Sage (Herb/Suppl)

Brand and Other Names:common sage, culinary sage, more...garden sage, meadow sage, salvia officinalis, true sage
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Suggested Dosing

Oral

Tincture: take 1/8 to 1/2 tspn dried sage leaves in a sip of water qDay/BID

Herbal Tea: drink several cups of sage tea qDay for several weeks

Gargle or take small sips of sage tea: PRN throughout day

Alzheimer's Disease

Salvia Officinalis Hydroalcoholic Extract: equivalent to 1 g sage PO qDay OR

Salvia Lavandulaefolia Extract: titrated up to 2.5 mg PO TID

Herpes Labialis

Topical cream: 23 mg/d of sage extract and rhubartd exract applied q 2-4hr x10-14 days

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Suggested Uses

Treatment of alzheimer's disease and herpes labialis

Treatement of diarrhea, colds, and excessive perspiration

GI antispasmodic/antiflatulent, relieves abdominal cramps & bloating

Antibacterial/antimicrobial

Treatment for bright red, abundant uterine bleeding & cramps

May be of benefit for menopausal hot flashes accompanied by profuse perspiration

Treatment of coughs & tonsil or throat infections

Stop breast-milk production when weaning a child from breastfeeding

Hair rinse for dandruff, oily hair, or scalp infections; may restore color to gray or white hair

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Interactions

Interaction Checker

and Sage

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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

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            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (1)

                • topiramate

                  sage and topiramate both increase sedation. Use Caution/Monitor.

                Minor (204)

                • acarbose

                  sage increases effects of acarbose by pharmacodynamic synergism. Minor/Significance Unknown.

                • acetazolamide

                  sage decreases effects of acetazolamide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • albuterol

                  sage increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • alfentanil

                  alfentanil and sage both increase sedation. Minor/Significance Unknown.

                • alprazolam

                  alprazolam and sage both increase sedation. Minor/Significance Unknown.

                • amitriptyline

                  amitriptyline and sage both increase sedation. Minor/Significance Unknown.

                • amobarbital

                  amobarbital and sage both increase sedation. Minor/Significance Unknown.

                • amoxapine

                  amoxapine and sage both increase sedation. Minor/Significance Unknown.

                • apomorphine

                  apomorphine and sage both increase sedation. Minor/Significance Unknown.

                • arformoterol

                  sage increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • aripiprazole

                  aripiprazole and sage both increase sedation. Minor/Significance Unknown.

                • armodafinil

                  sage increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • azelastine

                  azelastine and sage both increase sedation. Minor/Significance Unknown.

                • baclofen

                  baclofen and sage both increase sedation. Minor/Significance Unknown.

                • belladonna and opium

                  belladonna and opium and sage both increase sedation. Minor/Significance Unknown.

                • benperidol

                  benperidol and sage both increase sedation. Minor/Significance Unknown.

                • benzphetamine

                  sage increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • brompheniramine

                  brompheniramine and sage both increase sedation. Minor/Significance Unknown.

                • buprenorphine

                  buprenorphine and sage both increase sedation. Minor/Significance Unknown.

                • buprenorphine buccal

                  buprenorphine buccal and sage both increase sedation. Minor/Significance Unknown.

                • butabarbital

                  butabarbital and sage both increase sedation. Minor/Significance Unknown.

                • butalbital

                  butalbital and sage both increase sedation. Minor/Significance Unknown.

                • butorphanol

                  butorphanol and sage both increase sedation. Minor/Significance Unknown.

                • caffeine

                  sage increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • calcium/magnesium/potassium/sodium oxybates

                  sage and calcium/magnesium/potassium/sodium oxybates both increase sedation. Minor/Significance Unknown.

                • carbamazepine

                  sage decreases effects of carbamazepine by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • carbinoxamine

                  carbinoxamine and sage both increase sedation. Minor/Significance Unknown.

                • carisoprodol

                  carisoprodol and sage both increase sedation. Minor/Significance Unknown.

                • chloral hydrate

                  chloral hydrate and sage both increase sedation. Minor/Significance Unknown.

                • chlordiazepoxide

                  chlordiazepoxide and sage both increase sedation. Minor/Significance Unknown.

                • chlorpheniramine

                  chlorpheniramine and sage both increase sedation. Minor/Significance Unknown.

                • chlorpromazine

                  chlorpromazine and sage both increase sedation. Minor/Significance Unknown.

                • chlorpropamide

                  sage increases effects of chlorpropamide by pharmacodynamic synergism. Minor/Significance Unknown.

                • chlorzoxazone

                  chlorzoxazone and sage both increase sedation. Minor/Significance Unknown.

                • cinnarizine

                  cinnarizine and sage both increase sedation. Minor/Significance Unknown.

                • clemastine

                  clemastine and sage both increase sedation. Minor/Significance Unknown.

