Suggested Dosing
500 mg PO TID standardized extract
Gugulipid: standardized to 5% guggulsterone
Nodulocystic Acne
Dose of the guggulipid equivalent up to 25 mg guggulsterones twice a day has been used
Suggested Uses
Type IIb, type IV hyperlipidemias, nodulocystic acne.
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (1)
- propranolol
guggul decreases levels of propranolol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
Minor (3)
- levothyroxine
guggul decreases effects of levothyroxine by pharmacodynamic antagonism. Minor/Significance Unknown.
- liothyronine
guggul decreases effects of liothyronine by pharmacodynamic antagonism. Minor/Significance Unknown.
- thyroid desiccated
guggul decreases effects of thyroid desiccated by pharmacodynamic antagonism. Minor/Significance Unknown.
Adverse Effects
Frequency Not Defined
Rash
Diarrhea associated with crude gum guggul
Standardized gugulipid much less toxic
Warnings
Contraindications
See product label
Pregnancy & Lactation
Pregnancy Category: N/A
Lactation: N/A
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Metabolism: N/A
Excretion: N/A
Mechanism of Action
Increase LDL uptake by liver; stimulates thyroid function
