Indication-specific dosing for (celandine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

Sections

Sections Celandine
Suggested Dosing
Suggested Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology

Suggested Dosing

Average 2-5 g/day

Ukrain: 5-20 mg parenterally qD-q3d

Cancer: 50-300 mg IV qDay, with 100 mg IV qday most common

Available in Europe & Mexico & alternative/complementary health centers in the US

Dyspepsia

Oral: 1 mL TID

Suggested Uses

Intestinal spasms, dyspepsia, liver disease, prevention of gallstone formation

Ukrain (celandine+thiotepa): cancers

Efficacy

Approved by German Commission E for intestinal spasms

Ukrain has selective cytotoicity against neoplastic cells in vitro; also some positive results but in small & possibly poorly-designed clinical studies

Interaction Checker

Enter a drug name and Celandine

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No Interactions Found

Interactions Found

Contraindicated

Serious - Use Alternative

Significant - Monitor Closely

Minor

All Interactions Sort By:

Contraindicated (0)

Serious - Use Alternative (0)

Monitor Closely (0)

Minor (18)

dextroamphetamine
celandine increases effects of dextroamphetamine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.
duloxetine
celandine decreases effects of duloxetine by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
fluoxetine
celandine decreases effects of fluoxetine by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
isocarboxazid
celandine increases effects of isocarboxazid by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.
linezolid
celandine increases effects of linezolid by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.
lisdexamfetamine
celandine increases effects of lisdexamfetamine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.
methamphetamine
celandine increases effects of methamphetamine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.
methylenedioxymethamphetamine
celandine increases effects of methylenedioxymethamphetamine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.
milnacipran
celandine decreases effects of milnacipran by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
morphine
celandine increases effects of morphine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.
nefazodone
celandine decreases effects of nefazodone by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
paroxetine
celandine decreases effects of paroxetine by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
phenelzine
celandine increases effects of phenelzine by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.
procarbazine
celandine increases effects of procarbazine by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.
sertraline
celandine decreases effects of sertraline by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
tranylcypromine
celandine increases effects of tranylcypromine by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.
trazodone
celandine decreases effects of trazodone by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
venlafaxine
celandine decreases effects of venlafaxine by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.

dextroamphetamine
Minor (1)celandine increases effects of dextroamphetamine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.
duloxetine
Minor (1)celandine decreases effects of duloxetine by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
fluoxetine
Minor (1)celandine decreases effects of fluoxetine by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
isocarboxazid
Minor (1)celandine increases effects of isocarboxazid by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.
linezolid
Minor (1)celandine increases effects of linezolid by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.
lisdexamfetamine
Minor (1)celandine increases effects of lisdexamfetamine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.
methamphetamine
Minor (1)celandine increases effects of methamphetamine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.
methylenedioxymethamphetamine
Minor (1)celandine increases effects of methylenedioxymethamphetamine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.
milnacipran
Minor (1)celandine decreases effects of milnacipran by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
morphine
Minor (1)celandine increases effects of morphine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.
nefazodone
Minor (1)celandine decreases effects of nefazodone by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
paroxetine
Minor (1)celandine decreases effects of paroxetine by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
phenelzine
Minor (1)celandine increases effects of phenelzine by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.
procarbazine
Minor (1)celandine increases effects of procarbazine by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.
sertraline
Minor (1)celandine decreases effects of sertraline by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
tranylcypromine
Minor (1)celandine increases effects of tranylcypromine by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.
trazodone
Minor (1)celandine decreases effects of trazodone by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
venlafaxine
Minor (1)celandine decreases effects of venlafaxine by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.

Adverse Effects

Rashes, itching, serious allergic reactions

Contraindications

Pregnancy, breastfeeding

Cautions

Potential risk of hepatitis

Parts of the plant (esp roots) may be toxic

Pregnancy & Lactation

Pregnancy Category: avoid

Lactation: avoid

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Pharmacology

Metabolism: N/A

Excretion: N/A

Mechanism of Action

Strong cholagogue

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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