Suggested Dosing
Oral
Tincture: take 1/8 to 1/2 tspn dried sage leaves in a sip of water qDay/BID
Herbal Tea: drink several cups of sage tea qDay for several weeks
Gargle or take small sips of sage tea: PRN throughout day
Alzheimer's Disease
Salvia Officinalis Hydroalcoholic Extract: equivalent to 1 g sage PO qDay OR
Salvia Lavandulaefolia Extract: titrated up to 2.5 mg PO TID
Herpes Labialis
Topical cream: 23 mg/d of sage extract and rhubartd exract applied q 2-4hr x10-14 days
Suggested Uses
Treatment of alzheimer's disease and herpes labialis
Treatement of diarrhea, colds, and excessive perspiration
GI antispasmodic/antiflatulent, relieves abdominal cramps & bloating
Antibacterial/antimicrobial
Treatment for bright red, abundant uterine bleeding & cramps
May be of benefit for menopausal hot flashes accompanied by profuse perspiration
Treatment of coughs & tonsil or throat infections
Stop breast-milk production when weaning a child from breastfeeding
Hair rinse for dandruff, oily hair, or scalp infections; may restore color to gray or white hair
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (1)
- topiramate
sage and topiramate both increase sedation. Use Caution/Monitor.
Minor (204)
- acarbose
sage increases effects of acarbose by pharmacodynamic synergism. Minor/Significance Unknown.
- acetazolamide
sage decreases effects of acetazolamide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.
- albuterol
sage increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- alfentanil
alfentanil and sage both increase sedation. Minor/Significance Unknown.
- alprazolam
alprazolam and sage both increase sedation. Minor/Significance Unknown.
- amitriptyline
amitriptyline and sage both increase sedation. Minor/Significance Unknown.
- amobarbital
amobarbital and sage both increase sedation. Minor/Significance Unknown.
- amoxapine
amoxapine and sage both increase sedation. Minor/Significance Unknown.
- apomorphine
apomorphine and sage both increase sedation. Minor/Significance Unknown.
- arformoterol
sage increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- aripiprazole
aripiprazole and sage both increase sedation. Minor/Significance Unknown.
- armodafinil
sage increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- azelastine
azelastine and sage both increase sedation. Minor/Significance Unknown.
- baclofen
baclofen and sage both increase sedation. Minor/Significance Unknown.
- belladonna and opium
belladonna and opium and sage both increase sedation. Minor/Significance Unknown.
- benperidol
benperidol and sage both increase sedation. Minor/Significance Unknown.
- benzphetamine
sage increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- brompheniramine
brompheniramine and sage both increase sedation. Minor/Significance Unknown.
- buprenorphine
buprenorphine and sage both increase sedation. Minor/Significance Unknown.
- buprenorphine buccal
buprenorphine buccal and sage both increase sedation. Minor/Significance Unknown.
- butabarbital
butabarbital and sage both increase sedation. Minor/Significance Unknown.
- butalbital
butalbital and sage both increase sedation. Minor/Significance Unknown.
- butorphanol
butorphanol and sage both increase sedation. Minor/Significance Unknown.
- caffeine
sage increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- calcium/magnesium/potassium/sodium oxybates
sage and calcium/magnesium/potassium/sodium oxybates both increase sedation. Minor/Significance Unknown.
- carbamazepine
sage decreases effects of carbamazepine by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.
- carbinoxamine
carbinoxamine and sage both increase sedation. Minor/Significance Unknown.
- carisoprodol
carisoprodol and sage both increase sedation. Minor/Significance Unknown.
- chloral hydrate
chloral hydrate and sage both increase sedation. Minor/Significance Unknown.
- chlordiazepoxide
chlordiazepoxide and sage both increase sedation. Minor/Significance Unknown.
- chlorpheniramine
chlorpheniramine and sage both increase sedation. Minor/Significance Unknown.
- chlorpromazine
chlorpromazine and sage both increase sedation. Minor/Significance Unknown.
- chlorpropamide
sage increases effects of chlorpropamide by pharmacodynamic synergism. Minor/Significance Unknown.
- chlorzoxazone
chlorzoxazone and sage both increase sedation. Minor/Significance Unknown.
- cinnarizine
cinnarizine and sage both increase sedation. Minor/Significance Unknown.
- clemastine
clemastine and sage both increase sedation. Minor/Significance Unknown.
- clomipramine
clomipramine and sage both increase sedation. Minor/Significance Unknown.
