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      Drugs & Diseases

      nabilone (Rx)

      Brand and Other Names:Cesamet
      • Print

      Dosing & Uses

      AdultPediatricGeriatric

      Dosage Forms & Strengths

      capsule: Schedule II

      • 1mg

      Chemotherapy-Induced Nausea/Vomiting

      1-2 mg PO q8-12hr

      Renal Impairment

      Dose adjustment not necessary

      Administration

      Give 1-3 hours before chemotherapy

      May give one dose the night before chemotherapy

      May continue 24 hours after chemotherapy

      No more than 6 mg/day

      Dosage Forms & Strengths

      capsule: Schedule II

      • 1mg

      Chemotherapy-Induced Nausea/Vomiting (Off-label)

      >4 years

      • <18 kg: 0.5 mg PO q12hr
      • 18-30 kg: 1 mg PO q12hr
      • >30 kg: 1 mg PO q8hr

      Chemotherapy-induced nausea/vomiting

      1-2 mg PO q8-12hr; not to exceed 6 mg divided q8hr

      Next:

      Interactions

      Interaction Checker

      and nabilone

      No Results

         activity indicator 
        No Interactions Found
        Interactions Found

        Contraindicated

          Serious - Use Alternative

            Significant - Monitor Closely

              Minor

                All Interactions Sort By:
                 activity indicator 

                Contraindicated (0)

                  Serious - Use Alternative (5)

                  • calcium/magnesium/potassium/sodium oxybates

                    nabilone, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

                  • metoclopramide intranasal

                    nabilone, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.

                  • olopatadine intranasal

                    nabilone and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.

                  • ropeginterferon alfa 2b

                    ropeginterferon alfa 2b and nabilone both increase Other (see comment). Avoid or Use Alternate Drug. Narcotics, hypnotics or sedatives can produce additive neuropsychiatric side effects. Avoid use and monitor patients receiving the combination for effects of excessive CNS toxicity.

                  • sodium oxybate

                    nabilone, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

                  Monitor Closely (172)

                  • albuterol

                    nabilone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • alfentanil

                    alfentanil and nabilone both increase sedation. Use Caution/Monitor.

                  • alprazolam

                    alprazolam and nabilone both increase sedation. Use Caution/Monitor.

                  • amitriptyline

                    amitriptyline and nabilone both increase sedation. Use Caution/Monitor.

                  • amobarbital

                    amobarbital and nabilone both increase sedation. Use Caution/Monitor.

                  • amoxapine

                    amoxapine and nabilone both increase sedation. Use Caution/Monitor.

                  • apomorphine

                    apomorphine and nabilone both increase sedation. Use Caution/Monitor.

                  • arformoterol

                    nabilone increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • aripiprazole

                    aripiprazole and nabilone both increase sedation. Use Caution/Monitor.

                  • armodafinil

                    nabilone increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • azelastine

                    azelastine and nabilone both increase sedation. Use Caution/Monitor.

                  • baclofen

                    baclofen and nabilone both increase sedation. Use Caution/Monitor.

                  • belladonna and opium

                    belladonna and opium and nabilone both increase sedation. Use Caution/Monitor.

                  • benperidol

                    benperidol and nabilone both increase sedation. Use Caution/Monitor.

                  • benzphetamine

                    nabilone increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • brompheniramine

                    brompheniramine and nabilone both increase sedation. Use Caution/Monitor.

                  • buprenorphine

                    buprenorphine and nabilone both increase sedation. Use Caution/Monitor.

                  • buprenorphine buccal

                    buprenorphine buccal and nabilone both increase sedation. Use Caution/Monitor.

                  • butabarbital

                    butabarbital and nabilone both increase sedation. Use Caution/Monitor.

                  • butalbital

                    butalbital and nabilone both increase sedation. Use Caution/Monitor.

                  • butorphanol

                    butorphanol and nabilone both increase sedation. Use Caution/Monitor.

