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      Drugs & Diseases

      Huperzine A (Herb/Suppl)

      Brand and Other Names:Chinese club moss, Huperzine Rx-Brain, more...HUP, HUP A, Memorall, selagine
      • Print

      Suggested Dosing

      Alzheimer Disease & Multi-infarct Dementia

      50-200 mcg PO BID

      Senile or presenile dementia

      30 mcg PO BID

      Prevention of muscle weakness in myasthenia gravis

      400 mcg IM qDay

      Next:

      Suggested Uses

      Improve memory; treatment of Alzheimer's disease, protection from neurotoxic agents including organophosphate nerve gases, glutamate toxicity, and treating myasthenia gravis

      Efficacy

      Clinical studies in progress; preliminary results promising

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      Interactions

      Interaction Checker

      and Huperzine A

      No Results

         activity indicator 
        No Interactions Found
        Interactions Found

        Contraindicated

          Serious - Use Alternative

            Significant - Monitor Closely

              Minor

                All Interactions Sort By:
                 activity indicator 

                Contraindicated (0)

                  Serious - Use Alternative (0)

                    Monitor Closely (65)

                    • aclidinium

                      huperzine A increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • amitriptyline

                      huperzine A increases and amitriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • amoxapine

                      huperzine A increases and amoxapine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • anticholinergic/sedative combos

                      huperzine A increases and anticholinergic/sedative combos decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • atracurium

                      huperzine A increases and atracurium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • atropine

                      huperzine A increases and atropine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • atropine IV/IM

                      huperzine A increases and atropine IV/IM decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

                    • belladonna alkaloids

                      huperzine A increases and belladonna alkaloids decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • belladonna and opium

                      huperzine A increases and belladonna and opium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • bethanechol

                      bethanechol and huperzine A both increase cholinergic effects/transmission. Use Caution/Monitor.

                    • carbachol

                      carbachol and huperzine A both increase cholinergic effects/transmission. Use Caution/Monitor.

                    • cevimeline

                      cevimeline and huperzine A both increase cholinergic effects/transmission. Use Caution/Monitor.

                    • cisatracurium

                      huperzine A increases and cisatracurium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • clomipramine

                      huperzine A increases and clomipramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • cyclizine

                      huperzine A increases and cyclizine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • cyclobenzaprine

                      huperzine A increases and cyclobenzaprine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • darifenacin

                      huperzine A increases and darifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • desipramine

                      huperzine A increases and desipramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • dicyclomine

                      huperzine A increases and dicyclomine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • diphenhydramine

                      huperzine A increases and diphenhydramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • donepezil

                      donepezil and huperzine A both increase cholinergic effects/transmission. Use Caution/Monitor.

                    • dosulepin

                      huperzine A increases and dosulepin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • doxepin

                      huperzine A increases and doxepin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • echothiophate iodide

                      echothiophate iodide and huperzine A both increase cholinergic effects/transmission. Use Caution/Monitor.

                    • fesoterodine

                      huperzine A increases and fesoterodine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • flavoxate

                      huperzine A increases and flavoxate decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • galantamine

                      galantamine and huperzine A both increase cholinergic effects/transmission. Use Caution/Monitor.

                    • glycopyrrolate

                      huperzine A increases and glycopyrrolate decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • glycopyrrolate inhaled

                      huperzine A increases and glycopyrrolate inhaled decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • henbane

                      huperzine A increases and henbane decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • homatropine

                      huperzine A increases and homatropine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • hyoscyamine

                      huperzine A increases and hyoscyamine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • hyoscyamine spray

                      huperzine A increases and hyoscyamine spray decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

                    • imipramine

                      huperzine A increases and imipramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • incobotulinumtoxinA

                      huperzine A increases and incobotulinumtoxinA decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • ipratropium

                      huperzine A increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • lofepramine

                      huperzine A increases and lofepramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • maprotiline

                      huperzine A increases and maprotiline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • meclizine

                      huperzine A increases and meclizine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • methscopolamine

                      huperzine A increases and methscopolamine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • neostigmine

                      huperzine A and neostigmine both increase cholinergic effects/transmission. Use Caution/Monitor.

                    • nortriptyline

                      huperzine A increases and nortriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • onabotulinumtoxinA

                      huperzine A increases and onabotulinumtoxinA decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • orphenadrine

                      huperzine A increases and orphenadrine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • oxybutynin

                      huperzine A increases and oxybutynin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • oxybutynin topical

                      huperzine A increases and oxybutynin topical decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • oxybutynin transdermal

                      huperzine A increases and oxybutynin transdermal decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • pancuronium

                      huperzine A increases and pancuronium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • physostigmine

                      huperzine A and physostigmine both increase cholinergic effects/transmission. Use Caution/Monitor.

                    • pilocarpine

                      huperzine A and pilocarpine both increase cholinergic effects/transmission. Use Caution/Monitor.

                    • pralidoxime

                      huperzine A increases and pralidoxime decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • propantheline

                      huperzine A increases and propantheline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • protriptyline

                      huperzine A increases and protriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • pyridostigmine

                      huperzine A and pyridostigmine both increase cholinergic effects/transmission. Use Caution/Monitor.

                    • rapacuronium

                      huperzine A increases and rapacuronium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • rocuronium

                      huperzine A increases and rocuronium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • scopolamine

                      huperzine A increases and scopolamine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • solifenacin

                      huperzine A increases and solifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • succinylcholine

                      huperzine A and succinylcholine both increase cholinergic effects/transmission. Use Caution/Monitor.

                    • tiotropium

                      huperzine A increases and tiotropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • tolterodine

                      huperzine A increases and tolterodine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • trazodone

                      huperzine A increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • trimipramine

                      huperzine A increases and trimipramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • trospium chloride

                      huperzine A increases and trospium chloride decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • vecuronium

                      huperzine A increases and vecuronium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    Minor (4)

                    • donepezil

                      donepezil increases effects of huperzine A by pharmacodynamic synergism. Minor/Significance Unknown.

                    • galantamine

                      galantamine increases effects of huperzine A by pharmacodynamic synergism. Minor/Significance Unknown.

                    • pantothenic acid

                      pantothenic acid, huperzine A. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.

                    • procainamide

                      procainamide decreases effects of huperzine A by pharmacodynamic antagonism. Minor/Significance Unknown.

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                    Adverse Effects

                    Frequency Not Defined

                    Gastrointestinal effects (eg, nausea, diarrhea)

                    Sweating

                    Blurred vision

                    Fasciculations

                    Dizziness

                    See cholinergic syndrome

                    Previous
                    Next:

                    Warnings

                    Contraindications

                    Seizure disorders, cardiac arrhythmias, asthma, IBS, IBD & malabsorption syndromes

                    Previous
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                    Pregnancy & Lactation

                    Pregnancy Category: avoid

                    Lactation: avoid

                    Pregnancy Categories

                    A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                    B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                    C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                    D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                    X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                    NA: Information not available.

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                    Pharmacology

                    Absorption: readily from GI tract

                    Distribution: wide, including brain

                    Peak Plasma Time: 80 min

                    Metabolism: some first pass metabolism in liver

                    Excretion: N/A

                    Mechanism of Action

                    Cholinesterase inhibitor

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                    Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
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