calcium citrate (OTC)

Brand and Other Names:Cal-Cee, Cal-C-Cap
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet/capsule

  • 150mg
  • 200mg
  • 250mg
  • 950mg
  • 1040mg

Granules

  • 760mg/3.5g

RDA (Elemental Calcium)

<50 years: 1 g/day

>50 years females: 1.2 g/day

>50 years males: 1 g/day

>70 years males: 1.2 g/day

Hypocalcemia Prevention

1 g/day in divided doses

Primary Osteoporosis Prevention

1-1.5 g/day in divided doses

Other Information

211 mg elemental Ca per gram of calcium citrate

Most commercial products also contain Vitamin D

Other Indications & Uses

Oral Ca supplements may protect against renal calculi formation by chelating with oxalate in gut and preventing its absorption

Dosage Forms & Strengths

tablet/capsule

  • 150mg
  • 200mg
  • 250mg
  • 950mg
  • 1040mg

Granules

  • 760mg/3.5g

RDA (Elemental Calcium)

<6 months old: 200 mg/day

6-12 months old: 260 mg/day

1-3 years old: 700 mg/day

4-8 years old: 1000 mg/day

9-18 years old: 1300 mg/day

Hypocalcemia

Neonates: 50-150 mg/kg/day divided q4-6hr PO; dose expressed as elemental calcium; no more than 1g/day  

Children: 45-65 mg/kg/day divided q6hr PO; dose expressed as elemental calcium

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Interactions

Interaction Checker

and calcium citrate

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            Adverse Effects

            Frequency Not Defined

            Hypotension

            Headache

            Constipation

            Diarrhea

            Flatulence

            Nausea

            Vomiting

            Hypophosphatemia

            Hypomagnesemia

            Hypercalcemia

            • Anorexia
            • Coma
            • Confusion
            • Delirium
            • Headache
            • Lethargy
            • Milk-alkali syndrome (very high, chronic dosing)
            • Nausea/Vomiting
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            Warnings

            Contraindications

            Documented hypersensitivity, hypercalciuria, renal calculi, hypophosphatemia, hypercalcemia, ventricula fibrillation

            Cautions

            Hypercalcemia and hypercalciuria may result from long term use

            Advise patients to limit intake of oxalate-rich foods (soy, green leafy vegetables, animal protein) to avoid reduced absorption through Ca-oxalate formation

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: safe, crosses the placenta; appears in breast milk

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Dietary supplement: prevents or treats negative Ca balance

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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.