                  • caffeine

                    nabilone increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • carbinoxamine

                    carbinoxamine and nabilone both increase sedation. Use Caution/Monitor.

                  • carisoprodol

                    carisoprodol and nabilone both increase sedation. Use Caution/Monitor.

                  • chloral hydrate

                    chloral hydrate and nabilone both increase sedation. Use Caution/Monitor.

                  • chlordiazepoxide

                    chlordiazepoxide and nabilone both increase sedation. Use Caution/Monitor.

                  • chlorpheniramine

                    chlorpheniramine and nabilone both increase sedation. Use Caution/Monitor.

                  • chlorpromazine

                    chlorpromazine and nabilone both increase sedation. Use Caution/Monitor.

                  • chlorzoxazone

                    chlorzoxazone and nabilone both increase sedation. Use Caution/Monitor.

                  • cinnarizine

                    cinnarizine and nabilone both increase sedation. Use Caution/Monitor.

                  • clemastine

                    clemastine and nabilone both increase sedation. Use Caution/Monitor.

                  • clobazam

                    nabilone, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).

                  • clomipramine

                    clomipramine and nabilone both increase sedation. Use Caution/Monitor.

                  • clonazepam

                    clonazepam and nabilone both increase sedation. Use Caution/Monitor.

                  • clonidine

                    clonidine, nabilone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.

                  • clorazepate

                    clorazepate and nabilone both increase sedation. Use Caution/Monitor.

                  • clozapine

                    clozapine and nabilone both increase sedation. Use Caution/Monitor.

                  • codeine

                    codeine and nabilone both increase sedation. Use Caution/Monitor.

                  • cyclizine

                    cyclizine and nabilone both increase sedation. Use Caution/Monitor.

                  • cyclobenzaprine

                    cyclobenzaprine and nabilone both increase sedation. Use Caution/Monitor.

                  • cyproheptadine

                    cyproheptadine and nabilone both increase sedation. Use Caution/Monitor.

                  • dantrolene

                    dantrolene and nabilone both increase sedation. Use Caution/Monitor.

                  • daridorexant

                    nabilone and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.

                  • desflurane

                    desflurane and nabilone both increase sedation. Use Caution/Monitor.

                  • desipramine

                    desipramine and nabilone both increase sedation. Use Caution/Monitor.

                  • dexchlorpheniramine

                    dexchlorpheniramine and nabilone both increase sedation. Use Caution/Monitor.

                  • dexfenfluramine

                    nabilone increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dexmedetomidine

                    dexmedetomidine and nabilone both increase sedation. Use Caution/Monitor.

                  • dexmethylphenidate

                    nabilone increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dextroamphetamine

                    nabilone increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dextromoramide

                    dextromoramide and nabilone both increase sedation. Use Caution/Monitor.

                  • diamorphine

                    diamorphine and nabilone both increase sedation. Use Caution/Monitor.

                  • diazepam

                    diazepam and nabilone both increase sedation. Use Caution/Monitor.

                  • diethylpropion

                    nabilone increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • difelikefalin

                    difelikefalin and nabilone both increase sedation. Use Caution/Monitor.

                  • difenoxin hcl

                    difenoxin hcl and nabilone both increase sedation. Use Caution/Monitor.

                  • dimenhydrinate

                    dimenhydrinate and nabilone both increase sedation. Use Caution/Monitor.

                  • diphenhydramine

                    diphenhydramine and nabilone both increase sedation. Use Caution/Monitor.

                  • diphenoxylate hcl

                    diphenoxylate hcl and nabilone both increase sedation. Use Caution/Monitor.

                  • dipipanone

                    dipipanone and nabilone both increase sedation. Use Caution/Monitor.

                  • dobutamine

                    nabilone increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dopamine

                    nabilone increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dopexamine

                    nabilone increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • doxepin

                    doxepin and nabilone both increase sedation. Use Caution/Monitor.

                  • doxylamine

                    doxylamine and nabilone both increase sedation. Use Caution/Monitor.

