Colestid (colestipol) dosing, indications, interactions, adverse effects, and more

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Sections colestipol
Dosing & Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology
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Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

granules, bottle

granules, packets

tablet

Hyperlipidemia

Tablets: 2 g PO qDay or q12hr; increases of 2 g should occur at 1- or 2-month intervals; titrate not to exceed 16 g/day

Granules: 5 g PO qDay; increases of 5 g should occur at 1- or 2-month intervals; titrate not to exceed 30 g/day

Overdose Management

Generally considered safe in acute overdose although not formally studied

Adverse drug reactions in overdose may include peripheral neuropathy, diarrhea, increase K+, myopathy , rhabdomyolysis, acute renal failure, elevated liver function tests, eye lens opacities)

Check renal function tests, urine myoglobin, CPK, LFT's

Administration

Mix dry form in water/fluids to avoid inhalation or esophageal distress

Mix granules in fluids or food; take before meals

Do not crush, chew, or cut tablets

Take 1 tablet at a time; swallow with water or other fluids

Other Information

Monitor: Serum cholesterol, triglycerides

Other Indications & Uses

Used in relief of pruritus associated with elevated levels of bile

Used to decrease plasma half-life of digoxin in toxicity

Hypercholesterolemia (adjunct to diet for Type IIa & IIb hyperlipidemia)

Safety & efficacy not established

Tablets: 2 g PO qDay or q12hr; increases of 2 g should occur at 1- or 2-month intervals; titrate not to exceed 16 g/day

Granules: 5 g PO qDay; increases of 5 g should occur at 1- or 2-month intervals; titrate not to exceed 30 g/day

Interaction Checker

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Interactions Found

Contraindicated

Serious - Use Alternative

Significant - Monitor Closely

Minor

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>10%

Gastrointestinal (mostly)

Constipation

1-10%

Stomach pain

Belching

Nausea/vomiting

Flatulance

Diarrhea

Dizziness

Anxiety

Vertigo

Fatigue

Drowsiness

Frequency Not Defined

Heartburn

Steatorrhea

Malabsorption of fat-soluble vitamins

Gallstones

Dysphagia

GI bleeding

Cholecystitis

Peptic ulceration

Transient esophageal obstruction

Contraindications

Hypersensitivity to colestipol

Bowel obstruction

Cautions

Increased risk of bleeding due to hypoprothrombinemia from vitamin K deficiency

May interfere with fat absorption, and decrease absorption of fat-soluble vitamins (A, D, E, K)

May worsen pre-existing constipation

Take other medications 1 hr before or 4 hr after colestipol

If significant increase in triglycerides, consider dose reduction, discontinuation or alternatives

Pregnancy & Lactation

Pregnancy Category: C

Lactation: use caution; may interfere with vitamin absorption in infants

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Forms a soluble complex after binding to bile acid, increasing fecal loss of bile acid-bound low-density lipoprotein cholesterol

Pharmacokinetics

Onset: initial effect: 24-48 hr; max effect: 1 wk

Bioavailability: Not absorbed

Metabolism: Not metabolized

Excretion: feces 100%

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Patient Handout

Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Create Your List of Plans

Adding plans allows you to:

View the formulary and any restrictions for each plan.
Manage and view all your plans together – even plans in different states.
Compare formulary status to other drugs in the same class.
Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

Tier	Description
1	This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2	This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC	NOT COVERED – Drugs that are not covered by the plan.

Code	Definition
PA	Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL	Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST	Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR	Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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Sections colestipol
Dosing & Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout
Formulary

colestipol (Rx)