                • clomipramine

                  clomipramine and sage both increase sedation. Minor/Significance Unknown.

                • clonazepam

                  clonazepam and sage both increase sedation. Minor/Significance Unknown.

                  sage decreases effects of clonazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • clorazepate

                  clorazepate and sage both increase sedation. Minor/Significance Unknown.

                • clozapine

                  clozapine and sage both increase sedation. Minor/Significance Unknown.

                • codeine

                  codeine and sage both increase sedation. Minor/Significance Unknown.

                • cyclizine

                  cyclizine and sage both increase sedation. Minor/Significance Unknown.

                • cyclobenzaprine

                  cyclobenzaprine and sage both increase sedation. Minor/Significance Unknown.

                • cyproheptadine

                  cyproheptadine and sage both increase sedation. Minor/Significance Unknown.

                • dantrolene

                  dantrolene and sage both increase sedation. Minor/Significance Unknown.

                • desipramine

                  desipramine and sage both increase sedation. Minor/Significance Unknown.

                • dexchlorpheniramine

                  dexchlorpheniramine and sage both increase sedation. Minor/Significance Unknown.

                • dexfenfluramine

                  sage increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • dexmedetomidine

                  dexmedetomidine and sage both increase sedation. Minor/Significance Unknown.

                • dexmethylphenidate

                  sage increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • dextroamphetamine

                  sage increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • dextromoramide

                  dextromoramide and sage both increase sedation. Minor/Significance Unknown.

                • diamorphine

                  diamorphine and sage both increase sedation. Minor/Significance Unknown.

                • diazepam

                  diazepam and sage both increase sedation. Minor/Significance Unknown.

                  sage decreases effects of diazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • diethylpropion

                  sage increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • difenoxin hcl

                  difenoxin hcl and sage both increase sedation. Minor/Significance Unknown.

                • dimenhydrinate

                  dimenhydrinate and sage both increase sedation. Minor/Significance Unknown.

                • diphenhydramine

                  diphenhydramine and sage both increase sedation. Minor/Significance Unknown.

                • diphenoxylate hcl

                  diphenoxylate hcl and sage both increase sedation. Minor/Significance Unknown.

                • dipipanone

                  dipipanone and sage both increase sedation. Minor/Significance Unknown.

                • dobutamine

                  sage increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • dopamine

                  sage increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • dopexamine

                  sage increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • doxepin

                  doxepin and sage both increase sedation. Minor/Significance Unknown.

                • doxylamine

                  doxylamine and sage both increase sedation. Minor/Significance Unknown.

                • droperidol

                  droperidol and sage both increase sedation. Minor/Significance Unknown.

                • ephedrine

                  sage increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • epinephrine

                  sage increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • epinephrine racemic

                  sage increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • estazolam

                  estazolam and sage both increase sedation. Minor/Significance Unknown.

                • ethanol

                  ethanol and sage both increase sedation. Minor/Significance Unknown.

                • ethosuximide

                  sage decreases effects of ethosuximide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • etomidate

                  etomidate and sage both increase sedation. Minor/Significance Unknown.

                • eucalyptus

                  eucalyptus and sage both increase sedation. Minor/Significance Unknown.

                • felbamate

                  sage decreases effects of felbamate by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • fenfluramine

                  sage increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • fluphenazine

                  fluphenazine and sage both increase sedation. Minor/Significance Unknown.

                • flurazepam

                  flurazepam and sage both increase sedation. Minor/Significance Unknown.

                • formoterol

                  sage increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • fosphenytoin

                  sage decreases effects of fosphenytoin by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • gabapentin

                  sage decreases effects of gabapentin by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • gabapentin enacarbil

                  sage decreases effects of gabapentin enacarbil by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • glimepiride

                  sage increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown.

                • glipizide

                  sage increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.

                • glyburide

                  sage increases effects of glyburide by pharmacodynamic synergism. Minor/Significance Unknown.

                • haloperidol

                  haloperidol and sage both increase sedation. Minor/Significance Unknown.

                • hydromorphone

                  hydromorphone and sage both increase sedation. Minor/Significance Unknown.

                • hydroxyzine

                  hydroxyzine and sage both increase sedation. Minor/Significance Unknown.

                • iloperidone

                  iloperidone and sage both increase sedation. Minor/Significance Unknown.

                • imipramine

                  imipramine and sage both increase sedation. Minor/Significance Unknown.

                • insulin aspart

                  sage increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown.

                • insulin detemir

                  sage increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown.

                • insulin glargine

                  sage increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown.

                • insulin glulisine

                  sage increases effects of insulin glulisine by pharmacodynamic synergism. Minor/Significance Unknown.

                • insulin lispro

                  sage increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown.

                • insulin NPH

                  sage increases effects of insulin NPH by pharmacodynamic synergism. Minor/Significance Unknown.