                  • droperidol

                    droperidol and nabilone both increase sedation. Use Caution/Monitor.

                  • ephedrine

                    nabilone increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • epinephrine

                    nabilone increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • epinephrine racemic

                    nabilone increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • estazolam

                    estazolam and nabilone both increase sedation. Use Caution/Monitor.

                  • ethanol

                    ethanol and nabilone both increase sedation. Use Caution/Monitor.

                  • etomidate

                    etomidate and nabilone both increase sedation. Use Caution/Monitor.

                  • fenfluramine

                    nabilone increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • fluphenazine

                    fluphenazine and nabilone both increase sedation. Use Caution/Monitor.

                  • flurazepam

                    flurazepam and nabilone both increase sedation. Use Caution/Monitor.

                  • formoterol

                    nabilone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • haloperidol

                    haloperidol and nabilone both increase sedation. Use Caution/Monitor.

                  • hydromorphone

                    hydromorphone and nabilone both increase sedation. Use Caution/Monitor.

                  • hydroxyzine

                    hydroxyzine and nabilone both increase sedation. Use Caution/Monitor.

                  • iloperidone

                    iloperidone and nabilone both increase sedation. Use Caution/Monitor.

                  • imipramine

                    imipramine and nabilone both increase sedation. Use Caution/Monitor.

                  • isoproterenol

                    nabilone increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • ketamine

                    ketamine and nabilone both increase sedation. Use Caution/Monitor.

                  • ketotifen, ophthalmic

                    ketotifen, ophthalmic and nabilone both increase sedation. Use Caution/Monitor.

                  • levalbuterol

                    nabilone increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • levorphanol

                    levorphanol and nabilone both increase sedation. Use Caution/Monitor.

                  • lisdexamfetamine

                    nabilone increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • lofepramine

                    lofepramine and nabilone both increase sedation. Use Caution/Monitor.

                  • lofexidine

                    lofexidine and nabilone both increase sedation. Use Caution/Monitor.

                  • loprazolam

                    loprazolam and nabilone both increase sedation. Use Caution/Monitor.

                  • lorazepam

                    lorazepam and nabilone both increase sedation. Use Caution/Monitor.

                  • lormetazepam

                    lormetazepam and nabilone both increase sedation. Use Caution/Monitor.

                  • loxapine

                    loxapine and nabilone both increase sedation. Use Caution/Monitor.

                  • loxapine inhaled

                    loxapine inhaled and nabilone both increase sedation. Use Caution/Monitor.

                  • lurasidone

                    lurasidone, nabilone. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.

                  • maprotiline

                    maprotiline and nabilone both increase sedation. Use Caution/Monitor.

                  • marijuana

                    marijuana and nabilone both increase sedation. Use Caution/Monitor.

                  • melatonin

                    melatonin and nabilone both increase sedation. Use Caution/Monitor.

                  • meperidine

                    meperidine and nabilone both increase sedation. Use Caution/Monitor.

                  • meprobamate

                    meprobamate and nabilone both increase sedation. Use Caution/Monitor.

                  • metaproterenol

                    nabilone increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • metaxalone

                    metaxalone and nabilone both increase sedation. Use Caution/Monitor.

                  • methadone

                    methadone and nabilone both increase sedation. Use Caution/Monitor.

                  • methamphetamine

                    nabilone increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • methocarbamol

                    methocarbamol and nabilone both increase sedation. Use Caution/Monitor.

                  • methylenedioxymethamphetamine

                    nabilone increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • midazolam

                    midazolam and nabilone both increase sedation. Use Caution/Monitor.

                  • midazolam intranasal

                    midazolam intranasal, nabilone. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.

                  • midodrine

                    nabilone increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • mirtazapine

                    mirtazapine and nabilone both increase sedation. Use Caution/Monitor.

                  • modafinil

                    nabilone increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • morphine

                    morphine and nabilone both increase sedation. Use Caution/Monitor.

