News & Perspective
Drugs & Diseases
CME & Education
Academy
Video
Decision Point
Edition: English

Medscape

English
Deutsch
Español
Français
Português
UKNew

Univadis

Sign Up It's Free!
English Edition

Medscape

Univadis

    X
    Univadis from Medscape

    No Results

      News & Perspective Drugs & Diseases CME & Education Academy Video Decision Point
      Drugs & Diseases

      Sage (Herb/Suppl)

      Brand and Other Names:common sage, culinary sage, more...garden sage, meadow sage, salvia officinalis, true sage
      • Print

      Suggested Dosing

      Oral

      Tincture: take 1/8 to 1/2 tspn dried sage leaves in a sip of water qDay/BID

      Herbal Tea: drink several cups of sage tea qDay for several weeks

      Gargle or take small sips of sage tea: PRN throughout day

      Alzheimer's Disease

      Salvia Officinalis Hydroalcoholic Extract: equivalent to 1 g sage PO qDay OR

      Salvia Lavandulaefolia Extract: titrated up to 2.5 mg PO TID

      Herpes Labialis

      Topical cream: 23 mg/d of sage extract and rhubartd exract applied q 2-4hr x10-14 days

      Next:

      Suggested Uses

      Treatment of alzheimer's disease and herpes labialis

      Treatement of diarrhea, colds, and excessive perspiration

      GI antispasmodic/antiflatulent, relieves abdominal cramps & bloating

      Antibacterial/antimicrobial

      Treatment for bright red, abundant uterine bleeding & cramps

      May be of benefit for menopausal hot flashes accompanied by profuse perspiration

      Treatment of coughs & tonsil or throat infections

      Stop breast-milk production when weaning a child from breastfeeding

      Hair rinse for dandruff, oily hair, or scalp infections; may restore color to gray or white hair

      Previous
      Next:

      Interactions

      Interaction Checker

      and Sage

      No Results

         activity indicator 
        No Interactions Found
        Interactions Found

        Contraindicated

          Serious - Use Alternative

            Significant - Monitor Closely

              Minor

                All Interactions Sort By:
                 activity indicator 

                Contraindicated (0)

                  Serious - Use Alternative (0)

                    Monitor Closely (1)

                    • topiramate

                      sage and topiramate both increase sedation. Use Caution/Monitor.

                    Minor (204)

                    • acarbose

                      sage increases effects of acarbose by pharmacodynamic synergism. Minor/Significance Unknown.

                    • acetazolamide

                      sage decreases effects of acetazolamide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • albuterol

                      sage increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • alfentanil

                      alfentanil and sage both increase sedation. Minor/Significance Unknown.

                    • alprazolam

                      alprazolam and sage both increase sedation. Minor/Significance Unknown.

                    • amitriptyline

                      amitriptyline and sage both increase sedation. Minor/Significance Unknown.

                    • amobarbital

                      amobarbital and sage both increase sedation. Minor/Significance Unknown.

                    • amoxapine

                      amoxapine and sage both increase sedation. Minor/Significance Unknown.

                    • apomorphine

                      apomorphine and sage both increase sedation. Minor/Significance Unknown.

                    • arformoterol

                      sage increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • aripiprazole

                      aripiprazole and sage both increase sedation. Minor/Significance Unknown.

                    • armodafinil

                      sage increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • azelastine

                      azelastine and sage both increase sedation. Minor/Significance Unknown.

                    • baclofen

                      baclofen and sage both increase sedation. Minor/Significance Unknown.

                    • belladonna and opium

                      belladonna and opium and sage both increase sedation. Minor/Significance Unknown.

                    • benperidol

                      benperidol and sage both increase sedation. Minor/Significance Unknown.

                    • benzphetamine

                      sage increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • brompheniramine

                      brompheniramine and sage both increase sedation. Minor/Significance Unknown.

                    • buprenorphine

                      buprenorphine and sage both increase sedation. Minor/Significance Unknown.

                    • buprenorphine buccal

                      buprenorphine buccal and sage both increase sedation. Minor/Significance Unknown.

                    • butabarbital

                      butabarbital and sage both increase sedation. Minor/Significance Unknown.

                    • butalbital

                      butalbital and sage both increase sedation. Minor/Significance Unknown.

