Celandine (Herb/Suppl)

Brand and Other Names:celandine poppy, chelidonium majus, more...greater celandine, tetterwort, Ukrain
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Suggested Dosing

Average 2-5 g/day

Ukrain: 5-20 mg parenterally qD-q3d

Cancer: 50-300 mg IV qDay, with 100 mg IV qday most common

Available in Europe & Mexico & alternative/complementary health centers in the US

Dyspepsia

Oral: 1 mL TID

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Suggested Uses

Intestinal spasms, dyspepsia, liver disease, prevention of gallstone formation

Ukrain (celandine+thiotepa): cancers

Efficacy

Approved by German Commission E for intestinal spasms

Ukrain has selective cytotoicity against neoplastic cells in vitro; also some positive results but in small & possibly poorly-designed clinical studies

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Interactions

Interaction Checker

and Celandine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (0)

                  Minor (18)

                  • dextroamphetamine

                    celandine increases effects of dextroamphetamine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.

                  • duloxetine

                    celandine decreases effects of duloxetine by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.

                  • fluoxetine

                    celandine decreases effects of fluoxetine by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.

                  • isocarboxazid

                    celandine increases effects of isocarboxazid by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.

                  • linezolid

                    celandine increases effects of linezolid by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.

                  • lisdexamfetamine

                    celandine increases effects of lisdexamfetamine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.

                  • methamphetamine

                    celandine increases effects of methamphetamine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.

                  • methylenedioxymethamphetamine

                    celandine increases effects of methylenedioxymethamphetamine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.

                  • milnacipran

                    celandine decreases effects of milnacipran by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.

                  • morphine

                    celandine increases effects of morphine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.

                  • nefazodone

                    celandine decreases effects of nefazodone by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.

                  • paroxetine

                    celandine decreases effects of paroxetine by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.

                  • phenelzine

                    celandine increases effects of phenelzine by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.

                  • procarbazine

                    celandine increases effects of procarbazine by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.

                  • sertraline

                    celandine decreases effects of sertraline by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.

                  • tranylcypromine

                    celandine increases effects of tranylcypromine by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.

                  • trazodone

                    celandine decreases effects of trazodone by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.

                  • venlafaxine

                    celandine decreases effects of venlafaxine by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.

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                  Adverse Effects

                  Rashes, itching, serious allergic reactions

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                  Warnings

                  Contraindications

                  Pregnancy, breastfeeding

                  Cautions

                  Potential risk of hepatitis

                  Parts of the plant (esp roots) may be toxic

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                  Pregnancy & Lactation

                  Pregnancy Category: avoid

                  Lactation: avoid

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Metabolism: N/A

                  Excretion: N/A

                  Mechanism of Action

                  Strong cholagogue

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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.