                  • motherwort

                    motherwort and nabilone both increase sedation. Use Caution/Monitor.

                  • moxonidine

                    moxonidine and nabilone both increase sedation. Use Caution/Monitor.

                  • nalbuphine

                    nalbuphine and nabilone both increase sedation. Use Caution/Monitor.

                  • naltrexone

                    naltrexone increases effects of nabilone by Other (see comment). Use Caution/Monitor. Comment: Naltrexone may enhance therapeutic effects of cannabinoids. .

                  • norepinephrine

                    nabilone increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • nortriptyline

                    nortriptyline and nabilone both increase sedation. Use Caution/Monitor.

                  • olanzapine

                    olanzapine and nabilone both increase sedation. Use Caution/Monitor.

                  • opium tincture

                    opium tincture and nabilone both increase sedation. Use Caution/Monitor.

                  • orphenadrine

                    orphenadrine and nabilone both increase sedation. Use Caution/Monitor.

                  • oxazepam

                    oxazepam and nabilone both increase sedation. Use Caution/Monitor.

                  • oxycodone

                    oxycodone and nabilone both increase sedation. Use Caution/Monitor.

                  • oxymorphone

                    oxymorphone and nabilone both increase sedation. Use Caution/Monitor.

                  • paliperidone

                    paliperidone and nabilone both increase sedation. Use Caution/Monitor.

                  • papaveretum

                    papaveretum and nabilone both increase sedation. Use Caution/Monitor.

                  • papaverine

                    nabilone and papaverine both increase sedation. Use Caution/Monitor.

                  • pentazocine

                    pentazocine and nabilone both increase sedation. Use Caution/Monitor.

                  • pentobarbital

                    pentobarbital and nabilone both increase sedation. Use Caution/Monitor.

                  • perphenazine

                    perphenazine and nabilone both increase sedation. Use Caution/Monitor.

                  • phendimetrazine

                    nabilone increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • phenobarbital

                    phenobarbital and nabilone both increase sedation. Use Caution/Monitor.

                  • phentermine

                    nabilone increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • phenylephrine

                    nabilone increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • phenylephrine PO

                    nabilone increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

                  • pholcodine

                    nabilone and pholcodine both increase sedation. Use Caution/Monitor.

                  • pimozide

                    pimozide and nabilone both increase sedation. Use Caution/Monitor.

                  • pirbuterol

                    nabilone increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • primidone

                    primidone and nabilone both increase sedation. Use Caution/Monitor.

                  • prochlorperazine

                    prochlorperazine and nabilone both increase sedation. Use Caution/Monitor.

                  • promethazine

                    promethazine and nabilone both increase sedation. Use Caution/Monitor.

                  • propofol

                    propofol and nabilone both increase sedation. Use Caution/Monitor.

                  • propylhexedrine

                    nabilone increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • protriptyline

                    protriptyline and nabilone both increase sedation. Use Caution/Monitor.

                  • quazepam

                    quazepam and nabilone both increase sedation. Use Caution/Monitor.

                  • quetiapine

                    quetiapine and nabilone both increase sedation. Use Caution/Monitor.

                  • ramelteon

                    nabilone and ramelteon both increase sedation. Use Caution/Monitor.

                  • risperidone

                    risperidone and nabilone both increase sedation. Use Caution/Monitor.

                  • salmeterol

                    nabilone increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • scullcap

                    nabilone and scullcap both increase sedation. Use Caution/Monitor.

                  • secobarbital

                    secobarbital and nabilone both increase sedation. Use Caution/Monitor.

                  • sevoflurane

                    sevoflurane and nabilone both increase sedation. Use Caution/Monitor.

                  • shepherd's purse

                    nabilone and shepherd's purse both increase sedation. Use Caution/Monitor.

                  • stiripentol

                    stiripentol, nabilone. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.

                  • sufentanil

                    sufentanil and nabilone both increase sedation. Use Caution/Monitor.

