Guggul (Herb/Suppl)

Brand and Other Names:commiphora mukul, gugulipid
  • Print

Suggested Dosing

500 mg PO TID standardized extract

Gugulipid: standardized to 5% guggulsterone

Nodulocystic Acne

Dose of the guggulipid equivalent up to 25 mg guggulsterones twice a day has been used

Next:

Suggested Uses

Type IIb, type IV hyperlipidemias, nodulocystic acne.

Previous
Next:

Interactions

Interaction Checker

and Guggul

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (1)

                • propranolol

                  guggul decreases levels of propranolol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                Minor (3)

                • levothyroxine

                  guggul decreases effects of levothyroxine by pharmacodynamic antagonism. Minor/Significance Unknown.

                • liothyronine

                  guggul decreases effects of liothyronine by pharmacodynamic antagonism. Minor/Significance Unknown.

                • thyroid desiccated

                  guggul decreases effects of thyroid desiccated by pharmacodynamic antagonism. Minor/Significance Unknown.

                Previous
                Next:

                Adverse Effects

                Frequency Not Defined

                Rash

                Diarrhea associated with crude gum guggul

                Standardized gugulipid much less toxic

                Previous
                Next:

                Warnings

                Contraindications

                See product label

                Previous
                Next:

                Pregnancy & Lactation

                Pregnancy Category: N/A

                Lactation: N/A

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

                Previous
                Next:

                Pharmacology

                Metabolism: N/A

                Excretion: N/A

                Mechanism of Action

                Increase LDL uptake by liver; stimulates thyroid function

                Previous
                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.