                • insulin regular human

                  sage increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown.

                • isoproterenol

                  sage increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • ketotifen, ophthalmic

                  ketotifen, ophthalmic and sage both increase sedation. Minor/Significance Unknown.

                • lacosamide

                  sage decreases effects of lacosamide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • lamotrigine

                  sage decreases effects of lamotrigine by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • levalbuterol

                  sage increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • levetiracetam

                  sage decreases effects of levetiracetam by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • levorphanol

                  levorphanol and sage both increase sedation. Minor/Significance Unknown.

                • lisdexamfetamine

                  sage increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • lofepramine

                  lofepramine and sage both increase sedation. Minor/Significance Unknown.

                • lofexidine

                  lofexidine and sage both increase sedation. Minor/Significance Unknown.

                • loprazolam

                  loprazolam and sage both increase sedation. Minor/Significance Unknown.

                • lorazepam

                  lorazepam and sage both increase sedation. Minor/Significance Unknown.

                  sage decreases effects of lorazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • lormetazepam

                  lormetazepam and sage both increase sedation. Minor/Significance Unknown.

                • loxapine

                  loxapine and sage both increase sedation. Minor/Significance Unknown.

                • loxapine inhaled

                  loxapine inhaled and sage both increase sedation. Minor/Significance Unknown.

                • maprotiline

                  maprotiline and sage both increase sedation. Minor/Significance Unknown.

                • marijuana

                  marijuana and sage both increase sedation. Minor/Significance Unknown.

                • melatonin

                  melatonin and sage both increase sedation. Minor/Significance Unknown.

                • meperidine

                  meperidine and sage both increase sedation. Minor/Significance Unknown.

                • meprobamate

                  meprobamate and sage both increase sedation. Minor/Significance Unknown.

                • metaproterenol

                  sage increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • metaxalone

                  metaxalone and sage both increase sedation. Minor/Significance Unknown.

                • metformin

                  sage increases effects of metformin by pharmacodynamic synergism. Minor/Significance Unknown.

                • methadone

                  methadone and sage both increase sedation. Minor/Significance Unknown.

                • methamphetamine

                  sage increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • methocarbamol

                  methocarbamol and sage both increase sedation. Minor/Significance Unknown.

                • methsuximide

                  sage decreases effects of methsuximide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • methylenedioxymethamphetamine

                  sage increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • midazolam

                  midazolam and sage both increase sedation. Minor/Significance Unknown.

                • midodrine

                  sage increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • miglitol

                  sage increases effects of miglitol by pharmacodynamic synergism. Minor/Significance Unknown.

                • mirtazapine

                  mirtazapine and sage both increase sedation. Minor/Significance Unknown.

                • modafinil

                  sage increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • morphine

                  morphine and sage both increase sedation. Minor/Significance Unknown.

                • motherwort

                  motherwort and sage both increase sedation. Minor/Significance Unknown.

                • moxonidine

                  moxonidine and sage both increase sedation. Minor/Significance Unknown.

                • nabilone

                  nabilone and sage both increase sedation. Minor/Significance Unknown.

                • nalbuphine

                  nalbuphine and sage both increase sedation. Minor/Significance Unknown.

                • nateglinide

                  sage increases effects of nateglinide by pharmacodynamic synergism. Minor/Significance Unknown.

                • norepinephrine

                  sage increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • nortriptyline

                  nortriptyline and sage both increase sedation. Minor/Significance Unknown.

                • olanzapine

                  olanzapine and sage both increase sedation. Minor/Significance Unknown.

                • opium tincture

                  opium tincture and sage both increase sedation. Minor/Significance Unknown.

                • orphenadrine

                  orphenadrine and sage both increase sedation. Minor/Significance Unknown.

                • oxazepam

                  oxazepam and sage both increase sedation. Minor/Significance Unknown.

                • oxcarbazepine

                  sage decreases effects of oxcarbazepine by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • oxycodone

                  oxycodone and sage both increase sedation. Minor/Significance Unknown.

                • oxymorphone

                  oxymorphone and sage both increase sedation. Minor/Significance Unknown.

                • paliperidone

                  paliperidone and sage both increase sedation. Minor/Significance Unknown.

                • papaveretum

                  papaveretum and sage both increase sedation. Minor/Significance Unknown.

                • papaverine

                  papaverine and sage both increase sedation. Minor/Significance Unknown.

                • pentazocine

                  pentazocine and sage both increase sedation. Minor/Significance Unknown.

                • pentobarbital

                  pentobarbital and sage both increase sedation. Minor/Significance Unknown.

                • perphenazine

                  perphenazine and sage both increase sedation. Minor/Significance Unknown.

                • phendimetrazine

                  sage increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • phenobarbital

                  phenobarbital and sage both increase sedation. Minor/Significance Unknown.

                  sage decreases effects of phenobarbital by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • phentermine

                  sage increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • phenylephrine

                  sage increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • phenylephrine PO

                  sage increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown. .