- clonazepam
clonazepam and sage both increase sedation. Minor/Significance Unknown.
sage decreases effects of clonazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions. - clorazepate
clorazepate and sage both increase sedation. Minor/Significance Unknown.
- clozapine
clozapine and sage both increase sedation. Minor/Significance Unknown.
- codeine
codeine and sage both increase sedation. Minor/Significance Unknown.
- cyclizine
cyclizine and sage both increase sedation. Minor/Significance Unknown.
- cyclobenzaprine
cyclobenzaprine and sage both increase sedation. Minor/Significance Unknown.
- cyproheptadine
cyproheptadine and sage both increase sedation. Minor/Significance Unknown.
- dantrolene
dantrolene and sage both increase sedation. Minor/Significance Unknown.
- desipramine
desipramine and sage both increase sedation. Minor/Significance Unknown.
- dexchlorpheniramine
dexchlorpheniramine and sage both increase sedation. Minor/Significance Unknown.
- dexfenfluramine
sage increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- dexmedetomidine
dexmedetomidine and sage both increase sedation. Minor/Significance Unknown.
- dexmethylphenidate
sage increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- dextroamphetamine
sage increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- dextromoramide
dextromoramide and sage both increase sedation. Minor/Significance Unknown.
- diamorphine
diamorphine and sage both increase sedation. Minor/Significance Unknown.
- diazepam
diazepam and sage both increase sedation. Minor/Significance Unknown.
sage decreases effects of diazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions. - diethylpropion
sage increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- difenoxin hcl
difenoxin hcl and sage both increase sedation. Minor/Significance Unknown.
- dimenhydrinate
dimenhydrinate and sage both increase sedation. Minor/Significance Unknown.
- diphenhydramine
diphenhydramine and sage both increase sedation. Minor/Significance Unknown.
- diphenoxylate hcl
diphenoxylate hcl and sage both increase sedation. Minor/Significance Unknown.
- dipipanone
dipipanone and sage both increase sedation. Minor/Significance Unknown.
- dobutamine
sage increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- dopamine
sage increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- dopexamine
sage increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- doxepin
doxepin and sage both increase sedation. Minor/Significance Unknown.
- doxylamine
doxylamine and sage both increase sedation. Minor/Significance Unknown.
- droperidol
droperidol and sage both increase sedation. Minor/Significance Unknown.
- ephedrine
sage increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- epinephrine
sage increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- epinephrine racemic
sage increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- estazolam
estazolam and sage both increase sedation. Minor/Significance Unknown.
- ethanol
ethanol and sage both increase sedation. Minor/Significance Unknown.
- ethosuximide
sage decreases effects of ethosuximide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.
- etomidate
etomidate and sage both increase sedation. Minor/Significance Unknown.
- eucalyptus
eucalyptus and sage both increase sedation. Minor/Significance Unknown.
- felbamate
sage decreases effects of felbamate by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.
- fenfluramine
sage increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- fluphenazine
fluphenazine and sage both increase sedation. Minor/Significance Unknown.
- flurazepam
flurazepam and sage both increase sedation. Minor/Significance Unknown.
- formoterol
sage increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- fosphenytoin
sage decreases effects of fosphenytoin by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.
- gabapentin
sage decreases effects of gabapentin by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.
- gabapentin enacarbil
sage decreases effects of gabapentin enacarbil by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.
- glimepiride
sage increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown.
- glipizide
sage increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
- glyburide
sage increases effects of glyburide by pharmacodynamic synergism. Minor/Significance Unknown.
- haloperidol
haloperidol and sage both increase sedation. Minor/Significance Unknown.
- hydromorphone
hydromorphone and sage both increase sedation. Minor/Significance Unknown.
- hydroxyzine
hydroxyzine and sage both increase sedation. Minor/Significance Unknown.
- iloperidone
iloperidone and sage both increase sedation. Minor/Significance Unknown.
- imipramine
imipramine and sage both increase sedation. Minor/Significance Unknown.
- insulin aspart
sage increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown.
- insulin detemir
sage increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown.
- insulin glargine
sage increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown.
- insulin glulisine
sage increases effects of insulin glulisine by pharmacodynamic synergism. Minor/Significance Unknown.
- insulin lispro
sage increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown.
- insulin NPH
sage increases effects of insulin NPH by pharmacodynamic synergism. Minor/Significance Unknown.
- insulin regular human
sage increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown.
