Dosing & Uses
Dosage Forms & Strengths
lotion
- 0.05%
cream
- 0.025%
- 0.05%
ointment
- 0.05%
tape
- 4mcg/cm²
Inflammatory/Pruritic Dermatoses
Tape: Apply qDay-q12hr
Cream/Lotion: apply qDay-q6hr (typically q8-12hr)
Dosage Forms & Strengths
lotion
- 0.05%
ointment/cream
- 0.025%
- 0.05%
tape
- 4mcg/cm²
Inflammatory/Pruritic Dermatoses
Tape: Apply qDay-q12hr
Cream/Lotion: apply qDay-q6hr (typically q8-12hr)
Limit to minimum amount necessary for therapeutic efficacy
Adverse Effects
Frequency Not Defined
Skin atrophy
Striae
Acneform lesions
Eruptions
Miliaria
Burning
Irritation
Secondary infection
Hypertrichosis
Acne
Pigmentation changes
HPA suppression (with higher potency used >2 wk)
Postmarketing Reports
Skin: Skin striae, hypersensitivity, skin atrophy, contact dermatitis, skin discoloration
Warnings
Contraindications
Lesions exuding serum
Intertriginous areas (tape)
Hypersensitivity
Ophthalmic use
Cautions
Chronic topical corticosteroid therapy may interfere with growth and development in children
Children may exhibit greater susceptibility to corticosteroid-induced HPA axis suppression and Cushing's syndrome due to larger skin surface area to body weight ratio
Use med to very high potency for <2 wk to reduce local and systemic side effects
Use low potency for chronic therapy
Kaposi's sarcoma reported with prolonged corticosteroid therapy
Avoid medium to very high potency on face, folds, groin because can increase steroid absorption
Use lower potency for children (ie, increase BSA/kg, therefore increase systemic absorption)
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Excretion in milk unknown; use with caution
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation
Pharmacokinetics
Absorption: Minimal (~1%); nature of skin at application; occlusion and inflammation may increase absorption
Distribution: Throughout local skin
Metabolism: Liver
Excretion: Urine; feces (small amounts)
Images
BRAND | FORM. | UNIT PRICE | PILL IMAGE |
---|---|---|---|
Cordran Tape Large Roll topical - | 4 mcg/cm2 tape | ![]() | |
flurandrenolide topical - | 0.05 % cream | ![]() | |
flurandrenolide topical - | 0.05 % lotion | ![]() | |
flurandrenolide topical - | 0.05 % cream | ![]() | |
flurandrenolide topical - | 0.05 % ointment | ![]() | |
flurandrenolide topical - | 0.05 % lotion | ![]() | |
Cordran topical - | 0.05 % lotion | ![]() | |
Cordran topical - | 0.05 % cream | ![]() | |
Cordran topical - | 0.025 % cream | ![]() | |
Cordran topical - | 0.05 % ointment | ![]() |
Copyright © 2010 First DataBank, Inc.
Patient Handout
flurandrenolide topical
FLURANDRENOLIDE TAPE - TOPICAL
(flewr-an-DREN-oh-lide)
COMMON BRAND NAME(S): Cordran
USES: This medication is used to treat a variety of skin conditions (such as eczema, dermatitis, allergies, rash). Flurandrenolide reduces the swelling, itching, and redness that can occur in these types of conditions. This medication is a medium-strength corticosteroid. The tape acts to protect the treated skin and makes the medication more effective and longer-lasting.
HOW TO USE: Use this medication on the skin only. However, do not use it on the face, groin, or underarms unless directed to do so by your doctor.Wash and dry your hands before using. Clean and dry the affected area before applying the tape. Measure the proper amount of tape to be used. Tape should always be cut, never torn. Apply the tape to the skin and press on the tape to keep it in place. Remove the tape after 12 hours and replace with fresh tape unless directed otherwise by your doctor. Do not use other bandages or cover/wrap the area unless directed to do so by your doctor.After applying the medication, wash your hands, unless you are using this medication to treat the hands. Use carefully if applying to the face. Avoid contact with the eyes because this may worsen or cause glaucoma. Also, avoid applying this medication in the nose or mouth. If you get the medication in your eyes, nose, or mouth, remove the tape and rinse with plenty of water.Use this medication only for the condition prescribed. Do not use more tape than prescribed, apply more often, or use for longer than prescribed. Your condition will not clear faster, but your risk of side effects may be increased.Tell your doctor if your condition lasts or gets worse after 2 weeks.
SIDE EFFECTS: Stinging, burning, itching, irritation, dryness, or redness of the skin may occur when the tape is first applied to the skin. These effects should disappear in a few days as your body adjusts to the medication. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: stretch marks, skin thinning/discoloration, acne, too much hair growth, small red bumps on the skin (folliculitis).Skin infections can become worse when using this medication. Notify your doctor promptly if redness, swelling, or irritation does not improve.Rarely, it is possible this medication will be absorbed from the skin into the bloodstream. This can lead to side effects of too much corticosteroid. These side effects are more likely in children, and in people who use this medication for a long time or over large areas of the skin. Tell your doctor right away if any of the following side effects occur: unusual/extreme tiredness, weight loss, headache, swelling ankles/feet, increased thirst/urination, vision problems.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before using flurandrenolide, tell your doctor or pharmacist if you are allergic to it; or to other corticosteroids (such as hydrocortisone, prednisone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: poor blood circulation, diabetes, immune system problems, other skin conditions (such as rosacea, perioral dermatitis).Do not use if there is an infection or sore in the area to be treated.Rarely, using corticosteroid medications for a long time or over large areas of skin can make it more difficult for your body to respond to physical stress. Before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past few months.Though it is unlikely, this medication may temporarily slow down a child's growth if used for a long time. See the doctor regularly so your child's height can be checked.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this drug passes into breast milk when applied to the skin. Similar medications pass into breast milk when taken by mouth. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: Do not share this medication with others. This medication has been prescribed for your current condition only. Do not use it later for another skin problem unless told to do so by your doctor. A different medication may be necessary in that case.Lab and/or medical tests (such as adrenal gland function) may be done while you are using this medication, especially if you use this drug for an extended period of time or apply it over large areas of the body. Keep all medical and lab appointments. Consult your doctor for more details.
MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.
STORAGE: Store at room temperature away from moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised May 2023. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
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