Dosing & Uses
Dosage Forms & Strengths
cream
- 10%
- 20%
- 30%
- 35%
- 40%
- 41%
- 45%
- 50%
lotion
- 10%
- 20%
- 25%
- 35%
- 40%
- 45%
gel
- 40%
- 45%
- 50%
suspension
- 40%
- 50%
solution
- 50%
ointment
- 10%
- 20%
- 50%
emulsion
- 40%
- 45%
- 50%
aerosol, foam
- 20%
- 30%
- 35%
- 40%
- 42%
Hyperkeratotic Skin Conditions
Indicated for hyperkeratotic conditions such as dry, rough skin; xerosis; ichthyosis; skin cracks and fissures; dermatitis; eczema; psoriasis; keratoses; and calluses
Apply topically to affected skin qDay or q8-12hr
Administration
Rub lotion/cream into skin until completely absorbed
Safety and efficacy not established
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (1)
- collagenase
urea topical decreases effects of collagenase by increasing metabolism. Use Caution/Monitor.
Minor (1)
- vasopressin
urea topical increases effects of vasopressin by pharmacodynamic synergism. Minor/Significance Unknown.
Adverse Effects
Frequency Not Defined
Local irritation
Transient stinging
Rash
Warnings
Contraindications
Hypersensitivity
Irritated, infected, or open skin (OTC use)
Cautions
Ischemic skin necrosis reported with high concentration or irrigation
Not for ophthalmic use or near the eye
Not to be used to treat any condition other than that for which prescribed; if redness or irritation occurs, discontinue use and consult a physician
Discontinue use of if condition becomes worse or if rash develops in area being treated or elsewhere; avoid contact with eyes, lips, and mucous membranes
Long-term animal studies for carcinogenic potential not performed on this product to date; studies on reproduction and fertility not performed
Pregnancy & Lactation
Pregnancy
Animal reproduction studies not performed; also not known whether product can affect reproduction capacity or cause fetal harm when administered to a pregnant woman; product should be used by a pregnant woman only if clearly needed or when potential benefits outweigh potential hazards to fetus
Lactation
Not known whether drug is excreted in human milk; because many drugs are excreted in human milk, caution should be exercised when product administered to a nursing woman
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Elicits emollient and keratolytic effects; softens hyperkeratotic areas by disolving intracellular matrix, which subsequently loosens horny layer of the skin, or softens and debrides the nail plate
