glycerin rectal (OTC)

Brand and Other Names:Colace Infant/Child Suppositories, Colace Suppositories, more...Fleet Glycerin Suppositories, Fleet Liquid Glycerin Suppositories, Pedia-Lax Glycerin Suppositories, Pedia-Lax Liquid Glycerin Suppositories
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

suppository

  • 1g
  • 1.5g
  • 2g
  • 2.1g
  • 2.8g

Occasional Constipation

suppository

  • 2-2.8 g suppository inserted in rectum, retain for about 15 min PRN or as directed

Dosage Forms & Strengths

suppository

  • 1g
  • 1.5g
  • 2g
  • 2.1g
  • 2.8g

Occasional Constipation

2-6 years

  • 1-1.7 g suppository, retain 15 min, PRN constipation

>6 years

  • 2-2.8 g suppository, retain 15 min, PRN constipation
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Adverse Effects

Frequency Not Defined

Burning sensation

Cramping pain

Rectal irritation

Tenesmus

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Warnings

Contraindications

GI obstruction, severe impaction

Cautions

Do not use when abdominal pain, nausea, or vomiting present (unless directed by physician)

Frequent or prolonged use of laxatives may result in dependence

Rectal bleeding or failure to have bowel movement requires physician care

Contact physician before use if experience sudden change in bowel habits that last >2 wk

Do not use for longer than 1 wk

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Pregnancy & Lactation

Pregnancy category: Data not available

Lactation: Unknown, but probably compatible with breastfeeding

Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

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Pharmacology

Mechanism of Action

Hyperosmotic dehydrating agent; draws fluid into colon, increases osmotic pressure, and stimulates evacuation

Pharmacokinetics

Onset of action: 15-30 min

Absorption: Poorly absorbed

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Administration

Rectal Administration

Patient should lie on left side with knees bent

Remove protective wrap before inserting

Gently insert tip into rectum with slight side-to-side movement (tip of suppository pointing toward navel)

For liquid suppository, squeeze bulb until all liquid is expelled and discard unit

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Images

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.