                    • butorphanol

                      butorphanol and sage both increase sedation. Minor/Significance Unknown.

                    • caffeine

                      sage increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • calcium/magnesium/potassium/sodium oxybates

                      sage and calcium/magnesium/potassium/sodium oxybates both increase sedation. Minor/Significance Unknown.

                    • carbamazepine

                      sage decreases effects of carbamazepine by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • carbinoxamine

                      carbinoxamine and sage both increase sedation. Minor/Significance Unknown.

                    • carisoprodol

                      carisoprodol and sage both increase sedation. Minor/Significance Unknown.

                    • chloral hydrate

                      chloral hydrate and sage both increase sedation. Minor/Significance Unknown.

                    • chlordiazepoxide

                      chlordiazepoxide and sage both increase sedation. Minor/Significance Unknown.

                    • chlorpheniramine

                      chlorpheniramine and sage both increase sedation. Minor/Significance Unknown.

                    • chlorpromazine

                      chlorpromazine and sage both increase sedation. Minor/Significance Unknown.

                    • chlorpropamide

                      sage increases effects of chlorpropamide by pharmacodynamic synergism. Minor/Significance Unknown.

                    • chlorzoxazone

                      chlorzoxazone and sage both increase sedation. Minor/Significance Unknown.

                    • cinnarizine

                      cinnarizine and sage both increase sedation. Minor/Significance Unknown.

                    • clemastine

                      clemastine and sage both increase sedation. Minor/Significance Unknown.

                    • clomipramine

                      clomipramine and sage both increase sedation. Minor/Significance Unknown.

                    • clonazepam

                      clonazepam and sage both increase sedation. Minor/Significance Unknown.

                      sage decreases effects of clonazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • clorazepate

                      clorazepate and sage both increase sedation. Minor/Significance Unknown.

                    • clozapine

                      clozapine and sage both increase sedation. Minor/Significance Unknown.

                    • codeine

                      codeine and sage both increase sedation. Minor/Significance Unknown.

                    • cyclizine

                      cyclizine and sage both increase sedation. Minor/Significance Unknown.

                    • cyclobenzaprine

                      cyclobenzaprine and sage both increase sedation. Minor/Significance Unknown.

                    • cyproheptadine

                      cyproheptadine and sage both increase sedation. Minor/Significance Unknown.

                    • dantrolene

                      dantrolene and sage both increase sedation. Minor/Significance Unknown.

                    • desipramine

                      desipramine and sage both increase sedation. Minor/Significance Unknown.

                    • dexchlorpheniramine

                      dexchlorpheniramine and sage both increase sedation. Minor/Significance Unknown.

                    • dexfenfluramine

                      sage increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • dexmedetomidine

                      dexmedetomidine and sage both increase sedation. Minor/Significance Unknown.

                    • dexmethylphenidate

                      sage increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • dextroamphetamine

                      sage increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • dextromoramide

                      dextromoramide and sage both increase sedation. Minor/Significance Unknown.

                    • diamorphine

                      diamorphine and sage both increase sedation. Minor/Significance Unknown.

                    • diazepam

                      diazepam and sage both increase sedation. Minor/Significance Unknown.

                      sage decreases effects of diazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • diethylpropion

                      sage increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • difenoxin hcl

                      difenoxin hcl and sage both increase sedation. Minor/Significance Unknown.

                    • dimenhydrinate

                      dimenhydrinate and sage both increase sedation. Minor/Significance Unknown.

                    • diphenhydramine

                      diphenhydramine and sage both increase sedation. Minor/Significance Unknown.

                    • diphenoxylate hcl

                      diphenoxylate hcl and sage both increase sedation. Minor/Significance Unknown.

                    • dipipanone

                      dipipanone and sage both increase sedation. Minor/Significance Unknown.

                    • dobutamine

                      sage increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • dopamine

                      sage increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • dopexamine

                      sage increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • doxepin

                      doxepin and sage both increase sedation. Minor/Significance Unknown.

                    • doxylamine

                      doxylamine and sage both increase sedation. Minor/Significance Unknown.

                    • droperidol

                      droperidol and sage both increase sedation. Minor/Significance Unknown.

                    • ephedrine

                      sage increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • epinephrine

                      sage increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • epinephrine racemic

                      sage increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • estazolam

                      estazolam and sage both increase sedation. Minor/Significance Unknown.

