urea topical (OTC)

Brand and Other Names:Carmol 10, Keralac, more...Carmol 20, Carmol 40, Gordon's Urea, Aquacare, Ureacin 10, Ureacin 20, Utopic, Vanamide
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

cream

  • 10%
  • 20%
  • 30%
  • 35%
  • 40%
  • 41%
  • 45%
  • 50%

lotion

  • 10%
  • 20%
  • 25%
  • 35%
  • 40%
  • 45%

gel

  • 40%
  • 45%
  • 50%

suspension

  • 40%
  • 50%

solution

  • 50%

ointment

  • 10%
  • 20%
  • 50%

emulsion

  • 40%
  • 45%
  • 50%

aerosol, foam

  • 20%
  • 30%
  • 35%
  • 40%
  • 42%

Hyperkeratotic Skin Conditions

Indicated for hyperkeratotic conditions such as dry, rough skin; xerosis; ichthyosis; skin cracks and fissures; dermatitis; eczema; psoriasis; keratoses; and calluses

Apply topically to affected skin qDay or q8-12hr

Administration

Rub lotion/cream into skin until completely absorbed

Safety and efficacy not established

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Interactions

Interaction Checker

and urea topical

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    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Local irritation

            Transient stinging

            Rash

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            Warnings

            Contraindications

            Hypersensitivity

            Irritated, infected, or open skin (OTC use)

            Cautions

            Ischemic skin necrosis reported with high concentration or irrigation

            Not for ophthalmic use or near the eye

            Not to be used to treat any condition other than that for which prescribed; if redness or irritation occurs, discontinue use and consult a physician

            Discontinue use of if condition becomes worse or if rash develops in area being treated or elsewhere; avoid contact with eyes, lips, and mucous membranes

            Long-term animal studies for carcinogenic potential not performed on this product to date; studies on reproduction and fertility not performed

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            Pregnancy & Lactation

            Pregnancy

            Animal reproduction studies not performed; also not known whether product can affect reproduction capacity or cause fetal harm when administered to a pregnant woman; product should be used by a pregnant woman only if clearly needed or when potential benefits outweigh potential hazards to fetus

            Lactation

            Not known whether drug is excreted in human milk; because many drugs are excreted in human milk, caution should be exercised when product administered to a nursing woman

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Elicits emollient and keratolytic effects; softens hyperkeratotic areas by disolving intracellular matrix, which subsequently loosens horny layer of the skin, or softens and debrides the nail plate

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            Images

            No images available for this drug.
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            Patient Handout

            A Patient Handout is not currently available for this monograph.
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.