- isoproterenol
sage increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- ketotifen, ophthalmic
ketotifen, ophthalmic and sage both increase sedation. Minor/Significance Unknown.
- lacosamide
sage decreases effects of lacosamide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.
- lamotrigine
sage decreases effects of lamotrigine by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.
- levalbuterol
sage increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- levetiracetam
sage decreases effects of levetiracetam by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.
- levorphanol
levorphanol and sage both increase sedation. Minor/Significance Unknown.
- lisdexamfetamine
sage increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- lofepramine
lofepramine and sage both increase sedation. Minor/Significance Unknown.
- lofexidine
lofexidine and sage both increase sedation. Minor/Significance Unknown.
- loprazolam
loprazolam and sage both increase sedation. Minor/Significance Unknown.
- lorazepam
lorazepam and sage both increase sedation. Minor/Significance Unknown.
sage decreases effects of lorazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions. - lormetazepam
lormetazepam and sage both increase sedation. Minor/Significance Unknown.
- loxapine
loxapine and sage both increase sedation. Minor/Significance Unknown.
- loxapine inhaled
loxapine inhaled and sage both increase sedation. Minor/Significance Unknown.
- maprotiline
maprotiline and sage both increase sedation. Minor/Significance Unknown.
- marijuana
marijuana and sage both increase sedation. Minor/Significance Unknown.
- melatonin
melatonin and sage both increase sedation. Minor/Significance Unknown.
- meperidine
meperidine and sage both increase sedation. Minor/Significance Unknown.
- meprobamate
meprobamate and sage both increase sedation. Minor/Significance Unknown.
- metaproterenol
sage increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- metaxalone
metaxalone and sage both increase sedation. Minor/Significance Unknown.
- metformin
sage increases effects of metformin by pharmacodynamic synergism. Minor/Significance Unknown.
- methadone
methadone and sage both increase sedation. Minor/Significance Unknown.
- methamphetamine
sage increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- methocarbamol
methocarbamol and sage both increase sedation. Minor/Significance Unknown.
- methsuximide
sage decreases effects of methsuximide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.
- methylenedioxymethamphetamine
sage increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- midazolam
midazolam and sage both increase sedation. Minor/Significance Unknown.
- midodrine
sage increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- miglitol
sage increases effects of miglitol by pharmacodynamic synergism. Minor/Significance Unknown.
- mirtazapine
mirtazapine and sage both increase sedation. Minor/Significance Unknown.
- modafinil
sage increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- morphine
morphine and sage both increase sedation. Minor/Significance Unknown.
- motherwort
motherwort and sage both increase sedation. Minor/Significance Unknown.
- moxonidine
moxonidine and sage both increase sedation. Minor/Significance Unknown.
- nabilone
nabilone and sage both increase sedation. Minor/Significance Unknown.
- nalbuphine
nalbuphine and sage both increase sedation. Minor/Significance Unknown.
- nateglinide
sage increases effects of nateglinide by pharmacodynamic synergism. Minor/Significance Unknown.
- norepinephrine
sage increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- nortriptyline
nortriptyline and sage both increase sedation. Minor/Significance Unknown.
- olanzapine
olanzapine and sage both increase sedation. Minor/Significance Unknown.
- opium tincture
opium tincture and sage both increase sedation. Minor/Significance Unknown.
- orphenadrine
orphenadrine and sage both increase sedation. Minor/Significance Unknown.
- oxazepam
oxazepam and sage both increase sedation. Minor/Significance Unknown.
- oxcarbazepine
sage decreases effects of oxcarbazepine by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.
- oxycodone
oxycodone and sage both increase sedation. Minor/Significance Unknown.
- oxymorphone
oxymorphone and sage both increase sedation. Minor/Significance Unknown.
- paliperidone
paliperidone and sage both increase sedation. Minor/Significance Unknown.
- papaveretum
papaveretum and sage both increase sedation. Minor/Significance Unknown.
- papaverine
papaverine and sage both increase sedation. Minor/Significance Unknown.
- pentazocine
pentazocine and sage both increase sedation. Minor/Significance Unknown.
- pentobarbital
pentobarbital and sage both increase sedation. Minor/Significance Unknown.
- perphenazine
perphenazine and sage both increase sedation. Minor/Significance Unknown.
- phendimetrazine
sage increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- phenobarbital
phenobarbital and sage both increase sedation. Minor/Significance Unknown.
sage decreases effects of phenobarbital by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions. - phentermine
sage increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- phenylephrine
sage increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- phenylephrine PO
sage increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown. .