                    • ethanol

                      ethanol and sage both increase sedation. Minor/Significance Unknown.

                    • ethosuximide

                      sage decreases effects of ethosuximide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • etomidate

                      etomidate and sage both increase sedation. Minor/Significance Unknown.

                    • eucalyptus

                      eucalyptus and sage both increase sedation. Minor/Significance Unknown.

                    • felbamate

                      sage decreases effects of felbamate by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • fenfluramine

                      sage increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • fluphenazine

                      fluphenazine and sage both increase sedation. Minor/Significance Unknown.

                    • flurazepam

                      flurazepam and sage both increase sedation. Minor/Significance Unknown.

                    • formoterol

                      sage increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • fosphenytoin

                      sage decreases effects of fosphenytoin by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • gabapentin

                      sage decreases effects of gabapentin by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • gabapentin enacarbil

                      sage decreases effects of gabapentin enacarbil by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • glimepiride

                      sage increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown.

                    • glipizide

                      sage increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.

                    • glyburide

                      sage increases effects of glyburide by pharmacodynamic synergism. Minor/Significance Unknown.

                    • haloperidol

                      haloperidol and sage both increase sedation. Minor/Significance Unknown.

                    • hydromorphone

                      hydromorphone and sage both increase sedation. Minor/Significance Unknown.

                    • hydroxyzine

                      hydroxyzine and sage both increase sedation. Minor/Significance Unknown.

                    • iloperidone

                      iloperidone and sage both increase sedation. Minor/Significance Unknown.

                    • imipramine

                      imipramine and sage both increase sedation. Minor/Significance Unknown.

                    • insulin aspart

                      sage increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown.

                    • insulin detemir

                      sage increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown.

                    • insulin glargine

                      sage increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown.

                    • insulin glulisine

                      sage increases effects of insulin glulisine by pharmacodynamic synergism. Minor/Significance Unknown.

                    • insulin lispro

                      sage increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown.

                    • insulin NPH

                      sage increases effects of insulin NPH by pharmacodynamic synergism. Minor/Significance Unknown.

                    • insulin regular human

                      sage increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown.

                    • isoproterenol

                      sage increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • ketotifen, ophthalmic

                      ketotifen, ophthalmic and sage both increase sedation. Minor/Significance Unknown.

                    • lacosamide

                      sage decreases effects of lacosamide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • lamotrigine

                      sage decreases effects of lamotrigine by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • levalbuterol

                      sage increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • levetiracetam

                      sage decreases effects of levetiracetam by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • levorphanol

                      levorphanol and sage both increase sedation. Minor/Significance Unknown.

                    • lisdexamfetamine

                      sage increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • lofepramine

                      lofepramine and sage both increase sedation. Minor/Significance Unknown.

                    • lofexidine

                      lofexidine and sage both increase sedation. Minor/Significance Unknown.

                    • loprazolam

                      loprazolam and sage both increase sedation. Minor/Significance Unknown.

                    • lorazepam

                      lorazepam and sage both increase sedation. Minor/Significance Unknown.

                      sage decreases effects of lorazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • lormetazepam

                      lormetazepam and sage both increase sedation. Minor/Significance Unknown.

                    • loxapine

                      loxapine and sage both increase sedation. Minor/Significance Unknown.

                    • loxapine inhaled

                      loxapine inhaled and sage both increase sedation. Minor/Significance Unknown.

                    • maprotiline

                      maprotiline and sage both increase sedation. Minor/Significance Unknown.

                    • marijuana

                      marijuana and sage both increase sedation. Minor/Significance Unknown.

                    • melatonin

                      melatonin and sage both increase sedation. Minor/Significance Unknown.

                    • meperidine

                      meperidine and sage both increase sedation. Minor/Significance Unknown.

                    • meprobamate

                      meprobamate and sage both increase sedation. Minor/Significance Unknown.

                    • metaproterenol

                      sage increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • metaxalone

                      metaxalone and sage both increase sedation. Minor/Significance Unknown.

                    • metformin

                      sage increases effects of metformin by pharmacodynamic synergism. Minor/Significance Unknown.

                    • methadone

                      methadone and sage both increase sedation. Minor/Significance Unknown.

