copper (Rx, OTC)

Brand and Other Names:

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsule

  • 5mg

tablet

  • 5mg

solution (iv)

  • 0.4mg/mL (10mL)

Dietary Supplement

2-5 mg PO qDay or more; not to exceed 8 mg/day

Alternatively (parenteral nutrition): 0.3-0.5 mg/day IV or 0.5-1.5 mg/day IV (per manufacturer)

High Output Fistula

  • May use twice the recommended daily allowance

RDA

  • Males: 900 mcg/day
  • Females: 900 mcg/day
  • Pregnant: 1,000 mcg/day
  • Nursing: 1,300 mcg/day
  • UL (>19 years old): 10,000 mcg/day

Keratoconus (Orphan)

Orphan designation for treatment of keratoconus

Sponsor

  • iVeena Drug Delivery Systems, Inc; 391 Chipeta Way, Suite I; Salt Lake City, Utah 84108

Dosage Forms & Strengths

capsule

  • 5mg

tablet

  • 5mg

solution (iv)

  • 0.4mg/mL (10mL)

Dietary Supplement

Parenteral nutrition: 20 mcg copper/kg/day IV

RDA

  • 0-6 months old: 200 mcg/day
  • 7-12 months old: 220 mcg/day
  • 1-3 years old: 340 mcg/day
  • 3-8 years old: 440 mcg/day
  • 8-13 years old: 700 mcg/day
  • 13-18 years old: (Male, Female) 890 mcg/day
Next:

Interactions

Interaction Checker

and copper

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (1)

              • baloxavir marboxil

                copper will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Avoid or Use Alternate Drug. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Human studies not conducted.

              Monitor Closely (3)

              • omadacycline

                copper will decrease the level or effect of omadacycline by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Separate dosing of tetracyclines from these products.

              • penicillamine

                copper decreases effects of penicillamine by pharmacodynamic antagonism. Use Caution/Monitor.

              • sarecycline

                copper will decrease the level or effect of sarecycline by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Separate dosing of tetracyclines from these products.

              Minor (3)

              • ascorbic acid

                ascorbic acid decreases levels of copper by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

              • rose hips

                rose hips decreases levels of copper by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

              • trientine

                trientine decreases levels of copper by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown. Indicated action (for Wilson's disease).

              Previous
              Next:

              Adverse Effects

              Frequency Not Defined

              Nausea/vomiting (10-60 mg dose)

              Hepatic dysfunction including necrosis

              Previous
              Next:

              Warnings

              Contraindications

              None listed by manufacturer

              Cautions

              Administration not recommended in Wilson disease

              Use caution in patients with hepatic impairment

              Injection contains aluminum; use caution in renal impairment and premature infants

              Acidic pH of the solution may cause tissue irritation

              Previous
              Next:

              Pregnancy & Lactation

              Pregnancy Category: C

              Lactation: Excretion in milk unknown; use with caution

              Pregnancy Categories

              A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

              B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

              C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

              D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

              X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

              NA: Information not available.

              Previous
              Next:

              Pharmacology

              Mechanism of Action

              Cofactor in many enzymes, including ceruloplasmin; involved in formation of iron carrier protein, transferrin

              Helps maintain normal rates of red and white blood cell formation and helps prevent development of deficiency symptoms

              Pharmacokinetics

              Excretion: Intestinal wall, urine, and bile

              Previous
              Next:

              Administration

              Not for direct administration; must dilute; administer only after dilution in not less than 100 mL

              No preservatives - use promptly & discard unused portion

              Previous
              Next:

              Images

              No images available for this drug.
              Previous
              Next:

              Patient Handout

              A Patient Handout is not currently available for this monograph.
              Previous
              Next:

              Formulary

              FormularyPatient Discounts

              Adding plans allows you to compare formulary status to other drugs in the same class.

              To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

              Adding plans allows you to:

              • View the formulary and any restrictions for each plan.
              • Manage and view all your plans together – even plans in different states.
              • Compare formulary status to other drugs in the same class.
              • Access your plan list on any device – mobile or desktop.

              The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

              Tier Description
              1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
              2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
              3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
              4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              NC NOT COVERED – Drugs that are not covered by the plan.
              Code Definition
              PA Prior Authorization
              Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
              QL Quantity Limits
              Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
              ST Step Therapy
              Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
              OR Other Restrictions
              Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
              Additional Offers
              Email to Patient

              From:

              To:

              The recipient will receive more details and instructions to access this offer.

              By clicking send, you acknowledge that you have permission to email the recipient with this information.

              Email Forms to Patient

              From:

              To:

              The recipient will receive more details and instructions to access this offer.

              By clicking send, you acknowledge that you have permission to email the recipient with this information.

              Previous
              Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.