Indication-specific dosing for Convallaria majalis, Jacob's Ladder, May Bells, May Lily (lily of the valley), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

Sections

Sections Lily Of The Valley
Suggested Dosing
Suggested Uses
Interactions
Warnings
Pregnancy
Pharmacology

Suggested Dosing

Cardiac Glycosides

Insufficient reliable evidence available for effectiveness

600 mg/day PO average amount

Tincture: 6 g/day divided TID PO

Liquid extract: 600 mg/day divided TID PO

Dried extract: 150 mg/day PO

Suggested Uses

Circulatory disorders, heart palpitations, arrhythmia, CHF, cardiac edema, cardiac asthma, kidney and bladder stones, UTI

Efficacy

Contains cardiac glycosides similar to those in digitalis

Interaction Checker

Enter a drug name and Lily Of The Valley

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No Interactions Found

Interactions Found

Contraindicated

Serious - Use Alternative

Significant - Monitor Closely

Minor

All Interactions Sort By:

Contraindicated (0)

Serious - Use Alternative (1)

digoxin
digoxin, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated.

Monitor Closely (13)

bendroflumethiazide
bendroflumethiazide increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
bumetanide
bumetanide increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
chlorothiazide
chlorothiazide increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
chlorthalidone
chlorthalidone increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
cyclopenthiazide
cyclopenthiazide increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
ethacrynic acid
ethacrynic acid increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
furosemide
furosemide increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
hydrochlorothiazide
hydrochlorothiazide increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
indapamide
indapamide increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
methyclothiazide
methyclothiazide increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
metolazone
metolazone increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
senna
senna increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
torsemide
torsemide increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.

Minor (23)

acebutolol
acebutolol, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
adenosine
adenosine, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
amiodarone
amiodarone, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
calcium acetate
calcium acetate increases effects of lily of the valley by unspecified interaction mechanism. Minor/Significance Unknown.
calcium carbonate
calcium carbonate increases effects of lily of the valley by unspecified interaction mechanism. Minor/Significance Unknown.
calcium chloride
calcium chloride increases effects of lily of the valley by unspecified interaction mechanism. Minor/Significance Unknown.
calcium citrate
calcium citrate increases effects of lily of the valley by unspecified interaction mechanism. Minor/Significance Unknown.
calcium gluconate
calcium gluconate increases effects of lily of the valley by unspecified interaction mechanism. Minor/Significance Unknown.
diltiazem
diltiazem, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
disopyramide
disopyramide, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
encainide
encainide, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
esmolol
esmolol, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
flecainide
flecainide, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
ibutilide
ibutilide, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
lidocaine
lidocaine, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
mexiletine
mexiletine, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
phenytoin
phenytoin, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
procainamide
procainamide, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
propafenone
propafenone, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
propranolol
propranolol, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
quinidine
quinidine, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
sotalol
sotalol, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
verapamil
verapamil, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.

acebutolol
Minor (1)acebutolol, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
adenosine
Minor (1)adenosine, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
amiodarone
Minor (1)amiodarone, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
bendroflumethiazide
Monitor Closely (1)bendroflumethiazide increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
bumetanide
Monitor Closely (1)bumetanide increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
calcium acetate
Minor (1)calcium acetate increases effects of lily of the valley by unspecified interaction mechanism. Minor/Significance Unknown.
calcium carbonate
Minor (1)calcium carbonate increases effects of lily of the valley by unspecified interaction mechanism. Minor/Significance Unknown.
calcium chloride
Minor (1)calcium chloride increases effects of lily of the valley by unspecified interaction mechanism. Minor/Significance Unknown.
calcium citrate
Minor (1)calcium citrate increases effects of lily of the valley by unspecified interaction mechanism. Minor/Significance Unknown.
calcium gluconate
Minor (1)calcium gluconate increases effects of lily of the valley by unspecified interaction mechanism. Minor/Significance Unknown.
chlorothiazide
Monitor Closely (1)chlorothiazide increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
chlorthalidone
Monitor Closely (1)chlorthalidone increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
cyclopenthiazide
Monitor Closely (1)cyclopenthiazide increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
digoxin
Serious - Use Alternative (1)digoxin, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated.
diltiazem
Minor (1)diltiazem, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
disopyramide
Minor (1)disopyramide, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
encainide
Minor (1)encainide, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
esmolol
Minor (1)esmolol, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
ethacrynic acid
Monitor Closely (1)ethacrynic acid increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
flecainide
Minor (1)flecainide, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
furosemide
Monitor Closely (1)furosemide increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
hydrochlorothiazide
Monitor Closely (1)hydrochlorothiazide increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
ibutilide
Minor (1)ibutilide, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
indapamide
Monitor Closely (1)indapamide increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
lidocaine
Minor (1)lidocaine, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
methyclothiazide
Monitor Closely (1)methyclothiazide increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
metolazone
Monitor Closely (1)metolazone increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
mexiletine
Minor (1)mexiletine, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
phenytoin
Minor (1)phenytoin, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
procainamide
Minor (1)procainamide, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
propafenone
Minor (1)propafenone, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
propranolol
Minor (1)propranolol, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
quinidine
Minor (1)quinidine, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
senna
Monitor Closely (1)senna increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
sotalol
Minor (1)sotalol, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.
torsemide
Monitor Closely (1)torsemide increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
verapamil
Minor (1)verapamil, lily of the valley. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown.

Contraindications

High BP, kidney/liver disease, potassium deficiency

Pregnancy

Cautions

Use only under qualified supervision: potentially fatal if overdosed

Taking more than recommended dose may cause nausea, vomiting, headache, stupor, disorders of color perception, and irregular heartbeat

Pregnancy & Lactation

Pregnancy Category: avoid

Lactation: N/A

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Cardiac glycosides increase force and power of heartbeat without increasing amount of oxygen required by cardiac muscle

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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Sections Lily Of The Valley
Suggested Dosing
Suggested Uses
Interactions
Warnings
Pregnancy
Pharmacology

Lily Of The Valley (Herb/Suppl)