                    • methamphetamine

                      sage increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • methocarbamol

                      methocarbamol and sage both increase sedation. Minor/Significance Unknown.

                    • methsuximide

                      sage decreases effects of methsuximide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • methylenedioxymethamphetamine

                      sage increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • midazolam

                      midazolam and sage both increase sedation. Minor/Significance Unknown.

                    • midodrine

                      sage increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • miglitol

                      sage increases effects of miglitol by pharmacodynamic synergism. Minor/Significance Unknown.

                    • mirtazapine

                      mirtazapine and sage both increase sedation. Minor/Significance Unknown.

                    • modafinil

                      sage increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • morphine

                      morphine and sage both increase sedation. Minor/Significance Unknown.

                    • motherwort

                      motherwort and sage both increase sedation. Minor/Significance Unknown.

                    • moxonidine

                      moxonidine and sage both increase sedation. Minor/Significance Unknown.

                    • nabilone

                      nabilone and sage both increase sedation. Minor/Significance Unknown.

                    • nalbuphine

                      nalbuphine and sage both increase sedation. Minor/Significance Unknown.

                    • nateglinide

                      sage increases effects of nateglinide by pharmacodynamic synergism. Minor/Significance Unknown.

                    • norepinephrine

                      sage increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • nortriptyline

                      nortriptyline and sage both increase sedation. Minor/Significance Unknown.

                    • olanzapine

                      olanzapine and sage both increase sedation. Minor/Significance Unknown.

                    • opium tincture

                      opium tincture and sage both increase sedation. Minor/Significance Unknown.

                    • orphenadrine

                      orphenadrine and sage both increase sedation. Minor/Significance Unknown.

                    • oxazepam

                      oxazepam and sage both increase sedation. Minor/Significance Unknown.

                    • oxcarbazepine

                      sage decreases effects of oxcarbazepine by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • oxycodone

                      oxycodone and sage both increase sedation. Minor/Significance Unknown.

                    • oxymorphone

                      oxymorphone and sage both increase sedation. Minor/Significance Unknown.

                    • paliperidone

                      paliperidone and sage both increase sedation. Minor/Significance Unknown.

                    • papaveretum

                      papaveretum and sage both increase sedation. Minor/Significance Unknown.

                    • papaverine

                      papaverine and sage both increase sedation. Minor/Significance Unknown.

                    • pentazocine

                      pentazocine and sage both increase sedation. Minor/Significance Unknown.

                    • pentobarbital

                      pentobarbital and sage both increase sedation. Minor/Significance Unknown.

                    • perphenazine

                      perphenazine and sage both increase sedation. Minor/Significance Unknown.

                    • phendimetrazine

                      sage increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • phenobarbital

                      phenobarbital and sage both increase sedation. Minor/Significance Unknown.

                      sage decreases effects of phenobarbital by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • phentermine

                      sage increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • phenylephrine

                      sage increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • phenylephrine PO

                      sage increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown. .

                    • phenytoin

                      sage decreases effects of phenytoin by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • pholcodine

                      pholcodine and sage both increase sedation. Minor/Significance Unknown.

                    • pimozide

                      pimozide and sage both increase sedation. Minor/Significance Unknown.

                    • pioglitazone

                      sage increases effects of pioglitazone by pharmacodynamic synergism. Minor/Significance Unknown.

                    • pirbuterol

                      sage increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • primidone

                      primidone and sage both increase sedation. Minor/Significance Unknown.

                      sage decreases effects of primidone by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • prochlorperazine

                      prochlorperazine and sage both increase sedation. Minor/Significance Unknown.

                    • promethazine

                      promethazine and sage both increase sedation. Minor/Significance Unknown.

                    • propylhexedrine

                      sage increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • protriptyline

                      protriptyline and sage both increase sedation. Minor/Significance Unknown.

                    • quazepam

                      quazepam and sage both increase sedation. Minor/Significance Unknown.

                    • quetiapine

                      quetiapine and sage both increase sedation. Minor/Significance Unknown.

                    • ramelteon

                      ramelteon and sage both increase sedation. Minor/Significance Unknown.

                    • repaglinide

                      sage increases effects of repaglinide by pharmacodynamic synergism. Minor/Significance Unknown.

                    • risperidone

                      risperidone and sage both increase sedation. Minor/Significance Unknown.

