Cinnamon (Herb/Suppl)

Brand and Other Names:Cinnamon Cassia, batavia cassia, more...batavia cinnamon, cassia aromaticum, Ceylon cinnamon, Chinese cinnamon, cinnamomum sp, padang cassia, panang cinnamon, Saigon cassia, Saigon cinnamon
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Suggested Dosing

Diabetes Type 1 & 2

1-6 grams (1 teaspoon = 4.75 grams) of cassia cinnamon PO qD for up to 4 months

Dried Bark

2-6 g/d PO

Tincture

3-7 mL PO TID

Essential Oil

0.05-0.2 mL/d

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Suggested Uses

Diabetes, GI antispasmodic/antiflatulent, diarrhea, dysmenorrhea

Cold, influenza, general antimicrobial (essential oil)

Efficacy

Placebo-controlled human trial demonstrated decr blood glucose, triglycerides, LDL, total cholesterol in type 2 diabetes (dose-dependent: 6 g/d most effective)

Possibly effective as antispasmodic

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Interactions

Interaction Checker

and Cinnamon

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            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (97)

                • acarbose

                  cinnamon increases effects of acarbose by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • aceclofenac

                  aceclofenac and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • acemetacin

                  acemetacin and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • agrimony

                  agrimony and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • albiglutide

                  cinnamon increases effects of albiglutide by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • alfalfa

                  alfalfa and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • alteplase

                  alteplase and cinnamon both increase anticoagulation. Use Caution/Monitor. In theory, cinnamon may interact with blood-thinning medications due to the presence of coumarin.

                • American ginseng

                  American ginseng and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • antithrombin alfa

                  antithrombin alfa and cinnamon both increase anticoagulation. Modify Therapy/Monitor Closely.

                • antithrombin III

                  antithrombin III and cinnamon both increase anticoagulation. Modify Therapy/Monitor Closely.

                • argatroban

                  argatroban and cinnamon both increase anticoagulation. Modify Therapy/Monitor Closely.

                • aspirin

                  aspirin and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • aspirin rectal

                  aspirin rectal and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • aspirin/citric acid/sodium bicarbonate

                  aspirin/citric acid/sodium bicarbonate and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • bemiparin

                  bemiparin and cinnamon both increase anticoagulation. Modify Therapy/Monitor Closely.

                • bivalirudin

                  bivalirudin and cinnamon both increase anticoagulation. Modify Therapy/Monitor Closely.

                • celecoxib

                  celecoxib and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • chlorpropamide

                  cinnamon increases effects of chlorpropamide by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • choline magnesium trisalicylate

                  choline magnesium trisalicylate and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • cordyceps

                  cinnamon and cordyceps both increase anticoagulation. Use Caution/Monitor.

                • dabigatran

                  dabigatran and cinnamon both increase anticoagulation. Modify Therapy/Monitor Closely.

                • dalteparin

                  dalteparin and cinnamon both increase anticoagulation. Modify Therapy/Monitor Closely.

                • diclofenac

                  diclofenac and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • diflunisal

                  diflunisal and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • dong quai

                  cinnamon and dong quai both increase anticoagulation. Use Caution/Monitor.

                • enoxaparin

                  enoxaparin and cinnamon both increase anticoagulation. Modify Therapy/Monitor Closely.

                • epoprostenol

                  cinnamon and epoprostenol both increase anticoagulation. Use Caution/Monitor.

                • etodolac

                  etodolac and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • exenatide injectable solution

                  cinnamon increases effects of exenatide injectable solution by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • exenatide injectable suspension

                  cinnamon increases effects of exenatide injectable suspension by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • fennel

                  cinnamon and fennel both increase anticoagulation. Use Caution/Monitor.

                • fenoprofen

                  fenoprofen and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • feverfew

                  cinnamon and feverfew both increase anticoagulation. Use Caution/Monitor.

                • flurbiprofen

                  flurbiprofen and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • fondaparinux

                  fondaparinux and cinnamon both increase anticoagulation. Modify Therapy/Monitor Closely.

                • forskolin

                  cinnamon and forskolin both increase anticoagulation. Use Caution/Monitor.

                • garlic

                  cinnamon and garlic both increase anticoagulation. Use Caution/Monitor.

                • ginger

                  cinnamon and ginger both increase anticoagulation. Use Caution/Monitor.

                • ginkgo biloba

                  cinnamon and ginkgo biloba both increase anticoagulation. Use Caution/Monitor.

                • glimepiride

                  cinnamon increases effects of glimepiride by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • glipizide

                  cinnamon increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • glyburide

                  cinnamon increases effects of glyburide by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • heparin

                  heparin and cinnamon both increase anticoagulation. Modify Therapy/Monitor Closely.

