Chamomile (Herb/Suppl)

Flatulence, GI inflammatory disorders, GI spasms, inflammation (skin or mucous membrane), insomnia, menstrual cramps, motion sickness

Topical: hemorrhoids, mucositis (chemo-induced)

Efficacy

Classified as effective by German Commission E

Possibly effective for dyspepsia, colic and mucositis

Frequency Not Defined

Generally regarded as safe

Anaphylaxis

Contact dermatitis

Hypersensitivity reactions

Vomiting

Contraindications

Hypersensitivity to Asteraceae/Compositae plants chrysanthemums, daisies, marigolds, ragweed

Cautions

Asthma, concurrent CYP 3A4 substrates

Pregnancy Category: avoid use

Lactation: N/A

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Metabolism: N/A

Excretion: N/A

Mechanism of Action

Tiglic acid esters: antispasmodic, anti-inflammatory

Chamazulene: antispasmodic, anti-inflammatory, anti-allergic, antibacterial

Apigenin: anti-inflammatory (comparable to NSAIDs)

Azulene: anti-inflammatory

Umbelliferone: fungicidal

Bisabolols: antimicrobial, antipyretic, anti-inflammatory, antispasmodic