxacin

                levofloxacin increases levels of green tea by decreasing elimination. Minor/Significance Unknown. (Caffeine). Some quinolones can inhibit the hepatic clearance of caffeine. Caution is advised.

              • lithium

                green tea increases levels of lithium by unspecified interaction mechanism. Minor/Significance Unknown. Lithium levels may increase following abrupt caffeine withdrawal.

              • lorazepam

                green tea decreases effects of lorazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.

              • mestranol

                mestranol increases levels of green tea by decreasing elimination. Minor/Significance Unknown. (Caffeine).

              • midazolam

                green tea decreases effects of midazolam by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.

              • oxazepam

                green tea decreases effects of oxazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.

              • panax ginseng

                green tea, panax ginseng. Other (see comment). Minor/Significance Unknown. Comment: Use caution when combining green tea with herbs that exhibit antiplatelet effects or anticoagulant activity.

              • phenobarbital

                phenobarbital will decrease the level or effect of green tea by increasing metabolism. Minor/Significance Unknown. Green tea products may contain caffeine. The metabolism of xanthines, such as caffeine, can be increased by concurrent use with barbiturates.

              • primidone

                primidone will decrease the level or effect of green tea by increasing metabolism. Minor/Significance Unknown. Green tea products may contain caffeine. The metabolism of xanthines, such as caffeine, can be increased by concurrent use with barbiturates.

              • St John's Wort

                St John's Wort will decrease the level or effect of green tea by increasing metabolism. Minor/Significance Unknown.

              • temazepam

                green tea decreases effects of temazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.

              • willow bark

                green tea, willow bark. Other (see comment). Minor/Significance Unknown. Comment: Use caution when combining green tea with herbs that exhibit antiplatelet effects or anticoagulant activity.

              • zolpidem

                green tea decreases effects of zolpidem by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of zolpidem.

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              Adverse Effects

              Frequency Not Defined

              Agitation

              Anxiety

              Arrhythmias

              Constipation

              Convulsions

              Delirium

              Dependence

              Diarrhea

              Diuresis

              Dizziness

              GI upset

              Headache

              Heartburn

              Hepatotoxicity

              Hyperglycemia

              Hypertension

              Increased cholesterol

              Increased respiration

              Insomnia

              Irritability

              Loss of appetite

              Nausea/vomiting

              Nervousness

              Palpitations

              Restlessness

              Tachycardia

              Tinnitus

              Tremor

              Withdrawal symptoms

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              Warnings

              Contraindications

              Hypersensitivity

              Avoid prior to surgery: may cause bleeding

              Cautions

              Anxiety disorders, arrhythmias, cardiac disease, depression, diabetes mellitus, hypertension, kidney disease, ulcers (gastric/duodenal)

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              Pregnancy & Lactation

              Pregnancy Category: avoid use

              Lactation: avoid use

              Pregnancy Categories

              A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

              B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

              C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

              D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

              X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

              NA: Information not available.

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              Pharmacology

              Metabolism: N/A

              Excretion: N/A

              Mechanism of Action

              Contains polyphenols (flavonoids): antioxidant, reduce DNA oxidative damage, inhib. carcinogen formation (e.g., nitrosamines)

              Caffeine: CNS stimulant

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              Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.