timolol/brimonidine (Rx)

5-15%

Allergic conjunctivitis

Conjunctival folliculosis

Conjunctival hyperemia

Eye pruritus

Ocular burning

Stinging

1-5%

Asthenia

Blepharitis

Corneal erosion

Depression

Epiphora

Eye discharge

Eye dryness

Eye irritation

Eye pain

Eyelid edema

Eyelid erythema

Eyelid pruritus

Foreign body sensation

Headache

Hypertension

Oral dryness

Somnolence

Superficial punctate keratitis

Visual disturbance

Contraindications

Hypersensitivity to either product or other components

Reactive airway disease, including severe COPD or active or history of bronchial asthma

Sinus bradycardia, 2°/3° AV block, overt cardiac failure, cardiogenic shock

Concurrency with MAO inhibitors

Cautions

Not to be used alone for acute angle-closure glaucoma

Depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension, thromboangiitis obliterans, diabetes mellitus, severe cardiovascular dz, renal/hepatic impairment, myasthenia gravis

Ocular hypersensitivity reported with brimonidine ophthalmic solutions; including some reports with Increased IOP

If other eye drops used, instill at least 5 min apart

May mask hyperthyroidism/thyrotoxicosis symptoms

Remove soft contact lenses; may reinsert 15 min post-instillation

Pregnancy Category: C

Lactation: use caution

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.