Coenzyme Q10 (Herb/Suppl)

Brand and Other Names:CoQ10, ibedenone, more...mitoquinone, ubidecarenone, ubiquinone, vitamin Q10
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Suggested Dosing

50-200 mg PO daily

CHF: 100 mg/day div BID-TID PO

Myocardial preservation for heart surgery: 200 mg/day PO

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Suggested Uses

Angina, chronic fatigue syndrome, CHF, diabetes mellitus, doxorubicin-induced cardiotoxicity (prevention), HIV/AIDS immunostimulant, hypertension, mitochondrial cytopathies, muscular dystrophies, myopathy (statin-induced)

Efficacy may be effective in CHF, MI, mitochondrial encephalomyopathies

Reduces BP; more studies need before recommendation in hypertension

Inconclusive for stable angina, cardiomyopathy, periodontal disease

Huntington Disease (Orphan)

Orphan indication sponsors

  • Integrative Therapeutics, Inc; 825 Challenger Drive; Green Bay , WI 54311
  • Gel-Tec, Division of Tishcon Corp; 30 New York Avenue; PO Box 331; Westbury, NY 11590

Mitochondrial Cytopathies (Orphan)

Orphan indication sponsor

  • Gel-Tec, Division of TISHCON Corporation; 30 New York Avenue; PO Box 331; Westbury, NY 11590

Pediatric Congestive Heart Failure (Orphan)

Orphan indication sponsor

  • Gel-Tec, Division of TISHCON Corporation; 30 New York Avenue; PO Box 331; Westbury, NY 11590

Epidermolysis Bullosa (Orphan)

Orphan designation of ubidecarenone for treatment of epidermolysis bullosa

Sponsor

  • Berg, LLC (BERG)l 500 Old Connecticut Path, Building B; Framingham, Massachusetts 01701
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Interactions

Interaction Checker

and Coenzyme Q10

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (0)

                  Minor (17)

                  • atorvastatin

                    atorvastatin decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown.

                  • fluvastatin

                    fluvastatin decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown.

                  • glyburide

                    glyburide decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown.

                  • insulin aspart

                    coenzyme Q10 increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown. Monitor insulin requirements.

                  • insulin detemir

                    coenzyme Q10 increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown. Monitor insulin requirements.

                  • insulin glargine

                    coenzyme Q10 increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown. Monitor insulin requirements.

                  • insulin glulisine

                    coenzyme Q10 increases effects of insulin glulisine by pharmacodynamic synergism. Minor/Significance Unknown. Monitor insulin requirements.

                  • insulin lispro

                    coenzyme Q10 increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown. Monitor insulin requirements.

                  • insulin NPH

                    coenzyme Q10 increases effects of insulin NPH by pharmacodynamic synergism. Minor/Significance Unknown. Monitor insulin requirements.

                  • insulin regular human

                    coenzyme Q10 increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown. Monitor insulin requirements.

                  • lovastatin

                    lovastatin decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown.

                  • pitavastatin

                    pitavastatin decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown.

                  • pravastatin

                    pravastatin decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown.

                  • rosuvastatin

                    rosuvastatin decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown.

                  • simvastatin

                    simvastatin decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown.

                  • tolazamide

                    tolazamide decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown.

                  • warfarin

                    coenzyme Q10 decreases effects of warfarin by pharmacodynamic antagonism. Minor/Significance Unknown.

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                  Adverse Effects

                  Frequency Not Defined

                  Diarrhea

                  Appetite decreased

                  Elevated LFTs

                  Gastric distress

                  Nausea

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                  Warnings

                  Cautions

                  Biliary obstruction, concurrent antihypertensives, concurrent cancer chemotherapy, concurrent radiation therapy, hepatic insufficiency, hypertension

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                  Pregnancy & Lactation

                  Pregnancy Category: N/A

                  Lactation: N/A

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Metabolism: N/A

                  Excretion: N/A

                  Mechanism of Action

                  Ubiquinone: involved in electron transport chain

                  Ubiquinol: antioxidant, membrane stabilizer

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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.