                • phenytoin

                  sage decreases effects of phenytoin by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • pholcodine

                  pholcodine and sage both increase sedation. Minor/Significance Unknown.

                • pimozide

                  pimozide and sage both increase sedation. Minor/Significance Unknown.

                • pioglitazone

                  sage increases effects of pioglitazone by pharmacodynamic synergism. Minor/Significance Unknown.

                • pirbuterol

                  sage increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • primidone

                  primidone and sage both increase sedation. Minor/Significance Unknown.

                  sage decreases effects of primidone by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • prochlorperazine

                  prochlorperazine and sage both increase sedation. Minor/Significance Unknown.

                • promethazine

                  promethazine and sage both increase sedation. Minor/Significance Unknown.

                • propylhexedrine

                  sage increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • protriptyline

                  protriptyline and sage both increase sedation. Minor/Significance Unknown.

                • quazepam

                  quazepam and sage both increase sedation. Minor/Significance Unknown.

                • quetiapine

                  quetiapine and sage both increase sedation. Minor/Significance Unknown.

                • ramelteon

                  ramelteon and sage both increase sedation. Minor/Significance Unknown.

                • repaglinide

                  sage increases effects of repaglinide by pharmacodynamic synergism. Minor/Significance Unknown.

                • risperidone

                  risperidone and sage both increase sedation. Minor/Significance Unknown.

                • rosiglitazone

                  sage increases effects of rosiglitazone by pharmacodynamic synergism. Minor/Significance Unknown.

                • rufinamide

                  sage decreases effects of rufinamide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • salmeterol

                  sage increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • saxagliptin

                  sage increases effects of saxagliptin by pharmacodynamic synergism. Minor/Significance Unknown.

                • scullcap

                  sage and scullcap both increase sedation. Minor/Significance Unknown.

                • secobarbital

                  secobarbital and sage both increase sedation. Minor/Significance Unknown.

                • shepherd's purse

                  sage and shepherd's purse both increase sedation. Minor/Significance Unknown.

                • sitagliptin

                  sage increases effects of sitagliptin by pharmacodynamic synergism. Minor/Significance Unknown.

                • sodium oxybate

                  sage and sodium oxybate both increase sedation. Minor/Significance Unknown.

                • sufentanil

                  sufentanil and sage both increase sedation. Minor/Significance Unknown.

                • tapentadol

                  tapentadol and sage both increase sedation. Minor/Significance Unknown.

                • temazepam

                  temazepam and sage both increase sedation. Minor/Significance Unknown.

                • terbutaline

                  sage increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • thioridazine

                  thioridazine and sage both increase sedation. Minor/Significance Unknown.

                • thiothixene

                  thiothixene and sage both increase sedation. Minor/Significance Unknown.

                • tiagabine

                  sage decreases effects of tiagabine by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • tolazamide

                  sage increases effects of tolazamide by pharmacodynamic synergism. Minor/Significance Unknown.

                • tolbutamide

                  sage increases effects of tolbutamide by pharmacodynamic synergism. Minor/Significance Unknown.

                • topiramate

                  sage decreases effects of topiramate by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • tramadol

                  tramadol and sage both increase sedation. Minor/Significance Unknown.

                • trazodone

                  trazodone and sage both increase sedation. Minor/Significance Unknown.

                • triazolam

                  triazolam and sage both increase sedation. Minor/Significance Unknown.

                • triclofos

                  triclofos and sage both increase sedation. Minor/Significance Unknown.

                • trifluoperazine

                  trifluoperazine and sage both increase sedation. Minor/Significance Unknown.

                • trimipramine

                  trimipramine and sage both increase sedation. Minor/Significance Unknown.

                • triprolidine

                  triprolidine and sage both increase sedation. Minor/Significance Unknown.

                • valproic acid

                  sage decreases effects of valproic acid by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

                • vildagliptin

                  sage increases effects of vildagliptin by pharmacodynamic synergism. Minor/Significance Unknown.

                • xylometazoline

                  sage increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • yohimbine

                  sage increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • ziconotide

                  sage and ziconotide both increase sedation. Minor/Significance Unknown.

                • ziprasidone

                  ziprasidone and sage both increase sedation. Minor/Significance Unknown.

                • zonisamide

                  sage decreases effects of zonisamide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.

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                Adverse Effects

                Headaches & irritability can occur when consuming excessive amounts of sage

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                Warnings

                Contraindications

                Hx of seizures

                Epilepsy

                Pregnancy (>amounts found in food)

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                Pregnancy & Lactation

                Pregnancy Category: N/A

                Lactation: N/A

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Metabolism: N/A

                Excretion: N/A

                Mechanism of Action

                Beta-thujone, a volatile oil occurs in significant amounts in sage

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.