Suggested Dosing
Average 2-5 g/day
Ukrain: 5-20 mg parenterally qD-q3d
Cancer: 50-300 mg IV qDay, with 100 mg IV qday most common
Available in Europe & Mexico & alternative/complementary health centers in the US
Dyspepsia
Oral: 1 mL TID
Suggested Uses
Intestinal spasms, dyspepsia, liver disease, prevention of gallstone formation
Ukrain (celandine+thiotepa): cancers
Efficacy
Approved by German Commission E for intestinal spasms
Ukrain has selective cytotoicity against neoplastic cells in vitro; also some positive results but in small & possibly poorly-designed clinical studies
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Adverse Effects
Rashes, itching, serious allergic reactions
Warnings
Contraindications
Pregnancy, breastfeeding
Cautions
Potential risk of hepatitis
Parts of the plant (esp roots) may be toxic
Pregnancy & Lactation
Pregnancy Category: avoid
Lactation: avoid
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Metabolism: N/A
Excretion: N/A
Mechanism of Action
Strong cholagogue
