Suggested Dosing
10-200 mg/day PO
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Suggested Uses
Atherosclerosis, hypercholesterolemia, cancer prevention
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Adverse Effects
None reported
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Warnings
Contraindications
Hypersensitivity
Pregnancy (red wine)
Cautions
None reported
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Pregnancy & Lactation
Pregnancy Category: avoid red wine
Lactation: unknown; not recommended
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Previous
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Pharmacology
Metabolism: N/A
Excretion: N/A
Mechanism of Action
Polyphenol found in grape skins, dark red wines; supplements usually derived from Japanese knotweed (Polygonium cuspidatum)
Antioxidant, antiplatelet, antimutagenic, and phytoestrogenic properties
Inhibits COX 1 & 2 and 5-lipoxygenase
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
