Suggested Dosing
Average 2-5 g/day
Ukrain: 5-20 mg parenterally qD-q3d
Cancer: 50-300 mg IV qDay, with 100 mg IV qday most common
Available in Europe & Mexico & alternative/complementary health centers in the US
Dyspepsia
Oral: 1 mL TID
Suggested Uses
Intestinal spasms, dyspepsia, liver disease, prevention of gallstone formation
Ukrain (celandine+thiotepa): cancers
Efficacy
Approved by German Commission E for intestinal spasms
Ukrain has selective cytotoicity against neoplastic cells in vitro; also some positive results but in small & possibly poorly-designed clinical studies
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (0)
Minor (18)
- dextroamphetamine
celandine increases effects of dextroamphetamine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.
- duloxetine
celandine decreases effects of duloxetine by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
- fluoxetine
celandine decreases effects of fluoxetine by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
- isocarboxazid
celandine increases effects of isocarboxazid by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.
- linezolid
celandine increases effects of linezolid by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.
- lisdexamfetamine
celandine increases effects of lisdexamfetamine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.
- methamphetamine
celandine increases effects of methamphetamine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.
- methylenedioxymethamphetamine
celandine increases effects of methylenedioxymethamphetamine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.
- milnacipran
celandine decreases effects of milnacipran by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
- morphine
celandine increases effects of morphine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.
- nefazodone
celandine decreases effects of nefazodone by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
- paroxetine
celandine decreases effects of paroxetine by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
- phenelzine
celandine increases effects of phenelzine by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.
- procarbazine
celandine increases effects of procarbazine by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.
- sertraline
celandine decreases effects of sertraline by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
- tranylcypromine
celandine increases effects of tranylcypromine by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.
- trazodone
celandine decreases effects of trazodone by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
- venlafaxine
celandine decreases effects of venlafaxine by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
Adverse Effects
Rashes, itching, serious allergic reactions
Warnings
Contraindications
Pregnancy, breastfeeding
Cautions
Potential risk of hepatitis
Parts of the plant (esp roots) may be toxic
Pregnancy & Lactation
Pregnancy Category: avoid
Lactation: avoid
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Metabolism: N/A
Excretion: N/A
Mechanism of Action
Strong cholagogue