                • horse chestnut seed

                  cinnamon and horse chestnut seed both increase anticoagulation. Use Caution/Monitor.

                • ibuprofen

                  ibuprofen and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • ibuprofen IV

                  ibuprofen IV and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • indomethacin

                  indomethacin and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • insulin aspart

                  cinnamon increases effects of insulin aspart by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • insulin detemir

                  cinnamon increases effects of insulin detemir by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • insulin glargine

                  cinnamon increases effects of insulin glargine by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • insulin glulisine

                  cinnamon increases effects of insulin glulisine by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • insulin lispro

                  cinnamon increases effects of insulin lispro by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • insulin NPH

                  cinnamon increases effects of insulin NPH by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • insulin regular human

                  cinnamon increases effects of insulin regular human by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • ketoprofen

                  ketoprofen and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • ketorolac

                  ketorolac and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • ketorolac intranasal

                  ketorolac intranasal and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • liraglutide

                  cinnamon increases effects of liraglutide by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • lornoxicam

                  lornoxicam and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • meclofenamate

                  meclofenamate and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • mefenamic acid

                  mefenamic acid and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • meloxicam

                  meloxicam and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • metformin

                  cinnamon increases effects of metformin by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • miglitol

                  cinnamon increases effects of miglitol by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • mistletoe

                  cinnamon increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • nabumetone

                  nabumetone and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • naproxen

                  naproxen and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • nateglinide

                  cinnamon increases effects of nateglinide by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • nettle

                  cinnamon increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • oxaprozin

                  oxaprozin and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • panax ginseng

                  cinnamon and panax ginseng both increase anticoagulation. Use Caution/Monitor.

                • parecoxib

                  parecoxib and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • pau d'arco

                  cinnamon and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • phenindione

                  phenindione and cinnamon both increase anticoagulation. Modify Therapy/Monitor Closely.

                • phytoestrogens

                  cinnamon and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • pioglitazone

                  cinnamon increases effects of pioglitazone by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • piroxicam

                  piroxicam and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • protamine

                  protamine and cinnamon both increase anticoagulation. Modify Therapy/Monitor Closely.

                • reishi

                  cinnamon and reishi both increase anticoagulation. Use Caution/Monitor.

                • repaglinide

                  cinnamon increases effects of repaglinide by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • reteplase

                  reteplase and cinnamon both increase anticoagulation. Modify Therapy/Monitor Closely.

                • rosiglitazone

                  cinnamon increases effects of rosiglitazone by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • salicylates (non-asa)

                  salicylates (non-asa) and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • salsalate

                  salsalate and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • saxagliptin

                  cinnamon increases effects of saxagliptin by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • Siberian ginseng

                  cinnamon and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • sitagliptin

                  cinnamon increases effects of sitagliptin by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • sulfasalazine

                  sulfasalazine and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • sulindac

                  sulindac and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • tenecteplase

                  tenecteplase and cinnamon both increase anticoagulation. Modify Therapy/Monitor Closely.

                • tolazamide

                  cinnamon increases effects of tolazamide by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • tolbutamide

                  cinnamon increases effects of tolbutamide by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • tolfenamic acid

                  tolfenamic acid and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • tolmetin

                  tolmetin and cinnamon both increase anticoagulation. Use Caution/Monitor.

                • turmeric

                  cinnamon and turmeric both increase anticoagulation. Use Caution/Monitor.

                • vildagliptin

                  cinnamon increases effects of vildagliptin by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.

                • warfarin

                  warfarin and cinnamon both increase anticoagulation. Modify Therapy/Monitor Closely.

                Minor (3)

                • anamu

                  anamu and cinnamon both increase anticoagulation. Minor/Significance Unknown.

                • danshen

                  cinnamon and danshen both increase anticoagulation. Minor/Significance Unknown.

                • devil's claw

                  cinnamon and devil's claw both increase anticoagulation. Minor/Significance Unknown.

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                Adverse Effects

                Frequency Not Defined

                Essential oil may irritate mucous membranes

                Excessive doses may cause hypoglycemia

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                Warnings

                Contraindications

                Hypersensitivity

                Pregnancy (> amounts found in food)

                Cautions

                Most preparations contain cassia cinnamon, a coumarin-containing variety

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                Pregnancy & Lactation

                Pregnancy Category: N/A

                Lactation: N/A

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Metabolism: N/A

                Excretion: N/A

                Mechanism of Action

                Cinnamic Acid - hypoglycemic properties

                Volatile (essential) oils demonstrate antimicrobial activity in vitro, & decrease smooth muscle spasm

                Tannins are astringent (anti-hemorrhagic)

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.