                  • tapentadol

                    tapentadol and nabilone both increase sedation. Use Caution/Monitor.

                  • temazepam

                    temazepam and nabilone both increase sedation. Use Caution/Monitor.

                  • terbutaline

                    nabilone increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • thioridazine

                    thioridazine and nabilone both increase sedation. Use Caution/Monitor.

                  • thiothixene

                    thiothixene and nabilone both increase sedation. Use Caution/Monitor.

                  • topiramate

                    nabilone and topiramate both increase sedation. Modify Therapy/Monitor Closely.

                  • tramadol

                    tramadol and nabilone both increase sedation. Use Caution/Monitor.

                  • trazodone

                    trazodone and nabilone both increase sedation. Use Caution/Monitor.

                  • triazolam

                    triazolam and nabilone both increase sedation. Use Caution/Monitor.

                  • triclofos

                    triclofos and nabilone both increase sedation. Use Caution/Monitor.

                  • trifluoperazine

                    trifluoperazine and nabilone both increase sedation. Use Caution/Monitor.

                  • trimipramine

                    trimipramine and nabilone both increase sedation. Use Caution/Monitor.

                  • triprolidine

                    triprolidine and nabilone both increase sedation. Use Caution/Monitor.

                  • xylometazoline

                    nabilone increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • yohimbine

                    nabilone increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • ziconotide

                    nabilone and ziconotide both increase sedation. Use Caution/Monitor.

                  • ziprasidone

                    ziprasidone and nabilone both increase sedation. Use Caution/Monitor.

                  Minor (4)

                  • benazepril

                    nabilone, benazepril. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. May increase risk of hypotension.

                  • captopril

                    nabilone, captopril. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. May increase risk of hypotension.

                  • eucalyptus

                    eucalyptus and nabilone both increase sedation. Minor/Significance Unknown.

                  • sage

                    nabilone and sage both increase sedation. Minor/Significance Unknown.

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                  Adverse Effects

                  >10%

                  Vertigo (52%)

                  Drowsiness (52%)

                  Dry mouth (36%)

                  Ataxia (14%)

                  Visual disturbance (13%)

                  Blurred vision (12.8%)

                  Concentration difficulties (12%)

                  Euphoria (11%)

                  Sleep disturbance (11%)

                  1-10%

                  Depersonalization

                  Disorientation

                  Dysphoria

                  Headache

                  Hypotension

                  Nausea

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                  Warnings

                  Contraindications

                  Hypersensitivity to cannabinoids

                  History of psychotic reactions

                  Cautions

                  Severe liver impairment

                  Give only to patients in whom conventional antiemetics have failed

                  Emotionally disturbed patients (non-psychotic)

                  Concomitant use of alcohol or other psychoactive substances can potentiate psychotropic effects

                  May cause tachycardia and orthostatic hypotension

                  May impair ability to drive or perform hazardous tasks

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                  Pregnancy & Lactation

                  Pregnancy Category: C

                  Lactation: not recommended

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Mechanism of Action

                  Cannabinoid antiemetic may act in the central nervous system by acting on cannabinoid receptors

                  Pharmacokinetics

                  Excretion: Feces (65%; primarily bile); urine (20%)

                  Half-life elimination: 2 hr (parent compound); 35 hr (metabolites)

                  Peak plasma time: 2 hr

                  Distribution: 12.5 L/kg

                  Metabolism: Direct enzymatic oxidation and possibly CYP450 enzymes

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                  Images

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                  Patient Handout

                  A Patient Handout is not currently available for this monograph.
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                  Formulary

                  FormularyPatient Discounts

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                  The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                  View explanations for tiers and restrictions
                  Tier Description
                  1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                  2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                  3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                  4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  NC NOT COVERED – Drugs that are not covered by the plan.
                  Code Definition
                  PA Prior Authorization
                  Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                  QL Quantity Limits
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                  ST Step Therapy
                  Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
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