- phenytoin
sage decreases effects of phenytoin by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.
- pholcodine
pholcodine and sage both increase sedation. Minor/Significance Unknown.
- pimozide
pimozide and sage both increase sedation. Minor/Significance Unknown.
- pioglitazone
sage increases effects of pioglitazone by pharmacodynamic synergism. Minor/Significance Unknown.
- pirbuterol
sage increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- primidone
primidone and sage both increase sedation. Minor/Significance Unknown.
sage decreases effects of primidone by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions. - prochlorperazine
prochlorperazine and sage both increase sedation. Minor/Significance Unknown.
- promethazine
promethazine and sage both increase sedation. Minor/Significance Unknown.
- propylhexedrine
sage increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- protriptyline
protriptyline and sage both increase sedation. Minor/Significance Unknown.
- quazepam
quazepam and sage both increase sedation. Minor/Significance Unknown.
- quetiapine
quetiapine and sage both increase sedation. Minor/Significance Unknown.
- ramelteon
ramelteon and sage both increase sedation. Minor/Significance Unknown.
- repaglinide
sage increases effects of repaglinide by pharmacodynamic synergism. Minor/Significance Unknown.
- risperidone
risperidone and sage both increase sedation. Minor/Significance Unknown.
- rosiglitazone
sage increases effects of rosiglitazone by pharmacodynamic synergism. Minor/Significance Unknown.
- rufinamide
sage decreases effects of rufinamide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.
- salmeterol
sage increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- saxagliptin
sage increases effects of saxagliptin by pharmacodynamic synergism. Minor/Significance Unknown.
- scullcap
sage and scullcap both increase sedation. Minor/Significance Unknown.
- secobarbital
secobarbital and sage both increase sedation. Minor/Significance Unknown.
- shepherd's purse
sage and shepherd's purse both increase sedation. Minor/Significance Unknown.
- sitagliptin
sage increases effects of sitagliptin by pharmacodynamic synergism. Minor/Significance Unknown.
- sodium oxybate
sage and sodium oxybate both increase sedation. Minor/Significance Unknown.
- sufentanil
sufentanil and sage both increase sedation. Minor/Significance Unknown.
- tapentadol
tapentadol and sage both increase sedation. Minor/Significance Unknown.
- temazepam
temazepam and sage both increase sedation. Minor/Significance Unknown.
- terbutaline
sage increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- thioridazine
thioridazine and sage both increase sedation. Minor/Significance Unknown.
- thiothixene
thiothixene and sage both increase sedation. Minor/Significance Unknown.
- tiagabine
sage decreases effects of tiagabine by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.
- tolazamide
sage increases effects of tolazamide by pharmacodynamic synergism. Minor/Significance Unknown.
- tolbutamide
sage increases effects of tolbutamide by pharmacodynamic synergism. Minor/Significance Unknown.
- topiramate
sage decreases effects of topiramate by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.
- tramadol
tramadol and sage both increase sedation. Minor/Significance Unknown.
- trazodone
trazodone and sage both increase sedation. Minor/Significance Unknown.
- triazolam
triazolam and sage both increase sedation. Minor/Significance Unknown.
- triclofos
triclofos and sage both increase sedation. Minor/Significance Unknown.
- trifluoperazine
trifluoperazine and sage both increase sedation. Minor/Significance Unknown.
- trimipramine
trimipramine and sage both increase sedation. Minor/Significance Unknown.
- triprolidine
triprolidine and sage both increase sedation. Minor/Significance Unknown.
- valproic acid
sage decreases effects of valproic acid by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.
- vildagliptin
sage increases effects of vildagliptin by pharmacodynamic synergism. Minor/Significance Unknown.
- xylometazoline
sage increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- yohimbine
sage increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
- ziconotide
sage and ziconotide both increase sedation. Minor/Significance Unknown.
- ziprasidone
ziprasidone and sage both increase sedation. Minor/Significance Unknown.
- zonisamide
sage decreases effects of zonisamide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.
Adverse Effects
Headaches & irritability can occur when consuming excessive amounts of sage
Warnings
Contraindications
Hx of seizures
Epilepsy
Pregnancy (>amounts found in food)
Pregnancy & Lactation
Pregnancy Category: N/A
Lactation: N/A
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Metabolism: N/A
Excretion: N/A
Mechanism of Action
Beta-thujone, a volatile oil occurs in significant amounts in sage