                    • rosiglitazone

                      sage increases effects of rosiglitazone by pharmacodynamic synergism. Minor/Significance Unknown.

                    • rufinamide

                      sage decreases effects of rufinamide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • salmeterol

                      sage increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • saxagliptin

                      sage increases effects of saxagliptin by pharmacodynamic synergism. Minor/Significance Unknown.

                    • scullcap

                      sage and scullcap both increase sedation. Minor/Significance Unknown.

                    • secobarbital

                      secobarbital and sage both increase sedation. Minor/Significance Unknown.

                    • shepherd's purse

                      sage and shepherd's purse both increase sedation. Minor/Significance Unknown.

                    • sitagliptin

                      sage increases effects of sitagliptin by pharmacodynamic synergism. Minor/Significance Unknown.

                    • sodium oxybate

                      sage and sodium oxybate both increase sedation. Minor/Significance Unknown.

                    • sufentanil

                      sufentanil and sage both increase sedation. Minor/Significance Unknown.

                    • tapentadol

                      tapentadol and sage both increase sedation. Minor/Significance Unknown.

                    • temazepam

                      temazepam and sage both increase sedation. Minor/Significance Unknown.

                    • terbutaline

                      sage increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • thioridazine

                      thioridazine and sage both increase sedation. Minor/Significance Unknown.

                    • thiothixene

                      thiothixene and sage both increase sedation. Minor/Significance Unknown.

                    • tiagabine

                      sage decreases effects of tiagabine by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • tolazamide

                      sage increases effects of tolazamide by pharmacodynamic synergism. Minor/Significance Unknown.

                    • tolbutamide

                      sage increases effects of tolbutamide by pharmacodynamic synergism. Minor/Significance Unknown.

                    • topiramate

                      sage decreases effects of topiramate by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • tramadol

                      tramadol and sage both increase sedation. Minor/Significance Unknown.

                    • trazodone

                      trazodone and sage both increase sedation. Minor/Significance Unknown.

                    • triazolam

                      triazolam and sage both increase sedation. Minor/Significance Unknown.

                    • triclofos

                      triclofos and sage both increase sedation. Minor/Significance Unknown.

                    • trifluoperazine

                      trifluoperazine and sage both increase sedation. Minor/Significance Unknown.

                    • trimipramine

                      trimipramine and sage both increase sedation. Minor/Significance Unknown.

                    • triprolidine

                      triprolidine and sage both increase sedation. Minor/Significance Unknown.

                    • valproic acid

                      sage decreases effects of valproic acid by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    • vildagliptin

                      sage increases effects of vildagliptin by pharmacodynamic synergism. Minor/Significance Unknown.

                    • xylometazoline

                      sage increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • yohimbine

                      sage increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • ziconotide

                      sage and ziconotide both increase sedation. Minor/Significance Unknown.

                    • ziprasidone

                      ziprasidone and sage both increase sedation. Minor/Significance Unknown.

                    • zonisamide

                      sage decreases effects of zonisamide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                    Previous
                    Next:

                    Adverse Effects

                    Headaches & irritability can occur when consuming excessive amounts of sage

                    Previous
                    Next:

                    Warnings

                    Contraindications

                    Hx of seizures

                    Epilepsy

                    Pregnancy (>amounts found in food)

                    Previous
                    Next:

                    Pregnancy & Lactation

                    Pregnancy Category: N/A

                    Lactation: N/A

                    Pregnancy Categories

                    A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                    B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                    C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                    D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                    X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                    NA: Information not available.

                    Previous
                    Next:

                    Pharmacology

                    Metabolism: N/A

                    Excretion: N/A

                    Mechanism of Action

                    Beta-thujone, a volatile oil occurs in significant amounts in sage

                    Previous
                    Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
                    Find Us On
                    About
                    About Medscape Privacy Policy Editorial Policy Cookies Terms of Use Advertising Policy Help Center
                    Membership
                    Become a Member About You Professional Information Newsletters & Alerts Market Research
                    App
                    Medscape
                    WebMD Network
                    Medscape Live Events WebMD MedicineNet eMedicineHealth RxList WebMD Corporate
                    Editions
                    English Deutsch Español Français Português
                    All material on this website is protected by copyright, Copyright © 1994-2022 by WebMD LLC. This website also contains material copyrighted by 3rd parties.